PANTHER Gene Information   
Gene Symbol(s): Icmt
Organism: Rattus norvegicus
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Gene Name: Protein-S-isoprenylcysteine O-methyltransferase
Gene ID: 621618
Protein ID: Q9WVM4
Persistent Id: PTN000295620
Alternate Ids:
14548071(GI) Farnesyl cysteine carboxyl methyltransferase(Synonym)
2.1.1.100 {ECO:0000250|UniProtKB:O60725}(EC) ENSRNOG00000010953(Ensembl)
G3V7G5(AltAccession) NP_579844(refSeq)
AAD42926(EMBL-CDS) ICMT_RAT(UniProtKB-ID)
ENSRNOT00000014625(Ensembl_TRS) CH473968(EMBL)
CHEMBL2298(ChEMBL) Icmt{ECO:0000312|RGD:621618}(Symbol)
ENSRNOP00000014625(Ensembl_PRO) 621618(RGD)
170818(GeneID)
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PANTHER Classification
PANTHER Family: PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE (PTHR12714)
PANTHER Subfamily: PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE (PTHR12714:SF9)  
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:
PANTHER protein class: protein modifying enzyme
Pathway Categories: No pathway information available
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: cAMP response element binding protein binding, protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
GO BP Complete: multicellular organism growth, bone mineralization, regulation of protein localization, CAAX-box protein maturation, determination of adult lifespan, C-terminal protein methylation, neuromuscular process, protein localization, regulation of Ras protein signal transduction, TOR signaling, S-adenosylmethioninamine metabolic process, protein methylation, fibroblast proliferation, in utero embryonic development, S-adenosylhomocysteine metabolic process, liver development, positive regulation of fibroblast proliferation, regulation of cellular senescence, methylation
GO CC Complete: endoplasmic reticulum membrane, cytoplasmic side of rough endoplasmic reticulum membrane, endoplasmic reticulum, large ribosomal subunit
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: MAPK1/MAPK3 signaling, Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, MAPK family signaling cascades, Signal Transduction, RAF/MAP kinase cascade, RAS processing, Metabolism of proteins, Post-translational protein modification

Orthologs