PANTHER Gene Information

Gene Symbol(s):

brat

Organism:

Drosophila melanogaster

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Gene Name:

Brain tumor protein

Gene ID:

FBgn0010300

Protein ID:

Q8MQJ9

Persistent Id:

PTN001188233

Alternate Ids:

45552407(GI)	NP_476945(refSeq)
AAF13929(EMBL-CDS)	FBgn0010300(Ensembl)
DQ138866(EMBL)	35197(GeneID)
FBgn0010300(FlyBase)	A4V0U9(AltAccession)
FBpp0080703(Ensembl_PRO)	FBtr0344846(Ensembl_TRS)
BRAT_DROME(UniProtKB-ID)	BRAT(Synonym)
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PANTHER Classification

PANTHER Family:	E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED (PTHR24104)
PANTHER Subfamily:	BRAIN TUMOR PROTEIN (PTHR24104:SF41)
PANTHER GO-slim Molecular Function:	ubiquitin protein ligase activity mRNA 3'-UTR binding
PANTHER GO-slim Biological Process:	protein polyubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process
PANTHER GO-slim Cellular Component:
PANTHER protein class:	ubiquitin-protein ligase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	zinc ion binding, translation regulator activity, protein binding, translation repressor activity, mRNA 3'-UTR binding
GO BP Complete:	asymmetric neuroblast division resulting in ganglion mother cell formation, regulation of neuroblast proliferation, segmentation, neuron differentiation, negative regulation of cell population proliferation, regulation of synaptic assembly at neuromuscular junction, neural precursor cell proliferation, regulation of synaptic vesicle endocytosis, rRNA transcription, neuroblast fate determination, asymmetric cell division, brain development, ganglion mother cell fate determination, regulation of translation, ventral cord development, negative regulation of gene expression, neuroblast proliferation, negative regulation of neuroblast proliferation, oogenesis, neuroblast development, negative regulation of translation, regulation of neurogenesis, neuroblast differentiation
GO CC Complete:	cytoplasm, cytosol, apical cortex, neuronal cell body, basal cortex

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Immune System, Innate Immune System, Neutrophil degranulation

Orthologs

ID	Organism	Type
HUMAN\|HGNC=15974\|UniProtKB=Q9C040	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000016522.6\|UniProtKB=A0A2I3TV72	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000007303.3\|UniProtKB=A0A2I2Y1K2	Gorilla gorilla gorilla	O
MOUSE\|MGI=MGI=1933163\|UniProtKB=Q9ESN6	Mus musculus	O
RAT\|RGD=1310981\|UniProtKB=D3ZQG6	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000008816\|UniProtKB=A4IF63	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000029200.4\|UniProtKB=A0A8W4F9B9	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000020605.4\|UniProtKB=A0A3Q2LI79	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000031235.4\|UniProtKB=A0A2I2U228	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845008493.1\|UniProtKB=A0A8I3MY29	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000001127.4\|UniProtKB=A0A5F8G5X1	Monodelphis domestica	O
CHICK\|Ensembl=ENSGALG00010014102.1\|UniProtKB=F1NEW3	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000016475.3\|UniProtKB=A0A803TMP4	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000015934.4\|UniProtKB=G1KRX0	Anolis carolinensis	O
XENLA\|Gene=trim2.L\|UniProtKB=A0A8J0UBJ6	Xenopus laevis	O
XENLA\|Gene=trim2.S\|UniProtKB=Q6GQA4	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-942459\|UniProtKB=Q6DJS4	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000002573.2\|UniProtKB=H2LBD6	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-090312-70\|UniProtKB=B8A5M1	Danio rerio	O
ORYLA\|Ensembl=ENSORLG00000008416.2\|UniProtKB=H2LWS3	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-050327-99\|UniProtKB=F1QFW2	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000008498.1\|UniProtKB=W5MPN3	lepisosteus oculatus	O
HUMAN\|HGNC=10064\|UniProtKB=O75382	Homo sapiens	O
GORGO\|Ensembl=ENSGGOG00000013289.3\|UniProtKB=G3RBV0	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000007728.4\|UniProtKB=F7C974	Macaca mulatta	O
MOUSE\|MGI=MGI=1860040\|UniProtKB=Q9R1R2	Mus musculus	O
RAT\|RGD=70074\|UniProtKB=O70277	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000003565.5\|UniProtKB=A7MB36	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000059302.1\|UniProtKB=A0A287B897	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000056285.1\|UniProtKB=A0A9L0TCR6	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000004634.6\|UniProtKB=A0A2I2U851	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845008173.1\|UniProtKB=A0A8I3RVW6	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000018582.4\|UniProtKB=F7FDA8	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000001409.3\|UniProtKB=F7D344	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010001617.1\|UniProtKB=A0A8V0X2Y8	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000010088.4\|UniProtKB=H9GFZ1	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000015325.3\|UniProtKB=H9GM75	Anolis carolinensis	O
XENLA\|Gene=trim3.S\|UniProtKB=A0A8J1MCR1	Xenopus laevis	O
XENLA\|Gene=trim3.L\|UniProtKB=A0A1L8HJV3	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-5826034\|UniProtKB=F6TSI0	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000003504.2\|UniProtKB=A0A3B3IML7	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-080522-4\|UniProtKB=E7F1U3	Danio rerio	O
ORYLA\|Ensembl=ENSORLG00000004188.2\|UniProtKB=A0A3B3HRZ8	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-070112-1132\|UniProtKB=A0A8M2B1X4	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000008640.1\|UniProtKB=W5MQ45	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000012056.2\|UniProtKB=F6Z0X9	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000005321.1\|UniProtKB=F7BPN8	Ciona intestinalis	O
BRAFL\|Gene=LOC118413625\|UniProtKB=A0A9J7KYW4	Branchiostoma floridae	O
BRAFL\|Gene=LOC118427258\|UniProtKB=A0A9J7M2J8	Branchiostoma floridae	O
BRAFL\|Gene=LOC118422926\|UniProtKB=A0A9J7N258	Branchiostoma floridae	O
BRAFL\|Gene=LOC118407546\|UniProtKB=A0A9J7HR11	Branchiostoma floridae	O
BRAFL\|Gene=LOC118432513\|UniProtKB=A0A9J7MFU8	Branchiostoma floridae	O
BRAFL\|Gene=LOC118408724\|UniProtKB=A0A9J7KL64	Branchiostoma floridae	O
BRAFL\|Gene=LOC118431812\|UniProtKB=A0A9J7ME97	Branchiostoma floridae	O
BRAFL\|Gene=LOC118431520\|UniProtKB=A0A9J7MEP0	Branchiostoma floridae	O
BRAFL\|Gene=LOC118416255\|UniProtKB=A0A9J7L6V8	Branchiostoma floridae	O
BRAFL\|Gene=LOC118423263\|UniProtKB=A0A9J7N2M2	Branchiostoma floridae	O
BRAFL\|Gene=LOC118419218\|UniProtKB=A0A9J7LEP1	Branchiostoma floridae	O
BRAFL\|Gene=LOC118422507\|UniProtKB=A0A9J7LQ32	Branchiostoma floridae	O
BRAFL\|Gene=LOC118412317\|UniProtKB=A0A9J7MKJ9	Branchiostoma floridae	O
BRAFL\|Gene=LOC118420452\|UniProtKB=A0A9J7MVQ0	Branchiostoma floridae	O
BRAFL\|Gene=LOC118418771\|UniProtKB=A0A9J7LD99	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC592222\|UniProtKB=A0A7M7NKF8	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00003559\|UniProtKB=P34611	Caenorhabditis elegans	LDO
ANOGA\|EnsemblGenome=AGAP029444\|UniProtKB=A0A453YZF6	Anopheles gambiae	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_299638\|UniProtKB=E9FRJ8	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW011089\|UniProtKB=B7Q429	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG112963\|UniProtKB=T1EFN6	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g245515\|UniProtKB=A7SIN0	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g119814\|UniProtKB=A7SIM9	Nematostella vectensis	O
NEMVE\|Gene_ORFName=NEMVEDRAFT_v1g197055\|UniProtKB=A7RH37	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g160201\|UniProtKB=A7RLP9	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g199481\|UniProtKB=A7RMX0	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g88772\|UniProtKB=A7RP84	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g199475\|UniProtKB=A7RMW4	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g215519\|UniProtKB=A7SPQ3	Nematostella vectensis	O
ENTH1\|EnsemblGenome=CL6EHI_198840\|UniProtKB=C4LWT0	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_023460\|UniProtKB=C4LUQ5	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_053120\|UniProtKB=C4M3D0	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_086360\|UniProtKB=C4M8Y4	Entamoeba histolytica	O
DICPU\|EnsemblGenome=DICPUDRAFT_153743\|UniProtKB=F0ZPN2	Dictyostelium purpureum	O