PANTHER Gene Information

Gene Symbol(s):

raskol

Organism:

Drosophila melanogaster

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Gene Name:

Ras GTPase-activating protein raskol

Gene ID:

FBgn0261570

Protein ID:

Q8T498

Persistent Id:

PTN000023172

Alternate Ids:

GAP2_DROME(UniProtKB-ID)	AE014298(EMBL)
32754(GeneID)	Q95TL0(AltAccession)
raskol{ECO:0000303\|PubMed:30763317}(Symbol)	FBgn0261570(FlyBase)
FBgn0261570(Ensembl)	221222525(GI)
GAP2(Synonym)	AAL90028(EMBL-CDS)
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PANTHER Classification

PANTHER Family:	RAS GTPASE-ACTIVATING PROTEINS (PTHR10194)
PANTHER Subfamily:	RAS GTPASE-ACTIVATING PROTEIN RASKOL (PTHR10194:SF60)
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:
PANTHER protein class:	GTPase-activating protein

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	-
GO BP Complete:	negative regulation of Ras protein signal transduction
GO CC Complete:	apical cortex

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

MAPK1/MAPK3 signaling, Regulation of RAS by GAPs, MAPK family signaling cascades, RAF/MAP kinase cascade, Signal Transduction

Orthologs

ID	Organism	Type
HUMAN\|HGNC=26129\|UniProtKB=Q86YV0	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000033776.3\|UniProtKB=H2RCL7	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000000560.3\|UniProtKB=G3QE65	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000003030.4\|UniProtKB=F6VMV1	Macaca mulatta	O
MOUSE\|MGI=MGI=2444128\|UniProtKB=Q8C2K5	Mus musculus	O
RAT\|RGD=1309019\|UniProtKB=A0A8I6GE24	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000011602\|UniProtKB=A6QQ91	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000013839.5\|UniProtKB=F1SA02	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000009236.3\|UniProtKB=A0A9L0TFR0	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000018305.5\|UniProtKB=M3WNT3	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845016503.1\|UniProtKB=A0A8I3RZE0	Canis lupus familiaris	O
ORNAN\|Ensembl=ENSOANG00000005135.4\|UniProtKB=F6WGI2	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010003815.1\|UniProtKB=A0A8V0XAM2	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000016567.4\|UniProtKB=G1KSS9	Anolis carolinensis	O
XENLA\|Gene=rasal3.L\|UniProtKB=A0A8J1MNR9	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-6048180\|UniProtKB=A0A6I8Q1V3	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000001820.2\|UniProtKB=A0A3B3HZL3	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-101130-3\|UniProtKB=E7FDZ7	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000006735.1\|UniProtKB=W5MIC6	lepisosteus oculatus	O
HUMAN\|HGNC=9874\|UniProtKB=Q9UJF2	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000001717.6\|UniProtKB=A0A2I3RED3	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000001070.3\|UniProtKB=G3QD74	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000021073.4\|UniProtKB=F7GY93	Macaca mulatta	LDO
MOUSE\|MGI=MGI=2443881\|UniProtKB=E9PW37	Mus musculus	LDO
RAT\|RGD=1307566\|UniProtKB=A0A8I6AI87	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000015537.6\|UniProtKB=E1B800	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00005029882.1\|UniProtKB=A0A8D1YF92	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000012126.4\|UniProtKB=A0A5F5PXK1	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000014404.6\|UniProtKB=A0A2I2UEF2	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845007594.1\|UniProtKB=A0A8I3MXA3	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000005974.4\|UniProtKB=F6VZA7	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000000953.4\|UniProtKB=A0A6I8P4T0	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010011342.1\|UniProtKB=A0A8V0YAH9	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000012811.4\|UniProtKB=A0A803TCI9	Anolis carolinensis	LDO
XENLA\|Gene=rasal2.S\|UniProtKB=A0A8J1KJC3	Xenopus laevis	O
XENLA\|Gene=dab2ip.L\|UniProtKB=A0A8J1MYT0	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-5795955\|UniProtKB=A0A8J0R128	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000007349.2\|UniProtKB=A0A3B3HXV3	Oryzias latipes	LDO
DANRE\|Gene=rasal2\|UniProtKB=A0A8M2BIR4	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000009149.1\|UniProtKB=W5MRZ7	lepisosteus oculatus	LDO
HUMAN\|HGNC=11497\|UniProtKB=Q96PV0	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000033928.3\|UniProtKB=A0A2I3RBQ9	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000009923.3\|UniProtKB=G3RM60	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000010659.4\|UniProtKB=A0A1D5Q7A3	Macaca mulatta	O
MOUSE\|MGI=MGI=3039785\|UniProtKB=F6SEU4	Mus musculus	O
RAT\|RGD=621090\|UniProtKB=Q9QUH6	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000020975.6\|UniProtKB=F1MBI8	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000001513.5\|UniProtKB=A0A8W4FKW6	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000020868.4\|UniProtKB=A0A3Q2GXR9	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000013656.6\|UniProtKB=A0A337SGI6	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845022368.1\|UniProtKB=A0A8I3S6G2	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000014104.4\|UniProtKB=F6QIV3	Monodelphis domestica	O
ANOCA\|Ensembl=ENSACAG00000011297.4\|UniProtKB=A0A803T5C7	Anolis carolinensis	O
XENLA\|Gene=syngap1.S\|UniProtKB=A0A8J1LNL3	Xenopus laevis	O
XENLA\|Gene=LOC108698543\|UniProtKB=A0A8J1LGT1	Xenopus laevis	O
XENTR\|Gene=syngap1\|UniProtKB=A0A8J1IRI8	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000003202.2\|UniProtKB=A0A3B3IG04	Oryzias latipes	O
DANRE\|Gene=syngap1a\|UniProtKB=A0A8M2B5U5	Danio rerio	O
ORYLA\|Ensembl=ENSORLG00000016229.2\|UniProtKB=A0A3B3HQL4	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-100921-2\|UniProtKB=E7F1U4	Danio rerio	O
HUMAN\|HGNC=17294\|UniProtKB=Q5VWQ8	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000021317.5\|UniProtKB=H2RC65	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000000186.3\|UniProtKB=A0A2I2Y8Y8	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000004639.4\|UniProtKB=A0A5F7ZR20	Macaca mulatta	O
MOUSE\|MGI=MGI=1916851\|UniProtKB=Q3UHC7	Mus musculus	O
RAT\|RGD=621686\|UniProtKB=Q6P730	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000008232.6\|UniProtKB=A0A3Q1LQ88	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000005524.5\|UniProtKB=A0A5G2QPI5	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000024868.4\|UniProtKB=A0A3Q2HBN4	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000013406.6\|UniProtKB=A0A2I2U836	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845014246.1\|UniProtKB=A0A8I3RY24	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000019667.4\|UniProtKB=A0A5F8H0M0	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000011959.5\|UniProtKB=A0A6I8NK08	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010027720.1\|UniProtKB=A0A8V1A5A8	Gallus gallus	O
XENLA\|Gene=LOC108699920\|UniProtKB=A0A8J1LQV9	Xenopus laevis	O
XENLA\|Gene=LOC108698203\|UniProtKB=A0A8J1LFI5	Xenopus laevis	O
XENTR\|Gene=dab2ip\|UniProtKB=A0A8J1IQP6	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000017607.2\|UniProtKB=H2MTD5	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000003707.2\|UniProtKB=A0A3B3IIB9	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-030131-2449\|UniProtKB=A5PF31	Danio rerio	O
DANRE\|Gene=dab2ipa\|UniProtKB=A0A8M6YZX5	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000003915.1\|UniProtKB=W5M8I3	lepisosteus oculatus	O
BRAFL\|Gene=LOC118421705\|UniProtKB=A0A9J7LNM2	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC574558\|UniProtKB=A0A7M7PLT6	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00001516\|UniProtKB=Q8MLZ5	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG16118\|UniProtKB=A8XP25	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00106980\|UniProtKB=A0A2A6D0F5	Pristionchus pacificus	LDO
ANOGA\|EnsemblGenome=AGAP004692\|UniProtKB=A0NFG1	Anopheles gambiae	LDO
IXOSC\|EnsemblGenome=ISCW015673\|UniProtKB=B7P6L4	Ixodes scapularis	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g245865\|UniProtKB=A7SKG2	Nematostella vectensis	LDO
YEAST\|SGD=S000001575\|UniProtKB=P33314	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_ABR021W\|UniProtKB=Q75DK0	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000177461\|UniProtKB=A0A1D8PFE8	Candida albicans	O
CANAL\|CGD=CAL0000199838\|UniProtKB=Q5A506	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_D23903g\|UniProtKB=Q6C802	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_03735\|UniProtKB=Q5B6U5	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_6G12340\|UniProtKB=Q4WLU0	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU03852\|UniProtKB=Q7RW81	Neurospora crassa	LDO
SCLS1\|EnsemblGenome=SS1G_04989\|UniProtKB=A7EI47	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_05526\|UniProtKB=Q0URT8	Phaeosphaeria nodorum	LDO
USTMA\|EnsemblGenome=UMAG_05039\|UniProtKB=A0A0D1BZN3	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_11646\|UniProtKB=E3KNL5	Puccinia graminis	LDO
PUCGT\|EnsemblGenome=PGTG_11670\|UniProtKB=E3KNN9	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_92146\|UniProtKB=F4PCP2	Batrachochytrium dendrobatidis	LDO
ENTH1\|EnsemblGenome=CL6EHI_156210\|UniProtKB=C4M4C1	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0271750\|UniProtKB=Q55AR6	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_79326\|UniProtKB=F0ZM90	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0282055\|UniProtKB=Q54T13	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_155156\|UniProtKB=F0ZT79	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0284177\|UniProtKB=Q54Q13	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_96454\|UniProtKB=F0Z8L5	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0277675\|UniProtKB=Q86JJ7	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_156697\|UniProtKB=F0ZX68	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0274211\|UniProtKB=Q8SSU4	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_4386\|UniProtKB=F0Z641	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0278483\|UniProtKB=Q54Y08	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_160044\|UniProtKB=F1A5K7	Dictyostelium purpureum	LDO
TRIV3\|Gene_ORFName=TVAG_277960\|UniProtKB=A2DU37	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_059750\|UniProtKB=A2FB27	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_268180\|UniProtKB=A2DLG7	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_232110\|UniProtKB=A2G2R5	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_523070\|UniProtKB=A2GF60	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_254050\|UniProtKB=A2DMS2	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_556880\|UniProtKB=A2GDU5	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_281880\|UniProtKB=A2E9Q3	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_419730\|UniProtKB=A2EIU7	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_148180\|UniProtKB=A2FFI6	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_118810\|UniProtKB=A2EAY4	Trichomonas vaginalis	LDO
PHYRM\|Gene=H3GMA0_PHYRM\|UniProtKB=H3GMA0	Phytophthora ramorum	O
PHYRM\|Gene=H3GJ72_PHYRM\|UniProtKB=H3GJ72	Phytophthora ramorum	LDO