PANTHER Gene Information

Gene Symbol(s):

folA

Organism:

Escherichia coli

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Gene Name:

Dihydrofolate reductase

Gene ID:

BAB96616

Protein ID:

P0ABQ4

Persistent Id:

PTN001356377

Alternate Ids:

75169947(GeneID)	157833645(GI)
CHEMBL2364669(ChEMBL)	AAC73159(Ensembl_PRO)
DYR(Synonym)	folA(Symbol)
P00379(AltAccession)	DYR_ECOLI(UniProtKB-ID)
MetaCyc:DIHYDROFOLATEREDUCT-MON(BioCyc)	NC_000913(refSeq)
AAC73159(Ensembl_TRS)	1.5.1.3(EC)
AAA87976(EMBL-CDS)	U00096(EMBL)
b0048(Ensembl)
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PANTHER Classification

PANTHER Family:	DIHYDROFOLATE REDUCTASE (PTHR48069)
PANTHER Subfamily:	DIHYDROFOLATE REDUCTASE (PTHR48069:SF3)
PANTHER GO-slim Molecular Function:	nucleotide binding oxidoreductase activity
PANTHER GO-slim Biological Process:	dicarboxylic acid metabolic process amide metabolic process organonitrogen compound biosynthetic process organic cyclic compound biosynthetic process cellular nitrogen compound biosynthetic process aromatic compound biosynthetic process heterocycle biosynthetic process folic acid-containing compound metabolic process
PANTHER GO-slim Cellular Component:
PANTHER protein class:	reductase

Pathway Categories:

Tetrahydrofolate biosynthesis

Dihydrofolate synthase

Formyltetrahydrofolate biosynthesis

Dihydrofolate reductase

Tetrahydrofolate biosynthesis

Dihydrofolate reductase

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	NADP binding, dihydrofolic acid binding, protein binding, oxidoreductase activity, methotrexate binding, NADP+ binding, NADPH binding, dihydrofolate reductase activity, folic acid binding
GO BP Complete:	response to methotrexate, dihydrofolate metabolic process, folic acid metabolic process, response to antibiotic, folic acid biosynthetic process, 10-formyltetrahydrofolate biosynthetic process, response to xenobiotic stimulus, tetrahydrofolate biosynthetic process, one-carbon metabolic process
GO CC Complete:	cytosol

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
XENLA\|Gene=dhfrl.S\|UniProtKB=A0A8J1MSA8	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-975267\|UniProtKB=Q28J42	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000016391.2\|UniProtKB=H2MP65	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-060929-1190\|UniProtKB=Q1LWC6	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000015270.1\|UniProtKB=W5NDT1	lepisosteus oculatus	O
HUMAN\|HGNC=27309\|UniProtKB=Q86XF0	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000051799.1\|UniProtKB=A0A2I3TPN8	Pan troglodytes	O
HUMAN\|HGNC=2861\|UniProtKB=P00374	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000017042.5\|UniProtKB=H2QR61	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000022366.2\|UniProtKB=A0A2I2Z6I4	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000004229.4\|UniProtKB=F6SNN4	Macaca mulatta	O
MACMU\|Ensembl=ENSMMUG00000018283.4\|UniProtKB=H9YW18	Macaca mulatta	LDO
MOUSE\|MGI=MGI=94890\|UniProtKB=P00375	Mus musculus	LDO
RAT\|RGD=2500\|UniProtKB=Q920D2	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000007681.6\|UniProtKB=A0A140T872	Bos taurus	O
BOVIN\|Gene=DHFR\|UniProtKB=P00376	Bos taurus	LDO
PIG\|Gene=DHFR\|UniProtKB=P00377	Sus scrofa	O
PIG\|Ensembl=ENSSSCG00000031117.2\|UniProtKB=A0A287ABU6	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000026827.4\|UniProtKB=A0A9L0SH18	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000026745.4\|UniProtKB=A0A5F5XZH0	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845026663.1\|UniProtKB=A0A5F4C1E3	Canis lupus familiaris	O
CANLF\|Ensembl=ENSCAFG00845000096.1\|UniProtKB=A0A8I3RQM2	Canis lupus familiaris	O
CANLF\|Ensembl=ENSCAFG00845005830.1\|UniProtKB=A0A8I3N1Y0	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000044210.1\|UniProtKB=A0A5F8HIZ3	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000024860.3\|UniProtKB=F7A9L9	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000001607.4\|UniProtKB=A0A6I8NIG7	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010007224.1\|UniProtKB=A3RKL3	Gallus gallus	LDO
CHICK\|Gene=DHFR\|UniProtKB=P00378	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000010508.3\|UniProtKB=G1KK77	Anolis carolinensis	LDO
XENLA\|Gene=dhfr.L\|UniProtKB=Q5U543	Xenopus laevis	LDO
ORYLA\|Ensembl=ENSORLG00000005055.2\|UniProtKB=H2LK22	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-010406-5\|UniProtKB=Q6IQS4	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000005217.1\|UniProtKB=W5MD25	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000019832.1\|UniProtKB=H2XNW6	Ciona intestinalis	LDO
CIOIN\|Ensembl=ENSCING00000022228.1\|UniProtKB=H2XLB1	Ciona intestinalis	O
BRAFL\|Gene=LOC118412318\|UniProtKB=A0A9J7KUU4	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC575335\|UniProtKB=A0A7M7RBU0	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00007974\|UniProtKB=Q93341	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00033316\|UniProtKB=A8XF85	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00099425\|UniProtKB=A0A2A6C9P0	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00110364\|UniProtKB=A0A2A6D2B5	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00274181\|UniProtKB=A0A2A6BKN1	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0004087\|UniProtKB=P17719	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP010278\|UniProtKB=Q7Q0L5	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC030679\|UniProtKB=D6WRE9	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_240087\|UniProtKB=E9GAU4	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_301858\|UniProtKB=E9GAU3	Daphnia pulex	LDO
HELRO\|EnsemblGenome=HelroG98642\|UniProtKB=T1G9P0	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g210271\|UniProtKB=A7SCT0	Nematostella vectensis	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g146670\|UniProtKB=A7T5F9	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG52382\|UniProtKB=B3RI81	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_29079\|UniProtKB=A9VA22	Monosiga brevicollis	LDO
YEAST\|SGD=S000005762\|UniProtKB=P07807	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_ACR124W\|UniProtKB=Q75BZ5	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000177250\|UniProtKB=Q5A5E0	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_C12771g\|UniProtKB=Q6CC38	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_06108\|UniProtKB=Q5B022	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_2G08890\|UniProtKB=Q4X1T0	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU16651\|UniProtKB=U9W889	Neurospora crassa	LDO
SCLS1\|Gene_ORFName=SS1G_08803\|UniProtKB=A7ETZ6	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_13852\|UniProtKB=Q0U312	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPCC1223.08c\|UniProtKB=P36591	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_01198\|UniProtKB=B6K009	Schizosaccharomyces japonicus	LDO
CRYNJ\|EnsemblGenome=CNJ01940\|UniProtKB=Q07801	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_10394\|UniProtKB=A0A0D1CPU1	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_11433\|UniProtKB=E3KLR5	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_91777\|UniProtKB=F4PBG6	Batrachochytrium dendrobatidis	LDO
DICDI\|dictyBase=DDB_G0286755\|UniProtKB=Q54LA0	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_88906\|UniProtKB=F0ZSE1	Dictyostelium purpureum	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_261857\|UniProtKB=B8BYC4	Thalassiosira pseudonana	LDO
MAIZE\|EnsemblGenome=Zm00001eb027080\|UniProtKB=A0A804LPV2	Zea mays	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr15g0709291\|UniProtKB=A0A251SBZ0	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C500271850\|UniProtKB=A0A9R1X9X5	Lactuca sativa	LDO
GOSHI\|Gene=LOC107960692\|UniProtKB=A0A1U8PQF3	Gossypium hirsutum	O
GOSHI\|Gene=LOC107905452\|UniProtKB=A0A1U8JFU3	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_034096\|UniProtKB=A0A061FK09	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g024737mg\|UniProtKB=A0A067HA24	Citrus sinensis	LDO
POPTR\|EnsemblGenome=POPTR_005G230700v3\|UniProtKB=A0A2K2AL36	Populus trichocarpa	O
POPTR\|Gene_ORFName=POPTR_005G230400\|UniProtKB=A0A3N7GB50	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_18G020100\|UniProtKB=A0A2C9TZL9	Manihot esculenta	LDO
MYCTU\|Gene_OrderedLocusName=Rv2763c\|UniProtKB=P9WNX1	Mycobacterium tuberculosis	LDO
MYCGE\|EnsemblGenome=MG_228\|UniProtKB=P47470	mycoplasma genitalium	LDO
STRR6\|EnsemblGenome=spr1429\|UniProtKB=Q7CRB0	Streptococcus pneumoniae	LDO
STAA8\|EnsemblGenome=SAOUHSC_01434\|UniProtKB=Q2FYK6	Staphylococcus aureus	LDO
LISMO\|Gene=Q8Y627_LISMO\|UniProtKB=Q8Y627	Listeria monocytogenes	LDO
THEMA\|EnsemblGenome=TM_1641\|UniProtKB=Q60034	Thermotoga maritima	LDO
DEIRA\|EnsemblGenome=DR_2632\|UniProtKB=Q9RR65	Deinococcus radiodurans	LDO
GLOVI\|Gene=Q7NHQ9_GLOVI\|UniProtKB=Q7NHQ9	Gloeobacter violaceus	LDO
BACTN\|EnsemblGenome=BT_2048\|UniProtKB=Q8A638	Bacteroides thetaiotaomicron	LDO
CHLTR\|EnsemblGenome=CT_612\|UniProtKB=O84618	Chlamydia trachomatis	LDO
RHOBA\|EnsemblGenome=RB12617\|UniProtKB=Q7UIC9	Rhodopirellula baltica	LDO
FUSNN\|EnsemblGenome=FN0241\|UniProtKB=Q8RGP5	Fusobacterium nucleatum	LDO
NEIMB\|EnsemblGenome=NMB0308\|UniProtKB=Q9K168	Neisseria meningitidis serogroup b	LDO
GEOSL\|EnsemblGenome=GSU0571\|UniProtKB=Q74FN5	Geobacter sulfurreducens	LDO
BRADU\|Gene=folA\|UniProtKB=Q89G37	Bradyrhizobium diazoefficiens	LDO
COXBU\|EnsemblGenome=CBU_1993\|UniProtKB=Q83AB2	Coxiella burnetii	LDO
HAEIN\|EnsemblGenome=HI_0899\|UniProtKB=P43791	Haemophilus influenzae	LDO
SHEON\|Gene_OrderedLocusName=SO_3646\|UniProtKB=Q8EB86	Shewanella oneidensis	LDO
VIBCH\|EnsemblGenome=VC_0440\|UniProtKB=Q9KUS5	Vibrio cholerae	LDO
XANCP\|EnsemblGenome=XCC0788\|UniProtKB=Q8PCE6	Xanthomonas campestris	LDO
PSEAE\|EnsemblGenome=PA0350\|UniProtKB=Q9I6E3	Pseudomonas aeruginosa	LDO
SALTY\|EnsemblGenome=STM0087\|UniProtKB=Q8ZRW1	Salmonella typhimurium	LDO
YERPE\|Gene_OrderedLocusName=YPO0486\|UniProtKB=A0A3N4BLI0	Yersinia pestis	LDO