PANTHER Gene Information   
Gene Symbol(s): PRKN
Organism: Equus caballus
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Gene Name: E3 ubiquitin-protein ligase parkin
Gene ID: ENSECAG00000004645.5
Protein ID: A0A5F5PHB2
Persistent Id: PTN002580850
Alternate Ids:
A0A5F5PHB2(Synonym) ENSECAT00000073370(Ensembl_TRS)
ENSECAP00000047792(Ensembl_PRO) ENSECAG00000004645(Ensembl)
A0A5F5PHB2_HORSE(UniProtKB-ID)
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PANTHER Classification
PANTHER Family: UBIQUILIN (PTHR10677)
PANTHER Subfamily: UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN (PTHR10677:SF40)  
PANTHER GO-slim Molecular Function: polyubiquitin modification-dependent protein binding
PANTHER GO-slim Biological Process: ubiquitin-dependent protein catabolic process
PANTHER GO-slim Cellular Component: cytosol
PANTHER protein class: scaffold/adaptor protein
Pathway Categories: No pathway information available
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: tubulin binding, ubiquitin protein ligase activity, protein-containing complex binding, G protein-coupled receptor binding, F-box domain binding, ubiquitin binding, phospholipase binding, protein-folding chaperone binding, PDZ domain binding, cullin family protein binding, kinase binding, Hsp70 protein binding, protein kinase binding, heat shock protein binding, zinc ion binding, identical protein binding, histone deacetylase binding, polyubiquitin modification-dependent protein binding, beta-catenin binding, ubiquitin-specific protease binding, ubiquitin-protein transferase activity, ubiquitin conjugating enzyme binding, ubiquitin protein ligase binding, actin binding, transcription corepressor activity, metal ion binding, transferase activity, enzyme binding
GO BP Complete: norepinephrine metabolic process, dopamine metabolic process, mitochondrion to lysosome vesicle-mediated transport, adult locomotory behavior, negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, learning, type 2 mitophagy, regulation of cellular response to oxidative stress, regulation of mitochondrial membrane potential, autophagy, aggresome assembly, regulation of protein ubiquitination, proteasomal protein catabolic process, negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, positive regulation of protein localization to membrane, mitophagy, autophagy of mitochondrion, negative regulation of gene expression, proteasome-mediated ubiquitin-dependent protein catabolic process, positive regulation of gene expression, regulation of autophagy, modulation of chemical synaptic transmission, negative regulation of actin filament bundle assembly, regulation of mitochondrion organization, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, response to endoplasmic reticulum stress, protein ubiquitination, negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway, positive regulation of metabolic process, positive regulation of protein linear polyubiquitination, negative regulation of exosomal secretion, positive regulation of dendrite extension, positive regulation of tumor necrosis factor-mediated signaling pathway, negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator, negative regulation of intralumenal vesicle formation, positive regulation of canonical NF-kappaB signal transduction, negative regulation of insulin secretion, positive regulation of transcription by RNA polymerase II, positive regulation of proteasomal protein catabolic process, negative regulation of neuron apoptotic process, positive regulation of mitophagy, negative regulation of transcription by RNA polymerase II, synaptic transmission, dopaminergic, locomotory behavior, startle response, dopamine uptake involved in synaptic transmission, positive regulation of mitochondrial fusion, protein localization to mitochondrion, positive regulation of neurotransmitter uptake, regulation of reactive oxygen species metabolic process, free ubiquitin chain polymerization, protein autoubiquitination, negative regulation of reactive oxygen species metabolic process, regulation of neurotransmitter secretion, protein K11-linked ubiquitination, protein K48-linked ubiquitination, regulation protein catabolic process at presynapse, negative regulation of release of cytochrome c from mitochondria, negative regulation of spontaneous neurotransmitter secretion, negative regulation by host of viral genome replication, protein polyubiquitination, protein catabolic process, regulation of synaptic vesicle endocytosis, protein monoubiquitination, ubiquitin-dependent protein catabolic process, protein destabilization, negative regulation of canonical Wnt signaling pathway, regulation of protein stability, regulation of dopamine metabolic process, cellular response to toxic substance, protein K63-linked ubiquitination, positive regulation of type 2 mitophagy, protein stabilization, protein K6-linked ubiquitination, synaptic transmission, glutamatergic
GO CC Complete: nuclear speck, mitochondrion-derived vesicle, endoplasmic reticulum, Golgi apparatus, neuron projection, dopaminergic synapse, Parkin-FBXW7-Cul1 ubiquitin ligase complex, nucleus, presynapse, perinuclear region of cytoplasm, ubiquitin ligase complex, cytoplasm, mitochondrion, cytosol, protein-containing complex, aggresome
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: -

Orthologs