PANTHER Gene Information

Gene Symbol(s):

PIK3R3

Organism:

Equus caballus

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Gene Name:

Phosphoinositide-3-kinase regulatory subunit 3

Gene ID:

ENSECAG00000033344.3

Protein ID:

A0A3Q2H6M6

Persistent Id:

PTN007422719

Alternate Ids:

ENSECAP00000028821(Ensembl_PRO)	A0A3Q2H6M6_HORSE(UniProtKB-ID)
A0A3Q2H6M6(Synonym)	ENSECAG00000033344(Ensembl)
ENSECAT00000036699(Ensembl_TRS)
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PANTHER Classification

PANTHER Family:	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT (PTHR10155)
PANTHER Subfamily:	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT GAMMA (PTHR10155:SF2)
PANTHER GO-slim Molecular Function:	kinase regulator activity
PANTHER GO-slim Biological Process:	phosphatidylinositol phosphate biosynthetic process insulin receptor signaling pathway
PANTHER GO-slim Cellular Component:	phosphatidylinositol 3-kinase complex
PANTHER protein class:	kinase modulator

Pathway Categories:

VEGF signaling pathway

Phosphatidylinositol 3-kinase

PI3 kinase pathway

p85

T cell activation

Phosphatidylinositol 3-kinase

Hypoxia response via HIF activation

Phosphatidylinositol 3-kinase

Insulin/IGF pathway-protein kinase B signaling cascade

Phosphatidylinositol 3-kinase

Angiogenesis

Phosphatidylinositol 3-kinase

Integrin signalling pathway

Phosphatidylinositol 3-kinase

Axon guidance mediated by netrin

Phosphatidylinositol 3-kinase

Endothelin signaling pathway

Phosphatidylinositol 3-kinase

PDGF signaling pathway

Phosphatidylinositol 3-kinase

p53 pathway feedback loops 2

Phosphatidylinositol 3-kinase

p53 pathway

Phosphatidylinositol 3-kinase

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	phosphotyrosine residue binding, 1-phosphatidylinositol-3-kinase regulator activity
GO BP Complete:	phosphatidylinositol 3-kinase/protein kinase B signal transduction, insulin receptor signaling pathway, positive regulation of gene expression, cell migration involved in sprouting angiogenesis
GO CC Complete:	phosphatidylinositol 3-kinase complex, class IA, phosphatidylinositol 3-kinase complex

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=8981\|UniProtKB=Q92569	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000000685.7\|UniProtKB=H2PYY1	Pan troglodytes	LDO
MACMU\|Ensembl=ENSMMUG00000015080.4\|UniProtKB=H9G113	Macaca mulatta	LDO
MOUSE\|MGI=MGI=109277\|UniProtKB=Q64143	Mus musculus	LDO
RAT\|RGD=621042\|UniProtKB=Q63789	Rattus norvegicus	LDO
BOVIN\|Gene=PIK3R3\|UniProtKB=O46404	Bos taurus	LDO
BOVIN\|Ensembl=ENSBTAG00000002979.6\|UniProtKB=F1MDQ5	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000003909.5\|UniProtKB=A0A4X1W4S4	Sus scrofa	LDO
FELCA\|Ensembl=ENSFCAG00000024092.4\|UniProtKB=A0A337S8Q9	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845020552.1\|UniProtKB=A0A8I3P519	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000002139.4\|UniProtKB=F6YF70	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000005917.4\|UniProtKB=F6QM53	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010023309.1\|UniProtKB=A0A8V1A076	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000015856.4\|UniProtKB=A0A803T5A6	Anolis carolinensis	LDO
XENLA\|Gene=pik3r3.S\|UniProtKB=Q6DD15	Xenopus laevis	LDO
XENLA\|Gene=pik3r3.L\|UniProtKB=Q66IU1	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-6464721\|UniProtKB=Q28IS1	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000010655.2\|UniProtKB=H2M4J1	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000013341.2\|UniProtKB=A0A3B3HQV4	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-040426-1978\|UniProtKB=A0A0R4IUJ2	Danio rerio	O
DANRE\|Gene=pik3r3b\|UniProtKB=A0A8M9PLR5	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000005759.1\|UniProtKB=W5MEZ4	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000023616.1\|UniProtKB=F7BLX7	Ciona intestinalis	O
BRAFL\|Gene=LOC118432571\|UniProtKB=A0A9J7MFS2	Branchiostoma floridae	O
CAEEL\|WormBase=WBGene00000001\|UniProtKB=G5EDP9	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00032086\|UniProtKB=A8XBV2	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00117228\|UniProtKB=A0A2A6BTE0	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0020622\|UniProtKB=Q7KTZ2	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP005583\|UniProtKB=A0A1S4GQF6	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC030884\|UniProtKB=A0A139WP68	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_43714\|UniProtKB=E9G0D1	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_111818\|UniProtKB=E9HA70	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW011707\|UniProtKB=B7Q548	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG76166\|UniProtKB=T1G2G0	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g84479\|UniProtKB=A7RK55	Nematostella vectensis	O
MONBE\|EnsemblGenome=MONBRDRAFT_33139\|UniProtKB=A9V3X4	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_33736\|UniProtKB=A9V765	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_10565\|UniProtKB=A9V6R6	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_24251\|UniProtKB=A9UVV0	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_9122\|UniProtKB=A9V255	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_33646\|UniProtKB=A9V6S8	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_10537\|UniProtKB=A9V6N4	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_12142\|UniProtKB=A9VBC5	Monosiga brevicollis	O
PHYRM\|Gene=H3GME9_PHYRM\|UniProtKB=H3GME9	Phytophthora ramorum	O