PANTHER Gene Information

Gene Symbol(s):

HSD17B8

Organism:

Equus caballus

View Gene in Tree

Tree

Gene Name:

Hydroxysteroid 17-beta dehydrogenase 8

Gene ID:

ENSECAG00000058465.1

Protein ID:

A0A5F5PX36

Persistent Id:

PTN009164804

Alternate Ids:

ENSECAP00000052345(Ensembl_PRO)	ENSECAT00000074322(Ensembl_TRS)
A0A5F5PX36(Synonym)	A0A5F5PX36_HORSE(UniProtKB-ID)
ENSECAG00000058465(Ensembl)
Show All

PANTHER Classification

PANTHER Family:	SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER (PTHR42760)
PANTHER Subfamily:	HYDROXYSTEROID 17-BETA DEHYDROGENASE 8 (PTHR42760:SF128)
PANTHER GO-slim Molecular Function:	estradiol 17-beta-dehydrogenase [NAD(P)] activity small molecule binding
PANTHER GO-slim Biological Process:	fatty acid biosynthetic process hormone biosynthetic process steroid biosynthetic process
PANTHER GO-slim Cellular Component:
PANTHER protein class:	oxidoreductase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	estradiol 17-beta-dehydrogenase [NAD(P)+] activity, quinone binding, oxidoreductase activity, testosterone dehydrogenase (NAD+) activity, NADH binding, (3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity
GO BP Complete:	estrogen biosynthetic process, androgen metabolic process, estrogen metabolic process, fatty acid biosynthetic process, protein heterotetramerization
GO CC Complete:	mitochondrial matrix, oxidoreductase complex, membrane, mitochondrial envelope, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=3554\|UniProtKB=Q92506	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000018036.2\|UniProtKB=H2QSS7	Pan troglodytes	O
MACMU\|Ensembl=ENSMMUG00000003861.4\|UniProtKB=Q8WMN4	Macaca mulatta	O
MOUSE\|MGI=MGI=95911\|UniProtKB=P50171	Mus musculus	O
RAT\|RGD=1303158\|UniProtKB=Q6MGB5	Rattus norvegicus	O
PIG\|Ensembl=ENSSSCG00000001476.6\|UniProtKB=K7GLG0	Sus scrofa	LDO
FELCA\|Ensembl=ENSFCAG00000006986.5\|UniProtKB=M3W6V5	Felis catus	LDO
MONDO\|Ensembl=ENSMODG00000014232.3\|UniProtKB=F6T964	Monodelphis domestica	O
CHICK\|Ensembl=ENSGALG00010001700.1\|UniProtKB=A0A8V0X6I6	Gallus gallus	O
CHICK\|Ensembl=ENSGALG00010001642.1\|UniProtKB=A0A8V0XCB1	Gallus gallus	O
XENLA\|Gene=hsd17b8.S\|UniProtKB=A0A1L8F3J7	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-490296\|UniProtKB=Q28IT0	Xenopus tropicalis	O
DANRE\|ZFIN=ZDB-GENE-010110-1\|UniProtKB=Q561S1	Danio rerio	O
CIOIN\|Ensembl=ENSCING00000022654.1\|UniProtKB=H2XRG7	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000001307.2\|UniProtKB=F6WW36	Ciona intestinalis	O
BRAFL\|Gene=LOC118422026\|UniProtKB=A0A9J7LM35	Branchiostoma floridae	O
BRAFL\|Gene=LOC118418417\|UniProtKB=A0A9J7MTA6	Branchiostoma floridae	O
BRAFL\|Gene=LOC118420782\|UniProtKB=A0A9J7LIN5	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC592790\|UniProtKB=A0A7M7PLZ7	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00000988\|UniProtKB=Q19246	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00037777\|UniProtKB=A8XSG5	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00042605\|UniProtKB=A8WKV7	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00107010\|UniProtKB=A0A2A6B4M3	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0029648\|UniProtKB=Q9W4U2	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP009633\|UniProtKB=Q7Q1U0	Anopheles gambiae	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_231057\|UniProtKB=E9GN45	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW003821\|UniProtKB=B7PG28	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW017020\|UniProtKB=B7PA67	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW007844\|UniProtKB=B7PSR3	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW012432\|UniProtKB=B7QBJ7	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW013147\|UniProtKB=B7QCE4	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW016683\|UniProtKB=B7P8S3	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW002297\|UniProtKB=B7PAW7	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW007527\|UniProtKB=B7PX50	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW001832\|UniProtKB=B7PC62	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW001580\|UniProtKB=B7P335	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW004591\|UniProtKB=B7PHS8	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW002164\|UniProtKB=B7P9E2	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW023711\|UniProtKB=B7QHU9	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW017021\|UniProtKB=B7PA68	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW015306\|UniProtKB=B7QMN2	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW013859\|UniProtKB=B7QLV4	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW023710\|UniProtKB=A0A1S4M4F6	Ixodes scapularis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g241360\|UniProtKB=A7RXH2	Nematostella vectensis	O
EMENI\|EnsemblGenome=ANIA_01886\|UniProtKB=Q5BC44	Emericella nidulans	O
EMENI\|EnsemblGenome=ANIA_04186\|UniProtKB=Q5B5J4	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_7G04360\|UniProtKB=Q4WGA6	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU09035\|UniProtKB=Q7S2U0	Neurospora crassa	O
SCLS1\|EnsemblGenome=SS1G_10326\|UniProtKB=A7EYB1	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_08985\|UniProtKB=Q0UGX9	Phaeosphaeria nodorum	O
PHANO\|EnsemblGenome=SNOG_14192\|UniProtKB=Q0U229	Phaeosphaeria nodorum	O
CRYNJ\|EnsemblGenome=CNB05760\|UniProtKB=Q5KLC5	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_11693\|UniProtKB=A0A0D1E7P8	Ustilago maydis	O
THAPS\|EnsemblGenome=THAPSDRAFT_268493\|UniProtKB=B8BXZ7	Thalassiosira pseudonana	O
NITMS\|EnsemblGenome=Nmar_1043\|UniProtKB=A9A3K7	Nitrosopumilus maritimus	O
KORCO\|EnsemblGenome=Kcr_0635\|UniProtKB=B1L4K9	Korarchaeum cryptofilum	O
SACS2\|EnsemblGenome=SSO2289\|UniProtKB=Q97WD7	Sulfolobus solfataricus	O
PYRAE\|EnsemblGenome=PAE2089\|UniProtKB=Q8ZVW5	Pyrobaculum aerophilum	O
PYRAE\|EnsemblGenome=PAE1589\|UniProtKB=Q8ZWW4	Pyrobaculum aerophilum	O
PYRAE\|EnsemblGenome=PAE2832\|UniProtKB=Q8ZUD8	Pyrobaculum aerophilum	O
METAC\|EnsemblGenome=MA_0107\|UniProtKB=Q8TUG0	Methanosarcina acetivorans	O
HALSA\|EnsemblGenome=VNG_2632G\|UniProtKB=Q9HMA5	Halobacterium salinarum	O
HALSA\|EnsemblGenome=VNG_1341G\|UniProtKB=Q9HQ41	Halobacterium salinarum	O
STRCO\|Gene_OrderedLocusName=SCO0138\|UniProtKB=Q9RIX5	Streptomyces coelicolor	O
STRCO\|Gene_OrderedLocusName=SCO4169\|UniProtKB=Q9K4G9	Streptomyces coelicolor	O
MYCTU\|Gene_OrderedLocusName=Rv2750\|UniProtKB=P9WGS5	Mycobacterium tuberculosis	O
MYCTU\|Gene_OrderedLocusName=Rv2002\|UniProtKB=P9WGT1	Mycobacterium tuberculosis	O
BRADU\|Gene=Q89HJ4_BRADU\|UniProtKB=Q89HJ4	Bradyrhizobium diazoefficiens	O
BRADU\|Gene=Q89PU2_BRADU\|UniProtKB=Q89PU2	Bradyrhizobium diazoefficiens	O
BRADU\|Gene=Q89KQ8_BRADU\|UniProtKB=Q89KQ8	Bradyrhizobium diazoefficiens	O
BRADU\|Gene=Q89HL4_BRADU\|UniProtKB=Q89HL4	Bradyrhizobium diazoefficiens	O
BRADU\|Gene=Q89YC8_BRADU\|UniProtKB=Q89YC8	Bradyrhizobium diazoefficiens	O
STRCO\|Gene_OrderedLocusName=SCO4168\|UniProtKB=Q9K4H0	Streptomyces coelicolor	O
STRCO\|Gene_OrderedLocusName=SCO6249\|UniProtKB=Q9RKU3	Streptomyces coelicolor	O
SHEON\|Gene_OrderedLocusName=SO_2813\|UniProtKB=Q8EDE2	Shewanella oneidensis	O
PSEAE\|EnsemblGenome=PA0182\|UniProtKB=Q9I6V0	Pseudomonas aeruginosa	O
GLOVI\|Gene=Q7NEV1_GLOVI\|UniProtKB=Q7NEV1	Gloeobacter violaceus	O
BRADU\|EnsemblGenome=BAC47301\|UniProtKB=P05406	Bradyrhizobium diazoefficiens	O
BRADU\|Gene=fixR\|UniProtKB=Q89RY9	Bradyrhizobium diazoefficiens	O
PSEAE\|EnsemblGenome=PA5150\|UniProtKB=Q9HU34	Pseudomonas aeruginosa	O
STRCO\|Gene_OrderedLocusName=SCO4501\|UniProtKB=Q9L0U3	Streptomyces coelicolor	O
MYCTU\|Gene_OrderedLocusName=Rv0242c\|UniProtKB=I6Y778	Mycobacterium tuberculosis	O
DEIRA\|EnsemblGenome=DR_B0080\|UniProtKB=Q9RZP2	Deinococcus radiodurans	O
BRADU\|Gene=Q89IK0_BRADU\|UniProtKB=Q89IK0	Bradyrhizobium diazoefficiens	O
BRADU\|Gene=Q89BM8_BRADU\|UniProtKB=Q89BM8	Bradyrhizobium diazoefficiens	O
COXBU\|EnsemblGenome=CBU_0702\|UniProtKB=H7C7D5	Coxiella burnetii	O
CLOBH\|Gene_OrderedLocusName=CBO3413\|UniProtKB=A5I7D8	Clostridium botulinum	O
RHOBA\|EnsemblGenome=RB9574\|UniProtKB=Q7ULD3	Rhodopirellula baltica	O
DICTD\|EnsemblGenome=Dtur_0422\|UniProtKB=B8E1U2	Dictyoglomus turgidum	O
SALTY\|EnsemblGenome=STM2835\|UniProtKB=Q8ZMK0	Salmonella typhimurium	O
ECOLI\|EnsemblGenome=BAA16566\|UniProtKB=P05707	Escherichia coli	O
CHLAA\|EnsemblGenome=Caur_2614\|UniProtKB=A9WIU3	Chloroflexus aurantiacus	O
CHLAA\|EnsemblGenome=Caur_3184\|UniProtKB=A9WI87	Chloroflexus aurantiacus	O
CHLAA\|EnsemblGenome=Caur_2408\|UniProtKB=A9WHA5	Chloroflexus aurantiacus	O
CHLAA\|EnsemblGenome=Caur_2659\|UniProtKB=A9WJG1	Chloroflexus aurantiacus	O
CHLAA\|EnsemblGenome=Caur_2642\|UniProtKB=A9WIX1	Chloroflexus aurantiacus	O
CHLAA\|EnsemblGenome=Caur_1462\|UniProtKB=A9WAD1	Chloroflexus aurantiacus	O
CHLAA\|EnsemblGenome=Caur_3422\|UniProtKB=A9WKH9	Chloroflexus aurantiacus	O
STRCO\|Gene_OrderedLocusName=SCO3502\|UniProtKB=Q9X858	Streptomyces coelicolor	O
STRCO\|Gene_OrderedLocusName=SCO1335\|UniProtKB=Q9K3Z8	Streptomyces coelicolor	O
STRCO\|Gene_OrderedLocusName=SCO4052\|UniProtKB=Q9AK65	Streptomyces coelicolor	O
STRCO\|Gene_OrderedLocusName=SCO1346\|UniProtKB=Q9K3Y7	Streptomyces coelicolor	O
MYCTU\|Gene_OrderedLocusName=Rv3548c\|UniProtKB=P71853	Mycobacterium tuberculosis	O
MYCTU\|Gene_OrderedLocusName=Rv1856c\|UniProtKB=P9WGQ1	Mycobacterium tuberculosis	O
MYCTU\|Gene_OrderedLocusName=Rv3559c\|UniProtKB=I6YCF0	Mycobacterium tuberculosis	O
MYCTU\|Gene_OrderedLocusName=Rv0769\|UniProtKB=P9WGQ9	Mycobacterium tuberculosis	O
MYCTU\|Gene_OrderedLocusName=Rv1350\|UniProtKB=P9WGR9	Mycobacterium tuberculosis	O
CLOBH\|Gene_OrderedLocusName=CBO0502\|UniProtKB=A5HZ47	Clostridium botulinum	O
CLOBH\|Gene_OrderedLocusName=CBO3600\|UniProtKB=A5I7X4	Clostridium botulinum	O
STRR6\|EnsemblGenome=spr0381\|UniProtKB=Q8DR15	Streptococcus pneumoniae	O
STAA8\|EnsemblGenome=SAOUHSC_01199\|UniProtKB=Q2FZ53	Staphylococcus aureus	O
BACSU\|EnsemblGenome=BSU_29420\|UniProtKB=O34308	Bacillus subtilis	O
BACCR\|EnsemblGenome=BC_4624\|UniProtKB=Q817D2	Bacillus cereus	O
BACSU\|EnsemblGenome=BSU_16870\|UniProtKB=O31767	Bacillus subtilis	O
BACSU\|EnsemblGenome=BSU_15910\|UniProtKB=P51831	Bacillus subtilis	O
BACCR\|EnsemblGenome=BC_3556\|UniProtKB=Q81AK7	Bacillus cereus	O
BACCR\|EnsemblGenome=BC_5079\|UniProtKB=Q815Q6	Bacillus cereus	O
BACCR\|EnsemblGenome=BC_3849\|UniProtKB=Q819V6	Bacillus cereus	O
DEIRA\|EnsemblGenome=DR_A0200\|UniProtKB=Q9RYV6	Deinococcus radiodurans	O
DEIRA\|EnsemblGenome=DR_1943\|UniProtKB=Q9RT26	Deinococcus radiodurans	O
GLOVI\|Gene=Q7ND81_GLOVI\|UniProtKB=Q7ND81	Gloeobacter violaceus	O
GLOVI\|Gene=Q7NK97_GLOVI\|UniProtKB=Q7NK97	Gloeobacter violaceus	O
GLOVI\|Gene=Q7NFL8_GLOVI\|UniProtKB=Q7NFL8	Gloeobacter violaceus	O
SYNY3\|EnsemblGenome=BAA17883\|UniProtKB=P73826	Synechocystis	O
SYNY3\|EnsemblGenome=BAA17614\|UniProtKB=P73574	Synechocystis	O
LEPIN\|EnsemblGenome=LB_113\|UniProtKB=Q8EXU4	Leptospira interrogans	O
LEPIN\|EnsemblGenome=LA_0020\|UniProtKB=Q8FA17	Leptospira interrogans	O
RHOBA\|EnsemblGenome=RB2242\|UniProtKB=Q7UW64	Rhodopirellula baltica	O
RHOBA\|EnsemblGenome=RB6240\|UniProtKB=Q7TTZ6	Rhodopirellula baltica	O
RHOBA\|EnsemblGenome=RB10272\|UniProtKB=Q7UF85	Rhodopirellula baltica	O
AQUAE\|EnsemblGenome=aq_1716\|UniProtKB=O67610	Aquifex aeolicus	O
THEYD\|EnsemblGenome=THEYE_A0101\|UniProtKB=B5YHD1	Thermodesulfovibrio yellowstonii	O
DICTD\|EnsemblGenome=Dtur_0943\|UniProtKB=B8E196	Dictyoglomus turgidum	O
FUSNN\|EnsemblGenome=FN1687\|UniProtKB=Q8RIB5	Fusobacterium nucleatum	O
BRADU\|Gene=Q89P10_BRADU\|UniProtKB=Q89P10	Bradyrhizobium diazoefficiens	O
BRADU\|Gene=Q89PS7_BRADU\|UniProtKB=Q89PS7	Bradyrhizobium diazoefficiens	O
BRADU\|Gene=Q89P28_BRADU\|UniProtKB=Q89P28	Bradyrhizobium diazoefficiens	O
PSEAE\|EnsemblGenome=PA5524\|UniProtKB=Q9HT49	Pseudomonas aeruginosa	O
BRADU\|Gene=Q89P11_BRADU\|UniProtKB=Q89P11	Bradyrhizobium diazoefficiens	O
BRADU\|Gene=Q89GI7_BRADU\|UniProtKB=Q89GI7	Bradyrhizobium diazoefficiens	O
BRADU\|Gene=Q89EC2_BRADU\|UniProtKB=Q89EC2	Bradyrhizobium diazoefficiens	O
PSEAE\|EnsemblGenome=PA5521\|UniProtKB=Q9HT52	Pseudomonas aeruginosa	O
PSEAE\|EnsemblGenome=PA2515\|UniProtKB=Q9I0W7	Pseudomonas aeruginosa	O
BRADU\|Gene=Q89GQ7_BRADU\|UniProtKB=Q89GQ7	Bradyrhizobium diazoefficiens	O
BRADU\|Gene=Q89CL5_BRADU\|UniProtKB=Q89CL5	Bradyrhizobium diazoefficiens	O
PSEAE\|EnsemblGenome=PA1827\|UniProtKB=Q9I2R8	Pseudomonas aeruginosa	O
BRADU\|Gene=Q89ML0_BRADU\|UniProtKB=Q89ML0	Bradyrhizobium diazoefficiens	O
XANCP\|EnsemblGenome=XCC3212\|UniProtKB=Q8P5X1	Xanthomonas campestris	O
GEOSL\|EnsemblGenome=GSU0461\|UniProtKB=Q74FZ1	Geobacter sulfurreducens	O
GEOSL\|EnsemblGenome=GSU1603\|UniProtKB=Q74CR9	Geobacter sulfurreducens	O
BRADU\|Gene=Q89JI9_BRADU\|UniProtKB=Q89JI9	Bradyrhizobium diazoefficiens	O
BRADU\|Gene=Q89T83_BRADU\|UniProtKB=Q89T83	Bradyrhizobium diazoefficiens	O
BRADU\|Gene=Q89FM8_BRADU\|UniProtKB=Q89FM8	Bradyrhizobium diazoefficiens	O
BRADU\|Gene=Q89MH6_BRADU\|UniProtKB=Q89MH6	Bradyrhizobium diazoefficiens	O
BRADU\|Gene=Q89CB1_BRADU\|UniProtKB=Q89CB1	Bradyrhizobium diazoefficiens	O
BRADU\|Gene=Q89PN1_BRADU\|UniProtKB=Q89PN1	Bradyrhizobium diazoefficiens	O
BRADU\|Gene=Q89HQ3_BRADU\|UniProtKB=Q89HQ3	Bradyrhizobium diazoefficiens	O
BRADU\|Gene=Q89HL7_BRADU\|UniProtKB=Q89HL7	Bradyrhizobium diazoefficiens	O
BRADU\|Gene=Q89MM8_BRADU\|UniProtKB=Q89MM8	Bradyrhizobium diazoefficiens	O
BRADU\|Gene=Q89HL5_BRADU\|UniProtKB=Q89HL5	Bradyrhizobium diazoefficiens	O
BRADU\|Gene=Q89V28_BRADU\|UniProtKB=Q89V28	Bradyrhizobium diazoefficiens	O
SHEON\|Gene_OrderedLocusName=SO_1683\|UniProtKB=Q8EGC1	Shewanella oneidensis	O
PSEAE\|EnsemblGenome=PA4389\|UniProtKB=Q9HW15	Pseudomonas aeruginosa	O
COXBU\|EnsemblGenome=CBU_0495\|UniProtKB=Q820W9	Coxiella burnetii	O
HAEIN\|EnsemblGenome=HI_0155\|UniProtKB=P43713	Haemophilus influenzae	O
SHEON\|Gene_OrderedLocusName=SO_3263\|UniProtKB=Q8EC81	Shewanella oneidensis	O
SHEON\|Gene_OrderedLocusName=SO_2776\|UniProtKB=Q8EDH3	Shewanella oneidensis	O
VIBCH\|EnsemblGenome=VC_2021\|UniProtKB=Q9KQH7	Vibrio cholerae	O
XANCP\|EnsemblGenome=XCC1018\|UniProtKB=Q8PBU9	Xanthomonas campestris	O
PSEAE\|EnsemblGenome=PA4148\|UniProtKB=Q9HWN3	Pseudomonas aeruginosa	O
PSEAE\|EnsemblGenome=PA2967\|UniProtKB=O54438	Pseudomonas aeruginosa	O
SALTY\|EnsemblGenome=STM1195\|UniProtKB=P0A2C9	Salmonella typhimurium	O
YERPE\|Gene_OrderedLocusName=YPO1456\|UniProtKB=A0A3N4B4L2	Yersinia pestis	O
ECOLI\|EnsemblGenome=BAA35901\|UniProtKB=P0AEK2	Escherichia coli	O