PANTHER Gene Information

Gene Symbol(s):

SELENOT

Organism:

Homo sapiens

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Gene Name:

Thioredoxin reductase-like selenoprotein T

Gene ID:

HGNC:18136

Protein ID:

P62341

Enhancers:

View enhancers for HUMAN|HGNC=18136|UniProtKB=P62341

Genetic Variant Annotation:

Annoq

Persistent Id:

PTN001783127

Alternate Ids:

SELT_HUMAN(UniProtKB-ID)	AAH09611(EMBL-CDS)
NM_016275(refSeq)	Q9CZ45(AltAccession)
45766832(GI)	1.8.1.9 {ECO:0000250\|UniProtKB:Q1H5H1}(EC)
BC026350(EMBL)	ENSG00000198843(Ensembl)
SELENOT{ECO:0000303\|PubMed:27645994,ECO:0000312\|HGNC:HGNC:18136}(Symbol)	ENST00000471696(Ensembl_TRS)
607912(MIM)	SELT(Synonym)
HGNC:18136(HGNC)	ENSP00000418910(Ensembl_PRO)
51714(GeneID)
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PANTHER Classification

PANTHER Family:	SELENOPROTEIN T (PTHR13544)
PANTHER Subfamily:	THIOREDOXIN REDUCTASE-LIKE SELENOPROTEIN T (PTHR13544:SF0)
PANTHER GO-slim Molecular Function:	protein-disulfide reductase activity antioxidant activity
PANTHER GO-slim Biological Process:	cellular homeostasis
PANTHER GO-slim Cellular Component:	endoplasmic reticulum membrane
PANTHER protein class:

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	selenium binding, thioredoxin-disulfide reductase (NADPH) activity
GO BP Complete:	response to glucose, insulin secretion involved in cellular response to glucose stimulus, positive regulation of growth hormone secretion, selenocysteine incorporation, glucose homeostasis, cellular oxidant detoxification, cell redox homeostasis, positive regulation of cytosolic calcium ion concentration, pancreas development
GO CC Complete:	endoplasmic reticulum membrane, endoplasmic reticulum

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
PANTR\|Ensembl=ENSPTRG00000039581.2\|UniProtKB=H2RHW0	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000038683.1\|UniProtKB=A0A2I2YMD6	Gorilla gorilla gorilla	O
GORGO\|Ensembl=ENSGGOG00000028291.2\|UniProtKB=G3RUF4	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000017699.4\|UniProtKB=F6U3K0	Macaca mulatta	LDO
MOUSE\|MGI=MGI=1916477\|UniProtKB=P62342	Mus musculus	LDO
RAT\|RGD=1359128\|UniProtKB=Q1H5H1	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000031435\|UniProtKB=A6QP01	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00005025019.1\|UniProtKB=A0A8D0WIA3	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000028645.3\|UniProtKB=A0A3Q2H820	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000032562.3\|UniProtKB=A0A2I2UUQ2	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845025129.1\|UniProtKB=A0A8I3PXM7	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000002076.4\|UniProtKB=F6UZL6	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000021273.3\|UniProtKB=F6T2H6	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000013145.4\|UniProtKB=F6S7E9	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010001132\|UniProtKB=Q5ZJN8	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000007730.3\|UniProtKB=G1KGZ5	Anolis carolinensis	LDO
XENLA\|Gene=selenot.L\|UniProtKB=A0A8J0PNW7	Xenopus laevis	O
XENLA\|Gene=selenot.S\|UniProtKB=A0A8J0PNL7	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-5780991\|UniProtKB=Q6PBD1	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000020575.2\|UniProtKB=H2N216	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-030411-4\|UniProtKB=Q502K9	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000015360.1\|UniProtKB=W5NE44	lepisosteus oculatus	O
ORYLA\|Ensembl=ENSORLG00000016078.2\|UniProtKB=H2MN22	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-030327-6\|UniProtKB=Q802F2	Danio rerio	LDO
DANRE\|ZFIN=ZDB-GENE-030411-1\|UniProtKB=Q6PHY8	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000001846.1\|UniProtKB=W5M178	lepisosteus oculatus	LDO
BRAFL\|Gene=LOC118427533\|UniProtKB=A0A9J7M311	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC755635\|UniProtKB=A0A7M7NQV8	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00009238\|UniProtKB=Q19892	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00007955\|UniProtKB=Q9U3N5	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00036973\|UniProtKB=A8XQS9	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00096456\|UniProtKB=A0A2A6B4K1	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0031670\|UniProtKB=Q9VMV6	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP009202\|UniProtKB=A0A1S4H0D1	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC013470\|UniProtKB=D6WLC0	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_328140\|UniProtKB=E9HD19	Daphnia pulex	LDO
HELRO\|EnsemblGenome=HelroG193922\|UniProtKB=T1FVH3	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG75296\|UniProtKB=T1G234	helobdella robusta	LDO
NEMVE\|Gene_ORFName=NEMVEDRAFT_v1g139284\|UniProtKB=A7SZM5	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG29882\|UniProtKB=B3S5E6	Trichoplax adhaerens	LDO
LEIMA\|EnsemblGenome=LMJF_35_1110\|UniProtKB=E9AET5	Leishmania major	LDO
PARTE\|EnsemblGenome=GSPATT00028888001\|UniProtKB=A0BH36	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00027988001\|UniProtKB=A0BEI8	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00026017001\|UniProtKB=A0EEF4	Paramecium tetraurelia	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_21446\|UniProtKB=B8BVA3	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3HCH0_PHYRM\|UniProtKB=H3HCH0	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_14g616950v5\|UniProtKB=A0A2K3CXP3	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00007p00121870\|UniProtKB=W1PC46	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_118G00180\|UniProtKB=A0A0K9Q1I7	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma07_g23920\|UniProtKB=A0A804JZ45	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_002650mg\|UniProtKB=K3XL77	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3003G344900\|UniProtKB=C5XP02	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb368380\|UniProtKB=B6U144	Zea mays	LDO
ORYSJ\|EnsemblGenome=Os01g0832200\|UniProtKB=Q8S227	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_2g54067v3\|UniProtKB=I1HT25	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0303760\|UniProtKB=A0A8I6XR05	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS3B02G383700\|UniProtKB=A0A077S1D7	Triticum aestivum	LDO
WHEAT\|EnsemblGenome=TraesCS3A02G351200\|UniProtKB=A0A3B6EPX7	Triticum aestivum	LDO
WHEAT\|EnsemblGenome=TraesCS3D02G345400\|UniProtKB=A0A3B6H0X8	Triticum aestivum	LDO
SETIT\|EnsemblGenome=SETIT_023587mg\|UniProtKB=K3ZAL6	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3009G168000\|UniProtKB=A0A1Z5R2Z7	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb351750\|UniProtKB=B4F7T6	Zea mays	O
ORYSJ\|EnsemblGenome=Os05g0467300\|UniProtKB=Q6I5I7	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_2g22740v3\|UniProtKB=I1HIK2	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.1HG0072370\|UniProtKB=A0A8I6WDY7	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS1A02G292300\|UniProtKB=A0A3B5Y2T1	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1B02G301700\|UniProtKB=A0A3B5Z0G2	Triticum aestivum	O
NELNU\|Gene=LOC104594911\|UniProtKB=A0A1U7ZIN6	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110794868\|UniProtKB=A0A9R0IV32	Spinacia oleracea	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr13g0591531\|UniProtKB=A0A251SSM2	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C500283020\|UniProtKB=A0A9R1VIN1	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a012339mg\|UniProtKB=A0A022RPI9	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_23385\|UniProtKB=A0A2G2YS79	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG400004449\|UniProtKB=M0ZZG2	Solanum tuberosum	LDO
TOBAC\|Gene=LOC107781410\|UniProtKB=A0A1S3YZH3	Nicotiana tabacum	O
TOBAC\|Gene=LOC107763590\|UniProtKB=A0A1S3XCD4	Nicotiana tabacum	LDO
VITVI\|Gene_OrderedLocusName=VIT_03s0132g00310\|UniProtKB=D7TFW2	Vitis vinifera	O
VITVI\|EnsemblGenome=Vitvi08g00665\|UniProtKB=D7SY21	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_B02246\|UniProtKB=A0A059D4Q7	Eucalyptus grandis	O
BRANA\|Gene_ORFName=DARMORV10_A03P12090.1\|UniProtKB=A0A078JA43	Brassica napus	O
BRACM\|EnsemblGenome=Bra006750\|UniProtKB=M4CRA9	Brassica campestris	O
ARATH\|TAIR=locus=2178873\|UniProtKB=Q8W1E5	Arabidopsis thaliana	O
BRANA\|EnsemblGenome=GSBRNA2T00086995001\|UniProtKB=A0A078JV23	Brassica napus	O
BRACM\|EnsemblGenome=Bra002630\|UniProtKB=M4CEJ9	Brassica campestris	O
ARATH\|TAIR=locus=2099540\|UniProtKB=Q9STZ2	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107891612\|UniProtKB=A0A1U8I6U4	Gossypium hirsutum	O
GOSHI\|Gene=LOC107889068\|UniProtKB=A0A1U8HS64	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_041601\|UniProtKB=A0A061GWD1	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g027523mg\|UniProtKB=A0A067FUN1	Citrus sinensis	O
POPTR\|EnsemblGenome=POPTR_001G253000v3\|UniProtKB=B9GIG5	Populus trichocarpa	O
POPTR\|EnsemblGenome=POPTR_009G047000v3\|UniProtKB=A9P9D4	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_01G160400\|UniProtKB=A0A2C9WL67	Manihot esculenta	O
CITSI\|Gene_ORFName=CISIN_1g041777mg\|UniProtKB=A0A067ES44	Citrus sinensis	LDO
POPTR\|EnsemblGenome=POPTR_016G117600v3\|UniProtKB=B9IGA7	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_09G107600\|UniProtKB=A0A2C9VBE0	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_0186960\|UniProtKB=B9T1J6	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_03G056500\|UniProtKB=A0A0R0KFR5	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_4g015610\|UniProtKB=G7JN28	Medicago truncatula	LDO
SOYBN\|EnsemblGenome=GLYMA_02G227600\|UniProtKB=I1JHD7	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_14G194500\|UniProtKB=K7M816	Glycine max	O
MEDTR\|EnsemblGenome=MTR_5g071240\|UniProtKB=G7JZJ1	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr05_07270\|UniProtKB=A0A2I4EIH1	Juglans regia	O
JUGRE\|EnsemblGenome=Jr03_25810\|UniProtKB=A0A2I4F2K9	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_6G185250\|UniProtKB=A0A0A0KBM2	Cucumis sativus	O
CUCSA\|EnsemblGenome=Csa_3G731110\|UniProtKB=A0A0A0LCS3	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_6G055700\|UniProtKB=M5WCM6	Prunus persica	O
PRUPE\|EnsemblGenome=PRUPE_6G279000\|UniProtKB=A0A251NY98	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_79767\|UniProtKB=D8QXA1	Selaginella moellendorffii	LDO
SELML\|EnsemblGenome=SELMODRAFT_159344\|UniProtKB=D8SY44	Selaginella moellendorffii	LDO