The mission of the PANTHER knowledgebase is to support biomedical and other research by providing
comprehensive information about the evolution of protein-coding gene families, particularly
protein phylogeny, function and genetic variation impacting that function. Learn more

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Current Release: PANTHER 19.0 | 15,683 family phylogenetic trees | 144 species | News
Whole genome function views

PANTHER Gene Information

Gene Symbol(s):

Organism:

lepisosteus oculatus

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Tree

Gene Name:

Ryanodine receptor 2b (cardiac)

Gene ID:

ENSLOCG00000016594.1

Protein ID:

W5NIQ4

Persistent Id:

PTN002656601

Alternate Ids:

ENSLOCG00000016594(Ensembl)	AHAT01001723(EMBL)
ENSLOCP00000020513(Ensembl_PRO)	W5NIQ4_LEPOC(UniProtKB-ID)
W5NIQ4(Synonym)	ENSLOCT00000020548(Ensembl_TRS)
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PANTHER Classification

PANTHER Family:	B30.2/SPRY DOMAIN-CONTAINING PROTEIN (PTHR46399)
PANTHER Subfamily:	RYANODINE RECEPTOR 2 (PTHR46399:SF7)
PANTHER GO-slim Molecular Function:	calcium channel activity ligand-gated monoatomic cation channel activity
PANTHER GO-slim Biological Process:	release of sequestered calcium ion into cytosol striated muscle contraction
PANTHER GO-slim Cellular Component:	bounding membrane of organelle calcium channel complex endoplasmic reticulum membrane Z disc sarcoplasmic reticulum sarcolemma
PANTHER protein class:

Pathway Categories:

Beta1 adrenergic receptor signaling pathway

ER-type Ca2+ channel

CCKR signaling map

RYR1/2/3

Beta2 adrenergic receptor signaling pathway

ER-type Ca2+ channel

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	ryanodine-sensitive calcium-release channel activity, calcium channel activity, calcium ion binding
GO BP Complete:	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum, calcium ion transmembrane transport, striated muscle contraction, calcium-mediated signaling, intracellular calcium ion homeostasis
GO CC Complete:	Z disc, calcium channel complex, sarcoplasmic reticulum, smooth endoplasmic reticulum, sarcolemma, membrane, sarcoplasmic reticulum membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

-

Orthologs

ID	Organism	Type
HUMAN\|HGNC=10484\|UniProtKB=Q92736	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000002149.7\|UniProtKB=A0A2I3RIJ4	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000012582.3\|UniProtKB=A0A2I2ZE17	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000001060.4\|UniProtKB=F6QN38	Macaca mulatta	LDO
MOUSE\|MGI=MGI=99685\|UniProtKB=E9Q401	Mus musculus	LDO
RAT\|RGD=620314\|UniProtKB=B0LPN4	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000022886.6\|UniProtKB=E1BHV1	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000010142.5\|UniProtKB=A0A5G2R1W3	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000006795.5\|UniProtKB=F6WYX2	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000010961.6\|UniProtKB=A0A5F5XLI8	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845002388.1\|UniProtKB=A0A8I3MT21	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000007421.4\|UniProtKB=A0A5F8GGE3	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000010281.6\|UniProtKB=A0A6I8PDZ5	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010009054.1\|UniProtKB=A0A8V0Y8K1	Gallus gallus	LDO
ORYLA\|Ensembl=ENSORLG00000005221.2\|UniProtKB=H2LKN1	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000018368.2\|UniProtKB=H2MVY7	Oryzias latipes	LDO
DANRE\|Gene=ryr2b\|UniProtKB=A0A8M9P9G0	Danio rerio	LDO
PRIPA\|EnsemblGenome=WBGene00276305\|UniProtKB=A0A2A6CRA2	Pristionchus pacificus	O
TRICA\|EnsemblGenome=TC002610\|UniProtKB=D6WF72	Tribolium castaneum	O
IXOSC\|EnsemblGenome=ISCW017057\|UniProtKB=B7PA36	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG71321\|UniProtKB=T1G0J6	helobdella robusta	O