PANTHER Gene Information

Gene Symbol(s):

TPH2

Organism:

Macaca mulatta

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Gene Name:

Tryptophan 5-hydroxylase 2

Gene ID:

ENSMMUG00000007730

Protein ID:

Q2HZ26

Persistent Id:

PTN002607605

Alternate Ids:

ABC94730(EMBL-CDS)	TPH2(Symbol)
ENSMMUG00000007730(Ensembl)	DQ360113(EMBL)
664730(GeneID)	90265819(GI)
1.14.16.4(EC)	ENSMMUP00000010151(Ensembl_PRO)
TPH2_MACMU(UniProtKB-ID)	NP_001035035(refSeq)
ENSMMUT00000010821(Ensembl_TRS)	Tryptophan 5-monooxygenase 2(Synonym)
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PANTHER Classification

PANTHER Family:	AROMATIC AMINO ACID HYDROXYLASE (PTHR11473)
PANTHER Subfamily:	TRYPTOPHAN 5-HYDROXYLASE 2 (PTHR11473:SF16)
PANTHER GO-slim Molecular Function:	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen monooxygenase activity
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:	neuron projection
PANTHER protein class:	oxidoreductase

Pathway Categories:

5-Hydroxytryptamine biosynthesis

Tryptophan hydroxylase

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	iron ion binding, metal ion binding, monooxygenase activity, tryptophan 5-monooxygenase activity
GO BP Complete:	serotonin biosynthetic process, aromatic amino acid metabolic process
GO CC Complete:	neuron projection

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=20692\|UniProtKB=Q8IWU9	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000044968.1\|UniProtKB=A0A2I3TG35	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000012963.3\|UniProtKB=G3RB08	Gorilla gorilla gorilla	LDO
MOUSE\|MGI=MGI=2651811\|UniProtKB=Q8CGV2	Mus musculus	LDO
RAT\|RGD=631332\|UniProtKB=Q8CGU9	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000020792.6\|UniProtKB=E1BGX6	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000021122.4\|UniProtKB=F1SH22	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000013175\|UniProtKB=Q0EAB8	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000006179.6\|UniProtKB=M3W5F9	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845024186.1\|UniProtKB=A0A8I3PGT7	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000020417.5\|UniProtKB=F7GI81	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000012279.4\|UniProtKB=F7DVE5	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010012834.1\|UniProtKB=A0A8V0YNZ0	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000007531.4\|UniProtKB=G1KGT8	Anolis carolinensis	LDO
XENLA\|Gene=LOC108710258\|UniProtKB=A0A8J1MKL6	Xenopus laevis	O
XENLA\|Gene=tph2.S\|UniProtKB=A0A1L8GUD7	Xenopus laevis	LDO
XENTR\|Gene=tph2\|UniProtKB=A0A8J0QWL5	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000000223.2\|UniProtKB=H2L3G1	Oryzias latipes	LDO
DANRE\|Gene=tph2\|UniProtKB=A0A8M1P7E6	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000016249.1\|UniProtKB=W5NHD0	lepisosteus oculatus	LDO
BRAFL\|Gene=LOC118406966\|UniProtKB=A0A9J7HPQ7	Branchiostoma floridae	LDO
BRAFL\|Gene=LOC118406289\|UniProtKB=A0A9J7HM43	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC115922565\|UniProtKB=A0A7M7NK43	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00006600\|UniProtKB=G5EED8	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG12991\|UniProtKB=A8XGU6	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00283745\|UniProtKB=A0A2A6BZB3	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0035187\|UniProtKB=Q9W0K2	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP006020\|UniProtKB=A0A1S4GQZ6	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC003915\|UniProtKB=D6WHK1	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_44381\|UniProtKB=E9G1D2	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW000796\|UniProtKB=B7P4Z5	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG79745\|UniProtKB=T1G3S8	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g237576\|UniProtKB=A7SX22	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG32954\|UniProtKB=B3SC11	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_31770\|UniProtKB=A9UUJ8	Monosiga brevicollis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_8378\|UniProtKB=F4NS91	Batrachochytrium dendrobatidis	O
DICDI\|dictyBase=DDB_G0278781\|UniProtKB=Q54XS1	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_48007\|UniProtKB=F0ZME5	Dictyostelium purpureum	O
LEIMA\|EnsemblGenome=LMJF_28_1280\|UniProtKB=Q6WRI4	Leishmania major	O
PARTE\|EnsemblGenome=GSPATT00002185001\|UniProtKB=A0DG89	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00031660001\|UniProtKB=A0BSB2	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00006646001\|UniProtKB=A0C973	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00004497001\|UniProtKB=A0BCY6	Paramecium tetraurelia	O
THAPS\|EnsemblGenome=THAPSDRAFT_bd415\|UniProtKB=B8LE69	Thalassiosira pseudonana	O
PHYRM\|Gene=H3G9R5_PHYRM\|UniProtKB=H3G9R5	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_01g029250v5\|UniProtKB=A8HQD7	Chlamydomonas reinhardtii	O
PHYPA\|EnsemblGenome=Pp3c8_13930\|UniProtKB=E5KBU4	Physcomitrella patens	O
KLENI\|Gene_ORFName=KFL_001890200\|UniProtKB=A0A1Y1I6U4	Klebsormidium nitens	O
KLENI\|Gene_ORFName=KFL_003840020\|UniProtKB=A0A1Y1IAC0	Klebsormidium nitens	O
CHLAA\|EnsemblGenome=Caur_2799\|UniProtKB=A9WKC2	Chloroflexus aurantiacus	O
BACCR\|EnsemblGenome=BC_4352\|UniProtKB=Q818B4	Bacillus cereus	O
SHEON\|Gene_OrderedLocusName=SO_1666\|UniProtKB=Q8EGD8	Shewanella oneidensis	O
VIBCH\|EnsemblGenome=VC_A0828\|UniProtKB=Q9KLB8	Vibrio cholerae	O
XANCP\|EnsemblGenome=XCC0156\|UniProtKB=Q8PE27	Xanthomonas campestris	O
PSEAE\|EnsemblGenome=PA0872\|UniProtKB=P43334	Pseudomonas aeruginosa	O