PANTHER Gene Information

Gene Symbol(s):

TPH2

Organism:

Ornithorhynchus anatinus

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Gene Name:

tryptophan 5-monooxygenase

Gene ID:

ENSOANG00000012279.4

Protein ID:

F7DVE5

Persistent Id:

PTN001352319

Alternate Ids:

F7DVE5(Synonym)	ENSOANT00000019431(Ensembl_TRS)
ENSOANP00000019428(Ensembl_PRO)	ENSOANG00000012279(Ensembl)
F7DVE5_ORNAN(UniProtKB-ID)
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PANTHER Classification

PANTHER Family:	AROMATIC AMINO ACID HYDROXYLASE (PTHR11473)
PANTHER Subfamily:	TRYPTOPHAN 5-HYDROXYLASE 2 (PTHR11473:SF16)
PANTHER GO-slim Molecular Function:	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen monooxygenase activity
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:	neuron projection
PANTHER protein class:	oxidoreductase

Pathway Categories:

5-Hydroxytryptamine biosynthesis

Tryptophan hydroxylase

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen, iron ion binding, metal ion binding, monooxygenase activity, tryptophan 5-monooxygenase activity
GO BP Complete:	serotonin biosynthetic process, aromatic amino acid metabolic process
GO CC Complete:	neuron projection

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=20692\|UniProtKB=Q8IWU9	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000044968.1\|UniProtKB=A0A2I3TG35	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000012963.3\|UniProtKB=G3RB08	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000007730\|UniProtKB=Q2HZ26	Macaca mulatta	LDO
MOUSE\|MGI=MGI=2651811\|UniProtKB=Q8CGV2	Mus musculus	LDO
RAT\|RGD=631332\|UniProtKB=Q8CGU9	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000020792.6\|UniProtKB=E1BGX6	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000021122.4\|UniProtKB=F1SH22	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000013175\|UniProtKB=Q0EAB8	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000006179.6\|UniProtKB=M3W5F9	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845024186.1\|UniProtKB=A0A8I3PGT7	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000020417.5\|UniProtKB=F7GI81	Monodelphis domestica	LDO
CHICK\|Ensembl=ENSGALG00010012834.1\|UniProtKB=A0A8V0YNZ0	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000007531.4\|UniProtKB=G1KGT8	Anolis carolinensis	LDO
XENLA\|Gene=LOC108710258\|UniProtKB=A0A8J1MKL6	Xenopus laevis	O
XENLA\|Gene=tph2.S\|UniProtKB=A0A1L8GUD7	Xenopus laevis	LDO
XENTR\|Gene=tph2\|UniProtKB=A0A8J0QWL5	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000000223.2\|UniProtKB=H2L3G1	Oryzias latipes	LDO
DANRE\|Gene=tph2\|UniProtKB=A0A8M1P7E6	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000016249.1\|UniProtKB=W5NHD0	lepisosteus oculatus	LDO
BRAFL\|Gene=LOC118406966\|UniProtKB=A0A9J7HPQ7	Branchiostoma floridae	LDO
BRAFL\|Gene=LOC118406289\|UniProtKB=A0A9J7HM43	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC115922565\|UniProtKB=A0A7M7NK43	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00006600\|UniProtKB=G5EED8	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG12991\|UniProtKB=A8XGU6	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00283745\|UniProtKB=A0A2A6BZB3	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0035187\|UniProtKB=Q9W0K2	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP006020\|UniProtKB=A0A1S4GQZ6	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC003915\|UniProtKB=D6WHK1	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_44381\|UniProtKB=E9G1D2	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW000796\|UniProtKB=B7P4Z5	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG79745\|UniProtKB=T1G3S8	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g237576\|UniProtKB=A7SX22	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG32954\|UniProtKB=B3SC11	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_31770\|UniProtKB=A9UUJ8	Monosiga brevicollis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_8378\|UniProtKB=F4NS91	Batrachochytrium dendrobatidis	O
DICDI\|dictyBase=DDB_G0278781\|UniProtKB=Q54XS1	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_48007\|UniProtKB=F0ZME5	Dictyostelium purpureum	O
LEIMA\|EnsemblGenome=LMJF_28_1280\|UniProtKB=Q6WRI4	Leishmania major	O
PARTE\|EnsemblGenome=GSPATT00002185001\|UniProtKB=A0DG89	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00031660001\|UniProtKB=A0BSB2	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00006646001\|UniProtKB=A0C973	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00004497001\|UniProtKB=A0BCY6	Paramecium tetraurelia	O
THAPS\|EnsemblGenome=THAPSDRAFT_bd415\|UniProtKB=B8LE69	Thalassiosira pseudonana	O
PHYRM\|Gene=H3G9R5_PHYRM\|UniProtKB=H3G9R5	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_01g029250v5\|UniProtKB=A8HQD7	Chlamydomonas reinhardtii	O
PHYPA\|EnsemblGenome=Pp3c8_13930\|UniProtKB=E5KBU4	Physcomitrella patens	O
KLENI\|Gene_ORFName=KFL_001890200\|UniProtKB=A0A1Y1I6U4	Klebsormidium nitens	O
KLENI\|Gene_ORFName=KFL_003840020\|UniProtKB=A0A1Y1IAC0	Klebsormidium nitens	O
CHLAA\|EnsemblGenome=Caur_2799\|UniProtKB=A9WKC2	Chloroflexus aurantiacus	O
BACCR\|EnsemblGenome=BC_4352\|UniProtKB=Q818B4	Bacillus cereus	O
SHEON\|Gene_OrderedLocusName=SO_1666\|UniProtKB=Q8EGD8	Shewanella oneidensis	O
VIBCH\|EnsemblGenome=VC_A0828\|UniProtKB=Q9KLB8	Vibrio cholerae	O
XANCP\|EnsemblGenome=XCC0156\|UniProtKB=Q8PE27	Xanthomonas campestris	O
PSEAE\|EnsemblGenome=PA0872\|UniProtKB=P43334	Pseudomonas aeruginosa	O