PANTHER Gene Information

Gene Symbol(s):

MSTN

Organism:

Macaca mulatta

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Gene Name:

Growth_differentiation factor 8

Gene ID:

ENSMMUG00000014307

Protein ID:

A1C2U6

Persistent Id:

PTN000218815

Alternate Ids:

GDF8(Synonym)	ABI48518(EMBL-CDS)
DQ927195(EMBL)	146286186(GI)
NM_001080119(refSeq)	ENSMMUT00000020075(Ensembl_TRS)
MSTN(Symbol)	710114(GeneID)
ENSMMUG00000014307(Ensembl)	ENSMMUP00000018789(Ensembl_PRO)
GDF8_MACMU(UniProtKB-ID)
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PANTHER Classification

PANTHER Family:	TGF-BETA FAMILY (PTHR11848)
PANTHER Subfamily:	GROWTH_DIFFERENTIATION FACTOR 8 (PTHR11848:SF150)
PANTHER GO-slim Molecular Function:	cytokine activity
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:	extracellular space
PANTHER protein class:	growth factor

Pathway Categories:

TGF-beta signaling pathway

Transforming growth factor beta

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	growth factor activity, identical protein binding, protein homodimerization activity, heparin binding, cytokine activity, signaling receptor binding
GO BP Complete:	positive regulation of lamellipodium assembly, muscle cell cellular homeostasis, transforming growth factor beta receptor signaling pathway, negative regulation of satellite cell differentiation, negative regulation of insulin receptor signaling pathway, negative regulation of skeletal muscle satellite cell proliferation, skeletal muscle tissue regeneration, negative regulation of myoblast proliferation, negative regulation of skeletal muscle tissue growth, negative regulation of myoblast differentiation, positive regulation of DNA-templated transcription, myoblast migration involved in skeletal muscle regeneration, positive regulation of macrophage chemotaxis, skeletal muscle satellite cell differentiation, cellular response to dexamethasone stimulus, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO CC Complete:	extracellular space, extracellular region

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
PANTR\|Gene=MSTN\|UniProtKB=A1C2V0	Pan troglodytes	LDO
GORGO\|Gene=MSTN\|UniProtKB=A1C2V5	Gorilla gorilla gorilla	LDO
HUMAN\|HGNC=4223\|UniProtKB=O14793	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000012738.4\|UniProtKB=A0A2K6HHF2	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000027833.2\|UniProtKB=A0A2K5TIY7	Gorilla gorilla gorilla	LDO
MOUSE\|MGI=MGI=95691\|UniProtKB=O08689	Mus musculus	LDO
RAT\|RGD=3115\|UniProtKB=O35312	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000011808\|UniProtKB=O18836	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000016047\|UniProtKB=O18831	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000021373.3\|UniProtKB=F6S5D9	Equus caballus	LDO
HORSE\|Gene=MSTN\|UniProtKB=Q9GM97	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000029333.4\|UniProtKB=M3WPT7	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845024446\|UniProtKB=Q6UKZ8	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000011550.4\|UniProtKB=F6QWE0	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000043006.1\|UniProtKB=A0A6I8PB41	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010012852\|UniProtKB=O42220	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000004208.3\|UniProtKB=A0A803T4J9	Anolis carolinensis	LDO
XENLA\|Gene=mstn.2.S\|UniProtKB=A0A1L8EPU9	Xenopus laevis	O
XENLA\|Gene=LOC108701488\|UniProtKB=A0A1L8EX41	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-855713\|UniProtKB=A0A803JZQ6	Xenopus tropicalis	O
XENLA\|Gene=mstn.1.L\|UniProtKB=A0A1L8EX96	Xenopus laevis	O
XENLA\|Gene=mstn.1.S\|UniProtKB=A0A1L8EQ37	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-483324\|UniProtKB=A0A803JS15	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000015057.2\|UniProtKB=A0A3B3HAX7	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-050208-735\|UniProtKB=Q68IN2	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-990415-165\|UniProtKB=O42222	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000008826.1\|UniProtKB=W5MQS7	lepisosteus oculatus	LDO
BRAFL\|Gene=LOC118423923\|UniProtKB=A0A9J7N2V0	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC115918786\|UniProtKB=A0A7M7T176	Strongylocentrotus purpuratus	LDO
DROME\|FlyBase=FBgn0026199\|UniProtKB=Q9V4F4	Drosophila melanogaster	LDO
TRICA\|EnsemblGenome=TC015805\|UniProtKB=D2A418	Tribolium castaneum	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g196852\|UniProtKB=A7RGJ4	Nematostella vectensis	LDO