PANTHER Gene Information

Gene Symbol(s):

PRKCZ

Organism:

Macaca mulatta

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Gene Name:

Protein kinase C

Gene ID:

ENSMMUG00000018911.4

Protein ID:

F6ZZK4

Persistent Id:

PTN001220307

Alternate Ids:

XM_015133724(refSeq)	JV636268(EMBL)
ENSMMUT00000026588(Ensembl_TRS)	F6ZZK4(Synonym)
387541962(GI)	ENSMMUP00000024882(Ensembl_PRO)
710340(GeneID)	ENSMMUG00000018911(Ensembl)
F6ZZK4_MACMU(UniProtKB-ID)	AFJ71608(EMBL-CDS)
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PANTHER Classification

PANTHER Family:	SERINE/THREONINE-PROTEIN KINASE (PTHR24356)
PANTHER Subfamily:	PROTEIN KINASE C ZETA TYPE (PTHR24356:SF170)
PANTHER GO-slim Molecular Function:	protein serine/threonine kinase activity
PANTHER GO-slim Biological Process:	peptidyl-serine phosphorylation intracellular signal transduction
PANTHER GO-slim Cellular Component:
PANTHER protein class:	non-receptor serine/threonine protein kinase

Pathway Categories:

Gonadotropin-releasing hormone receptor pathway

PKCs

Histamine H1 receptor mediated signaling pathway

Protein kinase C

Inflammation mediated by chemokine and cytokine signaling pathway

Protein kinase C, zeta

Inflammation mediated by chemokine and cytokine signaling pathway

Protein kinase C

Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway

Protein kinase C

Wnt signaling pathway

Protein Kinase C

Muscarinic acetylcholine receptor 1 and 3 signaling pathway

Protein kinase C

Oxytocin receptor mediated signaling pathway

Protein kinase C

FGF signaling pathway

Protein kinase C

Thyrotropin-releasing hormone receptor signaling pathway

Protein kinase C

Angiogenesis

Protein kinase B

VEGF signaling pathway

Protein kinase C

Endothelin signaling pathway

protein kinase c

Alzheimer disease-amyloid secretase pathway

Protein kinase C

EGF receptor signaling pathway

PKC

5HT2 type receptor mediated signaling pathway

Protein kinase C

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	diacylglycerol-dependent, calcium-independent serine/threonine kinase activity, ATP binding, metal ion binding, protein kinase activity, protein serine/threonine kinase activity, calcium,diacylglycerol-dependent serine/threonine kinase activity, protein serine kinase activity, diacylglycerol-dependent serine/threonine kinase activity
GO BP Complete:	positive regulation of T-helper 2 cell differentiation, microtubule cytoskeleton organization, negative regulation of insulin receptor signaling pathway, cellular response to insulin stimulus, positive regulation of interleukin-13 production, neuron projection extension, positive regulation of ERK1 and ERK2 cascade, establishment of cell polarity, negative regulation of protein-containing complex assembly, positive regulation of interleukin-10 production, positive regulation of interleukin-4 production, intracellular signal transduction, protein localization to plasma membrane, positive regulation of interleukin-5 production, positive regulation of T-helper 2 cell cytokine production
GO CC Complete:	apical cortex, axon hillock, plasma membrane, nuclear envelope, nucleus, bicellular tight junction, cell-cell junction, microtubule organizing center, cytoplasm, cell cortex, cytosol, nuclear matrix, vesicle, myelin sheath abaxonal region, apical plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=9412\|UniProtKB=Q05513	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000046709.1\|UniProtKB=A0A2I3SQA3	Pan troglodytes	LDO
MOUSE\|MGI=MGI=97602\|UniProtKB=Q02956	Mus musculus	LDO
RAT\|RGD=3399\|UniProtKB=P09217	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000014119.6\|UniProtKB=A0JNH7	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000030361.4\|UniProtKB=A0A480VNP1	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000014312.4\|UniProtKB=A0A9L0R6F8	Equus caballus	LDO
CANLF\|Ensembl=ENSCAFG00845016558.1\|UniProtKB=A0A8I3NXR9	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000022776.3\|UniProtKB=A0A5F8GMR3	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000024997.3\|UniProtKB=A0A5F8G493	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000024996.2\|UniProtKB=F6TU13	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000020916.4\|UniProtKB=A0A5F8G3Q6	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000010041.3\|UniProtKB=A0A6I8PDS5	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010020059.1\|UniProtKB=E1BQN6	Gallus gallus	LDO
DANRE\|Gene=prkcz\|UniProtKB=A0A8M3B1V2	Danio rerio	LDO
CIOIN\|Ensembl=ENSCING00000003055.3\|UniProtKB=F6PPJ1	Ciona intestinalis	O
CAEEL\|WormBase=WBGene00004034\|UniProtKB=Q19266	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00025443\|UniProtKB=A8WUG4	Caenorhabditis briggsae	O
DROME\|FlyBase=FBgn0261854\|UniProtKB=A1Z9X0	Drosophila melanogaster	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_319272\|UniProtKB=E9GL76	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW023594\|UniProtKB=B7QJI7	Ixodes scapularis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g202173\|UniProtKB=A7RU22	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG57608\|UniProtKB=B3RZX4	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_31267\|UniProtKB=A9USR5	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_10752\|UniProtKB=A9V750	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_21555\|UniProtKB=A9V1T6	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_34036\|UniProtKB=A9V9H6	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_39232\|UniProtKB=A9VD19	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_20766\|UniProtKB=A9UXQ2	Monosiga brevicollis	O
YEAST\|SGD=S000000201\|UniProtKB=P24583	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_ACR191C\|UniProtKB=Q75BT0	Eremothecium gossypii	O
CANAL\|CGD=CAL0000201435\|UniProtKB=Q5ANK2	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_F09746g\|UniProtKB=Q6C292	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_00106\|UniProtKB=C8VQM0	Emericella nidulans	O
NEUCR\|EnsemblGenome=NCU06544\|UniProtKB=P87253	Neurospora crassa	O
PHANO\|EnsemblGenome=SNOG_07073\|UniProtKB=Q0UME1	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPAC17G8.14c\|UniProtKB=P36582	Schizosaccharomyces pombe	O
SCHPO\|PomBase=SPBC12D12.04c\|UniProtKB=P36583	Schizosaccharomyces pombe	O
CRYNJ\|EnsemblGenome=CNE01630\|UniProtKB=Q5KH12	Cryptococcus neoformans	O
CRYNJ\|EnsemblGenome=CNC03300\|UniProtKB=Q5KKE3	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_15023\|UniProtKB=A0A0D1DRE2	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_12641\|UniProtKB=E3KRH5	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_15370\|UniProtKB=F4NTP5	Batrachochytrium dendrobatidis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_19449\|UniProtKB=F4P170	Batrachochytrium dendrobatidis	O
ENTH1\|EnsemblGenome=CL6EHI_125820\|UniProtKB=C4LVW8	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_097620\|UniProtKB=C4M933	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_188930\|UniProtKB=C4M2W0	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_044470\|UniProtKB=B1N2G7	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_042150\|UniProtKB=C4M4G9	Entamoeba histolytica	O
ENTH1\|EnsemblGenome=CL6EHI_053040\|UniProtKB=C4M3C2	Entamoeba histolytica	O
ENTH1\|Gene_ORFName=EHI_138540\|UniProtKB=A0A8U0WPI4	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0288795\|UniProtKB=Q54IF2	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_149347\|UniProtKB=F0ZDG7	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0268620\|UniProtKB=P54644	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_152431\|UniProtKB=F0ZLC3	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_38849\|UniProtKB=F0ZVB0	Dictyostelium purpureum	O
LEIMA\|EnsemblGenome=LMJF_30_0800\|UniProtKB=Q4Q7M5	Leishmania major	O
TRYB2\|Gene_ORFName=Tb11.01.2290\|UniProtKB=Q383M7	Trypanosoma brucei	O
TRYB2\|Gene_ORFName=Tb927.3.2690\|UniProtKB=Q582Y1	Trypanosoma brucei	O
GIAIC\|EnsemblGenome=GL50803_11364\|UniProtKB=E2RTY0	Giardia intestinalis	O
TRIV3\|Gene_ORFName=TVAG_195270\|UniProtKB=A2FLX7	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_324020\|UniProtKB=A2F4A4	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_430560\|UniProtKB=A2E382	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_316050\|UniProtKB=A2FAW3	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_447920\|UniProtKB=A2DS63	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_047250\|UniProtKB=A2FHJ2	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_267830\|UniProtKB=A2DLD2	Trichomonas vaginalis	O
SACS2\|EnsemblGenome=SSO3207\|UniProtKB=Q97U18	Sulfolobus solfataricus	O