PANTHER Gene Information

Gene Symbol(s):

KIT

Organism:

Macaca mulatta

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Gene Name:

Mast_stem cell growth factor receptor

Gene ID:

ENSMMUG00000060342.1

Protein ID:

A0A5F7Z806

Persistent Id:

PTN008404989

Alternate Ids:

ENSMMUT00000106455(Ensembl_TRS)	ENSMMUG00000060342(Ensembl)
ENSMMUP00000061240(Ensembl_PRO)	A0A5F7Z806(Synonym)
A0A5F7Z806_MACMU(UniProtKB-ID)
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PANTHER Classification

PANTHER Family:	TYROSINE-PROTEIN KINASE RECEPTOR (PTHR24416)
PANTHER Subfamily:	MAST_STEM CELL GROWTH FACTOR RECEPTOR KIT (PTHR24416:SF46)
PANTHER GO-slim Molecular Function:	growth factor binding transmembrane receptor protein tyrosine kinase activity
PANTHER GO-slim Biological Process:	transmembrane receptor protein tyrosine kinase signaling pathway B cell differentiation positive regulation of receptor signaling pathway via JAK-STAT cytokine-mediated signaling pathway positive regulation of cell migration positive regulation of MAPK cascade hematopoietic progenitor cell differentiation multicellular organism development regulation of MAP kinase activity positive regulation of protein serine/threonine kinase activity
PANTHER GO-slim Cellular Component:	receptor complex plasma membrane
PANTHER protein class:	transmembrane signal receptor

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	placental growth factor receptor activity, growth factor binding, macrophage colony-stimulating factor receptor activity, insulin-like growth factor receptor activity, protease binding, boss receptor activity, hepatocyte growth factor receptor activity, fibroblast growth factor receptor activity, ATP binding, protein tyrosine kinase activity, insulin receptor activity, transmembrane receptor protein tyrosine kinase activity, protein homodimerization activity, stem cell factor receptor activity, brain-derived neurotrophic factor receptor activity, protein tyrosine kinase collagen receptor activity, vascular endothelial growth factor receptor activity, GPI-linked ephrin receptor activity, SH2 domain binding, epidermal growth factor receptor activity, transmembrane-ephrin receptor activity, platelet-derived growth factor beta-receptor activity, platelet-derived growth factor alpha-receptor activity, metal ion binding, histone H2AXY142 kinase activity, histone H3Y41 kinase activity, cytokine binding
GO BP Complete:	positive regulation of vascular associated smooth muscle cell differentiation, male gonad development, embryonic hemopoiesis, epidermal growth factor receptor signaling pathway, response to radiation, fibroblast growth factor receptor signaling pathway, negative regulation of developmental process, negative regulation of programmed cell death, mast cell degranulation, lymphoid progenitor cell differentiation, hematopoietic progenitor cell differentiation, glycosphingolipid metabolic process, cell chemotaxis, inflammatory response, melanocyte migration, digestive tract development, myeloid progenitor cell differentiation, pigmentation, melanocyte adhesion, detection of mechanical stimulus involved in sensory perception of sound, intracellular signal transduction, Kit signaling pathway, positive regulation of mast cell cytokine production, ectopic germ cell programmed cell death, vascular endothelial growth factor receptor-1 signaling pathway, B cell differentiation, platelet-derived growth factor receptor-alpha signaling pathway, macrophage colony-stimulating factor signaling pathway, platelet-derived growth factor receptor-beta signaling pathway, insulin-like growth factor receptor signaling pathway, collagen-activated tyrosine kinase receptor signaling pathway, positive regulation of receptor signaling pathway via JAK-STAT, T cell differentiation, hepatocyte growth factor receptor signaling pathway, brain-derived neurotrophic factor receptor signaling pathway, erythrocyte differentiation, immature B cell differentiation, positive regulation of gene expression, ephrin receptor signaling pathway, hematopoietic stem cell migration, negative regulation of reproductive process, positive regulation of cell migration, cell population proliferation, regulation of cell shape, multicellular organism development, insulin receptor signaling pathway, hemopoiesis, Fc receptor signaling pathway, developmental pigmentation, positive regulation of dendritic cell cytokine production, chromatin remodeling, stem cell differentiation, mast cell proliferation, cytokine-mediated signaling pathway, megakaryocyte development, positive regulation of mast cell proliferation, mast cell differentiation, spermatid development, spermatogenesis, vascular endothelial growth factor signaling pathway, erythropoietin-mediated signaling pathway, positive regulation of MAPK cascade, mast cell chemotaxis, regulation of cell population proliferation, ovarian follicle development, melanocyte differentiation, lamellipodium assembly, programmed cell death, actin cytoskeleton organization
GO CC Complete:	extracellular space, cell-cell junction, external side of plasma membrane, receptor complex, fibrillar center, plasma membrane, cell surface

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=6342\|UniProtKB=P10721	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000016067.6\|UniProtKB=H2QPH5	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000015440.3\|UniProtKB=G3RHF1	Gorilla gorilla gorilla	LDO
MOUSE\|MGI=MGI=96677\|UniProtKB=P05532	Mus musculus	LDO
RAT\|RGD=620568\|UniProtKB=Q63116	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000002699.6\|UniProtKB=A0A452DHX3	Bos taurus	LDO
BOVIN\|Gene=KIT\|UniProtKB=P43481	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000008842.5\|UniProtKB=A0A5G2QNL8	Sus scrofa	O
PIG\|Gene=KIT\|UniProtKB=Q2HWD6	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000012032.4\|UniProtKB=F7BCJ8	Equus caballus	LDO
FELCA\|Gene=KIT\|UniProtKB=Q28889	Felis catus	LDO
FELCA\|Ensembl=ENSFCAG00000003112.6\|UniProtKB=A0A384DV37	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00000002065\|UniProtKB=O97799	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000020671.4\|UniProtKB=F7A906	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000003803.4\|UniProtKB=F6U370	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010013314\|UniProtKB=Q08156	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000009902.4\|UniProtKB=A0A803T4W4	Anolis carolinensis	LDO
XENLA\|Gene=g67.L\|UniProtKB=A0A8J0U7J8	Xenopus laevis	O
XENLA\|Gene=kit\|UniProtKB=Q91909	Xenopus laevis	LDO
XENLA\|Gene=kit.S\|UniProtKB=Q6P6Y9	Xenopus laevis	LDO
XENLA\|Gene=kit.L\|UniProtKB=A0A8J0UTF6	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-492512\|UniProtKB=B4F6V0	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000004401.2\|UniProtKB=H2LHQ6	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-050916-2\|UniProtKB=B8A5K6	Danio rerio	O
ORYLA\|Ensembl=ENSORLG00000000569.2\|UniProtKB=A0A3B3HC84	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-980526-464\|UniProtKB=Q8JFR5	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000014166.1\|UniProtKB=W5N9Z9	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000003493.3\|UniProtKB=F6TLX0	Ciona intestinalis	O
BRAFL\|Gene=LOC118418363\|UniProtKB=A0A9J7MV71	Branchiostoma floridae	O
BRAFL\|Gene=LOC118403946\|UniProtKB=A0A9J7HIK2	Branchiostoma floridae	O
BRAFL\|Gene=LOC118419709\|UniProtKB=A0A9J7LFS0	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC105444281\|UniProtKB=A0A7M7NBJ5	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105438002\|UniProtKB=A0A7M7NGH8	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC579430\|UniProtKB=A0A7M7NBH9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105437797\|UniProtKB=A0A7M7P5W9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115918442\|UniProtKB=A0A7M7NFV5	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC575248\|UniProtKB=A0A7M7NGI9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105443986\|UniProtKB=A0A7M7NDD9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC593142\|UniProtKB=A0A7M7PJZ3	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105445932\|UniProtKB=A0A7M7NC15	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105444011\|UniProtKB=A0A7M7NDZ4	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105443826\|UniProtKB=A0A7M7NBR9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105439256\|UniProtKB=A0A7M7NFB8	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC100892684\|UniProtKB=A0A7M7NF85	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC115921149\|UniProtKB=A0A7M7NC60	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC105444275\|UniProtKB=A0A7M7ND25	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC590825\|UniProtKB=A0A7M7NBI9	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC100888196\|UniProtKB=A0A7M7LL81	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC100888329\|UniProtKB=A0A7M7P467	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC579837\|UniProtKB=A0A7M7RCU0	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00017310\|UniProtKB=A0A2C9C3B4	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG19102\|UniProtKB=A8XUS9	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00103469\|UniProtKB=A0A2A6CRG6	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00008599\|UniProtKB=Q19238	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG05239\|UniProtKB=A8WZG4	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00107078\|UniProtKB=A0A2A6CZ19	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00002195\|UniProtKB=F3NWW5	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG22767\|UniProtKB=A8Y2V0	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00276578\|UniProtKB=A0A2A6B4J7	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00015087\|UniProtKB=Q10915	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG11187\|UniProtKB=A8XCN3	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00304683\|UniProtKB=A0A8R1Z946	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00011169\|UniProtKB=Q21868	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00002199\|UniProtKB=P34891	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00011339\|UniProtKB=O18008	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00002200\|UniProtKB=P34892	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG04906\|UniProtKB=A8WYS1	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG13386\|UniProtKB=A8XHW0	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG13385\|UniProtKB=A8XHW1	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00020678\|UniProtKB=A0A1I6CMA1	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG01733\|UniProtKB=A8WQZ3	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00021745\|UniProtKB=Q9N4T2	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00003862\|UniProtKB=Q17833	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00002211\|UniProtKB=O17955	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00003863\|UniProtKB=Q23677	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00011168\|UniProtKB=Q21867	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00012270\|UniProtKB=Q95ZK1	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00027499\|UniProtKB=A8WYS2	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG04913\|UniProtKB=A8WYS8	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00027448\|UniProtKB=A8WYM1	Caenorhabditis briggsae	O
CAEBR\|WormBase=WBGene00027500\|UniProtKB=A8WYS3	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00006897\|UniProtKB=Q21041	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00006894\|UniProtKB=G5ED65	Caenorhabditis elegans	O
CAEEL\|WormBase=WBGene00006896\|UniProtKB=Q21038	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG17535\|UniProtKB=A8XR68	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG17536\|UniProtKB=A8XR69	Caenorhabditis briggsae	O
CAEBR\|Gene_ORFName=CBG17534\|UniProtKB=A8XR67	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00278186\|UniProtKB=A0A2A6B1V3	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00278185\|UniProtKB=A0A2A6B2E3	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0032006\|UniProtKB=E1JHB7	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP008813\|UniProtKB=A0A1S4GZA9	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC007584\|UniProtKB=A0A139WIY2	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_58385\|UniProtKB=E9H5T6	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_305264\|UniProtKB=E9GQ40	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_48616\|UniProtKB=E9GD08	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_4284\|UniProtKB=E9GD15	Daphnia pulex	O
DAPPU\|Gene_ORFName=DAPPUDRAFT_44144\|UniProtKB=E9FZB6	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_43719\|UniProtKB=E9FZF2	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_308023\|UniProtKB=E9H5G0	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_114299\|UniProtKB=E9HHQ5	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_130278\|UniProtKB=E9HM17	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_110024\|UniProtKB=E9H4Z3	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_325477\|UniProtKB=E9H4U6	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_331276\|UniProtKB=E9HLZ6	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_110251\|UniProtKB=E9H5G3	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_61463\|UniProtKB=E9HD20	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_119760\|UniProtKB=E9HZE7	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_302458\|UniProtKB=E9HNF0	Daphnia pulex	O
DAPPU\|Gene_ORFName=DAPPUDRAFT_48631\|UniProtKB=E9GCS3	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_108386\|UniProtKB=E9H018	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_53509\|UniProtKB=E9GQD0	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_308030\|UniProtKB=E9H5J0	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_253800\|UniProtKB=E9H5G1	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_58353\|UniProtKB=E9H5T9	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_64428\|UniProtKB=E9HNF3	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_302459\|UniProtKB=E9HNF4	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_130102\|UniProtKB=E9HGU7	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW005359\|UniProtKB=B7PKS1	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG133386\|UniProtKB=T1EI07	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG170959\|UniProtKB=T1F3M5	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG75629\|UniProtKB=T1G278	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG141355\|UniProtKB=T1EJ33	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG89500\|UniProtKB=T1G7D9	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g94990\|UniProtKB=A7RVU0	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g115371\|UniProtKB=A7SEI8	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g94997\|UniProtKB=A7RVT8	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g87486\|UniProtKB=A7RN88	Nematostella vectensis	O
NEMVE\|Gene_ORFName=NEMVEDRAFT_v1g87445\|UniProtKB=A7RN91	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG50752\|UniProtKB=B3S5N3	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG25090\|UniProtKB=B3RWV1	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_30176\|UniProtKB=A9VD80	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_2692\|UniProtKB=A9UPY9	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_27311\|UniProtKB=A9V4X6	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_34526\|UniProtKB=A9VCA3	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_33842\|UniProtKB=A9V7V7	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_33860\|UniProtKB=A9V7Z4	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_44299\|UniProtKB=A9V2D0	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_44298\|UniProtKB=A9UWK2	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_27155\|UniProtKB=A9V4G9	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_16001\|UniProtKB=A9UW70	Monosiga brevicollis	O
MONBE\|EnsemblGenome=MONBRDRAFT_27552\|UniProtKB=A9V5L8	Monosiga brevicollis	O