PANTHER Gene Information   
Gene Symbol(s): Hdac3
Organism: Mus musculus
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Gene Name: Histone deacetylase 3
Gene ID: MGI:1343091
Protein ID: O88895
Persistent Id: PTN000066143
Alternate Ids:
AAC36306(EMBL-CDS) ENSMUSG00000024454(Ensembl)
HD3(Synonym) 223460026(GI)
Hdac3{ECO:0000303|PubMed:10491319,ECO:0000312|MGI:MGI:1343091}(Symbol) AF074882(EMBL)
Q3UM33(AltAccession) 3.5.1.- {ECO:0000269|PubMed:30279482}(EC)
CHEMBL5142(ChEMBL) 15183(GeneID)
MGI:1343091(MGI) HDAC3_MOUSE(UniProtKB-ID)
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PANTHER Classification
PANTHER Family: HISTONE DEACETYLASE HDAC1-RELATED (PTHR10625)
PANTHER Subfamily: HISTONE DEACETYLASE 3 (PTHR10625:SF36)  
PANTHER GO-slim Molecular Function: histone deacetylase activity
PANTHER GO-slim Biological Process: epigenetic regulation of gene expression
PANTHER GO-slim Cellular Component:
PANTHER protein class:
Pathway Categories: Wnt signaling pathway
   Histone deacetylase
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: histone H4K8 deacetylase activity, hydrolytic mechanism, histone H4K5 deacetylase activity, hydrolytic mechanism, histone H4K12 deacetylase activity, hydrolytic mechanism, protein decrotonylase activity, histone decrotonylase activity, GTPase binding, histone H3K14 deacetylase activity, hydrolytic mechanism, histone H3K9 deacetylase activity, hydrolytic mechanism, protein lysine deacetylase activity, DNA-binding transcription factor binding, chromatin DNA binding, histone deacetylase binding, tubulin deacetylase activity, chromatin binding, transcription factor binding, ubiquitin-specific protease binding, histone H3K4 deacetylase activity, hydrolytic mechanism, transcription corepressor binding, NF-kappaB binding, DNA binding, histone H4K16 deacetylase activity, hydrolytic mechanism, protein lysine delactylase activity, protein binding, histone deacetylase activity, transcription corepressor activity, metal ion binding, cyclin binding, protein de-2-hydroxyisobutyrylase activity, deacetylase activity, enzyme binding
GO BP Complete: protein modification process, regulation of multicellular organism growth, negative regulation of interleukin-1 production, neural precursor cell proliferation, epidermis development, transcription by RNA polymerase II, chromatin organization, regulation of circadian rhythm, positive regulation of transcription by RNA polymerase II, positive regulation of neuron apoptotic process, establishment of skin barrier, negative regulation of transcription by RNA polymerase II, spindle assembly, circadian regulation of gene expression, negative regulation of DNA-templated transcription, in utero embryonic development, cellular response to fluid shear stress, positive regulation of protein ubiquitination, positive regulation of type B pancreatic cell apoptotic process, positive regulation of cold-induced thermogenesis, positive regulation of TOR signaling, negative regulation of tumor necrosis factor production, positive regulation of protein import into nucleus, negative regulation of protein export from nucleus, cornified envelope assembly, protein deacetylation, negative regulation of DNA-binding transcription factor activity, negative regulation of JNK cascade, regulation of mitotic cell cycle, epigenetic regulation of gene expression, establishment of mitotic spindle orientation, regulation of protein stability, random inactivation of X chromosome, positive regulation of protein phosphorylation, negative regulation of cardiac muscle cell differentiation, DNA repair-dependent chromatin remodeling, gene expression
GO CC Complete: nucleus, mitotic spindle, cytoplasm, transcription repressor complex, histone deacetylase complex, cytosol, Golgi apparatus, chromatin, plasma membrane, nucleoplasm
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux, Transcriptional regulation of white adipocyte differentiation, Cellular responses to stimuli, Signaling by Receptor Tyrosine Kinases, Chromatin organization, Signal Transduction, Cellular response to chemical stress, Signaling by ALK, Cytoprotection by HMOX1, Generic Transcription Pathway, Signaling by Nuclear Receptors, Metabolism of lipids, Regulation of lipid metabolism by PPARalpha, Chromatin modifying enzymes, Gene expression (Transcription), NR1H2 and NR1H3-mediated signaling, Metabolism, STAT3 nuclear events downstream of ALK signaling, HDACs deacetylate histones, Developmental Biology, Cellular responses to stress, Notch-HLH transcription pathway, RNA Polymerase II Transcription

Orthologs