PANTHER Gene Information

Gene Symbol(s):

thyA

Organism:

Mycobacterium tuberculosis

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Tree

Gene Name:

Thymidylate synthase ThyA

Gene ID:

Rv2764c

Protein ID:

P9WFR9

Persistent Id:

PTN002264997

Alternate Ids:

2.1.1.45 {ECO:0000255\|HAMAP-Rule:MF_00008, ECO:0000269\|PubMed:18493582}(EC)	529281038(GI)
NZ_NVQJ01000020(refSeq)	TYSY_MYCTU(UniProtKB-ID)
AL123456(EMBL)	thyA{ECO:0000255\|HAMAP-Rule:MF_00008}(Symbol)
45426752(GeneID)	L0TD99(AltAccession)
CHEMBL1795162(ChEMBL)	MetaCyc:G185E-7013-MON(BioCyc)
CCP45563(EMBL-CDS)	TSase {ECO:0000255\|HAMAP-Rule:MF_00008}(Synonym)
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PANTHER Classification

PANTHER Family:	THYMIDYLATE SYNTHASE 1 (PTHR11548)
PANTHER Subfamily:	THYMIDYLATE SYNTHASE (PTHR11548:SF9)
PANTHER GO-slim Molecular Function:	methyltransferase activity
PANTHER GO-slim Biological Process:	pyrimidine nucleotide metabolic process nucleoside monophosphate metabolic process carbohydrate derivative biosynthetic process organonitrogen compound biosynthetic process nucleotide biosynthetic process
PANTHER GO-slim Cellular Component:	cytosol
PANTHER protein class:	methyltransferase

Pathway Categories:

Tetrahydrofolate biosynthesis

Dihydrofolate synthase

Formyltetrahydrofolate biosynthesis

Dihydrofolate reductase

De novo pyrimidine deoxyribonucleotide biosynthesis

Thymidylate synthase

Tetrahydrofolate biosynthesis

Dihydrofolate reductase

Formyltetrahydrofolate biosynthesis

Thymidylate synthase

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	thymidylate synthase activity, methyltransferase activity
GO BP Complete:	dUMP catabolic process, nucleotide biosynthetic process, response to antibiotic, dTMP biosynthetic process, dTTP biosynthetic process, methylation
GO CC Complete:	cytoplasm, cytosol

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=12441\|UniProtKB=P04818	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000009822.5\|UniProtKB=H2QE68	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000014000.3\|UniProtKB=G3SAP3	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000004046.4\|UniProtKB=F6ZR77	Macaca mulatta	O
MOUSE\|MGI=MGI=98878\|UniProtKB=P07607	Mus musculus	O
RAT\|RGD=3921\|UniProtKB=P45352	Rattus norvegicus	O
BOVIN\|Gene=TYMS\|UniProtKB=Q2TA32	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000053268.1\|UniProtKB=A0A3Q1NID0	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000007003.5\|UniProtKB=F1MY63	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000040678.3\|UniProtKB=A0A287AFN2	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000023203.4\|UniProtKB=A0A9L0T6Q2	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000009230.5\|UniProtKB=M3WB14	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845001914.1\|UniProtKB=A0A8I3MMV4	Canis lupus familiaris	O
ORNAN\|Ensembl=ENSOANG00000044424.1\|UniProtKB=A0A6I8NBI6	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010003884.1\|UniProtKB=A0A8V0XB09	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000008456.4\|UniProtKB=G1KHU7	Anolis carolinensis	O
XENLA\|Gene=tyms.L\|UniProtKB=A1L2V6	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-1001385\|UniProtKB=Q0IHX3	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000011063.2\|UniProtKB=H2M5Y9	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-040426-59\|UniProtKB=Q6P045	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000010997.1\|UniProtKB=W5MYN1	lepisosteus oculatus	O
BRAFL\|Gene=LOC118409720\|UniProtKB=A0A9J7KMW3	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC593137\|UniProtKB=A0A7M7P3M0	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00022455\|UniProtKB=Q9N588	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00039295\|UniProtKB=A8XXD3	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00097987\|UniProtKB=A0A2A6B4T4	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0024920\|UniProtKB=O76511	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP010457\|UniProtKB=Q7QDW7	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC004238\|UniProtKB=D7EIA1	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC007732\|UniProtKB=D2A1S6	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_319193\|UniProtKB=E9GKZ1	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_304293\|UniProtKB=E9GKZ0	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW024938\|UniProtKB=B7QMU1	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW014062\|UniProtKB=B7QLC8	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW000960\|UniProtKB=B7P7E2	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG87612\|UniProtKB=T1G6T0	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g227987\|UniProtKB=A7RH38	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG18453\|UniProtKB=B3RLB4	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_32402\|UniProtKB=A9UZA9	Monosiga brevicollis	O
YEAST\|SGD=S000005600\|UniProtKB=P06785	Saccharomyces cerevisiae	O
EREGS\|EnsemblGenome=AGOS_ADR219C\|UniProtKB=Q759Q4	Eremothecium gossypii	O
CANAL\|CGD=CAL0000189182\|UniProtKB=P12461	Candida albicans	O
YARLI\|EnsemblGenome=YALI0_C10901g\|UniProtKB=Q6CCB3	Yarrowia lipolytica	O
EMENI\|EnsemblGenome=ANIA_07028\|UniProtKB=C8VB77	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_4G04270\|UniProtKB=Q4W9N9	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU10053\|UniProtKB=Q7S072	Neurospora crassa	O
SCLS1\|EnsemblGenome=SS1G_08456\|UniProtKB=A7ET01	Sclerotinia sclerotiorum	O
PHANO\|EnsemblGenome=SNOG_12584\|UniProtKB=Q0U6N0	Phaeosphaeria nodorum	O
SCHPO\|PomBase=SPAC15E1.04\|UniProtKB=Q9UTI7	Schizosaccharomyces pombe	O
SCHJY\|EnsemblGenome=SJAG_04627\|UniProtKB=B6K7B9	Schizosaccharomyces japonicus	O
CRYNJ\|EnsemblGenome=CNJ01230\|UniProtKB=P0CS12	Cryptococcus neoformans	O
USTMA\|EnsemblGenome=UMAG_02407\|UniProtKB=A0A0D1E1R6	Ustilago maydis	O
PUCGT\|EnsemblGenome=PGTG_15305\|UniProtKB=E3KYR7	Puccinia graminis	O
BATDJ\|Gene_ORFName=BATDEDRAFT_10605\|UniProtKB=F4P0R5	Batrachochytrium dendrobatidis	O
LEIMA\|EnsemblGenome=LMJF_06_0860\|UniProtKB=P07382	Leishmania major	O
TRYB2\|Gene_ORFName=Tb927.7.5480\|UniProtKB=Q582G3	Trypanosoma brucei	O
PLAF7\|EnsemblGenome=PF3D7_0417200\|UniProtKB=Q8I1R6	Plasmodium falciparum	O
PARTE\|EnsemblGenome=GSPATT00019973001\|UniProtKB=Q27828	Paramecium tetraurelia	O
THAPS\|EnsemblGenome=THAPS_13647\|UniProtKB=B5YMV7	Thalassiosira pseudonana	O
PHYRM\|Gene=H3GWN7_PHYRM\|UniProtKB=H3GWN7	Phytophthora ramorum	O
CHLRE\|EnsemblGenome=CHLRE_17g715900v5\|UniProtKB=A0A2K3CPY4	Chlamydomonas reinhardtii	O
AMBTC\|EnsemblGenome=AMTR_s00014p00122790\|UniProtKB=W1PPK0	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_5G02610\|UniProtKB=A0A0K9NUT2	Zostera marina	O
MUSAM\|EnsemblGenome=Ma02_g16110\|UniProtKB=A0A804I3E0	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_026222mg\|UniProtKB=K3ZI20	Setaria italica	O
SETIT\|EnsemblGenome=SETIT_029497mg\|UniProtKB=K3ZSB7	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3005G115500\|UniProtKB=A0A1B6PRT5	Sorghum bicolor	O
MAIZE\|Gene=DRTS\|UniProtKB=O81395	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb169580\|UniProtKB=A0A1D6PSY9	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb112740\|UniProtKB=A0A1D6F5H8	Zea mays	O
ORYSJ\|Gene_OrderedLocusName=LOC_Os12g26060\|UniProtKB=Q2QRX6	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_4g07810v3\|UniProtKB=A0A0Q3HES9	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.2HG0205550\|UniProtKB=F2DUZ4	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS2D02G520000\|UniProtKB=A0A3B6DPV5	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2A02G518600\|UniProtKB=A0A3B6B884	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2B02G547000\|UniProtKB=A0A3B6CEZ9	Triticum aestivum	O
ORYSJ\|EnsemblGenome=Os11g0484400\|UniProtKB=Q2R481	Oryza sativa	O
NELNU\|Gene=LOC104595633\|UniProtKB=A0A1U8A108	Nelumbo nucifera	O
SPIOL\|Gene=LOC110803064\|UniProtKB=A0A9R0KB06	Spinacia oleracea	O
HELAN\|EnsemblGenome=HanXRQr2_Chr13g0619231\|UniProtKB=A0A251SYK8	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr03g0109521\|UniProtKB=A0A251V7L6	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C900499360\|UniProtKB=A0A9R1WW08	Lactuca sativa	O
LACSA\|Gene_ORFName=LSAT_V11C400194360\|UniProtKB=A0A9R1XF14	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a004601mg\|UniProtKB=A0A022R1Q8	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_00605\|UniProtKB=A0A1U8DXM1	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400000736\|UniProtKB=M0ZJD1	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc01g109830.3\|UniProtKB=A0A3Q7EUX7	Solanum lycopersicum	O
TOBAC\|Gene=LOC107794251\|UniProtKB=A0A1S4A6M3	Nicotiana tabacum	O
TOBAC\|Gene=LOC107792811\|UniProtKB=A0A1S4A1Q9	Nicotiana tabacum	O
VITVI\|Gene_OrderedLocusName=VIT_18s0001g12940\|UniProtKB=F6H1I8	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_F01594\|UniProtKB=A0A059BPA9	Eucalyptus grandis	O
JUGRE\|EnsemblGenome=Jr11_20980\|UniProtKB=A0A2I4ENY3	Juglans regia	O
JUGRE\|Gene=LOC108991352\|UniProtKB=A0A6P9ERY0	Juglans regia	O
VITVI\|EnsemblGenome=Vitvi03g04109\|UniProtKB=F6I0M2	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_A01332\|UniProtKB=A0A059DFL3	Eucalyptus grandis	O
EUCGR\|EnsemblGenome=EUGRSUZ_G01624\|UniProtKB=A0A059BCN4	Eucalyptus grandis	O
BRANA\|Gene_ORFName=GSBRNA2T00015870001\|UniProtKB=A0A078G7S1	Brassica napus	O
BRACM\|EnsemblGenome=Bra000581\|UniProtKB=M4C8Q3	Brassica campestris	O
ARATH\|TAIR=locus=2049389\|UniProtKB=Q9SIK4	Arabidopsis thaliana	O
BRACM\|EnsemblGenome=Bra013079\|UniProtKB=M4D9B9	Brassica campestris	O
BRACM\|EnsemblGenome=Bra011543\|UniProtKB=M4D4Y6	Brassica campestris	O
ARATH\|TAIR=locus=2042649\|UniProtKB=Q05762	Arabidopsis thaliana	O
BRANA\|Gene_ORFName=GSBRNA2T00081771001\|UniProtKB=A0A078I5G1	Brassica napus	O
BRACM\|EnsemblGenome=Bra017662\|UniProtKB=M4DMC9	Brassica campestris	O
ARATH\|TAIR=locus=2139544\|UniProtKB=Q05763	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107908795\|UniProtKB=A0A1U8JTF5	Gossypium hirsutum	O
GOSHI\|Gene=LOC107928896\|UniProtKB=A0A1U8LR30	Gossypium hirsutum	O
GOSHI\|Gene=LOC107927990\|UniProtKB=A0A1U8LJ43	Gossypium hirsutum	O
GOSHI\|Gene=LOC107937003\|UniProtKB=A0A1U8MEM0	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_006844\|UniProtKB=A0A061E0T8	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g009747mg\|UniProtKB=A0A067E213	Citrus sinensis	O
POPTR\|EnsemblGenome=POPTR_009G119200v3\|UniProtKB=B9HRK6	Populus trichocarpa	O
POPTR\|EnsemblGenome=POPTR_004G157400v3\|UniProtKB=A0A2K2AVA6	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_04G073700\|UniProtKB=A0A2C9W2M5	Manihot esculenta	O
MANES\|EnsemblGenome=MANES_11G084400\|UniProtKB=A0A2C9UZN7	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_1595270\|UniProtKB=B9R7Y4	Ricinus communis	O
RICCO\|Gene_ORFName=RCOM_1447960\|UniProtKB=B9RH79	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_12G041000\|UniProtKB=I1LQ11	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_06G010600\|UniProtKB=I1K754	Glycine max	O
SOYBN\|Gene=DRTS_SOYBN\|UniProtKB=P51820	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_04G010800\|UniProtKB=K7KHI6	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_11G115200\|UniProtKB=A0A0R0HFN7	Glycine max	O
MEDTR\|EnsemblGenome=MTR_6g015630\|UniProtKB=A0A072UH24	Medicago truncatula	O
MEDTR\|EnsemblGenome=MTR_3g117080\|UniProtKB=G7J765	Medicago truncatula	O
MEDTR\|EnsemblGenome=MTR_4g070670\|UniProtKB=G7JHF2	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr13_07690\|UniProtKB=A0A2I4E7I6	Juglans regia	O
JUGRE\|EnsemblGenome=Jr16_17840\|UniProtKB=A0A2I4DTY5	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_2G248730\|UniProtKB=A0A0A0LPA5	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_8G092500\|UniProtKB=A0A251MVI5	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_404548\|UniProtKB=D8QVP4	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_233517\|UniProtKB=D8SA97	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c14_22050\|UniProtKB=A0A2K1JJE8	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0082s0036\|UniProtKB=A0A2R6WJZ5	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_000430150\|UniProtKB=A0A1Y1HPI3	Klebsormidium nitens	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g145132\|UniProtKB=A7T438	Nematostella vectensis	O
TRIV3\|Gene_ORFName=TVAG_343240\|UniProtKB=A2E1C8	Trichomonas vaginalis	O
METAC\|EnsemblGenome=MA_4543\|UniProtKB=Q8THH4	Methanosarcina acetivorans	O
METJA\|EnsemblGenome=MJ_0511\|UniProtKB=Q57931	Methanocaldococcus jannaschii	O
MYCGE\|EnsemblGenome=MG_227\|UniProtKB=P47469	mycoplasma genitalium	LDO
CLOBH\|Gene_OrderedLocusName=CBO0768\|UniProtKB=A5HZW1	Clostridium botulinum	LDO
STAA8\|EnsemblGenome=SAOUHSC_01435\|UniProtKB=Q2FYK5	Staphylococcus aureus	LDO
LISMO\|EnsemblGenome=CAC99952\|UniProtKB=Q8Y626	Listeria monocytogenes	LDO
BACSU\|EnsemblGenome=BSU_21820\|UniProtKB=P11044	Bacillus subtilis	LDO
BACCR\|EnsemblGenome=BC_2191\|UniProtKB=Q81E05	Bacillus cereus	LDO
DEIRA\|EnsemblGenome=DR_2630\|UniProtKB=Q9RR67	Deinococcus radiodurans	LDO
BACTN\|EnsemblGenome=BT_2047\|UniProtKB=Q8A639	Bacteroides thetaiotaomicron	LDO
RHOBA\|EnsemblGenome=RB12614\|UniProtKB=Q7UID0	Rhodopirellula baltica	LDO
NEIMB\|EnsemblGenome=NMB1709\|UniProtKB=Q9JY72	Neisseria meningitidis serogroup b	LDO
BRADU\|EnsemblGenome=BAC51777\|UniProtKB=Q89G35	Bradyrhizobium diazoefficiens	LDO
COXBU\|EnsemblGenome=CBU_1547\|UniProtKB=Q83BG2	Coxiella burnetii	LDO
HAEIN\|EnsemblGenome=HI_0905\|UniProtKB=P44420	Haemophilus influenzae	LDO
SHEON\|Gene_OrderedLocusName=SO_1335\|UniProtKB=Q8EH94	Shewanella oneidensis	LDO
VIBCH\|EnsemblGenome=VC_0675\|UniProtKB=O66108	Vibrio cholerae	LDO
XANCP\|EnsemblGenome=XCC0787\|UniProtKB=Q8PCE7	Xanthomonas campestris	LDO
PSEAE\|EnsemblGenome=PA0342\|UniProtKB=Q9I6F1	Pseudomonas aeruginosa	LDO
SALTY\|EnsemblGenome=STM3001\|UniProtKB=Q8ZMA9	Salmonella typhimurium	LDO
YERPE\|EnsemblGenome=YP_2875\|UniProtKB=Q8ZHV1	Yersinia pestis	LDO
ECOLI\|EnsemblGenome=BAE76896\|UniProtKB=P0A884	Escherichia coli	LDO