PANTHER Gene Information

Gene Symbol(s):

Tb07.10C21.550

Organism:

Trypanosoma brucei

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Gene Name:

Bifunctional dihydrofolate reductase-thymidylate synthase

Gene ID:

Tb927.7.5480

Protein ID:

Q582G3

Persistent Id:

PTN002264988

Alternate Ids:

Q582G3_TRYB2(UniProtKB-ID)	XP_846171(refSeq)
Q582G3(Synonym)	CHEMBL5229(ChEMBL)
AAX78868(EMBL-CDS)	AC091553(EMBL)
72391754(GI)	3658761(GeneID)
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PANTHER Classification

PANTHER Family:	THYMIDYLATE SYNTHASE 1 (PTHR11548)
PANTHER Subfamily:	THYMIDYLATE SYNTHASE (PTHR11548:SF2)
PANTHER GO-slim Molecular Function:	methyltransferase activity
PANTHER GO-slim Biological Process:	pyrimidine nucleotide metabolic process nucleoside monophosphate metabolic process carbohydrate derivative biosynthetic process organonitrogen compound biosynthetic process nucleotide biosynthetic process
PANTHER GO-slim Cellular Component:	cytosol mitochondrion
PANTHER protein class:	methyltransferase

Pathway Categories:

Tetrahydrofolate biosynthesis

Dihydrofolate synthase

Formyltetrahydrofolate biosynthesis

Dihydrofolate reductase

De novo pyrimidine deoxyribonucleotide biosynthesis

Thymidylate synthase

Tetrahydrofolate biosynthesis

Dihydrofolate reductase

Formyltetrahydrofolate biosynthesis

Thymidylate synthase

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	thymidylate synthase activity, dihydrofolate reductase activity
GO BP Complete:	post-transcriptional regulation of gene expression, nucleotide biosynthetic process, thymidine biosynthetic process, dTMP biosynthetic process, glycine biosynthetic process
GO CC Complete:	cytoplasm, mitochondrion, cytosol

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=12441\|UniProtKB=P04818	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000009822.5\|UniProtKB=H2QE68	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000014000.3\|UniProtKB=G3SAP3	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000004046.4\|UniProtKB=F6ZR77	Macaca mulatta	LDO
MOUSE\|MGI=MGI=98878\|UniProtKB=P07607	Mus musculus	LDO
RAT\|RGD=3921\|UniProtKB=P45352	Rattus norvegicus	LDO
BOVIN\|Gene=TYMS\|UniProtKB=Q2TA32	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000053268.1\|UniProtKB=A0A3Q1NID0	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000007003.5\|UniProtKB=F1MY63	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000040678.3\|UniProtKB=A0A287AFN2	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000023203.4\|UniProtKB=A0A9L0T6Q2	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000009230.5\|UniProtKB=M3WB14	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845001914.1\|UniProtKB=A0A8I3MMV4	Canis lupus familiaris	LDO
ORNAN\|Ensembl=ENSOANG00000044424.1\|UniProtKB=A0A6I8NBI6	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010003884.1\|UniProtKB=A0A8V0XB09	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000008456.4\|UniProtKB=G1KHU7	Anolis carolinensis	LDO
XENLA\|Gene=tyms.L\|UniProtKB=A1L2V6	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-1001385\|UniProtKB=Q0IHX3	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000011063.2\|UniProtKB=H2M5Y9	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-040426-59\|UniProtKB=Q6P045	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000010997.1\|UniProtKB=W5MYN1	lepisosteus oculatus	LDO
BRAFL\|Gene=LOC118409720\|UniProtKB=A0A9J7KMW3	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC593137\|UniProtKB=A0A7M7P3M0	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00022455\|UniProtKB=Q9N588	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00039295\|UniProtKB=A8XXD3	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00097987\|UniProtKB=A0A2A6B4T4	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0024920\|UniProtKB=O76511	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP010457\|UniProtKB=Q7QDW7	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC004238\|UniProtKB=D7EIA1	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC007732\|UniProtKB=D2A1S6	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_319193\|UniProtKB=E9GKZ1	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_304293\|UniProtKB=E9GKZ0	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW024938\|UniProtKB=B7QMU1	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW014062\|UniProtKB=B7QLC8	Ixodes scapularis	O
IXOSC\|EnsemblGenome=ISCW000960\|UniProtKB=B7P7E2	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG87612\|UniProtKB=T1G6T0	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g227987\|UniProtKB=A7RH38	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG18453\|UniProtKB=B3RLB4	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_32402\|UniProtKB=A9UZA9	Monosiga brevicollis	LDO
YEAST\|SGD=S000005600\|UniProtKB=P06785	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_ADR219C\|UniProtKB=Q759Q4	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000189182\|UniProtKB=P12461	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_C10901g\|UniProtKB=Q6CCB3	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_07028\|UniProtKB=C8VB77	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_4G04270\|UniProtKB=Q4W9N9	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU10053\|UniProtKB=Q7S072	Neurospora crassa	LDO
SCLS1\|EnsemblGenome=SS1G_08456\|UniProtKB=A7ET01	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_12584\|UniProtKB=Q0U6N0	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPAC15E1.04\|UniProtKB=Q9UTI7	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_04627\|UniProtKB=B6K7B9	Schizosaccharomyces japonicus	LDO
CRYNJ\|EnsemblGenome=CNJ01230\|UniProtKB=P0CS12	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_02407\|UniProtKB=A0A0D1E1R6	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_15305\|UniProtKB=E3KYR7	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_10605\|UniProtKB=F4P0R5	Batrachochytrium dendrobatidis	LDO
LEIMA\|EnsemblGenome=LMJF_06_0860\|UniProtKB=P07382	Leishmania major	LDO
PLAF7\|EnsemblGenome=PF3D7_0417200\|UniProtKB=Q8I1R6	Plasmodium falciparum	LDO
PARTE\|EnsemblGenome=GSPATT00019973001\|UniProtKB=Q27828	Paramecium tetraurelia	LDO
THAPS\|EnsemblGenome=THAPS_13647\|UniProtKB=B5YMV7	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3GWN7_PHYRM\|UniProtKB=H3GWN7	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_17g715900v5\|UniProtKB=A0A2K3CPY4	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00014p00122790\|UniProtKB=W1PPK0	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_5G02610\|UniProtKB=A0A0K9NUT2	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma02_g16110\|UniProtKB=A0A804I3E0	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_026222mg\|UniProtKB=K3ZI20	Setaria italica	O
SETIT\|EnsemblGenome=SETIT_029497mg\|UniProtKB=K3ZSB7	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3005G115500\|UniProtKB=A0A1B6PRT5	Sorghum bicolor	LDO
MAIZE\|Gene=DRTS\|UniProtKB=O81395	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb169580\|UniProtKB=A0A1D6PSY9	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb112740\|UniProtKB=A0A1D6F5H8	Zea mays	LDO
ORYSJ\|Gene_OrderedLocusName=LOC_Os12g26060\|UniProtKB=Q2QRX6	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_4g07810v3\|UniProtKB=A0A0Q3HES9	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.2HG0205550\|UniProtKB=F2DUZ4	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS2D02G520000\|UniProtKB=A0A3B6DPV5	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2A02G518600\|UniProtKB=A0A3B6B884	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2B02G547000\|UniProtKB=A0A3B6CEZ9	Triticum aestivum	O
ORYSJ\|EnsemblGenome=Os11g0484400\|UniProtKB=Q2R481	Oryza sativa	LDO
NELNU\|Gene=LOC104595633\|UniProtKB=A0A1U8A108	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110803064\|UniProtKB=A0A9R0KB06	Spinacia oleracea	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr13g0619231\|UniProtKB=A0A251SYK8	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr03g0109521\|UniProtKB=A0A251V7L6	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C900499360\|UniProtKB=A0A9R1WW08	Lactuca sativa	O
LACSA\|Gene_ORFName=LSAT_V11C400194360\|UniProtKB=A0A9R1XF14	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a004601mg\|UniProtKB=A0A022R1Q8	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_00605\|UniProtKB=A0A1U8DXM1	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG400000736\|UniProtKB=M0ZJD1	Solanum tuberosum	LDO
SOLLC\|EnsemblGenome=Solyc01g109830.3\|UniProtKB=A0A3Q7EUX7	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107794251\|UniProtKB=A0A1S4A6M3	Nicotiana tabacum	O
TOBAC\|Gene=LOC107792811\|UniProtKB=A0A1S4A1Q9	Nicotiana tabacum	LDO
VITVI\|Gene_OrderedLocusName=VIT_18s0001g12940\|UniProtKB=F6H1I8	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_F01594\|UniProtKB=A0A059BPA9	Eucalyptus grandis	O
JUGRE\|EnsemblGenome=Jr11_20980\|UniProtKB=A0A2I4ENY3	Juglans regia	O
JUGRE\|Gene=LOC108991352\|UniProtKB=A0A6P9ERY0	Juglans regia	O
VITVI\|EnsemblGenome=Vitvi03g04109\|UniProtKB=F6I0M2	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_A01332\|UniProtKB=A0A059DFL3	Eucalyptus grandis	O
EUCGR\|EnsemblGenome=EUGRSUZ_G01624\|UniProtKB=A0A059BCN4	Eucalyptus grandis	LDO
BRANA\|Gene_ORFName=GSBRNA2T00015870001\|UniProtKB=A0A078G7S1	Brassica napus	O
BRACM\|EnsemblGenome=Bra000581\|UniProtKB=M4C8Q3	Brassica campestris	O
ARATH\|TAIR=locus=2049389\|UniProtKB=Q9SIK4	Arabidopsis thaliana	O
BRACM\|EnsemblGenome=Bra013079\|UniProtKB=M4D9B9	Brassica campestris	LDO
BRACM\|EnsemblGenome=Bra011543\|UniProtKB=M4D4Y6	Brassica campestris	LDO
ARATH\|TAIR=locus=2042649\|UniProtKB=Q05762	Arabidopsis thaliana	LDO
BRANA\|Gene_ORFName=GSBRNA2T00081771001\|UniProtKB=A0A078I5G1	Brassica napus	O
BRACM\|EnsemblGenome=Bra017662\|UniProtKB=M4DMC9	Brassica campestris	O
ARATH\|TAIR=locus=2139544\|UniProtKB=Q05763	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107908795\|UniProtKB=A0A1U8JTF5	Gossypium hirsutum	O
GOSHI\|Gene=LOC107928896\|UniProtKB=A0A1U8LR30	Gossypium hirsutum	O
GOSHI\|Gene=LOC107927990\|UniProtKB=A0A1U8LJ43	Gossypium hirsutum	O
GOSHI\|Gene=LOC107937003\|UniProtKB=A0A1U8MEM0	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_006844\|UniProtKB=A0A061E0T8	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g009747mg\|UniProtKB=A0A067E213	Citrus sinensis	LDO
POPTR\|EnsemblGenome=POPTR_009G119200v3\|UniProtKB=B9HRK6	Populus trichocarpa	O
POPTR\|EnsemblGenome=POPTR_004G157400v3\|UniProtKB=A0A2K2AVA6	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_04G073700\|UniProtKB=A0A2C9W2M5	Manihot esculenta	O
MANES\|EnsemblGenome=MANES_11G084400\|UniProtKB=A0A2C9UZN7	Manihot esculenta	LDO
RICCO\|Gene_ORFName=RCOM_1595270\|UniProtKB=B9R7Y4	Ricinus communis	O
RICCO\|Gene_ORFName=RCOM_1447960\|UniProtKB=B9RH79	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_12G041000\|UniProtKB=I1LQ11	Glycine max	LDO
SOYBN\|EnsemblGenome=GLYMA_06G010600\|UniProtKB=I1K754	Glycine max	O
SOYBN\|Gene=DRTS_SOYBN\|UniProtKB=P51820	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_04G010800\|UniProtKB=K7KHI6	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_11G115200\|UniProtKB=A0A0R0HFN7	Glycine max	O
MEDTR\|EnsemblGenome=MTR_6g015630\|UniProtKB=A0A072UH24	Medicago truncatula	O
MEDTR\|EnsemblGenome=MTR_3g117080\|UniProtKB=G7J765	Medicago truncatula	O
MEDTR\|EnsemblGenome=MTR_4g070670\|UniProtKB=G7JHF2	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr13_07690\|UniProtKB=A0A2I4E7I6	Juglans regia	O
JUGRE\|EnsemblGenome=Jr16_17840\|UniProtKB=A0A2I4DTY5	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_2G248730\|UniProtKB=A0A0A0LPA5	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_8G092500\|UniProtKB=A0A251MVI5	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_404548\|UniProtKB=D8QVP4	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_233517\|UniProtKB=D8SA97	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c14_22050\|UniProtKB=A0A2K1JJE8	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0082s0036\|UniProtKB=A0A2R6WJZ5	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_000430150\|UniProtKB=A0A1Y1HPI3	Klebsormidium nitens	LDO
METAC\|EnsemblGenome=MA_4543\|UniProtKB=Q8THH4	Methanosarcina acetivorans	O
METJA\|EnsemblGenome=MJ_0511\|UniProtKB=Q57931	Methanocaldococcus jannaschii	O
STRR6\|EnsemblGenome=spr0585\|UniProtKB=P67050	Streptococcus pneumoniae	O
BACSU\|EnsemblGenome=BSU_17680\|UniProtKB=P0CI79	Bacillus subtilis	O
FUSNN\|EnsemblGenome=FN0240\|UniProtKB=Q8RGP6	Fusobacterium nucleatum	O
MYCTU\|Gene_OrderedLocusName=Rv2764c\|UniProtKB=P9WFR9	Mycobacterium tuberculosis	O
MYCGE\|EnsemblGenome=MG_227\|UniProtKB=P47469	mycoplasma genitalium	O
CLOBH\|Gene_OrderedLocusName=CBO0768\|UniProtKB=A5HZW1	Clostridium botulinum	O
STAA8\|EnsemblGenome=SAOUHSC_01435\|UniProtKB=Q2FYK5	Staphylococcus aureus	O
LISMO\|EnsemblGenome=CAC99952\|UniProtKB=Q8Y626	Listeria monocytogenes	O
BACSU\|EnsemblGenome=BSU_21820\|UniProtKB=P11044	Bacillus subtilis	O
BACCR\|EnsemblGenome=BC_2191\|UniProtKB=Q81E05	Bacillus cereus	O
DEIRA\|EnsemblGenome=DR_2630\|UniProtKB=Q9RR67	Deinococcus radiodurans	O
BACTN\|EnsemblGenome=BT_2047\|UniProtKB=Q8A639	Bacteroides thetaiotaomicron	O
RHOBA\|EnsemblGenome=RB12614\|UniProtKB=Q7UID0	Rhodopirellula baltica	O
NEIMB\|EnsemblGenome=NMB1709\|UniProtKB=Q9JY72	Neisseria meningitidis serogroup b	O
BRADU\|EnsemblGenome=BAC51777\|UniProtKB=Q89G35	Bradyrhizobium diazoefficiens	O
COXBU\|EnsemblGenome=CBU_1547\|UniProtKB=Q83BG2	Coxiella burnetii	O
HAEIN\|EnsemblGenome=HI_0905\|UniProtKB=P44420	Haemophilus influenzae	O
SHEON\|Gene_OrderedLocusName=SO_1335\|UniProtKB=Q8EH94	Shewanella oneidensis	O
VIBCH\|EnsemblGenome=VC_0675\|UniProtKB=O66108	Vibrio cholerae	O
XANCP\|EnsemblGenome=XCC0787\|UniProtKB=Q8PCE7	Xanthomonas campestris	O
PSEAE\|EnsemblGenome=PA0342\|UniProtKB=Q9I6F1	Pseudomonas aeruginosa	O
SALTY\|EnsemblGenome=STM3001\|UniProtKB=Q8ZMA9	Salmonella typhimurium	O
YERPE\|EnsemblGenome=YP_2875\|UniProtKB=Q8ZHV1	Yersinia pestis	O
ECOLI\|EnsemblGenome=BAE76896\|UniProtKB=P0A884	Escherichia coli	O