PANTHER Gene Information

Gene Symbol(s):

SCX

Organism:

Pan troglodytes

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Gene Name:

Scleraxis bHLH transcription factor

Gene ID:

ENSPTRG00000049318.1

Protein ID:

A0A2I3S988

Persistent Id:

PTN004633986

Alternate Ids:

AACZ04054484(EMBL)	XM_009456212(refSeq)
ENSPTRT00000094120(Ensembl_TRS)	A0A2I3S988(Synonym)
A0A2I3S988_PANTR(UniProtKB-ID)	ENSPTRP00000073386(Ensembl_PRO)
ENSPTRG00000049318(Ensembl)	1034183458(GI)
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PANTHER Classification

PANTHER Family:	BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST (PTHR23349)
PANTHER Subfamily:	BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR SCLERAXIS (PTHR23349:SF5)
PANTHER GO-slim Molecular Function:	DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding
PANTHER GO-slim Biological Process:	regulation of transcription by RNA polymerase II
PANTHER GO-slim Cellular Component:
PANTHER protein class:	basic helix-loop-helix transcription factor

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, cis-regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, sequence-specific DNA binding, protein dimerization activity, DNA-binding transcription factor activity, RNA polymerase II-specific, bHLH transcription factor binding, E-box binding
GO BP Complete:	sclerotome development, regulation of cartilage development, positive regulation of cartilage development, positive regulation of cell population proliferation, chondrocyte differentiation, positive regulation of transcription by RNA polymerase II, heart valve morphogenesis, face morphogenesis, positive regulation of collagen biosynthetic process, skeletal muscle cell differentiation, negative regulation of DNA-templated transcription, positive regulation of DNA-templated transcription, cellular response to BMP stimulus, BMP signaling pathway, mesoderm formation, developmental process, tendon cell differentiation, tendon formation, deltoid tuberosity development, DNA-templated transcription, heart valve formation, embryonic skeletal system development, regulation of transcription by RNA polymerase II, tissue homeostasis, cellular response to transforming growth factor beta stimulus, cellular response to mechanical stimulus, positive regulation of gene expression, negative regulation of apoptotic process, cell differentiation, positive regulation of gastrulation, endochondral ossification, tendon development, collagen fibril organization
GO CC Complete:	nucleus, transcription regulator complex

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=32322\|UniProtKB=Q7RTU7	Homo sapiens	LDO
MACMU\|Ensembl=ENSMMUG00000045410.2\|UniProtKB=A0A1D5QV41	Macaca mulatta	LDO
MOUSE\|MGI=MGI=102934\|UniProtKB=Q64124	Mus musculus	LDO
RAT\|RGD=1588254\|UniProtKB=G3V8X3	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000009816.6\|UniProtKB=E1B9U0	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000034551.2\|UniProtKB=A0A287B335	Sus scrofa	LDO
FELCA\|Ensembl=ENSFCAG00000041246.2\|UniProtKB=A0A337SE52	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845009375.1\|UniProtKB=A0A8I3N2A5	Canis lupus familiaris	LDO
ORNAN\|Ensembl=ENSOANG00000047264.1\|UniProtKB=A0A6I8NTX8	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010009458.1\|UniProtKB=A0A8V0XXN0	Gallus gallus	LDO
CHICK\|Gene=SCX\|UniProtKB=P59101	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000012688.4\|UniProtKB=H9GJ55	Anolis carolinensis	LDO
XENLA\|Gene=scx.L\|UniProtKB=A5H9T7	Xenopus laevis	O
XENLA\|Gene=scx.S\|UniProtKB=C0J6N0	Xenopus laevis	LDO
XENTR\|Gene=scx\|UniProtKB=A0A8J0R888	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000006041.2\|UniProtKB=H2LNG5	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-090806-1\|UniProtKB=A0A8N7T827	Danio rerio	LDO
DANRE\|Gene=scxa\|UniProtKB=A0A8M1NCA2	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000007444.1\|UniProtKB=W5MKW9	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000000045.3\|UniProtKB=Q4H2Z7	Ciona intestinalis	O
BRAFL\|Gene_ORFName=BRAFLDRAFT_126491\|UniProtKB=C3YC00	Branchiostoma floridae	O
BRAFL\|Gene_ORFName=BRAFLDRAFT_101984\|UniProtKB=C3ZX20	Branchiostoma floridae	O
BRAFL\|Gene=LOC118424513\|UniProtKB=A0A9J7N469	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC100894088\|UniProtKB=A0A7M7LPM9	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00001954\|UniProtKB=Q23579	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG19244\|UniProtKB=A8XV62	Caenorhabditis briggsae	O
CAEEL\|WormBase=WBGene00001962\|UniProtKB=Q20941	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG27394\|UniProtKB=B6IH10	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00206222\|UniProtKB=A0A2A6BY93	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0053557\|UniProtKB=Q59E67	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP013406\|UniProtKB=F5HJS7	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC015754\|UniProtKB=D2A3T4	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_227979\|UniProtKB=E9HA92	Daphnia pulex	O
HELRO\|EnsemblGenome=HelroG91618\|UniProtKB=T1G863	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g199398\|UniProtKB=A7RMR1	Nematostella vectensis	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g106073\|UniProtKB=A7S669	Nematostella vectensis	O
CRYNJ\|EnsemblGenome=CNH00430\|UniProtKB=Q5KCB3	Cryptococcus neoformans	O