PANTHER Gene Information   
Gene Symbol(s): BLM
Organism: Sus scrofa
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Gene Name: DNA helicase
Gene ID: ENSSSCG00000001816.5
Protein ID: F1RMJ2
Persistent Id: PTN002492242
Alternate Ids:
ENSSSCP00000001986(Ensembl_PRO) F1RMJ2_PIG(UniProtKB-ID)
F1RMJ2(Synonym) ENSSSCG00000001816(Ensembl)
ENSSSCT00000002035(Ensembl_TRS)
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PANTHER Classification
PANTHER Family: DNA HELICASE RECQ FAMILY MEMBER (PTHR13710)
PANTHER Subfamily: RECQ-LIKE DNA HELICASE BLM (PTHR13710:SF153)  
PANTHER GO-slim Molecular Function: 3'-5' DNA helicase activity
PANTHER GO-slim Biological Process: DNA unwinding involved in DNA replication
double-strand break repair via homologous recombination
PANTHER GO-slim Cellular Component: nucleus
cytoplasm
chromosome
PANTHER protein class: DNA helicase
Pathway Categories: No pathway information available
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: zinc ion binding, protein homodimerization activity, double-stranded DNA helicase activity, 8-hydroxy-2'-deoxyguanosine DNA binding, bubble DNA binding, hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, Y-form DNA binding, four-way junction helicase activity, forked DNA-dependent helicase activity, 3'-5' DNA helicase activity, four-way junction DNA binding, telomeric D-loop binding, ATP binding, p53 binding, telomeric G-quadruplex DNA binding, DNA/DNA annealing activity, single-stranded 3'-5' DNA helicase activity, isomerase activity
GO BP Complete: mitotic G2 DNA damage checkpoint signaling, response to X-ray, DNA double-strand break processing, G-quadruplex DNA unwinding, double-strand break repair via homologous recombination, protein homooligomerization, telomere maintenance, telomeric D-loop disassembly, DNA unwinding involved in DNA replication, negative regulation of DNA recombination, positive regulation of DNA-templated transcription, negative regulation of cell division, cellular response to ionizing radiation, resolution of DNA recombination intermediates, cellular response to hydroxyurea, replication fork processing, cellular response to camptothecin, regulation of DNA-templated DNA replication
GO CC Complete: chromosome, telomeric region, nucleus, PML body, cytoplasm, lateral element, cytosol, nuclear matrix, chromosome, nucleolus, RecQ family helicase-topoisomerase III complex
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Resolution of D-loop Structures through Holliday Junction Intermediates, Telomere Maintenance, Processing of DNA double-strand break ends, Metabolism of proteins, Post-translational protein modification, Gene expression (Transcription), DNA Repair, SUMOylation of DNA damage response and repair proteins, Cell Cycle Checkpoints, HDR through Homologous Recombination (HRR), SUMO E3 ligases SUMOylate target proteins, G2/M Checkpoints, RNA Polymerase II Transcription, DNA Double-Strand Break Repair, Homologous DNA Pairing and Strand Exchange, Transcriptional Regulation by TP53, Resolution of D-Loop Structures, Homology Directed Repair, Presynaptic phase of homologous DNA pairing and strand exchange, SUMOylation, Regulation of TP53 Activity, Telomere C-strand (Lagging Strand) Synthesis, Regulation of TP53 Activity through Phosphorylation, Processive synthesis on the C-strand of the telomere, G2/M DNA damage checkpoint, Chromosome Maintenance, Generic Transcription Pathway, Cell Cycle, HDR through Single Strand Annealing (SSA), Extension of Telomeres

Orthologs