PANTHER Gene Information

Gene Symbol(s):

DPYD

Organism:

Sus scrofa

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Tree

Gene Name:

Dihydropyrimidine dehydrogenase [NADP(+)]

Gene ID:

ENSSSCG00000006878.5

Protein ID:

F1S550

Persistent Id:

PTN008449093

Alternate Ids:

ENSSSCP00000007333(Ensembl_PRO)	F1S550_PIG(UniProtKB-ID)
F1S550(Synonym)	ENSSSCG00000006878(Ensembl)
ENSSSCT00000007532(Ensembl_TRS)
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PANTHER Classification

PANTHER Family:	DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)] (PTHR43073)
PANTHER Subfamily:	DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)] (PTHR43073:SF2)
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:
PANTHER protein class:	dehydrogenase

Pathway Categories:

Pyrimidine Metabolism

Dihydrouracil Dehydrogenase

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	NADP binding, protein homodimerization activity, metal ion binding, dihydropyrimidine dehydrogenase (NADP+) activity, 4 iron, 4 sulfur cluster binding, uracil binding
GO BP Complete:	beta-alanine biosynthetic process, dUMP catabolic process, purine nucleobase catabolic process, uracil catabolic process, thymine catabolic process, CMP catabolic process, dCMP catabolic process, UMP catabolic process, thymidine catabolic process
GO CC Complete:	cytosol

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Metabolism, Metabolism of nucleotides, Pyrimidine catabolism, Nucleotide catabolism

Orthologs

ID	Organism	Type
HUMAN\|HGNC=3012\|UniProtKB=Q12882	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000000990.7\|UniProtKB=H2PZG2	Pan troglodytes	O
MACMU\|Ensembl=ENSMMUG00000020726.4\|UniProtKB=A0A5F7ZRM8	Macaca mulatta	O
MOUSE\|MGI=MGI=2139667\|UniProtKB=Q8CHR6	Mus musculus	O
RAT\|RGD=621218\|UniProtKB=O89000	Rattus norvegicus	O
BOVIN\|Gene=DPYD\|UniProtKB=Q28007	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000031358.4\|UniProtKB=F1N549	Bos taurus	O
HORSE\|Ensembl=ENSECAG00000010881.4\|UniProtKB=F7AQA4	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000039421.3\|UniProtKB=A0A2I2UPM5	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845014137.1\|UniProtKB=A0A8I3NMY5	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000004065.4\|UniProtKB=F6VWD0	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000003850.3\|UniProtKB=F7FH18	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010024191.1\|UniProtKB=A0A8V0ZWJ2	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000005513.4\|UniProtKB=G1KED2	Anolis carolinensis	O
XENLA\|Gene=dpyd.L\|UniProtKB=A0A1L8GMQ4	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-1000802\|UniProtKB=A0A6I8QRG6	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000013626.2\|UniProtKB=H2MET3	Oryzias latipes	O
DANRE\|Gene=dpyda.1\|UniProtKB=A0A8M6YVM7	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-040426-2459\|UniProtKB=Q6NYG8	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000008253.1\|UniProtKB=W5MNR9	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000003770.3\|UniProtKB=F6TIR0	Ciona intestinalis	O
BRAFL\|Gene_ORFName=BRAFLDRAFT_129513\|UniProtKB=C3YCJ1	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC575768\|UniProtKB=A0A7M7T4A2	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00016103\|UniProtKB=Q18164	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG14689\|UniProtKB=A8XKG6	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00115941\|UniProtKB=A0A2A6BF87	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0086450\|UniProtKB=Q9W374	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP001021\|UniProtKB=Q7QHY0	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC010364\|UniProtKB=D6WGA9	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_202177\|UniProtKB=E9HC99	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW022746\|UniProtKB=B7QG52	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG69873\|UniProtKB=T1FZZ2	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g190441\|UniProtKB=A7SJG5	Nematostella vectensis	O
ENTH1\|EnsemblGenome=CL6EHI_012980\|UniProtKB=C4LX69	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0267966\|UniProtKB=Q55FT1	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_94040\|UniProtKB=F0ZEL9	Dictyostelium purpureum	O
TRIV3\|Gene_ORFName=TVAG_151830\|UniProtKB=A2ELU8	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_468240\|UniProtKB=A2E0R3	Trichomonas vaginalis	O
PARTE\|EnsemblGenome=GSPATT00007208001\|UniProtKB=A0CDX9	Paramecium tetraurelia	O
CHLRE\|EnsemblGenome=CHLRE_13g578750v5\|UniProtKB=A0A2K3D064	Chlamydomonas reinhardtii	O
AMBTC\|EnsemblGenome=AMTR_s00176p00027530\|UniProtKB=W1PTJ4	Amborella trichopoda	O
ZOSMR\|Gene_ORFName=ZOSMA_66G00650\|UniProtKB=A0A0K9NUN1	Zostera marina	O
MUSAM\|EnsemblGenome=Ma08_g23660\|UniProtKB=A0A804K9Z8	Musa acuminata subsp. malaccensis	O
SETIT\|EnsemblGenome=SETIT_017307mg\|UniProtKB=K3YSR2	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3004G246200\|UniProtKB=C5XZ92	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb253890\|UniProtKB=B4FZU9	Zea mays	O
ORYSJ\|EnsemblGenome=Os02g0736400\|UniProtKB=Q6Z744	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_3g59890v3\|UniProtKB=I1IFH8	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.6HG0613490\|UniProtKB=F2DDM9	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS6D02G278900\|UniProtKB=A0A3B6QHL7	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS6B02G328700\|UniProtKB=A0A3B6PQ55	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS6A02G299200\|UniProtKB=A0A3B6NU95	Triticum aestivum	O
NELNU\|Gene=LOC104607306\|UniProtKB=A0A1U8B517	Nelumbo nucifera	O
SPIOL\|Gene=LOC110779297\|UniProtKB=A0A9R0HYS8	Spinacia oleracea	O
HELAN\|EnsemblGenome=HanXRQr2_Chr16g0747241\|UniProtKB=A0A251RYR3	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr15g0715731\|UniProtKB=A0A251SBM6	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C900475240\|UniProtKB=A0A9R1UDW5	Lactuca sativa	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a006949mg\|UniProtKB=A0A022QDC8	Erythranthe guttata	O
CAPAN\|EnsemblGenome=T459_09904\|UniProtKB=A0A2G3A0R6	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400033683\|UniProtKB=M1D7F6	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc03g097910.3\|UniProtKB=Q8H6B5	Solanum lycopersicum	O
TOBAC\|Gene=LOC107809801\|UniProtKB=A0A1S4BMA9	Nicotiana tabacum	O
TOBAC\|Gene=LOC107809767\|UniProtKB=A0A1S4BM72	Nicotiana tabacum	O
VITVI\|EnsemblGenome=Vitvi17g00163\|UniProtKB=F6GSP9	Vitis vinifera	O
EUCGR\|EnsemblGenome=EUGRSUZ_K02286\|UniProtKB=A0A059A4F5	Eucalyptus grandis	O
BRANA\|Gene_ORFName=DARMORV10_A01P36570.1\|UniProtKB=A0A078I7H7	Brassica napus	O
BRACM\|EnsemblGenome=Bra021275\|UniProtKB=M4DXM9	Brassica campestris	O
BRANA\|Gene_ORFName=DARMORV10_C01P46400.1\|UniProtKB=A0A078IIT4	Brassica napus	O
BRACM\|EnsemblGenome=Bra022246\|UniProtKB=M4E0E9	Brassica campestris	O
ARATH\|TAIR=locus=2088570\|UniProtKB=Q9LVI9	Arabidopsis thaliana	O
GOSHI\|Gene=LOC107890863\|UniProtKB=A0A1U8HY49	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_012994\|UniProtKB=A0A061FW13	Theobroma cacao	O
CITSI\|Gene_ORFName=CISIN_1g014581mg\|UniProtKB=A0A067DY11	Citrus sinensis	O
POPTR\|EnsemblGenome=POPTR_015G030600v3\|UniProtKB=B9N381	Populus trichocarpa	O
MANES\|EnsemblGenome=MANES_06G002900\|UniProtKB=A0A2C9VLK4	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_0084140\|UniProtKB=B9T6I2	Ricinus communis	O
SOYBN\|EnsemblGenome=GLYMA_07G105400\|UniProtKB=I1KJ84	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_09G172700\|UniProtKB=C6TKV3	Glycine max	O
MEDTR\|EnsemblGenome=MTR_6g071210\|UniProtKB=G7KQB6	Medicago truncatula	O
JUGRE\|EnsemblGenome=Jr06_16180\|UniProtKB=A0A6P9EI48	Juglans regia	O
JUGRE\|EnsemblGenome=Jr15_11180\|UniProtKB=A0A2I4EW38	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_1G042970\|UniProtKB=A0A0A0LTU0	Cucumis sativus	O
PRUPE\|EnsemblGenome=PRUPE_5G236800\|UniProtKB=M5WUB1	Prunus persica	O
SELML\|EnsemblGenome=SELMODRAFT_80950\|UniProtKB=D8QYS2	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c23_13670\|UniProtKB=A0A2K1IJ87	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c20_21870\|UniProtKB=A0A2K1IW28	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0033s0018\|UniProtKB=A0A2R6X677	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_000490300\|UniProtKB=A0A0U9HQY1	Klebsormidium nitens	O