PANTHER Gene Information

Gene Symbol(s):

Epx

Organism:

Rattus norvegicus

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Gene Name:

Eosinophil peroxidase

Gene ID:

1311882

Protein ID:

D3ZSY4

Persistent Id:

PTN000158831

Alternate Ids:

D3ZSY4(Synonym)	1311882(RGD)
ENSRNOT00000011735(Ensembl_TRS)	NM_001107037(refSeq)
ENSRNOG00000008707(Ensembl)	D3ZSY4_RAT(UniProtKB-ID)
ENSRNOP00000011735(Ensembl_PRO)
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PANTHER Classification

PANTHER Family:	OXIDASE/PEROXIDASE (PTHR11475)
PANTHER Subfamily:	EOSINOPHIL PEROXIDASE (PTHR11475:SF63)
PANTHER GO-slim Molecular Function:	oxidoreductase activity, acting on peroxide as acceptor antioxidant activity
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:	extracellular space
PANTHER protein class:	peroxidase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	peroxidase activity, metal ion binding, heme binding
GO BP Complete:	response to oxidative stress, biological_process, defense response to nematode, negative regulation of interleukin-5 production, negative regulation of interleukin-10 production, negative regulation of macrophage cytokine production, cellular oxidant detoxification, eosinophil migration, defense response to bacterium, positive regulation of interleukin-4 production
GO CC Complete:	extracellular space

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Neutrophil degranulation, Immune System, Innate Immune System

Orthologs

ID	Organism	Type
HUMAN\|HGNC=3423\|UniProtKB=P11678	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000009446.5\|UniProtKB=H2QDI6	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000003135.3\|UniProtKB=G3QKU8	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000011973.4\|UniProtKB=F7H275	Macaca mulatta	LDO
MOUSE\|MGI=MGI=107569\|UniProtKB=P49290	Mus musculus	LDO
PIG\|Ensembl=ENSSSCG00000017630.5\|UniProtKB=F1RSB4	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000017317.4\|UniProtKB=F6RBT1	Equus caballus	LDO
CANLF\|Ensembl=ENSCAFG00845017713.1\|UniProtKB=A0A8I3NYF9	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000014755.4\|UniProtKB=A0A5F8GRK9	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000040563.1\|UniProtKB=F6YEM5	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010029571.1\|UniProtKB=A0A8V1AP82	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000000090.3\|UniProtKB=H9G386	Anolis carolinensis	LDO
XENLA\|Gene=mpo.L\|UniProtKB=Q8QFX3	Xenopus laevis	O
XENLA\|Gene=mpo.S\|UniProtKB=A0A8J1MD77	Xenopus laevis	O
XENTR\|Gene=mpo\|UniProtKB=A0A8J0QMK7	Xenopus tropicalis	O
XENLA\|Gene=epx.L\|UniProtKB=B7ZR75	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-6039946\|UniProtKB=A0A8J0QNI7	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000023289.1\|UniProtKB=A0A3B3I439	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000029520.1\|UniProtKB=A0A3B3HEP2	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000027810.1\|UniProtKB=A0A3B3HIJ5	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000009349.2\|UniProtKB=H2LZT8	Oryzias latipes	LDO
DANRE\|Gene=epx\|UniProtKB=A0A8M9PHJ3	Danio rerio	O
DANRE\|Gene=mpx\|UniProtKB=A0A8M1P4H4	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000015220.1\|UniProtKB=W5NDM5	lepisosteus oculatus	O
LEPOC\|Ensembl=ENSLOCG00000007217.1\|UniProtKB=W5MK29	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000002735.3\|UniProtKB=F6TPL8	Ciona intestinalis	O
CIOIN\|Ensembl=ENSCING00000001200.3\|UniProtKB=F6TKP0	Ciona intestinalis	LDO
CIOIN\|Ensembl=ENSCING00000007419.3\|UniProtKB=F7B882	Ciona intestinalis	O
BRAFL\|Gene=LOC118405423\|UniProtKB=A0A9J7KI86	Branchiostoma floridae	O
BRAFL\|Gene=LOC118421694\|UniProtKB=A0A9J7MYR9	Branchiostoma floridae	O
BRAFL\|Gene=LOC118410320\|UniProtKB=A0A9J7KPR3	Branchiostoma floridae	O
BRAFL\|Gene=LOC118405412\|UniProtKB=A0A9J7HM94	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC593243\|UniProtKB=A0A7M7NRT7	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00004256\|UniProtKB=Q1ENI8	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG01526\|UniProtKB=A8WQH2	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00112475\|UniProtKB=A0A2A6C1L5	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00022743\|UniProtKB=Q23490	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG03680\|UniProtKB=A8WVK8	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00112969\|UniProtKB=A0A2A6B3L1	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00009897\|UniProtKB=Q20616	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00024013\|UniProtKB=A8WND4	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00112337\|UniProtKB=A0A2A6D383	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00015841\|UniProtKB=P91060	Caenorhabditis elegans	O
CAEBR\|WormBase=WBGene00037311\|UniProtKB=A8XRR7	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00278329\|UniProtKB=A0A2A6BYY8	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00017968\|UniProtKB=H2KZ53	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG13113\|UniProtKB=A8XH40	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00273835\|UniProtKB=A0A2A6B853	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00004257\|UniProtKB=G5EG78	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG17537\|UniProtKB=A8XR70	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00100463\|UniProtKB=A0A2A6C2W5	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0011828\|UniProtKB=Q9VZZ4	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP007237\|UniProtKB=A0A1S4GUJ9	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC001556\|UniProtKB=D6WFS4	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_318324\|UniProtKB=E9GIG8	Daphnia pulex	O
IXOSC\|EnsemblGenome=ISCW022537\|UniProtKB=B7QCX2	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG89299\|UniProtKB=T1G7B8	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g110667\|UniProtKB=A7SA38	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG22758\|UniProtKB=B3RSQ8	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG27445\|UniProtKB=B3S2M4	Trichoplax adhaerens	O
MONBE\|EnsemblGenome=MONBRDRAFT_26049\|UniProtKB=A9V180	Monosiga brevicollis	O
DICDI\|dictyBase=DDB_G0277275\|UniProtKB=Q6TMK4	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_83593\|UniProtKB=F1A000	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_95122\|UniProtKB=F0ZSF2	Dictyostelium purpureum	O
THAPS\|EnsemblGenome=THAPSDRAFT_267958\|UniProtKB=B8BPZ7	Thalassiosira pseudonana	O
GLOVI\|Gene=Q7NFC7_GLOVI\|UniProtKB=Q7NFC7	Gloeobacter violaceus	O
RHOBA\|EnsemblGenome=RB4293\|UniProtKB=Q7USU5	Rhodopirellula baltica	O
BRADU\|Gene=Q89E60_BRADU\|UniProtKB=Q89E60	Bradyrhizobium diazoefficiens	O