PANTHER Gene Information   
Gene Symbol(s): Srf
Organism: Rattus norvegicus
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Gene Name: Serum response factor
Gene ID: 1559787
Protein ID: D3ZHH8
Persistent Id: PTN000235394
Alternate Ids:
501099(GeneID) NM_001109302(refSeq)
1559787(RGD) ENSRNOP00000058149(Ensembl_PRO)
D3ZHH8(Synonym) ENSRNOT00000061430(Ensembl_TRS)
564367415(GI) ENSRNOG00000018232(Ensembl)
D3ZHH8_RAT(UniProtKB-ID)
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PANTHER Classification
PANTHER Family: SERUM RESPONSE FACTOR HOMOLOG (PTHR48019)
PANTHER Subfamily: SERUM RESPONSE FACTOR (PTHR48019:SF168)  
PANTHER GO-slim Molecular Function: RNA polymerase II cis-regulatory region sequence-specific DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific
PANTHER GO-slim Biological Process: positive regulation of transcription by RNA polymerase II
PANTHER GO-slim Cellular Component:
PANTHER protein class: MADS box transcription factor
Pathway Categories: CCKR signaling map
   SRF
p38 MAPK pathway
   serum response factor
Interleukin signaling pathway
   Serum response factor
PDGF signaling pathway
   c-fos
Ras Pathway
   Serum response factor
Gonadotropin-releasing hormone receptor pathway
   SRF
PDGF signaling pathway
   Serum response factor
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: chromatin DNA binding, protein homodimerization activity, histone deacetylase binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, sequence-specific DNA binding, chromatin binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA binding, DNA-binding transcription factor activity, protein binding, serum response element binding, RNA polymerase II-specific DNA-binding transcription factor binding, sequence-specific double-stranded DNA binding, primary miRNA binding, DNA-binding transcription factor binding
GO BP Complete: epithelial cell-cell adhesion, positive regulation of filopodium assembly, transcription by RNA polymerase II, actin filament organization, cell migration involved in sprouting angiogenesis, positive regulation of transcription by glucose, associative learning, stress fiber assembly, skin morphogenesis, positive regulation of DNA-binding transcription factor activity, face development, response to hypoxia, forebrain development, in utero embryonic development, positive regulation of DNA-templated transcription, cellular response to glucose stimulus, platelet formation, heart looping, cardiac myofibril assembly, dorsal aorta morphogenesis, mesoderm formation, long-term synaptic depression, trophectodermal cell differentiation, sarcomere organization, negative regulation of amyloid-beta clearance, positive regulation of axon extension, positive thymic T cell selection, morphogenesis of an epithelial sheet, response to hormone, leukocyte differentiation, long-term memory, epithelial structure maintenance, bicellular tight junction assembly, negative regulation of cell migration, response to cytokine, muscle cell cellular homeostasis, positive regulation of transcription initiation by RNA polymerase II, negative regulation of miRNA transcription, negative regulation of cell population proliferation, cellular senescence, tangential migration from the subventricular zone to the olfactory bulb, positive regulation of miRNA transcription, positive regulation of transcription by RNA polymerase II, heart trabecula formation, establishment of skin barrier, positive regulation of smooth muscle contraction, thymus development, lung morphogenesis, heart development, neuron migration, cardiac vascular smooth muscle cell differentiation, branching involved in blood vessel morphogenesis, megakaryocyte development, platelet activation, cell-matrix adhesion, lung smooth muscle development, neuron projection development, regulation of DNA-templated transcription, hematopoietic stem cell differentiation, hippocampus development, positive regulation of cell differentiation, erythrocyte development, developmental growth, bronchus cartilage development, filopodium assembly, cardiac muscle cell myoblast differentiation, trachea cartilage development, eyelid development in camera-type eye, gastrulation, thyroid gland development, axon extension, regulation of cell adhesion, cell-cell adhesion, actin cytoskeleton organization, primitive streak formation, contractile actin filament bundle assembly
GO CC Complete: nucleus, cytoplasm, chromatin
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: RHO GTPase Effectors, Signaling by NTRK1 (TRKA), Nuclear Events (kinase and transcription factor activation), Signaling by Rho GTPases, Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Signal Transduction, NGF-stimulated transcription, RHO GTPases Activate Formins, Signaling by Rho GTPases, Miro GTPases and RHOBTB3

Orthologs