PANTHER Gene Information

Gene Symbol(s):

Cacna2d1

Organism:

Rattus norvegicus

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Gene Name:

Voltage-dependent calcium channel subunit alpha-2_delta-1

Gene ID:

2247

Protein ID:

P54290

Persistent Id:

PTN000018402

Alternate Ids:

2247(RGD)	1705853(GI)
Cchl2a(Synonym)	CHEMBL3420(ChEMBL)
AAA41088(EMBL-CDS)	Cacna2d1(Symbol)
CA2D1_RAT(UniProtKB-ID)	M86621(EMBL)
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PANTHER Classification

PANTHER Family:	VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED (PTHR10166)
PANTHER Subfamily:	VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2_DELTA-1 (PTHR10166:SF6)
PANTHER GO-slim Molecular Function:	voltage-gated calcium channel activity
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:	sarcolemma voltage-gated calcium channel complex
PANTHER protein class:	voltage-gated ion channel

Pathway Categories:

Muscarinic acetylcholine receptor 2 and 4 signaling pathway

L-type Calcium Channel

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	voltage-gated calcium channel activity involved in bundle of His cell action potential, protein binding, metal ion binding, calcium channel activity, voltage-gated calcium channel activity
GO BP Complete:	cardiac muscle cell action potential involved in contraction, membrane depolarization during bundle of His cell action potential, positive regulation of voltage-gated calcium channel activity, cellular response to amyloid-beta, regulation of ventricular cardiac muscle cell membrane repolarization, calcium ion transmembrane transport via high voltage-gated calcium channel, calcium ion transport into cytosol, regulation of calcium ion transmembrane transport via high voltage-gated calcium channel, calcium ion transport, calcium ion transmembrane transport, regulation of membrane repolarization during action potential, regulation of heart rate by cardiac conduction, regulation of calcium ion transport
GO CC Complete:	GABA-ergic synapse, T-tubule, L-type voltage-gated calcium channel complex, neuronal dense core vesicle, sarcoplasmic reticulum, postsynaptic membrane, voltage-gated calcium channel complex, presynaptic active zone membrane, glutamatergic synapse, monoatomic ion channel complex, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=1399\|UniProtKB=P54289	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000019350.7\|UniProtKB=A0A2I3S420	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000027366.2\|UniProtKB=A0A2I2YH32	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000030244.3\|UniProtKB=A0A1D5QVR4	Macaca mulatta	LDO
MOUSE\|MGI=MGI=88295\|UniProtKB=O08532	Mus musculus	LDO
BOVIN\|Ensembl=ENSBTAG00000020569.7\|UniProtKB=F1N7F9	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000015402.5\|UniProtKB=A0A287BIN3	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000010809.4\|UniProtKB=A0A3Q2H0H3	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000029914.4\|UniProtKB=A0A2I2UTD9	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845026601.1\|UniProtKB=A0A8I3QBI1	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000012063.4\|UniProtKB=A0A5F8GKH5	Monodelphis domestica	O
MONDO\|Ensembl=ENSMODG00000017022.4\|UniProtKB=F6Y0X6	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000003483.4\|UniProtKB=A0A6I8PGU1	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010010410.1\|UniProtKB=A0A3Q2TVT0	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000012663.4\|UniProtKB=G1KNB8	Anolis carolinensis	LDO
XENLA\|Gene=cacna2d1.S\|UniProtKB=A0A8J1MRM7	Xenopus laevis	O
XENLA\|Gene=cacna2d1.L\|UniProtKB=A0A8J1MN54	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-964524\|UniProtKB=A1L1E0	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000015164.2\|UniProtKB=H2MK02	Oryzias latipes	O
ORYLA\|Ensembl=ENSORLG00000016214.2\|UniProtKB=H2MNI4	Oryzias latipes	LDO
DANRE\|Gene=cacna2d1a\|UniProtKB=A0A8M3B8Y7	Danio rerio	O
DANRE\|Gene=cacna2d1\|UniProtKB=A0A8M6Z241	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000015521.1\|UniProtKB=W5NEQ3	lepisosteus oculatus	LDO
BRAFL\|Gene=LOC118416228\|UniProtKB=A0A9J7L7X3	Branchiostoma floridae	O
BRAFL\|Gene=LOC118416201\|UniProtKB=A0A9J7L7V5	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC105441547\|UniProtKB=A0A7M7MZD9	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00007041\|UniProtKB=G5EG74	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG02926\|UniProtKB=A8WT73	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00278310\|UniProtKB=A0A2A6BZ90	Pristionchus pacificus	O
CAEEL\|WormBase=WBGene00006772\|UniProtKB=P34374	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG16666\|UniProtKB=A8XP97	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00096769\|UniProtKB=A0A2A6CBK0	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0028863\|UniProtKB=X2J9Z3	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP009598\|UniProtKB=A0A903XHE3	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC001887\|UniProtKB=A0A139WP66	Tribolium castaneum	O
DROME\|FlyBase=FBgn0261999\|UniProtKB=Q8IP22	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP009579\|UniProtKB=A0A1S4H1J5	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC004591\|UniProtKB=D6W834	Tribolium castaneum	O
DROME\|FlyBase=FBgn0261041\|UniProtKB=A0A0B4K866	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP005490\|UniProtKB=A0A1S4GQ08	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC008265\|UniProtKB=D2A0T3	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC034736\|UniProtKB=A0A139WGS5	Tribolium castaneum	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_324542\|UniProtKB=E9H214	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_317041\|UniProtKB=E9GER3	Daphnia pulex	O
HELRO\|EnsemblGenome=HelroG174990\|UniProtKB=T1F8P7	helobdella robusta	O
TRIAD\|EnsemblGenome=TriadG56910\|UniProtKB=B3RWW7	Trichoplax adhaerens	O
TRIAD\|EnsemblGenome=TriadG56917\|UniProtKB=B3RWX4	Trichoplax adhaerens	O
EMENI\|EnsemblGenome=ANIA_05167\|UniProtKB=Q5B2R3	Emericella nidulans	O
ASPFU\|EnsemblGenome=AFUA_6G06990\|UniProtKB=Q4WNB0	Neosartorya fumigata	O
NEUCR\|EnsemblGenome=NCU07565\|UniProtKB=Q7S1Y8	Neurospora crassa	O
SELML\|EnsemblGenome=SELMODRAFT_423100\|UniProtKB=D8SKK3	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_402207\|UniProtKB=D8QPX5	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_423098\|UniProtKB=D8SKK1	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_402199\|UniProtKB=D8QPW7	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_423092\|UniProtKB=D8SKJ4	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_402200\|UniProtKB=D8QPW8	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_402202\|UniProtKB=D8QPX0	Selaginella moellendorffii	O
PHYPA\|EnsemblGenome=Pp3c1_25930\|UniProtKB=A0A2K1L9Q7	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c10_3200\|UniProtKB=A0A2K1JXH6	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c2_5170\|UniProtKB=A0A2K1L0A2	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c7_20720\|UniProtKB=A0A2K1KCD4	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c7_19620\|UniProtKB=A0A2K1KC88	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c20_5240\|UniProtKB=A0A2K1IU47	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c22_5320\|UniProtKB=A0A2K1IMC0	Physcomitrella patens	O
PHYPA\|EnsemblGenome=Pp3c17_14540\|UniProtKB=A0A7I4B6P4	Physcomitrella patens	O
MARPO\|EnsemblGenome=MARPO_0123s0041\|UniProtKB=A0A2R6W9N0	Marchantia polymorpha	O
MARPO\|EnsemblGenome=MARPO_0009s0226\|UniProtKB=A0A2R6XM14	Marchantia polymorpha	O
MARPO\|EnsemblGenome=MARPO_0110s0042\|UniProtKB=A0A2R6WCH7	Marchantia polymorpha	O
MARPO\|EnsemblGenome=MARPO_0123s0042\|UniProtKB=A0A2R6W9N1	Marchantia polymorpha	O
MARPO\|EnsemblGenome=MARPO_0009s0220\|UniProtKB=A0A2R6XM18	Marchantia polymorpha	O
MARPO\|EnsemblGenome=MARPO_0200s0010\|UniProtKB=A0A2R6W0N0	Marchantia polymorpha	O
KLENI\|Gene_ORFName=KFL_006550030\|UniProtKB=A0A1Y1IIM7	Klebsormidium nitens	O
KLENI\|Gene_ORFName=KFL_006550020\|UniProtKB=A0A1Y1IKA2	Klebsormidium nitens	O
STRCO\|Gene_OrderedLocusName=SCO2721\|UniProtKB=Q9L1J5	Streptomyces coelicolor	O
CLOBH\|Gene_OrderedLocusName=CBO3213\|UniProtKB=A5I6U2	Clostridium botulinum	O
CLOBH\|Gene_OrderedLocusName=CBO0552\|UniProtKB=A5HZ97	Clostridium botulinum	O
BACTN\|EnsemblGenome=BT_4465\|UniProtKB=Q89ZB2	Bacteroides thetaiotaomicron	O
RHOBA\|EnsemblGenome=RB7099\|UniProtKB=Q7UP85	Rhodopirellula baltica	O
SHEON\|Gene_OrderedLocusName=SO_3552\|UniProtKB=Q8EBG6	Shewanella oneidensis	O
XANCP\|EnsemblGenome=XCC2915\|UniProtKB=Q8P6Q2	Xanthomonas campestris	O
SALTY\|EnsemblGenome=STM2315\|UniProtKB=Q8ZNE5	Salmonella typhimurium	O
ECOLI\|EnsemblGenome=BAE76678\|UniProtKB=P76481	Escherichia coli	O