PANTHER Gene Information   
Gene Symbol(s): Nos2
Organism: Rattus norvegicus
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Gene Name: Nitric oxide synthase, inducible
Gene ID: 3185
Protein ID: Q06518
Persistent Id: PTN000454008
Alternate Ids:
24599(GeneID) iNOS(Synonym)
CHEMBL3051(ChEMBL) 3185(RGD)
D12520(EMBL) Nos2(Symbol)
2245675(GI) BAA02090(EMBL-CDS)
NM_012611(refSeq) 1.14.13.39 {ECO:0000250|UniProtKB:P35228}(EC)
NOS2_RAT(UniProtKB-ID) O35766(AltAccession)
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PANTHER Classification
PANTHER Family: NITRIC OXIDE SYNTHASE-RELATED (PTHR19384)
PANTHER Subfamily: NITRIC OXIDE SYNTHASE, INDUCIBLE (PTHR19384:SF56)  
PANTHER GO-slim Molecular Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor
carbohydrate derivative binding
flavin adenine dinucleotide binding
PANTHER GO-slim Biological Process: response to hormone
cellular nitrogen compound biosynthetic process
intracellular signaling cassette
response to lipopolysaccharide
positive regulation of lyase activity
positive regulation of cyclase activity
L-amino acid metabolic process
defense response to bacterium
inflammatory response
amino acid catabolic process
positive regulation of phosphate metabolic process
positive regulation of nucleobase-containing compound metabolic process
proteinogenic amino acid metabolic process
arginine metabolic process
negative regulation of blood pressure
positive regulation of cellular biosynthetic process
PANTHER GO-slim Cellular Component: cytosol
nucleus
plasma membrane
PANTHER protein class: oxidoreductase
Pathway Categories: PI3 kinase pathway
   NOS
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: protein kinase binding, identical protein binding, protein homodimerization activity, FMN binding, beta-catenin binding, cAMP-dependent protein kinase regulator activity, heme binding, arginine binding, calmodulin binding, tetrahydrobiopterin binding, NADP binding, protein binding, actin binding, nitric-oxide synthase activity, metal ion binding, flavin adenine dinucleotide binding, cadherin binding, Hsp90 protein binding, nitric-oxide synthase binding
GO BP Complete: response to fructose, negative regulation of protein catabolic process, regulation of cytokine production involved in inflammatory response, regulation of insulin secretion, inflammatory response, response to glucose, response to hypoxia, glycoside metabolic process, intracellular signal transduction, nitric oxide mediated signal transduction, negative regulation of blood pressure, circadian rhythm, response to hormone, defense response to bacterium, arginine catabolic process, negative regulation of gene expression, cellular response to lithium ion, positive regulation of interleukin-8 production, superoxide metabolic process, response to estradiol, nitric oxide biosynthetic process, response to activity, prostaglandin secretion, response to immobilization stress, positive regulation of interleukin-6 production, cellular response to organic cyclic compound, response to tumor necrosis factor, cGMP-mediated signaling, G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger, Fc-gamma receptor signaling pathway involved in phagocytosis, response to mechanical stimulus, retinoic acid receptor signaling pathway, cellular response to tumor necrosis factor, peptidyl-cysteine S-nitrosylation, defense response to Gram-negative bacterium, regulation of blood pressure, regulation of cell population proliferation, cellular response to redox state, response to bacterium, blood vessel remodeling, cellular response to lipopolysaccharide, positive regulation of apoptotic process, endothelial cell proliferation, cellular response to interleukin-1, response to lipopolysaccharide, cellular response to cytokine stimulus, cellular response to xenobiotic stimulus, cellular response to type II interferon, response to oxygen-glucose deprivation, cellular response to vitamin D, response to dexamethasone
GO CC Complete: nucleus, peroxisome, extracellular space, perinuclear region of cytoplasm, cytoplasm, cytosol, plasma membrane, cortical cytoskeleton
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: ROS and RNS production in phagocytes, Immune System, Hemostasis, Platelet homeostasis, Nitric oxide stimulates guanylate cyclase, Innate Immune System, Peroxisomal protein import, Protein localization

Orthologs