PANTHER Gene Information

Gene Symbol(s):

Fdps

Organism:

Rattus norvegicus

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Gene Name:

Farnesyl pyrophosphate synthase

Gene ID:

68953

Protein ID:

P05369

Persistent Id:

PTN000162974

Alternate Ids:

AAH59125(EMBL-CDS)	Geranyltranstransferase(Synonym)
BC059125(EMBL)	2.5.1.10(EC)
CHEMBL1075093(ChEMBL)	NP_114028(refSeq)
Q6GT82(AltAccession)	120478(GI)
83791(GeneID)	FPPS_RAT(UniProtKB-ID)
Fdps(Symbol)	68953(RGD)
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PANTHER Classification

PANTHER Family:	FARNESYL-PYROPHOSPHATE SYNTHETASE (PTHR11525)
PANTHER Subfamily:	FARNESYL PYROPHOSPHATE SYNTHASE (PTHR11525:SF0)
PANTHER GO-slim Molecular Function:	prenyltransferase activity
PANTHER GO-slim Biological Process:	terpenoid biosynthetic process phospholipid biosynthetic process
PANTHER GO-slim Cellular Component:	cytoplasm
PANTHER protein class:	acyltransferase

Pathway Categories:

Cholesterol biosynthesis

Geranyl trans-transferase

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	geranyltranstransferase activity, prenyltransferase activity, metal ion binding, dimethylallyltranstransferase activity
GO BP Complete:	male gonad development, spermatogenesis, geranyl diphosphate biosynthetic process, cholesterol biosynthetic process, positive regulation of cholesterol biosynthetic process, isoprenoid biosynthetic process, response to xenobiotic stimulus, response to peptide hormone, farnesyl diphosphate biosynthetic process, cellular response to fatty acid, response to testosterone, positive regulation of cell growth involved in cardiac muscle cell development, response to cholesterol
GO CC Complete:	peroxisome, cytoplasm, mitochondrial matrix, cytosol, nucleoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Metabolism, Metabolism of lipids, Metabolism of steroids, Cholesterol biosynthesis

Orthologs

ID	Organism	Type
HUMAN\|HGNC=3631\|UniProtKB=P14324	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000001422.5\|UniProtKB=H2Q079	Pan troglodytes	LDO
MACMU\|Ensembl=ENSMMUG00000023144.4\|UniProtKB=F7FI27	Macaca mulatta	LDO
MOUSE\|MGI=MGI=104888\|UniProtKB=Q920E5	Mus musculus	LDO
PIG\|Ensembl=ENSSSCG00000006512.5\|UniProtKB=A0A287AWX3	Sus scrofa	LDO
FELCA\|Ensembl=ENSFCAG00000039350.3\|UniProtKB=A0A5F5XN41	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845011910.1\|UniProtKB=A0A8I3NF82	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000019060.3\|UniProtKB=H9H792	Monodelphis domestica	LDO
CHICK\|Ensembl=ENSGALG00010028374.1\|UniProtKB=A0A8V1AK88	Gallus gallus	LDO
CHICK\|Gene=FDPS\|UniProtKB=P08836	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000003450.3\|UniProtKB=H9G7J1	Anolis carolinensis	LDO
XENLA\|Gene=fdps.S\|UniProtKB=A0A1L8F590	Xenopus laevis	O
XENLA\|Gene=fdps.L\|UniProtKB=A0A1L8FDJ2	Xenopus laevis	LDO
XENTR\|Gene=fdps\|UniProtKB=A0A8J1ILE9	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000010041.2\|UniProtKB=H2M2F4	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-050506-78\|UniProtKB=Q4V916	Danio rerio	LDO
CIOIN\|Ensembl=ENSCING00000008276.3\|UniProtKB=F6QHP8	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118409624\|UniProtKB=A0A9J7KMF8	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC576515\|UniProtKB=A0A7M7T2B7	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00011058\|UniProtKB=O62336	Caenorhabditis elegans	LDO
CAEBR\|WormBase=WBGene00038065\|UniProtKB=A8XTW8	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00304433\|UniProtKB=A0A8R1V2Y2	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0025373\|UniProtKB=Q7KN61	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP007104\|UniProtKB=Q7QIW5	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC009256\|UniProtKB=D6WSE7	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC009257\|UniProtKB=D6WSE5	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_313317\|UniProtKB=E9G2F8	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW009264\|UniProtKB=B7Q0Y1	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG115552\|UniProtKB=T1EG91	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g185913\|UniProtKB=A7S5I7	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG31406\|UniProtKB=B3S8W6	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_6210\|UniProtKB=A9UT59	Monosiga brevicollis	LDO
YEAST\|SGD=S000003703\|UniProtKB=P08524	Saccharomyces cerevisiae	LDO
EREGS\|EnsemblGenome=AGOS_AEL122W\|UniProtKB=Q757Y2	Eremothecium gossypii	LDO
CANAL\|CGD=CAL0000188232\|UniProtKB=A0A1D8PH78	Candida albicans	LDO
YARLI\|EnsemblGenome=YALI0_E05753g\|UniProtKB=Q6C6W3	Yarrowia lipolytica	LDO
EMENI\|EnsemblGenome=ANIA_08012\|UniProtKB=Q5AUL8	Emericella nidulans	LDO
ASPFU\|EnsemblGenome=AFUA_5G02450\|UniProtKB=Q4WEB8	Neosartorya fumigata	LDO
NEUCR\|EnsemblGenome=NCU01175\|UniProtKB=Q92250	Neurospora crassa	LDO
SCLS1\|Gene_ORFName=SS1G_07659\|UniProtKB=A7EQQ6	Sclerotinia sclerotiorum	LDO
PHANO\|EnsemblGenome=SNOG_15418\|UniProtKB=Q0TY86	Phaeosphaeria nodorum	LDO
SCHPO\|PomBase=SPBC36.06c\|UniProtKB=O59703	Schizosaccharomyces pombe	O
SCHPO\|PomBase=SPAC6F12.13c\|UniProtKB=O14230	Schizosaccharomyces pombe	LDO
SCHJY\|EnsemblGenome=SJAG_00580\|UniProtKB=B6JW13	Schizosaccharomyces japonicus	O
SCHJY\|EnsemblGenome=SJAG_03352\|UniProtKB=B6K405	Schizosaccharomyces japonicus	LDO
CRYNJ\|EnsemblGenome=CNE04510\|UniProtKB=Q5KG83	Cryptococcus neoformans	LDO
USTMA\|EnsemblGenome=UMAG_11875\|UniProtKB=A0A0D1E775	Ustilago maydis	LDO
PUCGT\|EnsemblGenome=PGTG_16289\|UniProtKB=E3L168	Puccinia graminis	O
PUCGT\|EnsemblGenome=PGTG_00514\|UniProtKB=E3JPU5	Puccinia graminis	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_17386\|UniProtKB=F4P7S3	Batrachochytrium dendrobatidis	LDO
DICDI\|dictyBase=DDB_G0268742\|UniProtKB=Q55EU7	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_150024\|UniProtKB=F0ZF95	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0278823\|UniProtKB=Q54XP1	Dictyostelium discoideum	O
DICDI\|dictyBase=DDB_G0278735\|UniProtKB=Q9NH03	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_38391\|UniProtKB=F0ZUD6	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_38388\|UniProtKB=F0ZUD8	Dictyostelium purpureum	O
DICPU\|EnsemblGenome=DICPUDRAFT_147615\|UniProtKB=F0Z8Y9	Dictyostelium purpureum	LDO
LEIMA\|EnsemblGenome=LMJF_22_1360\|UniProtKB=Q4QBL1	Leishmania major	LDO
TRYB2\|Gene_ORFName=Tb927.7.3360\|UniProtKB=Q57WF1	Trypanosoma brucei	LDO
GIAIC\|EnsemblGenome=GL50803_6633\|UniProtKB=A8B433	Giardia intestinalis	LDO
TRIV3\|Gene_ORFName=TVAG_388030\|UniProtKB=A2E130	Trichomonas vaginalis	O
TRIV3\|Gene_ORFName=TVAG_150090\|UniProtKB=A2DRR1	Trichomonas vaginalis	LDO
TRIV3\|Gene_ORFName=TVAG_353270\|UniProtKB=A2EN50	Trichomonas vaginalis	O
PLAF7\|EnsemblGenome=PF3D7_1128400\|UniProtKB=Q8II79	Plasmodium falciparum	LDO
THAPS\|EnsemblGenome=THAPSDRAFT_30105\|UniProtKB=B8CD36	Thalassiosira pseudonana	LDO
PHYRM\|Gene=H3HB70_PHYRM\|UniProtKB=H3HB70	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_03g207700v5\|UniProtKB=A8IX41	Chlamydomonas reinhardtii	LDO
AMBTC\|EnsemblGenome=AMTR_s00061p00181710\|UniProtKB=U5DFJ8	Amborella trichopoda	LDO
ZOSMR\|Gene_ORFName=ZOSMA_70G00610\|UniProtKB=A0A0K9NSK0	Zostera marina	O
ZOSMR\|Gene_ORFName=ZOSMA_112G00130\|UniProtKB=A0A0K9Q373	Zostera marina	LDO
MUSAM\|EnsemblGenome=Ma03_g29760\|UniProtKB=A0A804IHU0	Musa acuminata subsp. malaccensis	LDO
MUSAM\|EnsemblGenome=Ma09_g22750\|UniProtKB=A0A804KML5	Musa acuminata subsp. malaccensis	LDO
SETIT\|EnsemblGenome=SETIT_022190mg\|UniProtKB=K3Z6M1	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3006G248000\|UniProtKB=A0A1B6PNS2	Sorghum bicolor	O
ORYSJ\|EnsemblGenome=Os04g0657100\|UniProtKB=Q0J9F2	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_5g24640v3\|UniProtKB=I1J2U5	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.2HG0202590\|UniProtKB=A0A8I6XHJ3	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS2A02G501900\|UniProtKB=A0A3B6B6C0	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2B02G530100\|UniProtKB=A0A3B6CGW5	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS2D02G502400\|UniProtKB=A0A3B6DL43	Triticum aestivum	O
SETIT\|EnsemblGenome=SETIT_022312mg\|UniProtKB=K3Z6Z2	Setaria italica	O
SORBI\|EnsemblGenome=SORBI_3009G216800\|UniProtKB=C5YUX0	Sorghum bicolor	O
MAIZE\|EnsemblGenome=Zm00001eb342550\|UniProtKB=P49353	Zea mays	O
ORYSJ\|EnsemblGenome=Os05g0543400\|UniProtKB=Q65XM9	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_2g17990v3\|UniProtKB=I1HGY9	Brachypodium distachyon	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.1HG0079800\|UniProtKB=F2D4M6	Hordeum vulgare subsp. vulgare	O
WHEAT\|EnsemblGenome=TraesCS1B02G383400\|UniProtKB=A0A3B5Z2T1	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1D02G371200\|UniProtKB=A0A3B5ZZS4	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS1A02G365800\|UniProtKB=A0A3B5Y680	Triticum aestivum	O
SETIT\|EnsemblGenome=SETIT_002022mg\|UniProtKB=K3XJE9	Setaria italica	LDO
SORBI\|EnsemblGenome=SORBI_3003G270500\|UniProtKB=C5XHL1	Sorghum bicolor	LDO
MAIZE\|EnsemblGenome=Zm00001eb361070\|UniProtKB=K7V8H3	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb155590\|UniProtKB=B4FVE3	Zea mays	LDO
ORYSJ\|EnsemblGenome=Os01g0695300\|UniProtKB=Q5N9P6	Oryza sativa	O
BRADI\|EnsemblGenome=BRADI_2g47310v3\|UniProtKB=I1HQM7	Brachypodium distachyon	O
WHEAT\|EnsemblGenome=TraesCS3A02G258600\|UniProtKB=A0A3B6EHL0	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3D02G258500\|UniProtKB=A0A3B6GUI1	Triticum aestivum	O
ORYSJ\|EnsemblGenome=Os01g0703400\|UniProtKB=O04882	Oryza sativa	LDO
BRADI\|EnsemblGenome=BRADI_2g47610v3\|UniProtKB=I1HQR4	Brachypodium distachyon	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0283300\|UniProtKB=F2CPK7	Hordeum vulgare subsp. vulgare	LDO
WHEAT\|EnsemblGenome=TraesCS3B02G286300\|UniProtKB=L7PE91	Triticum aestivum	O
WHEAT\|EnsemblGenome=TraesCS3A02G254300\|UniProtKB=A0A3B6ELC1	Triticum aestivum	LDO
WHEAT\|EnsemblGenome=TraesCS3D02G255200\|UniProtKB=A0A3B6GXJ4	Triticum aestivum	LDO
NELNU\|Gene=LOC104588689\|UniProtKB=A0A1U7Z2Y6	Nelumbo nucifera	LDO
NELNU\|Gene=LOC104594300\|UniProtKB=A0A1U7ZWG2	Nelumbo nucifera	LDO
SPIOL\|Gene=LOC110800321\|UniProtKB=A0A9R0K7F6	Spinacia oleracea	O
SPIOL\|Gene=LOC110782066\|UniProtKB=A0A9R0I2X6	Spinacia oleracea	O
SPIOL\|Gene=LOC110782060\|UniProtKB=A0A9R0I3I2	Spinacia oleracea	LDO
HELAN\|EnsemblGenome=HanXRQr2_Chr08g0350351\|UniProtKB=A0A251U7H3	Helianthus annuus	O
HELAN\|EnsemblGenome=HanXRQr2_Chr05g0234511\|UniProtKB=A0A251UT80	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C700387540\|UniProtKB=A0A9R1V2M3	Lactuca sativa	O
LACSA\|Gene_ORFName=LSAT_V11C500229030\|UniProtKB=A0A9R1VJI8	Lactuca sativa	LDO
ERYGU\|Gene_ORFName=MIMGU_mgv1a026653mg\|UniProtKB=A0A022QAV5	Erythranthe guttata	O
ERYGU\|Gene_ORFName=MIMGU_mgv1a008270mg\|UniProtKB=A0A022R0F5	Erythranthe guttata	LDO
CAPAN\|EnsemblGenome=T459_08678\|UniProtKB=A0A1U8G2J5	Capsicum annuum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400029788\|UniProtKB=M1CX22	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc12g015860.2\|UniProtKB=O65004	Solanum lycopersicum	O
TOBAC\|Gene=LOC107779968\|UniProtKB=A0A1S3YVG4	Nicotiana tabacum	O
TOBAC\|Gene=LOC107806551\|UniProtKB=A0A1S4BBL2	Nicotiana tabacum	O
CAPAN\|EnsemblGenome=T459_24642\|UniProtKB=A0A1U8EE36	Capsicum annuum	LDO
SOLTU\|EnsemblGenome=PGSC0003DMG400014369\|UniProtKB=M1B520	Solanum tuberosum	O
SOLLC\|EnsemblGenome=Solyc10g005840.3\|UniProtKB=A0A3Q7I9T2	Solanum lycopersicum	O
SOLTU\|EnsemblGenome=PGSC0003DMG400008690\|UniProtKB=M1AGP3	Solanum tuberosum	LDO
SOLLC\|EnsemblGenome=Solyc10g005820.2\|UniProtKB=A0A3Q7IB68	Solanum lycopersicum	LDO
TOBAC\|Gene=LOC107795792\|UniProtKB=A0A1S4ABD1	Nicotiana tabacum	O
TOBAC\|Gene=LOC107765018\|UniProtKB=A0A1S3XHA2	Nicotiana tabacum	LDO
VITVI\|EnsemblGenome=Vitvi19g00729\|UniProtKB=D7UAM1	Vitis vinifera	LDO
EUCGR\|EnsemblGenome=EUGRSUZ_E03835\|UniProtKB=A0A059C9Z7	Eucalyptus grandis	LDO
BRANA\|Gene_ORFName=GSBRNA2T00001929001\|UniProtKB=A0A078FXF0	Brassica napus	O
BRACM\|EnsemblGenome=Bra024917\|UniProtKB=M4E811	Brassica campestris	O
BRANA\|EnsemblGenome=GSBRNA2T00069140001\|UniProtKB=A0A078JML3	Brassica napus	O
BRANA\|Gene_ORFName=GSBRNA2T00041597001\|UniProtKB=A0A078GUT9	Brassica napus	LDO
BRACM\|EnsemblGenome=Bra022156\|UniProtKB=M4E059	Brassica campestris	LDO
ARATH\|TAIR=locus=2130654\|UniProtKB=Q43315	Arabidopsis thaliana	O
ARATH\|TAIR=locus=2160947\|UniProtKB=Q09152	Arabidopsis thaliana	LDO
GOSHI\|Gene=LOC107944620\|UniProtKB=A0A1U8N805	Gossypium hirsutum	O
GOSHI\|Gene=LOC107922380\|UniProtKB=A0A1U8KZP6	Gossypium hirsutum	O
THECC\|EnsemblGenome=TCM_030583\|UniProtKB=A0A061F3M2	Theobroma cacao	O
GOSHI\|Gene=LOC107905737\|UniProtKB=A0A1U8JH25	Gossypium hirsutum	O
GOSHI\|Gene=FPS2\|UniProtKB=A0A1B1HY16	Gossypium hirsutum	LDO
THECC\|EnsemblGenome=TCM_030459\|UniProtKB=A0A061GGK8	Theobroma cacao	LDO
CITSI\|Gene_ORFName=CISIN_1g019339mg\|UniProtKB=A0A067EVX1	Citrus sinensis	LDO
POPTR\|EnsemblGenome=POPTR_006G003400v3\|UniProtKB=A9PFL3	Populus trichocarpa	LDO
MANES\|EnsemblGenome=MANES_03G143700\|UniProtKB=A0A140GWW3	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_0523370\|UniProtKB=B9S9Y3	Ricinus communis	O
MANES\|EnsemblGenome=MANES_08G076500\|UniProtKB=A0A2C9VEA9	Manihot esculenta	LDO
MANES\|EnsemblGenome=MANES_09G084500\|UniProtKB=A0A140GWW1	Manihot esculenta	O
RICCO\|Gene_ORFName=RCOM_0426460\|UniProtKB=B9T7W9	Ricinus communis	LDO
SOYBN\|EnsemblGenome=GLYMA_20G047100\|UniProtKB=K7N1M8	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_09G015600\|UniProtKB=I1L053	Glycine max	O
SOYBN\|EnsemblGenome=GLYMA_15G121400\|UniProtKB=I1MFU1	Glycine max	LDO
MEDTR\|EnsemblGenome=MTR_2g027300\|UniProtKB=G7IQ36	Medicago truncatula	LDO
JUGRE\|EnsemblGenome=Jr09_16640\|UniProtKB=A0A2I4EST8	Juglans regia	O
JUGRE\|EnsemblGenome=Jr02_26210\|UniProtKB=A0A2I4E293	Juglans regia	O
CUCSA\|EnsemblGenome=Csa_7G278210\|UniProtKB=A0A0A0K997	Cucumis sativus	O
JUGRE\|Gene=LOC108996553\|UniProtKB=A0A6P9ENX6	Juglans regia	O
JUGRE\|EnsemblGenome=Jr04_12380\|UniProtKB=A0A2I4G0H5	Juglans regia	O
JUGRE\|EnsemblGenome=Jr03_13240\|UniProtKB=A0A2I4F8S5	Juglans regia	LDO
CUCSA\|EnsemblGenome=Csa_6G017060\|UniProtKB=A0A0A0K801	Cucumis sativus	LDO
PRUPE\|EnsemblGenome=PRUPE_6G028100\|UniProtKB=M5VZ02	Prunus persica	O
PRUPE\|EnsemblGenome=PRUPE_4G002700\|UniProtKB=A0A251PDK8	Prunus persica	LDO
SELML\|EnsemblGenome=SELMODRAFT_234027\|UniProtKB=D8SGZ0	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_127038\|UniProtKB=D8SX77	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_420677\|UniProtKB=D8SCS0	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_173042\|UniProtKB=D8RNV9	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_236261\|UniProtKB=D8T6V9	Selaginella moellendorffii	O
SELML\|EnsemblGenome=SELMODRAFT_159144\|UniProtKB=D8SXE9	Selaginella moellendorffii	LDO
PHYPA\|EnsemblGenome=Pp3c24_18700\|UniProtKB=A9SPQ1	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0024s0031\|UniProtKB=A0A2R6XBL8	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_002870200\|UniProtKB=A0A1Y1ICH6	Klebsormidium nitens	LDO