PANTHER Gene Information

Gene Symbol(s):

MARK2

Organism:

Gorilla gorilla gorilla

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Tree

Gene Name:

non-specific serine_threonine protein kinase

Gene ID:

ENSGGOG00000017093.3

Protein ID:

A0A2I2ZL60

Persistent Id:

PTN002804582

Alternate Ids:

ENSGGOT00000053103(Ensembl_TRS)	1099107234(GI)
XM_019037115(refSeq)	ENSGGOP00000048008(Ensembl_PRO)
CABD030079639(EMBL)	CABD030079643(EMBL)
CABD030079640(EMBL)	CABD030079642(EMBL)
A0A2I2ZL60(Synonym)	A0A2I2ZL60_GORGO(UniProtKB-ID)
ENSGGOG00000017093(Ensembl)	XP_018892660(refSeq)
CABD030079641(EMBL)
Show Unique Types

PANTHER Classification

PANTHER Family:	MAP/MICROTUBULE AFFINITY-REGULATING KINASE (PTHR24346)
PANTHER Subfamily:	SERINE_THREONINE-PROTEIN KINASE MARK2 (PTHR24346:SF56)
PANTHER GO-slim Molecular Function:	protein serine/threonine kinase activity
PANTHER GO-slim Biological Process:	microtubule cytoskeleton organization intracellular signal transduction
PANTHER GO-slim Cellular Component:	cytoplasm
PANTHER protein class:	non-receptor serine/threonine protein kinase

Pathway Categories:

No pathway information available

GENE ONTOLOGY DATABASE ANNOTATIONS

Click to Expand...

GO MF Complete:	magnesium ion binding, ribosomal protein S6 kinase activity, DNA-dependent protein kinase activity, ATP binding, histone H2AT120 kinase activity, AMP-activated protein kinase activity, histone H3S57 kinase activity, histone H4S1 kinase activity, histone H3S28 kinase activity, histone H3T45 kinase activity, histone H2AXS139 kinase activity, protein serine kinase activity, histone H3S10 kinase activity, histone H2BS14 kinase activity, histone H2AS1 kinase activity, eukaryotic translation initiation factor 2alpha kinase activity, protein serine/threonine kinase activity, 3-phosphoinositide-dependent protein kinase activity, tau-protein kinase activity, histone H2AS121 kinase activity, histone H3T3 kinase activity, histone H2BS36 kinase activity, Rho-dependent protein serine/threonine kinase activity, histone H3T11 kinase activity, histone H3T6 kinase activity
GO BP Complete:	chromatin remodeling, regulation of microtubule cytoskeleton organization, regulation of axonogenesis, establishment or maintenance of epithelial cell apical/basal polarity, establishment of cell polarity, positive regulation of neuron projection development, microtubule cytoskeleton organization, intracellular signal transduction
GO CC Complete:	dendrite, lateral plasma membrane, cytoplasm, membrane, microtubule bundle, actin filament, plasma membrane, nucleoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=3332\|UniProtKB=Q7KZI7	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000043914.1\|UniProtKB=A0A2I3RZW8	Pan troglodytes	LDO
MACMU\|Ensembl=ENSMMUG00000014131.4\|UniProtKB=F6TA28	Macaca mulatta	LDO
MOUSE\|MGI=MGI=99638\|UniProtKB=Q05512	Mus musculus	LDO
RAT\|RGD=150340794\|UniProtKB=A0A8J8XEH6	Rattus norvegicus	O
RAT\|RGD=150344259\|UniProtKB=A0A8I6A8U4	Rattus norvegicus	O
RAT\|RGD=41019284\|UniProtKB=A0A8I6A165	Rattus norvegicus	O
RAT\|RGD=1564409\|UniProtKB=A0A0G2K6V9	Rattus norvegicus	O
RAT\|RGD=708483\|UniProtKB=O08679	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000052622.1\|UniProtKB=A0A3Q1LS68	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000007825.6\|UniProtKB=A6QNL2	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000013050.5\|UniProtKB=F1RPY5	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000040530.1\|UniProtKB=A0A3Q2I2P7	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000027819.3\|UniProtKB=A0A3Q2H4K5	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000051759.1\|UniProtKB=A0A3Q2HWT0	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000028096.2\|UniProtKB=A0A3Q2H026	Equus caballus	O
HORSE\|Ensembl=ENSECAG00000021754.4\|UniProtKB=A0A9L0RDN8	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000014652.6\|UniProtKB=A0A2I2URJ0	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845030887.1\|UniProtKB=A0A8I3Q827	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000008796.4\|UniProtKB=A0A5F8GGQ1	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000036135.1\|UniProtKB=A0A6I8NX34	Ornithorhynchus anatinus	LDO
ANOCA\|Ensembl=ENSACAG00000003999.3\|UniProtKB=H9G8C3	Anolis carolinensis	O
ANOCA\|Ensembl=ENSACAG00000012178.4\|UniProtKB=H9GIS6	Anolis carolinensis	LDO
XENLA\|Gene=mark2.S\|UniProtKB=A0A8J1N118	Xenopus laevis	LDO
XENLA\|Gene=mark2.L\|UniProtKB=A0A1L8GJT7	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-876451\|UniProtKB=A0A6I8S976	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000005740.2\|UniProtKB=A0A3B3IL86	Oryzias latipes	LDO
DANRE\|Gene=mark2b\|UniProtKB=A0A8M3BAY8	Danio rerio	LDO
DANRE\|Gene=mark2a\|UniProtKB=A0A8M3B4V1	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000016257.1\|UniProtKB=W5NHE0	lepisosteus oculatus	O
LEPOC\|Ensembl=ENSLOCG00000015568.1\|UniProtKB=W5NEV5	lepisosteus oculatus	O
LEPOC\|Ensembl=ENSLOCG00000001763.1\|UniProtKB=W5M0Y8	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000008201.3\|UniProtKB=F6PJL4	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118411561\|UniProtKB=A0A9J7MJW1	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC100890266\|UniProtKB=A0A7M7SYA1	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC100889556\|UniProtKB=A0A7M7P9P4	Strongylocentrotus purpuratus	O
STRPU\|EnsemblGenome=LOC592325\|UniProtKB=A0A7M7HGN9	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00003916\|UniProtKB=Q9TW45	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG04756\|UniProtKB=A8WYE4	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00277629\|UniProtKB=A0A2A6BEG1	Pristionchus pacificus	O
PRIPA\|EnsemblGenome=WBGene00102456\|UniProtKB=A0A2A6BZY9	Pristionchus pacificus	LDO
PRIPA\|EnsemblGenome=WBGene00280367\|UniProtKB=A0A2A6C102	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0026064\|UniProtKB=Q9VGP9	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0026063\|UniProtKB=Q9VGQ0	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0260934\|UniProtKB=A1ZBL9	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP010341\|UniProtKB=A0A1S4H3R9	Anopheles gambiae	O
ANOGA\|EnsemblGenome=AGAP029469\|UniProtKB=A0A453YZQ5	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC032576\|UniProtKB=A0A139WKC9	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_313175\|UniProtKB=E9G331	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW014579\|UniProtKB=B7QKV7	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG192553\|UniProtKB=T1FU26	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG62924\|UniProtKB=T1FX78	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG84170\|UniProtKB=T1G5F9	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG71411\|UniProtKB=T1G0L1	helobdella robusta	LDO
HELRO\|EnsemblGenome=HelroG66187\|UniProtKB=T1FYI3	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG86903\|UniProtKB=T1G6J0	helobdella robusta	O
HELRO\|EnsemblGenome=HelroG83409\|UniProtKB=T1G552	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g139527\|UniProtKB=A7SZV3	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG27001\|UniProtKB=B3S0C9	Trichoplax adhaerens	LDO
MONBE\|EnsemblGenome=MONBRDRAFT_34468\|UniProtKB=A9VBY4	Monosiga brevicollis	LDO
CANAL\|CGD=CAL0000177153\|UniProtKB=A0A1D8PRN8	Candida albicans	LDO
ASPFU\|EnsemblGenome=AFUA_1G11080\|UniProtKB=Q4WSZ7	Neosartorya fumigata	LDO
SCHJY\|EnsemblGenome=SJAG_02838\|UniProtKB=B6K1B3	Schizosaccharomyces japonicus	LDO
ASPFU\|EnsemblGenome=AFUA_1G11930\|UniProtKB=E9RDZ3	Neosartorya fumigata	O
SCHJY\|EnsemblGenome=SJAG_04469\|UniProtKB=B6K6W9	Schizosaccharomyces japonicus	O
SCHJY\|EnsemblGenome=SJAG_03602\|UniProtKB=B6K4P0	Schizosaccharomyces japonicus	O
BATDJ\|Gene_ORFName=BATDEDRAFT_10042\|UniProtKB=F4NZ62	Batrachochytrium dendrobatidis	LDO
ENTH1\|EnsemblGenome=CL6EHI_073490\|UniProtKB=C4LXL3	Entamoeba histolytica	LDO
ENTH1\|Gene_ORFName=EHI_025300\|UniProtKB=A0A8U0WP54	Entamoeba histolytica	O
DICDI\|dictyBase=DDB_G0280133\|UniProtKB=Q54VU4	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_151676\|UniProtKB=F0ZJH1	Dictyostelium purpureum	O
DICDI\|dictyBase=DDB_G0292304\|UniProtKB=Q54DF2	Dictyostelium discoideum	LDO
DICPU\|EnsemblGenome=DICPUDRAFT_51418\|UniProtKB=F1A3P4	Dictyostelium purpureum	LDO
GIAIC\|EnsemblGenome=GL50803_9487\|UniProtKB=A8B530	Giardia intestinalis	LDO
PLAF7\|EnsemblGenome=PF3D7_1441300\|UniProtKB=Q8IL57	Plasmodium falciparum	LDO
PARTE\|EnsemblGenome=GSPATT00031618001\|UniProtKB=A0BS70	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00002297001\|UniProtKB=A0DGK1	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00020040001\|UniProtKB=A0DTJ2	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00018964001\|UniProtKB=A0DP01	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00030300001\|UniProtKB=A0BM97	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00004376001\|UniProtKB=A0BCL5	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00018952001\|UniProtKB=A0DNY9	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00026401001\|UniProtKB=A0EFI7	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00024498001\|UniProtKB=A0E900	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00024481001\|UniProtKB=A0E8Y3	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00017966001\|UniProtKB=A0DKR9	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00028068001\|UniProtKB=A0BER8	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00022278001\|UniProtKB=A0E1E2	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00009964001\|UniProtKB=A0CSC5	Paramecium tetraurelia	LDO
PARTE\|EnsemblGenome=GSPATT00025088001\|UniProtKB=A0EAN7	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00029968001\|UniProtKB=A0BLB9	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00014139001\|UniProtKB=A0D805	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00019068001\|UniProtKB=A0DPB9	Paramecium tetraurelia	O
PHYRM\|Gene=H3H0P0_PHYRM\|UniProtKB=H3H0P0	Phytophthora ramorum	LDO
CHLRE\|EnsemblGenome=CHLRE_07g329850v5\|UniProtKB=A0A2K3DJR9	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_09g403850v5\|UniProtKB=A0A2K3DCM7	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_13g568050v5\|UniProtKB=A0A2K3CZG1	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_16g685389v5\|UniProtKB=A0A2K3CW32	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_02g076000v5\|UniProtKB=A0A2K3E058	Chlamydomonas reinhardtii	LDO
CHLRE\|EnsemblGenome=CHLRE_01g036000v5\|UniProtKB=A0A2K3E716	Chlamydomonas reinhardtii	O
CHLRE\|EnsemblGenome=CHLRE_06g251050v5\|UniProtKB=A0A2K3DLY4	Chlamydomonas reinhardtii	O
HELAN\|Gene_ORFName=HanXRQr2_Chr05g0231561\|UniProtKB=A0A9K3J1W2	Helianthus annuus	O
LACSA\|Gene_ORFName=LSAT_V11C500236580\|UniProtKB=A0A9R1XB86	Lactuca sativa	O
KLENI\|Gene_ORFName=KFL_000330150\|UniProtKB=A0A1Y1HQV7	Klebsormidium nitens	O
LACSA\|Gene_ORFName=LSAT_V11C400212270\|UniProtKB=A0A9R1XHY6	Lactuca sativa	O
KLENI\|Gene_ORFName=KFL_000980330\|UniProtKB=A0A0U9HJG2	Klebsormidium nitens	O
KLENI\|Gene_ORFName=KFL_007820030\|UniProtKB=A0A1Y1IQA2	Klebsormidium nitens	O
KLENI\|Gene_ORFName=KFL_001250250\|UniProtKB=A0A1Y1I3Z9	Klebsormidium nitens	O
KLENI\|Gene_ORFName=KFL_000970360\|UniProtKB=A0A0U9HJE6	Klebsormidium nitens	O
MUSAM\|EnsemblGenome=Ma01_g02460\|UniProtKB=A0A804HPI0	Musa acuminata subsp. malaccensis	O
MUSAM\|EnsemblGenome=Ma00_g00400\|UniProtKB=A0A804HLY2	Musa acuminata subsp. malaccensis	LDO
MUSAM\|EnsemblGenome=Ma10_g08280\|UniProtKB=A0A804KTZ1	Musa acuminata subsp. malaccensis	LDO
MAIZE\|EnsemblGenome=Zm00001eb013270\|UniProtKB=Q6RXY1	Zea mays	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0320770\|UniProtKB=A0A8I7BB45	Hordeum vulgare subsp. vulgare	O
SETIT\|EnsemblGenome=SETIT_019716mg\|UniProtKB=K3YZK6	Setaria italica	O
HORVV\|EnsemblGenome=HORVU.MOREX.r3.1HG0060110\|UniProtKB=A0A8I6X3U9	Hordeum vulgare subsp. vulgare	O
MAIZE\|EnsemblGenome=Zm00001eb293240\|UniProtKB=A0A804Q4X7	Zea mays	O
MAIZE\|EnsemblGenome=Zm00001eb353700\|UniProtKB=A0A804QSJ7	Zea mays	LDO
HORVV\|EnsemblGenome=HORVU.MOREX.r3.3HG0286490\|UniProtKB=A0A8I6XFN7	Hordeum vulgare subsp. vulgare	LDO
SPIOL\|Gene=LOC110800356\|UniProtKB=A0A9R0J5M8	Spinacia oleracea	LDO
HELAN\|Gene_ORFName=HanXRQr2_Chr07g0308661\|UniProtKB=A0A9K3ING8	Helianthus annuus	LDO
LACSA\|Gene_ORFName=LSAT_V11C900467660\|UniProtKB=A0A9R1UGU9	Lactuca sativa	LDO
PHYPA\|EnsemblGenome=Pp3c3_5570\|UniProtKB=A0A7I4DGQ5	Physcomitrella patens	LDO
MARPO\|EnsemblGenome=MARPO_0038s0082\|UniProtKB=A0A2R6X3U9	Marchantia polymorpha	O
MARPO\|EnsemblGenome=MARPO_0160s0010\|UniProtKB=A0A2R6W3Y3	Marchantia polymorpha	LDO
KLENI\|Gene_ORFName=KFL_008220030\|UniProtKB=A0A1Y1INE1	Klebsormidium nitens	LDO
STRCO\|Gene_OrderedLocusName=SCO4820\|UniProtKB=Q9K3K0	Streptomyces coelicolor	O
STRCO\|Gene_OrderedLocusName=SCO4817\|UniProtKB=Q9K3K3	Streptomyces coelicolor	O
DEIRA\|EnsemblGenome=DR_1213\|UniProtKB=Q9RV17	Deinococcus radiodurans	O
RHOBA\|EnsemblGenome=RB12694\|UniProtKB=Q7UI82	Rhodopirellula baltica	O
AQUAE\|EnsemblGenome=aq_576\|UniProtKB=O66844	Aquifex aeolicus	O