PANTHER Gene Information   
Gene Symbol(s): Ep300
Organism: Mus musculus
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Gene Name: Histone acetyltransferase p300
Gene ID: MGI:1276116
Protein ID: B2RWS6
Persistent Id: PTN000351812
Alternate Ids:
P300(Synonym) MGI:1276116(MGI)
ENSMUST00000068387(Ensembl_TRS) AC102262(EMBL)
187956375(GI) Ep300(Symbol)
2.3.1.48 {ECO:0000269|PubMed:28576496}(EC) 328572(GeneID)
ENSMUSG00000055024(Ensembl) NM_177821(refSeq)
E9PYJ8(AltAccession) AAI50682(EMBL-CDS)
ENSMUSP00000066789(Ensembl_PRO) EP300_MOUSE(UniProtKB-ID)
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PANTHER Classification
PANTHER Family: CBP/P300-RELATED (PTHR13808)
PANTHER Subfamily: HISTONE ACETYLTRANSFERASE P300 (PTHR13808:SF29)  
PANTHER GO-slim Molecular Function: chromatin DNA binding
transcription coactivator activity
histone acetyltransferase activity
PANTHER GO-slim Biological Process: positive regulation of transcription by RNA polymerase II
PANTHER GO-slim Cellular Component: histone acetyltransferase complex
transcription regulator complex
PANTHER protein class: histone modifying enzyme
Pathway Categories: Gonadotropin-releasing hormone receptor pathway
   p300
TGF-beta signaling pathway
   Co-activators or corepressors
Huntington disease
   CREB binding protein
Wnt signaling pathway
   CREB binding protein
p53 pathway
   P300
p53 pathway
   CREB binding protein
Transcription regulation by bZIP transcription factor
   CBP/P300
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
   cAMP response element binding protein
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: nuclear receptor binding, acetyltransferase activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, histone H4K16 acetyltransferase activity, peptide-lysine-N-acetyltransferase activity, transcription coactivator binding, peroxisome proliferator activated receptor binding, bHLH transcription factor binding, protein-containing complex binding, p53 binding, promoter-specific chromatin binding, protein antigen binding, histone H3K14 acetyltransferase activity, acetylation-dependent protein binding, histone H4K16 propionyltransferase activity, protein kinase binding, histone H2AK5 acetyltransferase activity, zinc ion binding, histone lactyltransferase (CoA-dependent) activity, histone H3K9 acetyltransferase activity, cis-regulatory region sequence-specific DNA binding, histone H3K23 acetyltransferase activity, histone H3K18 acetyltransferase activity, histone H4K8 acetyltransferase activity, histone H4K5 acetyltransferase activity, protein propionyltransferase activity, histone H3K122 acetyltransferase activity, histone H4K12 acetyltransferase activity, NF-kappaB binding, lysine N-acetyltransferase activity, acting on acetyl phosphate as donor, protein binding, nuclear androgen receptor binding, histone H2AK9 acetyltransferase activity, histone butyryltransferase activity, peptide 2-hydroxyisobutyryltransferase activity, mitogen-activated protein kinase binding, peptide butyryltransferase activity, histone crotonyltransferase activity, histone H3 acetyltransferase activity, acyltransferase activity, histone H2BK5 acetyltransferase activity, histone H3K4 acetyltransferase activity, histone H2BK12 acetyltransferase activity, histone H3K36 acetyltransferase activity, histone H3K27 acetyltransferase activity, antigen binding, DNA-binding transcription factor binding, nuclear glucocorticoid receptor binding, chromatin DNA binding, chromatin binding, beta-catenin binding, damaged DNA binding, transcription coregulator binding, DNA binding, histone acetyltransferase activity, pre-mRNA intronic binding, transcription coactivator activity, SMAD binding, RNA polymerase II-specific DNA-binding transcription factor binding, STAT family protein binding, histone H3K56 acetyltransferase activity, histone H4 acetyltransferase activity
GO BP Complete: protein modification process, positive regulation of protein binding, response to estrogen, positive regulation of translation, transcription by RNA polymerase II, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, negative regulation of gluconeogenesis, positive regulation of hydrogen peroxide-mediated programmed cell death, positive regulation of protein acetylation, fat cell differentiation, positive regulation of DNA-binding transcription factor activity, face morphogenesis, regulation of androgen receptor signaling pathway, learning or memory, response to glucose, positive regulation of cell growth, response to hypoxia, positive regulation of collagen biosynthetic process, peptidyl-lysine acetylation, internal peptidyl-lysine acetylation, positive regulation of DNA-templated transcription, apoptotic process, N-terminal peptidyl-lysine acetylation, platelet formation, positive regulation of muscle atrophy, positive regulation of neuron projection development, positive regulation of protein secretion, positive regulation of protein import into nucleus, positive regulation of TORC1 signaling, transcription initiation-coupled chromatin remodeling, B cell differentiation, protein-DNA complex assembly, positive regulation of axon extension, circadian rhythm, animal organ morphogenesis, positive regulation of receptor signaling pathway via JAK-STAT, peptidyl-lysine propionylation, cellular response to nutrient levels, somitogenesis, negative regulation of autophagy, positive regulation of gene expression, behavioral defense response, macrophage derived foam cell differentiation, regulation of mitochondrion organization, positive regulation of cell growth involved in cardiac muscle cell development, peptidyl-lysine crotonylation, peptidyl-lysine butyrylation, cartilage development, multicellular organism growth, positive regulation by host of viral transcription, positive regulation of glycoprotein biosynthetic process, positive regulation of TORC2 signaling, response to xenobiotic stimulus, positive regulation of proteolysis, positive regulation of transcription by RNA polymerase II, positive regulation of cellular response to hypoxia, negative regulation of transcription by RNA polymerase II, heart development, chromatin remodeling, positive regulation of cell size, cellular response to L-leucine, thigmotaxis, cellular response to UV, megakaryocyte development, negative regulation of protein-containing complex assembly, positive regulation of T-helper 17 cell lineage commitment, lung development, regulation of angiotensin metabolic process, positive regulation of sarcomere organization, swimming, internal protein amino acid acetylation, regulation of tubulin deacetylation, regulation of glycolytic process, protein acetylation, canonical NF-kappaB signal transduction, regulation of transcription by RNA polymerase II, protein destabilization, negative regulation of miRNA metabolic process, skeletal muscle tissue development, response to calcium ion, positive regulation of protein phosphorylation, cellular response to interleukin-1, protein stabilization, positive regulation of transforming growth factor beta receptor signaling pathway, response to dexamethasone
GO CC Complete: nucleus, transcription regulator complex, cytoplasm, protein-DNA complex, cytosol, protein-containing complex, chromatin, histone acetyltransferase complex, nucleoplasm
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Immune System, Cellular responses to stimuli, Signaling by Receptor Tyrosine Kinases, Deubiquitination, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, KEAP1-NFE2L2 pathway, Formation of the beta-catenin:TCF transactivating complex, NOTCH1 Intracellular Domain Regulates Transcription, Signaling by Nuclear Receptors, FOXO-mediated transcription, Gene expression (Transcription), NR1H2 and NR1H3-mediated signaling, Cellular response to hypoxia, Regulation of FOXO transcriptional activity by acetylation, Estrogen-dependent gene expression, Gap-filling DNA repair synthesis and ligation in TC-NER, Dual incision in TC-NER, TCF dependent signaling in response to WNT, SUMOylation, Signaling by WNT, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux, HSF1-dependent transactivation, Innate Immune System, Signal Transduction, Regulation of TP53 Activity through Methylation, Metalloprotease DUBs, CD209 (DC-SIGN) signaling, PI5P Regulates TP53 Acetylation, DDX58/IFIH1-mediated induction of interferon-alpha/beta, Nucleotide Excision Repair, Regulation of TP53 Activity through Acetylation, RUNX3 regulates NOTCH signaling, Signaling by NOTCH, Cellular responses to stress, Post-translational protein modification, Regulation of RUNX3 expression and activity, SUMO E3 ligases SUMOylate target proteins, TRAF6 mediated IRF7 activation, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Generic Transcription Pathway, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function, Attenuation phase, Cytosolic sensors of pathogen-associated DNA , Positive epigenetic regulation of rRNA expression, RUNX3 regulates p14-ARF, ESR-mediated signaling, Regulation of gene expression by Hypoxia-inducible Factor, Regulation of TP53 Activity, Transcriptional Regulation by TP53, Transcriptional regulation by RUNX1, Formation of TC-NER Pre-Incision Complex, Signaling by NOTCH1, LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production, Cellular response to chemical stress, Signaling by ALK, Cellular response to heat stress, B-WICH complex positively regulates rRNA expression, Transcriptional regulation by RUNX3, Epigenetic regulation of gene expression, DNA Repair, SUMOylation of transcription cofactors, C-type lectin receptors (CLRs), Activation of the TFAP2 (AP-2) family of transcription factors, Nuclear events mediated by NFE2L2, STAT3 nuclear events downstream of ALK signaling, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, Metabolism of proteins, RNA Polymerase II Transcription

Orthologs