Pathway Component Details
| Name: | Co-activators or corepressors (Co-activators corepressors) |
| Definition: | Cell stimulation with TGF-β leads immediately to positive and negative changes in the expression of several hundred genes. Both activation and repression of gene expression use the same set of activated Smad proteins with the recruitment of transcriptional coactivators or corepressors to such genes depend on cell-type specific partner proteins. Smads must cooperate among each other and with other DNA binding proteins to elicit specific transcriptional responses. |
| Category ID: | P01282 |
| Synonyms: | |
| Upstream: | |
| Downstream: | |
| Number Families/Subfamilies: | 24 |
| Number of Associated Sequences: | 98 |
| GO Molecular Function: |
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| GO Biological Process: |
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| GO Cellular Component: |
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| PANTHER protein class: |
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| References: | Medline:11252892 |
Sequence Association
| Panther Subfamily | Associated Sequence | Definition | Confidence Code | Evidence |
| PTHR10005:SF15 | A0A0G2K628 | Ski oncogene | ISS | PubMed:10485843 |
| A0A8I3P330 | Ski oncogene | ISS | PubMed:10485843 | |
| F1N727 | Ski oncogene | ISS | PubMed:10485843 | |
| P12755 | Ski oncogene | IGI | PubMed:10485843 | |
| P49140 | Ski oncogene | IGI | PubMed:10485843 | |
| Q1ECW8 | Ski oncogene | IGI | PubMed:10485843 | |
| Q60698 | Ski oncogene | IGI | PubMed:10485843 | |
| PTHR10005:SF24 | Q9YI02 | Ski oncogene | IGI | PubMed:10485843 |
| PTHR10005:SF3 | A0A8I3PJY2 | SKI like proto-oncogene | ISS | PubMed:10485843 |
| D3ZWL1 | SKI-like proto-oncogene | ISS | PubMed:10485843 | |
| E1BJ37 | SKI like proto-onco | ISS | PubMed:10485843 | |
| F1P0N0 | SKI like proto-onco | IGI | PubMed:10485843 | |
| H2QNQ5 | SKI like proto-onco | ISS | PubMed:10485843 | |
| P12757 | Ski-like protein | IGI | PubMed:10485843 | |
| Q60665 | Ski-like protein | IGI | PubMed:10485843 | |
| PTHR11462:SF35 | P18289 | Transcription factor Jra | TAS | PubMed:10664585 |
| PTHR11462:SF37 | A0A8I3RZ30 | JunB proto-oncogene, AP-1 transcription factor subunit | ISS | PubMed:10664585 |
| F6U5C5 | JunB proto-onco, AP-1 transcription factor subunit | ISS | PubMed:10664585 | |
| H2R6C6 | Jun B proto-oncogene | ISS | PubMed:10664585 | |
| P09450 | Transcription factor JunB | TAS | PubMed:10664585 | |
| P17275 | Transcription factor JunB | TAS | PubMed:10664585 | |
| P24898 | Transcription factor JunB | TAS | PubMed:10664585 | |
| Q0VBZ5 | Transcription factor JunB | ISS | PubMed:10664585 | |
| Q7T3E3 | Jun B proto-oncogene, like | ISS | PubMed:10664585 | |
| PTHR11462:SF7 | P15066 | Transcription factor JunD | TAS | PubMed:10664585 |
| P17535 | Transcription factor JunD | TAS | PubMed:10664585 | |
| PTHR11462:SF8 | O77627 | Transcription factor Jun | ISS | PubMed:10421778 |
| O77627 | Transcription factor Jun | ISS | PubMed:10487205 | |
| O77627 | Transcription factor Jun | ISS | PubMed:10664585 | |
| O77627 | Transcription factor Jun | ISS | PubMed:11724916 | |
| O77627 | Transcription factor Jun | ISS | PubMed:11840290 | |
| O77627 | Transcription factor Jun | ISS | PubMed:14555214 | |
| O77627 | Transcription factor Jun | ISS | PubMed:14993273 | |
| O77627 | Transcription factor Jun | ISS | PubMed:3136397 | |
| P05412 | Transcription factor Jun | ISS | PubMed:10421778 | |
| P05412 | Transcription factor Jun | ISS | PubMed:10487205 | |
| P05412 | Transcription factor Jun | ISS | PubMed:10664585 | |
| P05412 | Transcription factor Jun | ISS | PubMed:11724916 | |
| P05412 | Transcription factor Jun | ISS | PubMed:14555214 | |
| P05412 | Transcription factor Jun | ISS | PubMed:14993273 | |
| P05627 | Transcription factor Jun | ISS | PubMed:10421778 | |
| P05627 | Transcription factor Jun | ISS | PubMed:10487205 | |
| P05627 | Transcription factor Jun | ISS | PubMed:10664585 | |
| P05627 | Transcription factor Jun | ISS | PubMed:11724916 | |
| P05627 | Transcription factor Jun | ISS | PubMed:14555214 | |
| P05627 | Transcription factor Jun | ISS | PubMed:14993273 | |
| P17325 | Transcription factor Jun | ISS | PubMed:10421778 | |
| P17325 | Transcription factor Jun | ISS | PubMed:10487205 | |
| P17325 | Transcription factor Jun | ISS | PubMed:10664585 | |
| P17325 | Transcription factor Jun | ISS | PubMed:11724916 | |
| P17325 | Transcription factor Jun | ISS | PubMed:14555214 | |
| P17325 | Transcription factor Jun | ISS | PubMed:14993273 | |
| P18870 | Transcription factor Jun | ISS | PubMed:10487205 | |
| P18870 | Transcription factor Jun | ISS | PubMed:10664585 | |
| P18870 | Transcription factor Jun | ISS | PubMed:11724916 | |
| P18870 | Transcription factor Jun | ISS | PubMed:14555214 | |
| PTHR11829:SF340 | Q9I9E1 | Forkhead box protein H1 | IGI | PubMed:8878477 |
| PTHR13808:SF1 | P34545 | Protein cbp-1 | TAS | PubMed:10664585 |
| P34545 | Protein cbp-1 | TAS | PubMed:10769018 | |
| P34545 | Protein cbp-1 | TAS | PubMed:10823891 | |
| P34545 | Protein cbp-1 | TAS | PubMed:8413673 | |
| Q9C5X9 | Histone acetyltransferase HAC1 | TAS | PubMed:10664585 | |
| Q9C5X9 | Histone acetyltransferase HAC1 | TAS | PubMed:10769018 | |
| Q9C5X9 | Histone acetyltransferase HAC1 | TAS | PubMed:10823891 | |
| Q9C5X9 | Histone acetyltransferase HAC1 | TAS | PubMed:8413673 | |
| Q9FWQ5 | Histone acetyltransferase HAC12 | TAS | PubMed:10664585 | |
| Q9FWQ5 | Histone acetyltransferase HAC12 | TAS | PubMed:10769018 | |
| Q9FWQ5 | Histone acetyltransferase HAC12 | TAS | PubMed:10823891 | |
| Q9FWQ5 | Histone acetyltransferase HAC12 | TAS | PubMed:8413673 | |
| Q9LG11 | Histone acetyltransferase HAC4 | TAS | PubMed:10664585 | |
| Q9LG11 | Histone acetyltransferase HAC4 | TAS | PubMed:10769018 | |
| Q9LG11 | Histone acetyltransferase HAC4 | TAS | PubMed:10823891 | |
| Q9LG11 | Histone acetyltransferase HAC4 | TAS | PubMed:8413673 | |
| PTHR13808:SF29 | A0A5F8AFL2 | histone acetyltransferase | ISS | PubMed:10664585 |
| A0A5F8AFL2 | histone acetyltransferase | ISS | PubMed:10769018 | |
| A0A5F8AFL2 | histone acetyltransferase | ISS | PubMed:10823891 | |
| A0A5F8AFL2 | histone acetyltransferase | ISS | PubMed:8413673 | |
| B2RWS6 | Histone acetyltransferase p300 | ISS | PubMed:10664585 | |
| B2RWS6 | Histone acetyltransferase p300 | ISS | PubMed:10769018 | |
| B2RWS6 | Histone acetyltransferase p300 | ISS | PubMed:10823891 | |
| B2RWS6 | Histone acetyltransferase p300 | ISS | PubMed:8413673 | |
| E1B8D6 | histone acetyltransferase | ISS | PubMed:10664585 | |
| E1B8D6 | histone acetyltransferase | ISS | PubMed:10769018 | |
| E1B8D6 | histone acetyltransferase | ISS | PubMed:10823891 | |
| E1B8D6 | histone acetyltransferase | ISS | PubMed:8413673 | |
| H2QLS0 | histone acetyltransferase | ISS | PubMed:10664585 | |
| H2QLS0 | histone acetyltransferase | ISS | PubMed:10769018 | |
| H2QLS0 | histone acetyltransferase | ISS | PubMed:10823891 | |
| H2QLS0 | histone acetyltransferase | ISS | PubMed:8413673 | |
| Q09472 | Histone acetyltransferase p300 | TAS | PubMed:10664585 | |
| Q09472 | Histone acetyltransferase p300 | TAS | PubMed:10769018 | |
| Q09472 | Histone acetyltransferase p300 | TAS | PubMed:10823891 | |
| Q09472 | Histone acetyltransferase p300 | TAS | PubMed:8413673 | |
| PTHR13808:SF30 | Q9LE42 | Histone acetyltransferase HAC5 | TAS | PubMed:10664585 |
| Q9LE42 | Histone acetyltransferase HAC5 | TAS | PubMed:10769018 | |
| Q9LE42 | Histone acetyltransferase HAC5 | TAS | PubMed:10823891 | |
| Q9LE42 | Histone acetyltransferase HAC5 | TAS | PubMed:8413673 | |
| PTHR13808:SF34 | A0A5F7ZKK8 | histone acetyltransferase | ISS | PubMed:10664585 |
| A0A5F7ZKK8 | histone acetyltransferase | ISS | PubMed:10769018 | |
| A0A5F7ZKK8 | histone acetyltransferase | ISS | PubMed:10823891 | |
| A0A5F7ZKK8 | histone acetyltransferase | ISS | PubMed:12732631 | |
| A0A5F7ZKK8 | histone acetyltransferase | ISS | PubMed:14526383 | |
| A0A5F7ZKK8 | histone acetyltransferase | ISS | PubMed:8413673 | |
| A0A5F7ZKK8 | histone acetyltransferase | ISS | PubMed:9865691 | |
| A0A8I3MJJ8 | histone acetyltransferase | ISS | PubMed:10664585 | |
| A0A8I3MJJ8 | histone acetyltransferase | ISS | PubMed:10769018 | |
| A0A8I3MJJ8 | histone acetyltransferase | ISS | PubMed:10823891 | |
| A0A8I3MJJ8 | histone acetyltransferase | ISS | PubMed:12732631 | |
| A0A8I3MJJ8 | histone acetyltransferase | ISS | PubMed:14526383 | |
| A0A8I3MJJ8 | histone acetyltransferase | ISS | PubMed:8413673 | |
| A0A8I3MJJ8 | histone acetyltransferase | ISS | PubMed:9865691 | |
| F1MD32 | histone acetyltransferase | ISS | PubMed:10664585 | |
| F1MD32 | histone acetyltransferase | ISS | PubMed:10769018 | |
| F1MD32 | histone acetyltransferase | ISS | PubMed:10823891 | |
| F1MD32 | histone acetyltransferase | ISS | PubMed:12732631 | |
| F1MD32 | histone acetyltransferase | ISS | PubMed:14526383 | |
| F1MD32 | histone acetyltransferase | ISS | PubMed:8413673 | |
| F1MD32 | histone acetyltransferase | ISS | PubMed:9865691 | |
| F7E905 | histone acetyltransferase | ISS | PubMed:10664585 | |
| F7E905 | histone acetyltransferase | ISS | PubMed:10769018 | |
| F7E905 | histone acetyltransferase | ISS | PubMed:10823891 | |
| F7E905 | histone acetyltransferase | ISS | PubMed:12732631 | |
| F7E905 | histone acetyltransferase | ISS | PubMed:14526383 | |
| F7E905 | histone acetyltransferase | ISS | PubMed:8413673 | |
| F7E905 | histone acetyltransferase | ISS | PubMed:9865691 | |
| K7DBC8 | histone acetyltransferase | ISS | PubMed:10664585 | |
| K7DBC8 | histone acetyltransferase | ISS | PubMed:10769018 | |
| K7DBC8 | histone acetyltransferase | ISS | PubMed:10823891 | |
| K7DBC8 | histone acetyltransferase | ISS | PubMed:12732631 | |
| K7DBC8 | histone acetyltransferase | ISS | PubMed:14526383 | |
| K7DBC8 | histone acetyltransferase | ISS | PubMed:8413673 | |
| K7DBC8 | histone acetyltransferase | ISS | PubMed:9865691 | |
| P45481 | Histone lysine acetyltransferase CREBBP | TAS | PubMed:10664585 | |
| P45481 | Histone lysine acetyltransferase CREBBP | TAS | PubMed:10769018 | |
| P45481 | Histone lysine acetyltransferase CREBBP | TAS | PubMed:10823891 | |
| P45481 | Histone lysine acetyltransferase CREBBP | TAS | PubMed:12732631 | |
| P45481 | Histone lysine acetyltransferase CREBBP | TAS | PubMed:14526383 | |
| P45481 | Histone lysine acetyltransferase CREBBP | TAS | PubMed:8413673 | |
| Q6JHU9 | Histone lysine acetyltransferase CREBBP | ISS | PubMed:10664585 | |
| Q6JHU9 | Histone lysine acetyltransferase CREBBP | ISS | PubMed:10769018 | |
| Q6JHU9 | Histone lysine acetyltransferase CREBBP | ISS | PubMed:10823891 | |
| Q6JHU9 | Histone lysine acetyltransferase CREBBP | ISS | PubMed:12732631 | |
| Q6JHU9 | Histone lysine acetyltransferase CREBBP | ISS | PubMed:14526383 | |
| Q6JHU9 | Histone lysine acetyltransferase CREBBP | ISS | PubMed:8413673 | |
| Q6JHU9 | Histone lysine acetyltransferase CREBBP | ISS | PubMed:9865691 | |
| Q92793 | CREB-binding protein | TAS | PubMed:10664585 | |
| Q92793 | CREB-binding protein | TAS | PubMed:10769018 | |
| Q92793 | CREB-binding protein | TAS | PubMed:10823891 | |
| Q92793 | CREB-binding protein | TAS | PubMed:12732631 | |
| Q92793 | CREB-binding protein | TAS | PubMed:14526383 | |
| Q92793 | CREB-binding protein | TAS | PubMed:8413673 | |
| Q92793 | CREB-binding protein | TAS | PubMed:9865691 | |
| PTHR13808:SF53 | Q9FYH1 | Histone acetyltransferase HAC2 | TAS | PubMed:10664585 |
| Q9FYH1 | Histone acetyltransferase HAC2 | TAS | PubMed:10769018 | |
| Q9FYH1 | Histone acetyltransferase HAC2 | TAS | PubMed:10823891 | |
| Q9FYH1 | Histone acetyltransferase HAC2 | TAS | PubMed:8413673 | |
| PTHR16290:SF0 | DCP1 | Decapping protein 1, isoform A | ISS | |
| PTHR16290:SF4 | D4AE80 | 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase | ISS | PubMed:12809600 |
| DCP1A | 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase | ISS | PubMed:12809600 | |
| DCP1A | 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase | ISS | ||
| Q91YD3 | mRNA-decapping enzyme 1A | TAS | PubMed:12809600 | |
| PTHR16290:SF5 | DCP1B | 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase | ISS | |
| DCP1B | mRNA-decapping enzyme 1B | ISS | ||
| PTHR17045:SF5 | A8E5L7 | Cbp_p300-interacting transactivator, with Glu_Asp-rich carboxy-terminal domain, 4b | TAS | PubMed:9865691 |
| Q9I8K7 | Cbp_p300-interacting transactivator 3 | TAS | PubMed:9865691 | |
| PTHR17045:SF6 | A0A0G2JVK0 | Cbp_p300-interacting transactivator with Glu_Asp-rich carboxy-terminal domain 1 | TAS | PubMed:9865691 |
| A0A2J8IVZ1 | Cbp_p300 interacting transactivator with Glu_Asp rich carboxy-terminal domain 1 | ISS | PubMed:9865691 | |
| P97769 | Cbp_p300-interacting transactivator 1 | TAS | PubMed:9865691 | |
| Q99966 | Cbp_p300-interacting transactivator 1 | TAS | PubMed:9865691 | |
| Q9BDI3 | Cbp_p300-interacting transactivator 1 | TAS | PubMed:9865691 | |
| PTHR17045:SF7 | A0A2I3SY88 | Cbp_p300 interacting transactivator with Glu_Asp rich carboxy-terminal domain 2 | ISS | PubMed:9865691 |
| O35740 | Cbp_p300-interacting transactivator 2 | TAS | PubMed:9865691 | |
| Q0VCT9 | Cbp_p300-interacting transactivator 2 | ISS | PubMed:9865691 | |
| Q99967 | Cbp_p300-interacting transactivator 2 | ISS | PubMed:9865691 | |
| Q99MA1 | Cbp_p300-interacting transactivator, with Glu_Asp-rich carboxy-terminal domain, 2 | ISS | PubMed:9865691 | |
| Q9DDW4 | Cbp_p300 interacting transactivator with Glu_Asp rich carboxy-terminal domain 2 | TAS | PubMed:9865691 | |
| PTHR19304:SF46 | A0A2I3RDV4 | Cyclic AMP-dependent transcription factor ATF-2 | ISS | PubMed:10207617 |
| A0A2I3RDV4 | Cyclic AMP-dependent transcription factor ATF-2 | ISS | PubMed:10487205 | |
| A0A2I3RDV4 | Cyclic AMP-dependent transcription factor ATF-2 | ISS | PubMed:10664585 | |
| A0A2I3RDV4 | Cyclic AMP-dependent transcription factor ATF-2 | ISS | PubMed:11390664 | |
| A0A2I3RDV4 | Cyclic AMP-dependent transcription factor ATF-2 | ISS | PubMed:15218628 | |
| A0A2I3RDV4 | Cyclic AMP-dependent transcription factor ATF-2 | ISS | PubMed:7875593 | |
| A0A2I3RDV4 | Cyclic AMP-dependent transcription factor ATF-2 | ISS | PubMed:9819389 | |
| PTHR19304:SF9 | A0A8I3P5P8 | Cyclic AMP-dependent transcription factor ATF-2 | ISS | PubMed:10207617 |
| A0A8I3P5P8 | Cyclic AMP-dependent transcription factor ATF-2 | ISS | PubMed:10487205 | |
| A0A8I3P5P8 | Cyclic AMP-dependent transcription factor ATF-2 | ISS | PubMed:10664585 | |
| A0A8I3P5P8 | Cyclic AMP-dependent transcription factor ATF-2 | ISS | PubMed:11390664 | |
| A0A8I3P5P8 | Cyclic AMP-dependent transcription factor ATF-2 | ISS | PubMed:15218628 | |
| A0A8I3P5P8 | Cyclic AMP-dependent transcription factor ATF-2 | ISS | PubMed:7875593 | |
| A0A8I3P5P8 | Cyclic AMP-dependent transcription factor ATF-2 | ISS | PubMed:9819389 | |
| F1N177 | Activating transcription factor 2 | ISS | PubMed:10207617 | |
| F1N177 | Activating transcription factor 2 | ISS | PubMed:10487205 | |
| F1N177 | Activating transcription factor 2 | ISS | PubMed:10664585 | |
| F1N177 | Activating transcription factor 2 | ISS | PubMed:11390664 | |
| F1N177 | Activating transcription factor 2 | ISS | PubMed:15218628 | |
| F1N177 | Activating transcription factor 2 | ISS | PubMed:7875593 | |
| F1N177 | Activating transcription factor 2 | ISS | PubMed:9819389 | |
| F7EVK3 | Cyclic AMP-dependent transcription factor ATF-2 | ISS | PubMed:10207617 | |
| F7EVK3 | Cyclic AMP-dependent transcription factor ATF-2 | ISS | PubMed:10487205 | |
| F7EVK3 | Cyclic AMP-dependent transcription factor ATF-2 | ISS | PubMed:10664585 | |
| F7EVK3 | Cyclic AMP-dependent transcription factor ATF-2 | ISS | PubMed:11390664 | |
| F7EVK3 | Cyclic AMP-dependent transcription factor ATF-2 | ISS | PubMed:15218628 | |
| F7EVK3 | Cyclic AMP-dependent transcription factor ATF-2 | ISS | PubMed:7875593 | |
| F7EVK3 | Cyclic AMP-dependent transcription factor ATF-2 | ISS | PubMed:9819389 | |
| O93602 | Cyclic AMP-dependent transcription factor ATF-2 | TAS | PubMed:10207617 | |
| O93602 | Cyclic AMP-dependent transcription factor ATF-2 | TAS | PubMed:10664585 | |
| O93602 | Cyclic AMP-dependent transcription factor ATF-2 | TAS | PubMed:11390664 | |
| O93602 | Cyclic AMP-dependent transcription factor ATF-2 | TAS | PubMed:9819389 | |
| P15336 | Cyclic AMP-dependent transcription factor ATF-2 | TAS | PubMed:10207617 | |
| P15336 | Cyclic AMP-dependent transcription factor ATF-2 | TAS | PubMed:10487205 | |
| P15336 | Cyclic AMP-dependent transcription factor ATF-2 | TAS | PubMed:10664585 | |
| P15336 | Cyclic AMP-dependent transcription factor ATF-2 | TAS | PubMed:11390664 | |
| P15336 | Cyclic AMP-dependent transcription factor ATF-2 | TAS | PubMed:15218628 | |
| P15336 | Cyclic AMP-dependent transcription factor ATF-2 | TAS | PubMed:7875593 | |
| P15336 | Cyclic AMP-dependent transcription factor ATF-2 | TAS | PubMed:9819389 | |
| P16951 | Cyclic AMP-dependent transcription factor ATF-2 | TAS | PubMed:10207617 | |
| P16951 | Cyclic AMP-dependent transcription factor ATF-2 | TAS | PubMed:10664585 | |
| P16951 | Cyclic AMP-dependent transcription factor ATF-2 | TAS | PubMed:11390664 | |
| P16951 | Cyclic AMP-dependent transcription factor ATF-2 | TAS | PubMed:7875593 | |
| PTHR23308:SF36 | F6VCH4 | Smad nuclear-interacting protein 1 | ISS | PubMed:10400677 |
| H2PYP1 | Smad nuclear interacting protein 1 | ISS | PubMed:10400677 | |
| Q8TAD8 | Smad nuclear-interacting protein 1 | IGI | PubMed:10400677 | |
| Q8W4D8 | FHA domain-containing protein DDL | ISS | ||
| Q9W5Q1 | RE68879p | ISS | ||
| PTHR23351:SF6 | A0A1D5QYS2 | FOS like 1, AP-1 transcription factor subunit | ISS | PubMed:10664585 |
| A0A8I3P2C8 | FOS like 1, AP-1 transcription factor subunit | ISS | PubMed:10664585 | |
| E1BNB5 | FOS like 1, AP-1 transcription factor subunit | ISS | PubMed:10664585 | |
| K7DT43 | FOS like 1, AP-1 transcription factor subunit | ISS | PubMed:10664585 | |
| P10158 | Fos-related antigen 1 | ISS | PubMed:10664585 | |
| P15407 | Fos-related antigen 1 | ISS | PubMed:10664585 | |
| P48755 | Fos-related antigen 1 | ISS | PubMed:10664585 | |
| PTHR47316:SF1 | G3V7Y6 | Forkhead box H1 | ISS | PubMed:8878477 |
| H2QWX3 | Forkhead box H1 | ISS | PubMed:8878477 | |
| H2QWX3 | Forkhead box H1 | ISS | PubMed:9288972 | |
| O75593 | Forkhead box protein H1 | IGI | PubMed:8878477 | |
| O75593 | Forkhead box protein H1 | IGI | PubMed:9288972 | |
| O88621 | Forkhead box protein H1 | IGI | PubMed:8878477 |
