PANTHER Gene Information   
Gene Symbol(s): Jun
Organism: Rattus norvegicus
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Gene Name: Transcription factor Jun
Gene ID: 2943
Protein ID: P17325
Persistent Id: PTN000157170
Alternate Ids:
AAH78738(EMBL-CDS) Jun(Symbol)
2943(RGD) ENSRNOP00000011732(Ensembl_PRO)
24516(GeneID) CHEMBL3341579(ChEMBL)
JUN_RAT(UniProtKB-ID) Transcription factor AP-1 subunit Jun {ECO:0000305}(Synonym)
57820(GI) NM_021835(refSeq)
BC078738(EMBL) ENSRNOG00000026293(Ensembl)
ENSRNOT00000011731(Ensembl_TRS)
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PANTHER Classification
PANTHER Family: JUN TRANSCRIPTION FACTOR-RELATED (PTHR11462)
PANTHER Subfamily: TRANSCRIPTION FACTOR JUN (PTHR11462:SF8)  
PANTHER GO-slim Molecular Function: RNA polymerase II cis-regulatory region sequence-specific DNA binding
transcription factor binding
DNA-binding transcription factor activity, RNA polymerase II-specific
PANTHER GO-slim Biological Process: regulation of transcription by RNA polymerase II
regulation of cell cycle
regulation of cell population proliferation
PANTHER GO-slim Cellular Component: transcription regulator complex
PANTHER protein class: basic leucine zipper transcription factor
Pathway Categories: Gonadotropin-releasing hormone receptor pathway
   JUN
B cell activation
   jun
PDGF signaling pathway
   c-Jun
Gonadotropin-releasing hormone receptor pathway
   Junc
CCKR signaling map
   JUN
Apoptosis signaling pathway
   c-Jun
CCKR signaling map
   JUN
Oxidative stress response
   jun sarcoma virus 17 oncogene homolog
TGF-beta signaling pathway
   Co-activators or corepressors
T cell activation
   jun
Ras Pathway
   activator protein-1
Toll receptor signaling pathway
   activator protein-1
FAS signaling pathway
   c-Jun
Inflammation mediated by chemokine and cytokine signaling pathway
   activator protein-1
Gonadotropin-releasing hormone receptor pathway
   Junc
CCKR signaling map
   JUN
Gonadotropin-releasing hormone receptor pathway
   Junc
Angiogenesis
   c-Jun Transcription Factor
Huntington disease
   c-Jun
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: cAMP response element binding, identical protein binding, HMG box domain binding, protein homodimerization activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, GTPase activator activity, double-stranded DNA binding, transcription cis-regulatory region binding, DNA-binding transcription activator activity, RNA polymerase II-specific, sequence-specific DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, chromatin binding, ubiquitin-like protein ligase binding, DNA-binding transcription factor activity, RNA polymerase II-specific, protein-containing complex binding, DNA binding, DNA-binding transcription factor activity, protein binding, ubiquitin protein ligase binding, RNA polymerase II-specific DNA-binding transcription factor binding, R-SMAD binding, sequence-specific double-stranded DNA binding, general transcription initiation factor binding, enzyme binding
GO BP Complete: transforming growth factor beta receptor signaling pathway, transcription by RNA polymerase II, learning, positive regulation of DNA-binding transcription factor activity, cellular response to potassium ion starvation, immune response, negative regulation of DNA-templated transcription, positive regulation of DNA-templated transcription, cellular response to anisomycin, apoptotic process, cellular response to prolactin, release from viral latency, cellular response to zinc ion starvation, regulation of cell cycle, cellular response to hypoxia, monocyte differentiation, response to muscle stretch, negative regulation of protein autophosphorylation, SMAD protein signal transduction, response to organic cyclic compound, response to hydrogen peroxide, circadian rhythm, positive regulation of monocyte differentiation, release of cytochrome c from mitochondria, leading edge cell differentiation, membrane depolarization, axon regeneration, response to endoplasmic reticulum stress, cell population proliferation, response to cytokine, negative regulation of cell population proliferation, positive regulation of cell population proliferation, outflow tract morphogenesis, response to cAMP, positive regulation of DNA replication, positive regulation of miRNA transcription, response to xenobiotic stimulus, positive regulation of transcription by RNA polymerase II, positive regulation of neuron apoptotic process, response to mechanical stimulus, negative regulation of neuron apoptotic process, negative regulation of transcription by RNA polymerase II, positive regulation of smooth muscle cell proliferation, response to ethanol, response to insulin, positive regulation of vascular associated smooth muscle cell proliferation, cellular response to calcium ion, angiogenesis, liver development, positive regulation of fibroblast proliferation, positive regulation of epithelial cell migration, DNA-templated transcription, regulation of DNA-templated transcription, response to steroid hormone, regulation of cell population proliferation, eyelid development in camera-type eye, regulation of transcription by RNA polymerase II, microglial cell activation, cellular response to lipopolysaccharide, negative regulation of apoptotic process, positive regulation of apoptotic process, positive regulation of ERK1 and ERK2 cascade, response to lipopolysaccharide, positive regulation of DNA-templated transcription initiation, positive regulation of endothelial cell proliferation, positive regulation of apoptotic signaling pathway
GO CC Complete: nucleus, transcription regulator complex, euchromatin, RNA polymerase II transcription regulator complex, transcription repressor complex, transcription factor AP-1 complex, protein-containing complex, chromatin, nucleoplasm
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Cellular Senescence, Cellular responses to stress, Fc epsilon receptor (FCERI) signaling, Oxidative Stress Induced Senescence, Toll Like Receptor 4 (TLR4) Cascade, ESR-mediated signaling, MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Cellular responses to stimuli, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Signaling by Interleukins, FCERI mediated MAPK activation, Estrogen-dependent gene expression, Signaling by Nuclear Receptors, Innate Immune System, MAP kinase activation, TRIF(TICAM1)-mediated TLR4 signaling , MyD88 cascade initiated on plasma membrane, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, Signal Transduction, MyD88-independent TLR4 cascade , Interleukin-17 signaling, Toll Like Receptor 5 (TLR5) Cascade, Immune System, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll-like Receptor Cascades, Activation of the AP-1 family of transcription factors, MyD88 dependent cascade initiated on endosome, Toll Like Receptor 2 (TLR2) Cascade, Cytokine Signaling in Immune system, MAPK targets/ Nuclear events mediated by MAP kinases

Orthologs