PANTHER Gene Information   
Gene Symbol(s): EP300
Organism: Homo sapiens
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Gene Name: Histone acetyltransferase p300
Gene ID: HGNC:3373
Protein ID: Q09472
Enhancers: View enhancers for HUMAN|HGNC=3373|UniProtKB=Q09472
Genetic Variant Annotation: Annoq
Persistent Id: PTN002492803
Alternate Ids:
EP300_HUMAN(UniProtKB-ID) 254839619(GI)
2.3.1.- {ECO:0000269|PubMed:31645732}(EC) NM_001429(refSeq)
AAA18639(EMBL-CDS) ENSG00000100393(Ensembl)
EP300(Symbol) ENST00000263253(Ensembl_TRS)
602700(MIM) Protein 2-hydroxyisobutyryltransferase p300(Synonym)
B1AKC2(AltAccession) ENSP00000263253(Ensembl_PRO)
CHEMBL3784(ChEMBL) CH471095(EMBL)
2033(GeneID) HGNC:3373(HGNC)
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PANTHER Classification
PANTHER Family: CBP/P300-RELATED (PTHR13808)
PANTHER Subfamily: HISTONE ACETYLTRANSFERASE P300 (PTHR13808:SF29)  
PANTHER GO-slim Molecular Function: chromatin DNA binding
transcription coactivator activity
histone acetyltransferase activity
PANTHER GO-slim Biological Process: positive regulation of transcription by RNA polymerase II
PANTHER GO-slim Cellular Component: histone acetyltransferase complex
transcription regulator complex
PANTHER protein class: histone modifying enzyme
Pathway Categories: Gonadotropin-releasing hormone receptor pathway
   p300
TGF-beta signaling pathway
   Co-activators or corepressors
Huntington disease
   CREB binding protein
Wnt signaling pathway
   CREB binding protein
p53 pathway
   P300
p53 pathway
   CREB binding protein
Transcription regulation by bZIP transcription factor
   CBP/P300
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
   cAMP response element binding protein
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: nuclear receptor binding, acetyltransferase activity, histone H4K16 acetyltransferase activity, peptide-lysine-N-acetyltransferase activity, transcription coactivator binding, p53 binding, histone H3K14 acetyltransferase activity, acetylation-dependent protein binding, histone H4K16 propionyltransferase activity, histone H2AK5 acetyltransferase activity, zinc ion binding, histone lactyltransferase (CoA-dependent) activity, histone H3K9 acetyltransferase activity, histone H3K23 acetyltransferase activity, histone H3K18 acetyltransferase activity, histone H4K8 acetyltransferase activity, histone H4K5 acetyltransferase activity, protein propionyltransferase activity, histone H3K122 acetyltransferase activity, histone H4K12 acetyltransferase activity, NF-kappaB binding, lysine N-acetyltransferase activity, acting on acetyl phosphate as donor, protein binding, nuclear androgen receptor binding, histone H2AK9 acetyltransferase activity, histone butyryltransferase activity, peptide 2-hydroxyisobutyryltransferase activity, peptide N-acetyltransferase activity, peptide butyryltransferase activity, histone crotonyltransferase activity, histone H3 acetyltransferase activity, acyltransferase activity, histone H2BK5 acetyltransferase activity, histone H2B acetyltransferase activity, histone H3K4 acetyltransferase activity, histone H2BK12 acetyltransferase activity, histone H3K36 acetyltransferase activity, histone H3K27 acetyltransferase activity, DNA-binding transcription factor binding, chromatin DNA binding, chromatin binding, beta-catenin binding, damaged DNA binding, transcription coregulator binding, DNA binding, histone acetyltransferase activity, pre-mRNA intronic binding, transcription coactivator activity, RNA polymerase II-specific DNA-binding transcription factor binding, tau protein binding, STAT family protein binding, histone H3K56 acetyltransferase activity, histone H4 acetyltransferase activity
GO BP Complete: response to estrogen, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, negative regulation of gluconeogenesis, fat cell differentiation, positive regulation of DNA-binding transcription factor activity, face morphogenesis, regulation of androgen receptor signaling pathway, learning or memory, response to hypoxia, peptidyl-lysine acetylation, internal peptidyl-lysine acetylation, positive regulation of DNA-templated transcription, apoptotic process, N-terminal peptidyl-lysine acetylation, platelet formation, positive regulation of neuron projection development, positive regulation of protein import into nucleus, positive regulation of TORC1 signaling, transcription initiation-coupled chromatin remodeling, B cell differentiation, regulation of signal transduction by p53 class mediator, circadian rhythm, animal organ morphogenesis, positive regulation of receptor signaling pathway via JAK-STAT, peptidyl-lysine propionylation, cellular response to nutrient levels, somitogenesis, negative regulation of autophagy, behavioral defense response, regulation of autophagy, regulation of mitochondrion organization, peptidyl-lysine crotonylation, peptidyl-lysine butyrylation, multicellular organism growth, positive regulation by host of viral transcription, regulation of cellular response to heat, nervous system development, positive regulation of TORC2 signaling, positive regulation of transcription by RNA polymerase II, stimulatory C-type lectin receptor signaling pathway, negative regulation of transcription by RNA polymerase II, heart development, cellular response to L-leucine, thigmotaxis, cellular response to UV, megakaryocyte development, negative regulation of protein-containing complex assembly, positive regulation of T-helper 17 cell lineage commitment, lung development, swimming, internal protein amino acid acetylation, regulation of tubulin deacetylation, regulation of glycolytic process, protein acetylation, canonical NF-kappaB signal transduction, protein destabilization, skeletal muscle tissue development, protein stabilization, positive regulation of transforming growth factor beta receptor signaling pathway
GO CC Complete: nucleus, transcription regulator complex, cytoplasm, protein-DNA complex, cytosol, chromatin, histone acetyltransferase complex, nucleoplasm
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Circadian Clock, Transcriptional regulation of granulopoiesis, STAT3 nuclear events downstream of ALK signaling, NR1H2 and NR1H3-mediated signaling, Chromatin modifying enzymes, RNA Polymerase II Transcription, Maternal to zygotic transition (MZT), Deubiquitination, Polo-like kinase mediated events, Gastrulation, Signaling by NTRKs, Activation of anterior HOX genes in hindbrain development during early embryogenesis, NFE2L2 regulating inflammation associated genes, Signaling by NOTCH3, NFE2L2 regulating anti-oxidant/detoxification enzymes, NFE2L2 regulates pentose phosphate pathway genes, Signaling by NOTCH1 in Cancer, Signaling by NOTCH1 PEST Domain Mutants in Cancer, Zygotic genome activation (ZGA), Constitutive Signaling by NOTCH1 PEST Domain Mutants, Formation of paraxial mesoderm, Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, Dual incision in TC-NER, SUMOylation of transcription cofactors, TRAF6 mediated IRF7 activation, TCF dependent signaling in response to WNT, Signaling by NOTCH, Metabolism, Pre-NOTCH Expression and Processing, Formation of the beta-catenin:TCF transactivating complex, Nuclear events mediated by NFE2L2, Gene expression (Transcription), RUNX3 regulates p14-ARF, Attenuation phase, Activation of HOX genes during differentiation, Activation of the TFAP2 (AP-2) family of transcription factors, Pre-NOTCH Transcription and Translation, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells, Transcriptional regulation by RUNX1, Innate Immune System, Signaling by TGF-beta Receptor Complex, Respiratory Syncytial Virus Infection Pathway, Cytosolic sensors of pathogen-associated DNA , B-WICH complex positively regulates rRNA expression, Transcriptional Regulation by TP53, DDX58/IFIH1-mediated induction of interferon-alpha/beta, Regulation of TP53 Activity, FOXO-mediated transcription of cell death genes, RORA activates gene expression, Metabolism of proteins, Regulation of NFE2L2 gene expression, Formation of TC-NER Pre-Incision Complex, Nuclear Events (kinase and transcription factor activation), Metalloprotease DUBs, HSF1-dependent transactivation, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Regulation of gene expression by Hypoxia-inducible Factor, Regulation of RUNX3 expression and activity, Immune System, Signaling by NTRK1 (TRKA), RUNX3 regulates NOTCH signaling, Nucleotide Excision Repair, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux, SARS-CoV Infections, Regulation of lipid metabolism by PPARalpha, Cell Cycle, Mitotic, G2/M Transition, FOXO-mediated transcription, Cellular responses to stimuli, Cellular response to hypoxia, Signaling by WNT, DNA Repair, Infectious disease, NOTCH3 Intracellular Domain Regulates Transcription, Diseases of signal transduction by growth factor receptors and second messengers, KEAP1-NFE2L2 pathway, SUMOylation, Regulation of FOXO transcriptional activity by acetylation, Signaling by Receptor Tyrosine Kinases, SARS-CoV-1 Infection, Signaling by Nuclear Receptors, NOTCH1 Intracellular Domain Regulates Transcription, Signaling by TGFB family members, Gap-filling DNA repair synthesis and ligation in TC-NER, Cellular response to heat stress, C-type lectin receptors (CLRs), Evasion by RSV of host interferon responses, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, SARS-CoV-1 targets host intracellular signalling and regulatory pathways, NGF-stimulated transcription, LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production, Cellular response to chemical stress, Transcriptional regulation by RUNX3, Positive epigenetic regulation of rRNA expression, Viral Infection Pathways, Metabolism of lipids, NOTCH4 Intracellular Domain Regulates Transcription, Signaling by NOTCH4, SUMO E3 ligases SUMOylate target proteins, Mitotic G2-G2/M phases, PPARA activates gene expression, RSV-host interactions, Transcriptional regulation of white adipocyte differentiation, Heme signaling, TRAF3-dependent IRF activation pathway, HATs acetylate histones, Cellular responses to stress, Regulation of TP53 Activity through Acetylation, TP53 Regulates Transcription of Cell Cycle Genes, Post-translational protein modification, ESR-mediated signaling, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function, Signal Transduction, Signaling by ALK, Signaling by NOTCH1, Developmental Biology, SARS-CoV-1-host interactions, NOTCH2 intracellular domain regulates transcription, Chromatin organization, Regulation of beta-cell development, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, Epigenetic regulation of gene expression, Regulation of TP53 Activity through Methylation, Cell Cycle, Generic Transcription Pathway, Disease, Signaling by NOTCH2, Estrogen-dependent gene expression, CD209 (DC-SIGN) signaling, NFE2L2 regulating ER-stress associated genes, PI5P Regulates TP53 Acetylation, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, NFE2L2 regulating tumorigenic genes, NFE2L2 regulating MDR associated enzymes

Orthologs