PANTHER Gene Information   
Gene Symbol(s): CREBBP
Organism: Homo sapiens
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Gene Name: CREB-binding protein
Gene ID: HGNC:2348
Protein ID: Q92793
Enhancers: View enhancers for HUMAN|HGNC=2348|UniProtKB=Q92793
Genetic Variant Annotation: Annoq
Persistent Id: PTN002492802
Alternate Ids:
CBP_HUMAN(UniProtKB-ID) 187609132(GI)
2.3.1.48 {ECO:0000269|PubMed:24616510}(EC) Q16376(AltAccession)
HGNC:2348(HGNC) 1387(GeneID)
CHEMBL5747(ChEMBL) 600140(MIM)
CREBBP{ECO:0000312|HGNC:HGNC:2348}(Symbol) Histone lysine acetyltransferase CREBBP(Synonym)
BAE06125(EMBL-CDS) AB210043(EMBL)
ENSG00000005339(Ensembl)
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PANTHER Classification
PANTHER Family: CBP/P300-RELATED (PTHR13808)
PANTHER Subfamily: CREB-BINDING PROTEIN (PTHR13808:SF34)  
PANTHER GO-slim Molecular Function: chromatin DNA binding
transcription coactivator activity
histone acetyltransferase activity
PANTHER GO-slim Biological Process: positive regulation of transcription by RNA polymerase II
PANTHER GO-slim Cellular Component: histone acetyltransferase complex
transcription regulator complex
PANTHER protein class: histone modifying enzyme
Pathway Categories: TGF-beta signaling pathway
   Co-activators or corepressors
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
   CREB binding protein
Huntington disease
   CREB binding protein
Wnt signaling pathway
   CREB binding protein
Hedgehog signaling pathway
   CREB binding protein
Hypoxia response via HIF activation
   p300
p53 pathway
   CREB binding protein
Transcription regulation by bZIP transcription factor
   CBP/P300
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
   cAMP response element binding protein
Gonadotropin-releasing hormone receptor pathway
   CBP
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: acetyltransferase activity, histone H2BK5 acetyltransferase activity, histone H3K4 acetyltransferase activity, histone H4K16 acetyltransferase activity, histone H2BK12 acetyltransferase activity, histone H3K36 acetyltransferase activity, histone H3K27 acetyltransferase activity, MRF binding, peptide-lysine-N-acetyltransferase activity, transcription coactivator binding, p53 binding, histone H3K14 acetyltransferase activity, DNA-binding transcription factor binding, chromatin DNA binding, histone H2AK5 acetyltransferase activity, zinc ion binding, peptide lactyltransferase (CoA-dependent) activity, histone lactyltransferase (CoA-dependent) activity, histone H3K9 acetyltransferase activity, histone H3K23 acetyltransferase activity, chromatin binding, histone H3K18 acetyltransferase activity, histone H4K8 acetyltransferase activity, damaged DNA binding, histone H4K5 acetyltransferase activity, histone H3K122 acetyltransferase activity, histone H4K12 acetyltransferase activity, histone acetyltransferase activity, protein binding, transcription coactivator activity, RNA polymerase II-specific DNA-binding transcription factor binding, transcription corepressor activity, histone H2AK9 acetyltransferase activity, peptide N-acetyltransferase activity, histone H3K56 acetyltransferase activity
GO BP Complete: positive regulation of protein localization to nucleus, protein-containing complex assembly, signal transduction, regulation of cellular response to heat, positive regulation of double-strand break repair via homologous recombination, regulation of DNA-templated transcription, protein acetylation, canonical NF-kappaB signal transduction, positive regulation of transcription by RNA polymerase II, stimulatory C-type lectin receptor signaling pathway, regulation of smoothened signaling pathway, embryonic digit morphogenesis, negative regulation of transcription by RNA polymerase II, protein destabilization, chromatin remodeling, response to hypoxia, cellular response to nutrient levels, rhythmic process, positive regulation of DNA-templated transcription, homeostatic process, N-terminal peptidyl-lysine acetylation, cellular response to UV, negative regulation of transcription by RNA polymerase I, positive regulation of transforming growth factor beta receptor signaling pathway
GO CC Complete: nucleus, transcription regulator complex, nuclear body, cytoplasm, cytosol, chromatin, histone acetyltransferase complex, nucleoplasm
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Circadian Clock, Chromatin modifying enzymes, RNA Polymerase II Transcription, Maternal to zygotic transition (MZT), Gastrulation, Activation of anterior HOX genes in hindbrain development during early embryogenesis, NFE2L2 regulating inflammation associated genes, Signaling by NOTCH3, NFE2L2 regulating anti-oxidant/detoxification enzymes, NFE2L2 regulates pentose phosphate pathway genes, Signaling by NOTCH1 in Cancer, Signaling by NOTCH1 PEST Domain Mutants in Cancer, Zygotic genome activation (ZGA), Constitutive Signaling by NOTCH1 PEST Domain Mutants, SARS-CoV-2 Infection, Formation of paraxial mesoderm, Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, SUMOylation of transcription cofactors, TRAF6 mediated IRF7 activation, TCF dependent signaling in response to WNT, Regulation of cholesterol biosynthesis by SREBP (SREBF), Signaling by NOTCH, Metabolism, Pre-NOTCH Expression and Processing, Formation of the beta-catenin:TCF transactivating complex, Nuclear events mediated by NFE2L2, Gene expression (Transcription), TP53 Regulates Transcription of Genes Involved in Cytochrome C Release, Attenuation phase, Activation of HOX genes during differentiation, Activation of the TFAP2 (AP-2) family of transcription factors, Pre-NOTCH Transcription and Translation, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells, Transcriptional regulation by RUNX1, Innate Immune System, Respiratory Syncytial Virus Infection Pathway, Cytosolic sensors of pathogen-associated DNA , Transcriptional Regulation by TP53, DDX58/IFIH1-mediated induction of interferon-alpha/beta, TP53 Regulates Transcription of Cell Death Genes, FOXO-mediated transcription of cell death genes, RORA activates gene expression, Metabolism of proteins, Transcriptional activation of mitochondrial biogenesis, Regulation of NFE2L2 gene expression, Activation of gene expression by SREBF (SREBP), HSF1-dependent transactivation, Regulation of gene expression by Hypoxia-inducible Factor, Immune System, RUNX3 regulates NOTCH signaling, SARS-CoV Infections, Regulation of lipid metabolism by PPARalpha, Mitochondrial biogenesis, FOXO-mediated transcription, Cellular responses to stimuli, Cellular response to hypoxia, Signaling by WNT, Infectious disease, NOTCH3 Intracellular Domain Regulates Transcription, Diseases of signal transduction by growth factor receptors and second messengers, KEAP1-NFE2L2 pathway, SUMOylation, Organelle biogenesis and maintenance, Regulation of FOXO transcriptional activity by acetylation, BMAL1:CLOCK,NPAS2 activates circadian gene expression, Cytoprotection by HMOX1, Signaling by Nuclear Receptors, NOTCH1 Intracellular Domain Regulates Transcription, Cellular response to heat stress, RUNX1 regulates transcription of genes involved in differentiation of myeloid cells, C-type lectin receptors (CLRs), Evasion by RSV of host interferon responses, LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production, Cellular response to chemical stress, Transcriptional regulation by RUNX3, Transcriptional Regulation by NPAS4, Viral Infection Pathways, Metabolism of lipids, NOTCH4 Intracellular Domain Regulates Transcription, Signaling by NOTCH4, SUMO E3 ligases SUMOylate target proteins, PPARA activates gene expression, RSV-host interactions, Transcriptional regulation of white adipocyte differentiation, Heme signaling, TRAF3-dependent IRF activation pathway, HATs acetylate histones, Cellular responses to stress, Post-translational protein modification, ESR-mediated signaling, Signal Transduction, Metabolism of steroids, Signaling by NOTCH1, Developmental Biology, SARS-CoV-2-host interactions, Chromatin organization, Regulation of beta-cell development, Generic Transcription Pathway, Disease, Estrogen-dependent gene expression, Notch-HLH transcription pathway, CD209 (DC-SIGN) signaling, NFE2L2 regulating ER-stress associated genes, NPAS4 regulates expression of target genes, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, NFE2L2 regulating tumorigenic genes, SARS-CoV-2 activates/modulates innate and adaptive immune responses, NFE2L2 regulating MDR associated enzymes

Orthologs