PANTHER Gene Information   
Gene Symbol(s): Crebbp
Organism: Mus musculus
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Gene Name: Histone lysine acetyltransferase CREBBP
Gene ID: MGI:1098280
Protein ID: P45481
Persistent Id: PTN000351844
Alternate Ids:
Protein-lysine acetyltransferase CREBBP(Synonym) AAB28651(EMBL-CDS)
AC132380(EMBL) Crebbp(Symbol)
2.3.1.- {ECO:0000269|PubMed:15220471}(EC) 387766026(GI)
CBP_MOUSE(UniProtKB-ID) E9QPH4(AltAccession)
MGI:1098280(MGI)
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PANTHER Classification
PANTHER Family: CBP/P300-RELATED (PTHR13808)
PANTHER Subfamily: CREB-BINDING PROTEIN (PTHR13808:SF34)  
PANTHER GO-slim Molecular Function: chromatin DNA binding
transcription coactivator activity
histone acetyltransferase activity
PANTHER GO-slim Biological Process: positive regulation of transcription by RNA polymerase II
PANTHER GO-slim Cellular Component: histone acetyltransferase complex
transcription regulator complex
PANTHER protein class: histone modifying enzyme
Pathway Categories: TGF-beta signaling pathway
   Co-activators or corepressors
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
   CREB binding protein
Huntington disease
   CREB binding protein
Wnt signaling pathway
   CREB binding protein
Hedgehog signaling pathway
   CREB binding protein
Hypoxia response via HIF activation
   p300
p53 pathway
   CREB binding protein
Transcription regulation by bZIP transcription factor
   CBP/P300
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
   cAMP response element binding protein
Gonadotropin-releasing hormone receptor pathway
   CBP
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: cAMP response element binding protein binding, acetyltransferase activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding, histone H2BK5 acetyltransferase activity, histone H3K4 acetyltransferase activity, histone H4K16 acetyltransferase activity, histone H2BK12 acetyltransferase activity, histone H3K36 acetyltransferase activity, histone H3K27 acetyltransferase activity, MRF binding, peptide-lysine-N-acetyltransferase activity, transcription coactivator binding, peroxisome proliferator activated receptor binding, protein-containing complex binding, p53 binding, TFIIB-class transcription factor binding, histone H3K14 acetyltransferase activity, DNA-binding transcription factor binding, molecular adaptor activity, chromatin DNA binding, histone H2AK5 acetyltransferase activity, zinc ion binding, protein domain specific binding, peptide lactyltransferase (CoA-dependent) activity, histone lactyltransferase (CoA-dependent) activity, histone H3K9 acetyltransferase activity, histone H3K23 acetyltransferase activity, chromatin binding, histone H3K18 acetyltransferase activity, histone H4K8 acetyltransferase activity, damaged DNA binding, histone H4K5 acetyltransferase activity, histone H3K122 acetyltransferase activity, histone H4K12 acetyltransferase activity, DNA binding, histone acetyltransferase activity, protein binding, transcription coactivator activity, SMAD binding, RNA polymerase II-specific DNA-binding transcription factor binding, transcription corepressor activity, histone H2AK9 acetyltransferase activity, histone H3K56 acetyltransferase activity, disordered domain specific binding
GO BP Complete: protein modification process, positive regulation of double-strand break repair via homologous recombination, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of transcription by RNA polymerase II, positive regulation of DNA-binding transcription factor activity, face morphogenesis, negative regulation of transcription by RNA polymerase II, chromatin remodeling, behavioral response to cocaine, positive regulation of DNA-templated transcription, N-terminal peptidyl-lysine acetylation, cellular response to UV, negative regulation of transcription by RNA polymerase I, negative regulation of interferon-beta production, positive regulation of protein localization to nucleus, positive regulation of cell adhesion molecule production, positive regulation of G1/S transition of mitotic cell cycle, regulation of DNA-templated transcription, negative regulation of viral process, positive regulation of dendritic spine development, protein acetylation, canonical NF-kappaB signal transduction, long-term memory, protein destabilization, cellular response to virus, cellular response to nutrient levels, rhythmic process, positive regulation of gene expression, germ-line stem cell population maintenance, cellular response to hepatocyte growth factor stimulus, positive regulation of CREB transcription factor activity, positive regulation of transforming growth factor beta receptor signaling pathway
GO CC Complete: nucleus, transcription regulator complex, nuclear body, PML body, RNA polymerase II transcription regulator complex, cytoplasm, protein-containing complex, outer kinetochore, chromatin, histone acetyltransferase complex, nucleoplasm
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Immune System, Cellular responses to stimuli, TRAF6 mediated IRF7 activation, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, KEAP1-NFE2L2 pathway, Formation of the beta-catenin:TCF transactivating complex, NOTCH1 Intracellular Domain Regulates Transcription, Generic Transcription Pathway, Attenuation phase, Cytosolic sensors of pathogen-associated DNA , Signaling by Nuclear Receptors, Metabolism of lipids, Regulation of lipid metabolism by PPARalpha, FOXO-mediated transcription, Gene expression (Transcription), Cellular response to hypoxia, Regulation of FOXO transcriptional activity by acetylation, ESR-mediated signaling, Regulation of gene expression by Hypoxia-inducible Factor, Estrogen-dependent gene expression, Transcriptional regulation by RUNX1, Signaling by NOTCH1, TCF dependent signaling in response to WNT, LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production, Signaling by WNT, HSF1-dependent transactivation, Innate Immune System, Signal Transduction, Cellular response to chemical stress, Cytoprotection by HMOX1, CD209 (DC-SIGN) signaling, Cellular response to heat stress, DDX58/IFIH1-mediated induction of interferon-alpha/beta, Transcriptional regulation by RUNX3, RUNX1 regulates transcription of genes involved in differentiation of myeloid cells, C-type lectin receptors (CLRs), Activation of the TFAP2 (AP-2) family of transcription factors, Nuclear events mediated by NFE2L2, Metabolism, RUNX3 regulates NOTCH signaling, Signaling by NOTCH, Cellular responses to stress, Notch-HLH transcription pathway, RNA Polymerase II Transcription

Orthologs