PANTHER Gene Information

Gene Symbol(s):

SIAH1

Organism:

Pan troglodytes

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Gene Name:

E3 ubiquitin-protein ligase

Gene ID:

ENSPTRG00000008094.6

Protein ID:

K7B016

Persistent Id:

PTN000034848

Alternate Ids:

694963461(GI)	ENSPTRP00000013820(Ensembl_PRO)
XP_009428999(refSeq)	JAA19223(EMBL-CDS)
GABF01002922(EMBL)	K7B016_PANTR(UniProtKB-ID)
K7B016(Synonym)	ENSPTRG00000008094(Ensembl)
465153(GeneID)	ENSPTRT00000014926(Ensembl_TRS)
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PANTHER Classification

PANTHER Family:	E3 UBIQUITIN-PROTEIN LIGASE SIAH2 (PTHR45877)
PANTHER Subfamily:	E3 UBIQUITIN-PROTEIN LIGASE SIAH1 (PTHR45877:SF7)
PANTHER GO-slim Molecular Function:	ubiquitin protein ligase activity ubiquitin-like protein conjugating enzyme binding
PANTHER GO-slim Biological Process:	proteasome-mediated ubiquitin-dependent protein catabolic process
PANTHER GO-slim Cellular Component:	cytoplasm
PANTHER protein class:	ubiquitin-protein ligase

Pathway Categories:

p53 pathway feedback loops 2

Seven in absentia homolog 1

Wnt signaling pathway

Seven in absentia homolog 1

p53 pathway

Seven in absentia homolog 1

p53 pathway feedback loops 2

Seven in absentia homolog 1

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	ubiquitin-protein transferase activity, zinc ion binding, ubiquitin conjugating enzyme binding, identical protein binding, ubiquitin protein ligase activity, metal ion binding, transferase activity
GO BP Complete:	proteasome-mediated ubiquitin-dependent protein catabolic process, protein catabolic process, positive regulation of apoptotic process, canonical Wnt signaling pathway, positive regulation of intrinsic apoptotic signaling pathway, ubiquitin-dependent protein catabolic process, protein ubiquitination
GO CC Complete:	beta-catenin destruction complex, cytoplasm

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=10857\|UniProtKB=Q8IUQ4	Homo sapiens	LDO
GORGO\|Ensembl=ENSGGOG00000000938.3\|UniProtKB=G3S6X6	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000007400.4\|UniProtKB=F6T3K3	Macaca mulatta	LDO
MOUSE\|MGI=MGI=108063\|UniProtKB=Q06985	Mus musculus	O
MOUSE\|MGI=MGI=108064\|UniProtKB=P61092	Mus musculus	LDO
RAT\|RGD=620449\|UniProtKB=Q920M9	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000053993.1\|UniProtKB=A0A3Q1MUP8	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000032923.4\|UniProtKB=G3X7V0	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000000237.5\|UniProtKB=F1N0S2	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000010868.6\|UniProtKB=F1N5G3	Bos taurus	LDO
HORSE\|Ensembl=ENSECAG00000044655.1\|UniProtKB=A0A9L0RPL4	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000013713.5\|UniProtKB=M3X8B7	Felis catus	O
FELCA\|Ensembl=ENSFCAG00000011336.5\|UniProtKB=M3WEX6	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845004556.1\|UniProtKB=A0A8I3RS36	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000012963.4\|UniProtKB=F7DC68	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000016047.2\|UniProtKB=A0A6I8N8S2	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010024220.1\|UniProtKB=F1P2G0	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000014413.3\|UniProtKB=H9GL05	Anolis carolinensis	LDO
XENLA\|Gene=siah1.L\|UniProtKB=A0A1L8GLB4	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-1014415\|UniProtKB=A0A6I8S8J7	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000013569.2\|UniProtKB=H2MEL0	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-010319-31\|UniProtKB=Q7ZVG6	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000007536.1\|UniProtKB=W5ML82	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000024656.1\|UniProtKB=H2XYF8	Ciona intestinalis	O
BRAFL\|Gene_ORFName=BRAFLDRAFT_129882\|UniProtKB=C3Y132	Branchiostoma floridae	O
STRPU\|EnsemblGenome=LOC592708\|UniProtKB=A0A7M7HK68	Strongylocentrotus purpuratus	O
CAEEL\|WormBase=WBGene00021369\|UniProtKB=Q965X6	Caenorhabditis elegans	O
CAEBR\|Gene_ORFName=CBG08288\|UniProtKB=A8X679	Caenorhabditis briggsae	O
PRIPA\|EnsemblGenome=WBGene00276945\|UniProtKB=A0A2A6CB22	Pristionchus pacificus	O
DROME\|FlyBase=FBgn0024997\|UniProtKB=Q9W4W4	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP000377\|UniProtKB=A0A1S4G9F3	Anopheles gambiae	O
DROME\|FlyBase=FBgn0259794\|UniProtKB=Q8T3Y0	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0003410\|UniProtKB=P21461	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP002322\|UniProtKB=Q7QBU9	Anopheles gambiae	O
ANOGA\|EnsemblGenome=AGAP011871\|UniProtKB=A0A1S4H8V4	Anopheles gambiae	O
ANOGA\|EnsemblGenome=AGAP006127\|UniProtKB=A7UU20	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC033791\|UniProtKB=A0A139WEW0	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC006740\|UniProtKB=D6WZ00	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC004464\|UniProtKB=D6WCR8	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC012298\|UniProtKB=D6X0M5	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC014617\|UniProtKB=D6WMY7	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC032619\|UniProtKB=A0A139WKH5	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC008901\|UniProtKB=D6WQJ0	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC005082\|UniProtKB=D2CG07	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC013427\|UniProtKB=D6WLK5	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC033973\|UniProtKB=A0A139WDR6	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC031964\|UniProtKB=A0A139WNH5	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC033498\|UniProtKB=A0A139WDN9	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC006600\|UniProtKB=D6WXS2	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC032019\|UniProtKB=A0A139WNI7	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC003283\|UniProtKB=D6WEL1	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC000502\|UniProtKB=D6W9Y6	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC001774\|UniProtKB=D6W8F0	Tribolium castaneum	O
IXOSC\|EnsemblGenome=ISCW015643\|UniProtKB=B7P4G7	Ixodes scapularis	O
HELRO\|EnsemblGenome=HelroG69385\|UniProtKB=T1FZU4	helobdella robusta	O
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g93606\|UniProtKB=A7RU12	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG19965\|UniProtKB=B3RLR7	Trichoplax adhaerens	O
GIAIC\|EnsemblGenome=GL50803_16157\|UniProtKB=D3KI79	Giardia intestinalis	O