PANTHER Pathway  >   Wnt signaling pathway >   Seven in absentia homolog 1

Pathway Component Details   
Name: Seven in absentia homolog 1 (SIAH-1)
Definition: Siah-1 promotes the destruction of Beta-catenin through ubiquitination in a process independent of Beta-catenin sites recognized by Beta-TrCP. Siah-1 recognizes the Beta-Catenin destruction complex through binding to APC and Ebi, an F box protein that binds Beta-catenin.
Category ID: P01433
Synonyms:
Upstream: Tumor protein p53  (p53)
Downstream:
Number Families/Subfamilies: 8
Number of Associated Sequences: 23
GO Molecular Function: -
GO Biological Process: -
GO Cellular Component: -
PANTHER protein class: -
References: Medline:11389839 

Sequence Association
Panther Subfamily Associated Sequence Definition Confidence Code Evidence
PTHR10315:SF117 Q9M2P4 E3 ubiquitin-protein ligase SINAT2 ISS PubMed:11389839  
PTHR10315:SF145 Q5NAX7 RING-type E3 ubiquitin transferase ISS PubMed:11389839  
PTHR10315:SF147 Q9FKD9 Putative E3 ubiquitin-protein ligase SINA-like 6 ISS PubMed:11389839  
PTHR10315:SF158 Q8S3N1 E3 ubiquitin-protein ligase SINAT5 IDA PubMed:11389839  
PTHR10315:SF80 Q84JL3 E3 ubiquitin-protein ligase SINAT3 IDA PubMed:11389839  
PTHR45877:SF2 P21461 E3 ubiquitin-protein ligase sina ISS PubMed:11389839  
  Q8T3Y0 Probable E3 ubiquitin-protein ligase sinah ISS PubMed:11389839  
  Q965X6 E3 ubiquitin-protein ligase siah-1 ISS PubMed:11389839  
PTHR45877:SF4 E1C3Q9 E3 ubiquitin-protein ligase ISS  
  F1MBM6 E3 ubiquitin-protein ligase ISS  
  F6TED2 E3 ubiquitin-protein ligase ISS  
  F7DVK7 E3 ubiquitin-protein ligase ISS  
  H2QNL0 E3 ubiquitin-protein ligase ISS  
  O43255 E3 ubiquitin-protein ligase SIAH2 IDA  
  Q06986 E3 ubiquitin-protein ligase SIAH2 IDA  
  Q8R4T2 E3 ubiquitin-protein ligase SIAH2 ISS  
PTHR45877:SF7 A0A6I8S8J7 E3 ubiquitin-protein ligase ISS PubMed:11389839  
  F6T3K3 E3 ubiquitin-protein ligase ISS PubMed:11389839  
  F6T3K3 E3 ubiquitin-protein ligase ISS PubMed:14985507  
  K7B016 E3 ubiquitin-protein ligase ISS PubMed:11389839  
  K7B016 E3 ubiquitin-protein ligase ISS PubMed:14985507  
  P61092 E3 ubiquitin-protein ligase SIAH1A IDA PubMed:11389839  
  P61092 E3 ubiquitin-protein ligase SIAH1A IDA PubMed:14985507  
  Q06985 E3 ubiquitin-protein ligase SIAH1B ISS PubMed:11389839  
  Q06985 E3 ubiquitin-protein ligase SIAH1B ISS PubMed:14985507  
  Q06985 E3 ubiquitin-protein ligase SIAH1B ISS PubMed:15326481  
  Q8IUQ4 E3 ubiquitin-protein ligase SIAH1 ISS PubMed:11389839  
  Q8IUQ4 E3 ubiquitin-protein ligase SIAH1 ISS PubMed:14985507  
  Q920M9 E3 ubiquitin-protein ligase SIAH1 ISS PubMed:11389839  
  Q920M9 E3 ubiquitin-protein ligase SIAH1 ISS PubMed:14985507