PANTHER Gene Information   
Gene Symbol(s): Siah2
Organism: Rattus norvegicus
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Gene Name: E3 ubiquitin-protein ligase SIAH2
Gene ID: 620778
Protein ID: Q8R4T2
Persistent Id: PTN000034825
Alternate Ids:
620778(RGD) AF389477(EMBL)
140593(GeneID) ENSRNOP00000018488(Ensembl_PRO)
ENSRNOG00000013703(Ensembl) BAB70754(EMBL-CDS)
Siah-2(Synonym) Siah2(Symbol)
19745174(GI) NP_604452(refSeq)
Q920M8(AltAccession) ENSRNOT00000018488(Ensembl_TRS)
2.3.2.27 {ECO:0000269|PubMed:11786535}(EC) SIAH2_RAT(UniProtKB-ID)
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PANTHER Classification
PANTHER Family: E3 UBIQUITIN-PROTEIN LIGASE SIAH2 (PTHR45877)
PANTHER Subfamily: E3 UBIQUITIN-PROTEIN LIGASE SIAH2 (PTHR45877:SF4)  
PANTHER GO-slim Molecular Function: ubiquitin protein ligase activity
ubiquitin-like protein conjugating enzyme binding
PANTHER GO-slim Biological Process: proteasome-mediated ubiquitin-dependent protein catabolic process
PANTHER GO-slim Cellular Component: cytoplasm
PANTHER protein class: ubiquitin-protein ligase
Pathway Categories: Wnt signaling pathway
   Seven in absentia homolog 1
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: ubiquitin-protein transferase activity, zinc ion binding, ubiquitin conjugating enzyme binding, ubiquitin protein ligase activity, protein binding, transferase activity
GO BP Complete: negative regulation of canonical Wnt signaling pathway, proteasome-mediated ubiquitin-dependent protein catabolic process, rhythmic process, negative regulation of apoptotic process, apoptotic process, canonical Wnt signaling pathway, negative regulation of extrinsic apoptotic signaling pathway, regulation of protein ubiquitination, regulation of circadian rhythm, negative regulation of cysteine-type endopeptidase activity, ubiquitin-dependent protein catabolic process, protein ubiquitination
GO CC Complete: early endosome, cytoplasm, intracellular membrane-bounded organelle, cytosol, neuronal cell body, nucleoplasm
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Class I MHC mediated antigen processing & presentation, Deubiquitination, Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Metabolism of proteins, Adaptive Immune System, Post-translational protein modification, Ub-specific processing proteases

Orthologs