PANTHER Gene Information

Gene Symbol(s):

sina

Organism:

Drosophila melanogaster

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Gene Name:

E3 ubiquitin-protein ligase sina

Gene ID:

FBgn0003410

Protein ID:

P21461

Persistent Id:

PTN000034887

Alternate Ids:

FBgn0003410(FlyBase)	FBpp0310636(Ensembl_PRO)
FBgn0003410(Ensembl)	17136476(GI)
FBtr0344230(Ensembl_TRS)	39884(GeneID)
Seven in absentia protein(Synonym)	sina(Symbol)
AAA28901(EMBL-CDS)	NM_001300160(refSeq)
A4V214(AltAccession)	2.3.2.27(EC)
AY060358(EMBL)	SINA_DROME(UniProtKB-ID)
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PANTHER Classification

PANTHER Family:	E3 UBIQUITIN-PROTEIN LIGASE SIAH2 (PTHR45877)
PANTHER Subfamily:	E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED (PTHR45877:SF2)
PANTHER GO-slim Molecular Function:
PANTHER GO-slim Biological Process:
PANTHER GO-slim Cellular Component:
PANTHER protein class:	ubiquitin-protein ligase

Pathway Categories:

Wnt signaling pathway

Seven in absentia homolog 1

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	ubiquitin-protein transferase activity, zinc ion binding, ubiquitin conjugating enzyme binding, ubiquitin protein ligase activity, protein binding
GO BP Complete:	proteasome-mediated ubiquitin-dependent protein catabolic process, enteroendocrine cell differentiation, R7 cell fate commitment, sevenless signaling pathway, regulation of R7 cell differentiation, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, sensory organ development, ubiquitin-dependent protein catabolic process, proteasomal protein catabolic process, protein ubiquitination
GO CC Complete:	nucleus, ubiquitin ligase complex, cytoplasm, cytosol

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Netrin-1 signaling, Class I MHC mediated antigen processing & presentation, Axon guidance, Deubiquitination, Antigen processing: Ubiquitination & Proteasome degradation, Immune System, Metabolism of proteins, Developmental Biology, Nervous system development, Adaptive Immune System, Ub-specific processing proteases, Post-translational protein modification

Orthologs

ID	Organism	Type
HUMAN\|HGNC=30553\|UniProtKB=Q8IW03	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000047082.1\|UniProtKB=A0A2I3T9C8	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000001856.3\|UniProtKB=G3QHJ8	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000041756.2\|UniProtKB=G7NK32	Macaca mulatta	O
MOUSE\|MGI=MGI=2685758\|UniProtKB=B2RWG3	Mus musculus	O
RAT\|RGD=1592168\|UniProtKB=F1M4M8	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000051729.1\|UniProtKB=A0A3Q1MK03	Bos taurus	O
PIG\|Ensembl=ENSSSCG00000038733.3\|UniProtKB=A0A287ABQ7	Sus scrofa	O
HORSE\|Ensembl=ENSECAG00000025105.4\|UniProtKB=F6Q610	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000018417.5\|UniProtKB=A0A2I2UBR6	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845008706.1\|UniProtKB=A0A8I3N5N6	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000014958.4\|UniProtKB=K7E4P4	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000051226.1\|UniProtKB=A0A6I8P9Z5	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010003718.1\|UniProtKB=R4GKE1	Gallus gallus	O
XENLA\|Gene=siah3.S\|UniProtKB=A0A1L8H9E7	Xenopus laevis	O
XENLA\|Gene=siah3.L\|UniProtKB=A0A1L8HHJ7	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-6035790\|UniProtKB=A0A6I8RL86	Xenopus tropicalis	O
HUMAN\|HGNC=10858\|UniProtKB=O43255	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000015532.4\|UniProtKB=H2QNL0	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000014662.3\|UniProtKB=G3RFD5	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000015590.4\|UniProtKB=F6TED2	Macaca mulatta	LDO
MOUSE\|MGI=MGI=108062\|UniProtKB=Q06986	Mus musculus	LDO
RAT\|RGD=620778\|UniProtKB=Q8R4T2	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000023445.5\|UniProtKB=F1MBM6	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000031388.2\|UniProtKB=A0A287ASV6	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000025153.3\|UniProtKB=F6SNK9	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000041639.2\|UniProtKB=A0A337S0I6	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845025518.1\|UniProtKB=A0A8I3PY49	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000021275.3\|UniProtKB=F7DVK7	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000037560.1\|UniProtKB=A0A6I8P7Q7	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010001127.1\|UniProtKB=E1C3Q9	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000007771.3\|UniProtKB=G1KH13	Anolis carolinensis	LDO
XENLA\|Gene=siah2\|UniProtKB=Q9I8X5	Xenopus laevis	LDO
XENTR\|Xenbase=XB-GENE-1004950\|UniProtKB=A4IIN1	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000026436.1\|UniProtKB=A0A3B3HXS7	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-030922-1\|UniProtKB=Q7SYL3	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000001908.1\|UniProtKB=W5M1E6	lepisosteus oculatus	O
LEPOC\|Ensembl=ENSLOCG00000014942.1\|UniProtKB=W5NCN7	lepisosteus oculatus	LDO
HUMAN\|HGNC=10857\|UniProtKB=Q8IUQ4	Homo sapiens	O
PANTR\|Ensembl=ENSPTRG00000008094.6\|UniProtKB=K7B016	Pan troglodytes	O
GORGO\|Ensembl=ENSGGOG00000000938.3\|UniProtKB=G3S6X6	Gorilla gorilla gorilla	O
MACMU\|Ensembl=ENSMMUG00000007400.4\|UniProtKB=F6T3K3	Macaca mulatta	O
MOUSE\|MGI=MGI=108063\|UniProtKB=Q06985	Mus musculus	O
MOUSE\|MGI=MGI=108064\|UniProtKB=P61092	Mus musculus	O
RAT\|RGD=620449\|UniProtKB=Q920M9	Rattus norvegicus	O
BOVIN\|Ensembl=ENSBTAG00000053993.1\|UniProtKB=A0A3Q1MUP8	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000032923.4\|UniProtKB=G3X7V0	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000000237.5\|UniProtKB=F1N0S2	Bos taurus	O
BOVIN\|Ensembl=ENSBTAG00000010868.6\|UniProtKB=F1N5G3	Bos taurus	O
HORSE\|Ensembl=ENSECAG00000044655.1\|UniProtKB=A0A9L0RPL4	Equus caballus	O
FELCA\|Ensembl=ENSFCAG00000013713.5\|UniProtKB=M3X8B7	Felis catus	O
FELCA\|Ensembl=ENSFCAG00000011336.5\|UniProtKB=M3WEX6	Felis catus	O
CANLF\|Ensembl=ENSCAFG00845004556.1\|UniProtKB=A0A8I3RS36	Canis lupus familiaris	O
MONDO\|Ensembl=ENSMODG00000012963.4\|UniProtKB=F7DC68	Monodelphis domestica	O
ORNAN\|Ensembl=ENSOANG00000016047.2\|UniProtKB=A0A6I8N8S2	Ornithorhynchus anatinus	O
CHICK\|Ensembl=ENSGALG00010024220.1\|UniProtKB=F1P2G0	Gallus gallus	O
ANOCA\|Ensembl=ENSACAG00000014413.3\|UniProtKB=H9GL05	Anolis carolinensis	O
XENLA\|Gene=siah1.L\|UniProtKB=A0A1L8GLB4	Xenopus laevis	O
XENTR\|Xenbase=XB-GENE-1014415\|UniProtKB=A0A6I8S8J7	Xenopus tropicalis	O
ORYLA\|Ensembl=ENSORLG00000013569.2\|UniProtKB=H2MEL0	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-010319-31\|UniProtKB=Q7ZVG6	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000007536.1\|UniProtKB=W5ML82	lepisosteus oculatus	O
CIOIN\|Ensembl=ENSCING00000024656.1\|UniProtKB=H2XYF8	Ciona intestinalis	LDO
BRAFL\|Gene_ORFName=BRAFLDRAFT_129882\|UniProtKB=C3Y132	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC592708\|UniProtKB=A0A7M7HK68	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00021369\|UniProtKB=Q965X6	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG08288\|UniProtKB=A8X679	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00276945\|UniProtKB=A0A2A6CB22	Pristionchus pacificus	LDO
ANOGA\|EnsemblGenome=AGAP002322\|UniProtKB=Q7QBU9	Anopheles gambiae	O
ANOGA\|EnsemblGenome=AGAP011871\|UniProtKB=A0A1S4H8V4	Anopheles gambiae	O
ANOGA\|EnsemblGenome=AGAP006127\|UniProtKB=A7UU20	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC033791\|UniProtKB=A0A139WEW0	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC006740\|UniProtKB=D6WZ00	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC004464\|UniProtKB=D6WCR8	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC012298\|UniProtKB=D6X0M5	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC014617\|UniProtKB=D6WMY7	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC032619\|UniProtKB=A0A139WKH5	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC008901\|UniProtKB=D6WQJ0	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC005082\|UniProtKB=D2CG07	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC013427\|UniProtKB=D6WLK5	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC033973\|UniProtKB=A0A139WDR6	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC031964\|UniProtKB=A0A139WNH5	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC033498\|UniProtKB=A0A139WDN9	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC006600\|UniProtKB=D6WXS2	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC032019\|UniProtKB=A0A139WNI7	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC003283\|UniProtKB=D6WEL1	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC000502\|UniProtKB=D6W9Y6	Tribolium castaneum	O
TRICA\|EnsemblGenome=TC001774\|UniProtKB=D6W8F0	Tribolium castaneum	LDO
IXOSC\|EnsemblGenome=ISCW015643\|UniProtKB=B7P4G7	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG69385\|UniProtKB=T1FZU4	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g93606\|UniProtKB=A7RU12	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG19965\|UniProtKB=B3RLR7	Trichoplax adhaerens	LDO
GIAIC\|EnsemblGenome=GL50803_16157\|UniProtKB=D3KI79	Giardia intestinalis	LDO