PANTHER Gene Information   
Gene Symbol(s): Siah1a
Organism: Mus musculus
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Gene Name: E3 ubiquitin-protein ligase SIAH1A
Gene ID: MGI:108064
Protein ID: P61092
Persistent Id: PTN000034855
Alternate Ids:
MGI:108064(MGI) 20437(GeneID)
18158802(GI) ENSMUSG00000036840(Ensembl)
Q06984(AltAccession) NM_009172(refSeq)
AAH46317(EMBL-CDS) SIA1A_MOUSE(UniProtKB-ID)
ENSMUST00000045296(Ensembl_TRS) BC046317(EMBL)
Siah-1a(Synonym) Siah1a(Symbol)
2.3.2.27 {ECO:0000269|PubMed:28546513}(EC) ENSMUSP00000044123(Ensembl_PRO)
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PANTHER Classification
PANTHER Family: E3 UBIQUITIN-PROTEIN LIGASE SIAH2 (PTHR45877)
PANTHER Subfamily: E3 UBIQUITIN-PROTEIN LIGASE SIAH1 (PTHR45877:SF7)  
PANTHER GO-slim Molecular Function: ubiquitin protein ligase activity
ubiquitin-like protein conjugating enzyme binding
PANTHER GO-slim Biological Process: proteasome-mediated ubiquitin-dependent protein catabolic process
PANTHER GO-slim Cellular Component: cytoplasm
PANTHER protein class: ubiquitin-protein ligase
Pathway Categories: p53 pathway feedback loops 2
   Seven in absentia homolog 1
Wnt signaling pathway
   Seven in absentia homolog 1
p53 pathway
   Seven in absentia homolog 1
p53 pathway feedback loops 2
   Seven in absentia homolog 1
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: ubiquitin-protein transferase activity, zinc ion binding, ubiquitin conjugating enzyme binding, identical protein binding, ubiquitin protein ligase activity, protein binding, protein homodimerization activity, disordered domain specific binding
GO BP Complete: regulation of multicellular organism growth, spermatogenesis, protein catabolic process, male meiosis I, post-embryonic development, ubiquitin-dependent protein catabolic process, protein destabilization, proteasome-mediated ubiquitin-dependent protein catabolic process, positive regulation of apoptotic process, cell differentiation, canonical Wnt signaling pathway, positive regulation of intrinsic apoptotic signaling pathway, neuron apoptotic process, protein ubiquitination
GO CC Complete: beta-catenin destruction complex, nucleus, early endosome, cytoplasm, cytosol, SCF ubiquitin ligase complex
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Adaptive Immune System

Orthologs