PANTHER Gene Information   
Gene Symbol(s): SIAH1
Organism: Homo sapiens
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Gene Name: E3 ubiquitin-protein ligase SIAH1
Gene ID: HGNC:10857
Protein ID: Q8IUQ4
Enhancers: View enhancers for HUMAN|HGNC=10857|UniProtKB=Q8IUQ4
Genetic Variant Annotation: Annoq
Persistent Id: PTN002469869
Alternate Ids:
O43269(AltAccession) 119603133(GI)
XM_011523279(refSeq) SIAH1_HUMAN(UniProtKB-ID)
2.3.2.27 {ECO:0000269|PubMed:19224863, ECO:0000269|PubMed:28546513}(EC) 6477(GeneID)
602212(MIM) HGNC:10857(HGNC)
SIAH1(Symbol) Seven in absentia homolog 1(Synonym)
ABK15529(EMBL-CDS) BX647064(EMBL)
ENSG00000196470(Ensembl)
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PANTHER Classification
PANTHER Family: E3 UBIQUITIN-PROTEIN LIGASE SIAH2 (PTHR45877)
PANTHER Subfamily: E3 UBIQUITIN-PROTEIN LIGASE SIAH1 (PTHR45877:SF7)  
PANTHER GO-slim Molecular Function: ubiquitin protein ligase activity
ubiquitin-like protein conjugating enzyme binding
PANTHER GO-slim Biological Process: proteasome-mediated ubiquitin-dependent protein catabolic process
PANTHER GO-slim Cellular Component: cytoplasm
PANTHER protein class: ubiquitin-protein ligase
Pathway Categories: p53 pathway feedback loops 2
   Seven in absentia homolog 1
Wnt signaling pathway
   Seven in absentia homolog 1
p53 pathway
   Seven in absentia homolog 1
p53 pathway feedback loops 2
   Seven in absentia homolog 1
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: ubiquitin-protein transferase activity, zinc ion binding, ubiquitin conjugating enzyme binding, identical protein binding, ubiquitin protein ligase activity, protein binding
GO BP Complete: spermatogenesis, protein catabolic process, nervous system development, axon guidance, anatomical structure morphogenesis, ubiquitin-dependent protein catabolic process, amyloid fibril formation, proteasome-mediated ubiquitin-dependent protein catabolic process, apoptotic process, positive regulation of apoptotic process, canonical Wnt signaling pathway, positive regulation of intrinsic apoptotic signaling pathway, neuron apoptotic process, protein ubiquitination
GO CC Complete: beta-catenin destruction complex, nucleus, cytoplasm, cytosol
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Metabolism of proteins, Amyloid fiber formation, Immune System, Developmental Biology, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Netrin-1 signaling, Axon guidance, Nervous system development

Orthologs