PANTHER Gene Information   
Gene Symbol(s): fgf8a
Organism: Danio rerio
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Gene Name: Fibroblast growth factor 8
Gene ID: ZDB-GENE-990415-72
Protein ID: O57341
Persistent Id: PTN000160264
Alternate Ids:
182891690(GI) BAF34588(EMBL-CDS)
fgf8a{ECO:0000312|ZFIN:ZDB-GENE-990415-72}(Symbol) BC086718(EMBL)
NP_571356(refSeq) FGF-8(Synonym)
30538(GeneID) ZDB-GENE-990415-72(ZFIN)
FGF8A_DANRE(UniProtKB-ID) Q5PRC3(AltAccession)
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PANTHER Classification
PANTHER Family: FIBROBLAST GROWTH FACTOR (PTHR11486)
PANTHER Subfamily: FIBROBLAST GROWTH FACTOR 8 (PTHR11486:SF3)  
PANTHER GO-slim Molecular Function: growth factor activity
fibroblast growth factor receptor binding
PANTHER GO-slim Biological Process: regulation of cell migration
neuron differentiation
fibroblast growth factor receptor signaling pathway
positive regulation of protein phosphorylation
dorsal/ventral pattern formation
positive regulation of MAPK cascade
positive regulation of gene expression
positive regulation of cell population proliferation
animal organ morphogenesis
PANTHER GO-slim Cellular Component: extracellular space
cytoplasm
PANTHER protein class: growth factor
Pathway Categories: FGF signaling pathway
   fibroblast growth factor

GO MF Complete: growth factor activity, type 2 fibroblast growth factor receptor binding, type 1 fibroblast growth factor receptor binding
GO BP Complete: inner ear development, retina development in camera-type eye, somite development, endoderm development, ventricular cardiac muscle cell differentiation, mesoderm development, anterior/posterior pattern specification, midbrain-hindbrain boundary morphogenesis, fibroblast growth factor receptor signaling pathway, neurogenesis, dorsal/ventral pattern formation, heart morphogenesis, midbrain development, notochord development, cardiac ventricle morphogenesis, hindbrain development, Kupffer's vesicle development, cell fate specification, cilium assembly, cerebellum development, locus ceruleus development, neuron differentiation, embryonic camera-type eye development, embryonic pattern specification, cerebellum formation, peripheral nervous system development, brain development, negative regulation of endodermal cell fate specification, pharyngeal system development, animal organ morphogenesis, positive regulation of somitomeric trunk muscle development, somitogenesis, positive regulation of Wnt signaling pathway, regulation of cell migration, positive regulation of cell migration, cartilage development, taste bud formation, positive regulation of cell population proliferation, paraxial mesoderm development, otic placode formation, ectodermal placode formation, determination of dorsal identity, striated muscle cell differentiation, neuron fate specification, otic vesicle development, closure of optic fissure, oligodendrocyte differentiation, embryonic neurocranium morphogenesis, midbrain-hindbrain boundary development, embryonic heart tube development, positive regulation of MAPK cascade, embryonic retina morphogenesis in camera-type eye, skeletal system morphogenesis, determination of left/right symmetry, rhombomere 5 development, rhombomere 6 development, thyroid gland development, regulation of bone remodeling, otic vesicle formation, cardioblast differentiation
GO CC Complete: extracellular space, cytoplasm, extracellular region, lysosome
Reactome Pathways: Intracellular signaling by second messengers, FGFR3 ligand binding and activation, Signal Transduction, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, FGFR2 ligand binding and activation, FGFR1 ligand binding and activation, Downstream signaling of activated FGFR2, FGFR4 ligand binding and activation, SHC-mediated cascade:FGFR2, FRS-mediated FGFR4 signaling, Negative regulation of the PI3K/AKT network, Phospholipase C-mediated cascade: FGFR1, Signaling by FGFR1, Signaling by FGFR2, Downstream signaling of activated FGFR4, MAPK family signaling cascades, PIP3 activates AKT signaling, Signaling by Receptor Tyrosine Kinases, FRS-mediated FGFR1 signaling, RAF/MAP kinase cascade, FGFR1c ligand binding and activation, Phospholipase C-mediated cascade; FGFR2, FGFRL1 modulation of FGFR1 signaling, Signaling by FGFR3, FGFR2c ligand binding and activation, SHC-mediated cascade:FGFR1, MAPK1/MAPK3 signaling, Signaling by FGFR4, Downstream signaling of activated FGFR1, Signaling by FGFR, Phospholipase C-mediated cascade; FGFR4, PI-3K cascade:FGFR1, Phospholipase C-mediated cascade; FGFR3, FRS-mediated FGFR2 signaling, Negative regulation of FGFR1 signaling, SHC-mediated cascade:FGFR3, FRS-mediated FGFR3 signaling, FGFR3b ligand binding and activation, Downstream signaling of activated FGFR3, FGFR3c ligand binding and activation