PANTHER Gene Information   
Gene Symbol(s): ADCY5
Organism: Homo sapiens
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Gene Name: Adenylate cyclase type 5
Gene ID: HGNC:236
Protein ID: O95622
Enhancers: View enhancers for HUMAN|HGNC=236|UniProtKB=O95622
Genetic Variant Annotation: Annoq
Persistent Id: PTN002484515
Alternate Ids:
ADCY5_HUMAN(UniProtKB-ID) ENSG00000173175(Ensembl)
4.6.1.1 {ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:24700542, ECO:0000269|PubMed:26206488}(EC) Q7RTV7(AltAccession)
111(GeneID) 25014055(GI)
619651(MIM) HGNC:236(HGNC)
Adenylyl cyclase 5(Synonym) CHEMBL3189(ChEMBL)
AC025571(EMBL) ADCY5(Symbol)
AAD00121(EMBL-CDS)
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PANTHER Classification
PANTHER Family: ADENYLATE CYCLASE TYPE 1 (PTHR45627)
PANTHER Subfamily: ADENYLATE CYCLASE TYPE 5 (PTHR45627:SF7)  
PANTHER GO-slim Molecular Function: adenylate cyclase activity
PANTHER GO-slim Biological Process: adenylate cyclase-activating G protein-coupled receptor signaling pathway
PANTHER GO-slim Cellular Component: plasma membrane
PANTHER protein class: adenylate cyclase
Pathway Categories: Endothelin signaling pathway
   Adenylate cyclase
GABA-B receptor II signaling
   adenylate cyclase
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
   Adenylyl cyclase
Inflammation mediated by chemokine and cytokine signaling pathway
   adenylate cyclase
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: ATP binding, scaffold protein binding, metal ion binding, adenylate cyclase binding, adenylate cyclase activity
GO BP Complete: cAMP biosynthetic process, regulation of insulin secretion involved in cellular response to glucose stimulus, G protein-coupled adenosine receptor signaling pathway, adenylate cyclase-activating dopamine receptor signaling pathway, locomotory behavior, adenylate cyclase-inhibiting dopamine receptor signaling pathway, cellular response to forskolin, adenylate cyclase-activating G protein-coupled receptor signaling pathway, intracellular signal transduction, neuromuscular process controlling balance, positive regulation of cytosolic calcium ion concentration
GO CC Complete: membrane, cilium, plasma membrane
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Signaling by Hedgehog, FCGR3A-mediated IL10 synthesis, Neuronal System, Opioid Signalling, Neurotransmitter receptors and postsynaptic signal transmission, Transmission across Chemical Synapses, Adenylate cyclase activating pathway, Infectious disease, Signaling by GPCR, ADORA2B mediated anti-inflammatory cytokines production, GABA receptor activation, Signal Transduction, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, GABA B receptor activation, Vasopressin regulates renal water homeostasis via Aquaporins, G alpha (s) signalling events, G alpha (z) signalling events, G alpha (i) signalling events, PKA activation, Glucagon signaling in metabolic regulation, Adrenaline,noradrenaline inhibits insulin secretion, GPCR downstream signalling, Leishmania parasite growth and survival, Calmodulin induced events, Adenylate cyclase inhibitory pathway, PKA-mediated phosphorylation of CREB, Hedgehog 'off' state, Activation of GABAB receptors, CaM pathway, Disease, Ca-dependent events, Anti-inflammatory response favouring Leishmania parasite infection, Leishmania infection, DAG and IP3 signaling, Metabolism, PLC beta mediated events, Integration of energy metabolism, PKA activation in glucagon signalling, G-protein mediated events, Aquaporin-mediated transport, Parasitic Infection Pathways, Regulation of insulin secretion, GPER1 signaling, Transport of small molecules, Intracellular signaling by second messengers

Orthologs