Pathway Component Details
| Name: | Adenylyl cyclase (cAMP cyclase) |
| Definition: | A transmembrane protein with enzymatic activity specific for the conversion of ATP to cAMP. cAMP is a potent second messenger molecule. A primary downstream result of increased cAMP levels is the activation of Protein Kinase A (PKA). The adenylyl cyclase molecule is regulated by Gs alpha-GTP which has a stimulatory effect on adenylyl cyclase, and by Gi alpha -GTP which has an inhibitory effect on adenylyl cyclase. |
| Category ID: | P00719 |
| Synonyms: | |
| Upstream: |
Gi-protein, alpha subunit
(Gialpha)
Gs alpha subunit (Gsalpha) |
| Downstream: | |
| Number Families/Subfamilies: | 9 |
| Number of Associated Sequences: | 57 |
| GO Molecular Function: |
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| GO Biological Process: |
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| GO Cellular Component: |
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| PANTHER protein class: |
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| References: |
Sequence Association
| Panther Subfamily | Associated Sequence | Definition | Confidence Code | Evidence |
| PTHR45627:SF1 | A0A1D5Q874 | Adenylate cyclase type 8 | ISS | PubMed:12890691 |
| A0A1D5Q874 | Adenylate cyclase type 8 | ISS | PubMed:2491850 | |
| A0A1D5Q874 | Adenylate cyclase type 8 | ISS | PubMed:8163524 | |
| A0A2I3SK46 | Adenylate cyclase type 8 | ISS | PubMed:12890691 | |
| A0A2I3SK46 | Adenylate cyclase type 8 | ISS | PubMed:2491850 | |
| A0A2I3SK46 | Adenylate cyclase type 8 | ISS | PubMed:8163524 | |
| A0A8I3NFX0 | Adenylate cyclase type 8 | ISS | PubMed:12890691 | |
| A0A8I3NFX0 | Adenylate cyclase type 8 | ISS | PubMed:2491850 | |
| A0A8I3NFX0 | Adenylate cyclase type 8 | ISS | PubMed:8163524 | |
| E1BQ12 | Adenylate cyclase type 8 | ISS | PubMed:12890691 | |
| E1BQ12 | Adenylate cyclase type 8 | ISS | PubMed:2491850 | |
| E1BQ12 | Adenylate cyclase type 8 | ISS | PubMed:8163524 | |
| F7BCI5 | Adenylate cyclase type 8 | ISS | PubMed:12890691 | |
| F7BCI5 | Adenylate cyclase type 8 | ISS | PubMed:2491850 | |
| F7BCI5 | Adenylate cyclase type 8 | ISS | PubMed:8163524 | |
| P40145 | Adenylate cyclase type 8 | IDA | PubMed:12890691 | |
| P40145 | Adenylate cyclase type 8 | IDA | PubMed:2491850 | |
| P40146 | Adenylate cyclase type 8 | IDA | PubMed:2491850 | |
| P40146 | Adenylate cyclase type 8 | IDA | PubMed:8163524 | |
| P97490 | Adenylate cyclase type 8 | IDA | PubMed:12890691 | |
| P97490 | Adenylate cyclase type 8 | IDA | PubMed:2491850 | |
| P97490 | Adenylate cyclase type 8 | IDA | PubMed:8163524 | |
| PTHR45627:SF10 | H2Q832 | Adenylate cyclase type 4 | ISS | PubMed:1946437 |
| H2Q832 | Adenylate cyclase type 4 | ISS | PubMed:2491850 | |
| H2Q832 | Adenylate cyclase type 4 | ISS | PubMed:9870949 | |
| P26770 | Adenylate cyclase type 4 | IDA | PubMed:1946437 | |
| P26770 | Adenylate cyclase type 4 | IDA | PubMed:2491850 | |
| Q8NFM4 | Adenylate cyclase type 4 | ISS | PubMed:1946437 | |
| Q8NFM4 | Adenylate cyclase type 4 | ISS | PubMed:2491850 | |
| Q8NFM4 | Adenylate cyclase type 4 | ISS | PubMed:9870949 | |
| Q91WF3 | Adenylate cyclase type 4 | IDA | PubMed:2491850 | |
| Q91WF3 | Adenylate cyclase type 4 | IDA | PubMed:9870949 | |
| PTHR45627:SF11 | A0A5F7ZH36 | Adenylate cyclase type 6 | ISS | PubMed:10978539 |
| A0A5F7ZH36 | Adenylate cyclase type 6 | ISS | PubMed:2491850 | |
| A0A5F7ZH36 | Adenylate cyclase type 6 | ISS | PubMed:92357702 | |
| A0A5F7ZH36 | Adenylate cyclase type 6 | ISS | PubMed:92409599 | |
| A0A5F7ZH36 | Adenylate cyclase type 6 | ISS | PubMed:93028552 | |
| E1B9K3 | Adenylate cyclase type 6 | ISS | PubMed:10978539 | |
| E1B9K3 | Adenylate cyclase type 6 | ISS | PubMed:2491850 | |
| E1B9K3 | Adenylate cyclase type 6 | ISS | PubMed:92357702 | |
| E1B9K3 | Adenylate cyclase type 6 | ISS | PubMed:92409599 | |
| E1B9K3 | Adenylate cyclase type 6 | ISS | PubMed:93028552 | |
| O43306 | Adenylate cyclase type 6 | IDA | PubMed:10978539 | |
| O43306 | Adenylate cyclase type 6 | IDA | PubMed:2491850 | |
| P30804 | Adenylate cyclase type 6 | IDA | PubMed:2491850 | |
| P30804 | Adenylate cyclase type 6 | IDA | PubMed:92409599 | |
| Q01341 | Adenylate cyclase type 6 | IDA | PubMed:2491850 | |
| Q01341 | Adenylate cyclase type 6 | IDA | PubMed:92357702 | |
| Q03343 | Adenylate cyclase type 6 | IDA | PubMed:2491850 | |
| Q03343 | Adenylate cyclase type 6 | IDA | PubMed:93028552 | |
| PTHR45627:SF26 | A0A5F7ZYU0 | Adenylate cyclase type 1 | ISS | PubMed:2491850 |
| A0A5F7ZYU0 | Adenylate cyclase type 1 | ISS | PubMed:89298382 | |
| D4A3N4 | Adenylate cyclase type 1 | ISS | PubMed:2491850 | |
| D4A3N4 | Adenylate cyclase type 1 | ISS | PubMed:89298382 | |
| H2QUJ4 | Adenylate cyclase type 1 | ISS | PubMed:2491850 | |
| H2QUJ4 | Adenylate cyclase type 1 | ISS | PubMed:89298382 | |
| O88444 | Adenylate cyclase type 1 | ISS | PubMed:2491850 | |
| O88444 | Adenylate cyclase type 1 | ISS | PubMed:89298382 | |
| P19754 | Adenylate cyclase type 1 | IDA | PubMed:2491850 | |
| P19754 | Adenylate cyclase type 1 | IDA | PubMed:89298382 | |
| Q08828 | Adenylate cyclase type 1 | ISS | PubMed:2491850 | |
| Q08828 | Adenylate cyclase type 1 | ISS | PubMed:89298382 | |
| PTHR45627:SF30 | A0A1D5QMQ7 | Adenylate cyclase type 3 | ISS | PubMed:12623444 |
| A0A1D5QMQ7 | Adenylate cyclase type 3 | ISS | PubMed:2255909 | |
| A0A1D5QMQ7 | Adenylate cyclase type 3 | ISS | PubMed:2491850 | |
| A0A8I3PTT1 | Adenylate cyclase type 3 | ISS | PubMed:12623444 | |
| A0A8I3PTT1 | Adenylate cyclase type 3 | ISS | PubMed:2255909 | |
| A0A8I3PTT1 | Adenylate cyclase type 3 | ISS | PubMed:2491850 | |
| F1MPC9 | Adenylate cyclase type 3 | ISS | PubMed:12623444 | |
| F1MPC9 | Adenylate cyclase type 3 | ISS | PubMed:2255909 | |
| F1MPC9 | Adenylate cyclase type 3 | ISS | PubMed:2491850 | |
| H2QHJ5 | Adenylate cyclase type 3 | ISS | PubMed:12623444 | |
| H2QHJ5 | Adenylate cyclase type 3 | ISS | PubMed:2255909 | |
| H2QHJ5 | Adenylate cyclase type 3 | ISS | PubMed:2491850 | |
| O60266 | Adenylate cyclase type 3 | IDA | PubMed:12623444 | |
| O60266 | Adenylate cyclase type 3 | IDA | PubMed:2491850 | |
| P21932 | Adenylate cyclase type 3 | IDA | PubMed:2255909 | |
| P21932 | Adenylate cyclase type 3 | IDA | PubMed:2491850 | |
| Q8VHH7 | Adenylate cyclase type 3 | IDA | PubMed:12623444 | |
| Q8VHH7 | Adenylate cyclase type 3 | IDA | PubMed:2255909 | |
| Q8VHH7 | Adenylate cyclase type 3 | IDA | PubMed:2491850 | |
| PTHR45627:SF6 | A0A1D5RHE7 | Adenylate cyclase type 2 | ISS | PubMed:12472880 |
| A0A1D5RHE7 | Adenylate cyclase type 2 | ISS | PubMed:15189569 | |
| A0A1D5RHE7 | Adenylate cyclase type 2 | ISS | PubMed:1719547 | |
| A0A1D5RHE7 | Adenylate cyclase type 2 | ISS | PubMed:2491850 | |
| F1MJV4 | Adenylate cyclase type 2 | ISS | PubMed:12472880 | |
| F1MJV4 | Adenylate cyclase type 2 | ISS | PubMed:2491850 | |
| F6V001 | Adenylate cyclase type 2 | ISS | PubMed:12472880 | |
| F6V001 | Adenylate cyclase type 2 | ISS | PubMed:15189569 | |
| F6V001 | Adenylate cyclase type 2 | ISS | PubMed:1719547 | |
| F6V001 | Adenylate cyclase type 2 | ISS | PubMed:2491850 | |
| F6ZAV4 | Adenylate cyclase type 2 | ISS | PubMed:12472880 | |
| F6ZAV4 | Adenylate cyclase type 2 | ISS | PubMed:15189569 | |
| F6ZAV4 | Adenylate cyclase type 2 | ISS | PubMed:1719547 | |
| F6ZAV4 | Adenylate cyclase type 2 | ISS | PubMed:2491850 | |
| P26769 | Adenylate cyclase type 2 | ISS | PubMed:12472880 | |
| P26769 | Adenylate cyclase type 2 | ISS | PubMed:2491850 | |
| Q08462 | Adenylate cyclase type 2 | IDA | PubMed:12472880 | |
| Q08462 | Adenylate cyclase type 2 | IDA | PubMed:15189569 | |
| Q08462 | Adenylate cyclase type 2 | IDA | PubMed:1719547 | |
| Q08462 | Adenylate cyclase type 2 | IDA | PubMed:2491850 | |
| Q80TL1 | Adenylate cyclase type 2 | ISS | PubMed:12472880 | |
| Q80TL1 | Adenylate cyclase type 2 | ISS | PubMed:15189569 | |
| Q80TL1 | Adenylate cyclase type 2 | ISS | PubMed:1719547 | |
| Q80TL1 | Adenylate cyclase type 2 | ISS | PubMed:2491850 | |
| PTHR45627:SF7 | E1BHU9 | Adenylate cyclase type 5 | ISS | PubMed:1409703 |
| E1BHU9 | Adenylate cyclase type 5 | ISS | PubMed:2491850 | |
| E1BHU9 | Adenylate cyclase type 5 | ISS | PubMed:94139935 | |
| O95622 | Adenylate cyclase type 5 | IDA | PubMed:1409703 | |
| O95622 | Adenylate cyclase type 5 | IDA | PubMed:2491850 | |
| O95622 | Adenylate cyclase type 5 | IDA | PubMed:92317082 | |
| O95622 | Adenylate cyclase type 5 | IDA | PubMed:94139935 | |
| P84309 | Adenylate cyclase type 5 | ISS | PubMed:1409703 | |
| P84309 | Adenylate cyclase type 5 | ISS | PubMed:2491850 | |
| P84309 | Adenylate cyclase type 5 | ISS | PubMed:93156838 | |
| P84309 | Adenylate cyclase type 5 | ISS | PubMed:94139935 | |
| Q04400 | Adenylate cyclase type 5 | IDA | PubMed:1409703 | |
| Q04400 | Adenylate cyclase type 5 | IDA | PubMed:2491850 | |
| Q04400 | Adenylate cyclase type 5 | IDA | PubMed:93156838 | |
| PTHR45627:SF8 | A0A8I3ME97 | Adenylate cyclase 9 | ISS | PubMed:2491850 |
| A8XSS7 | Protein CBR-ACY-1 | ISS | PubMed:22013858 | |
| A8XSS7 | Protein CBR-ACY-1 | ISS | PubMed:2491850 | |
| E1BM79 | Adenylate cyclase 9 | ISS | PubMed:2491850 | |
| K7CYN2 | Adenylate cyclase 9 | ISS | PubMed:2491850 | |
| M9PEP2 | Adenylyl cyclase 13E, isoform C | IDA | PubMed:2491850 | |
| M9PEP2 | Adenylyl cyclase 13E, isoform C | IDA | PubMed:97431620 | |
| O60503 | Adenylate cyclase type 9 | IDA | PubMed:2491850 | |
| P51830 | Adenylate cyclase type 9 | IDA | PubMed:2491850 | |
| Q19523 | Guanylate cyclase domain-containing protein | IDA | PubMed:22013858 | |
| Q19523 | Guanylate cyclase domain-containing protein | IDA | PubMed:2491850 | |
| Q9DGG6 | Adenylate cyclase type 9 | IDA | PubMed:21222856 | |
| Q9DGG6 | Adenylate cyclase type 9 | IDA | PubMed:2491850 | |
| PTHR45627:SF9 | A0A5F8ADK4 | Adenylate cyclase type 7 | ISS | PubMed:11665607 |
| A0A5F8ADK4 | Adenylate cyclase type 7 | ISS | PubMed:15581358 | |
| A0A5F8ADK4 | Adenylate cyclase type 7 | ISS | PubMed:2491850 | |
| F1LQT1 | Adenylate cyclase type 7 | ISS | PubMed:15581358 | |
| F1LQT1 | Adenylate cyclase type 7 | ISS | PubMed:2491850 | |
| K7ADQ0 | Adenylate cyclase type 7 | ISS | PubMed:11665607 | |
| K7ADQ0 | Adenylate cyclase type 7 | ISS | PubMed:15581358 | |
| K7ADQ0 | Adenylate cyclase type 7 | ISS | PubMed:2491850 | |
| P51828 | Adenylate cyclase type 7 | IDA | PubMed:11665607 | |
| P51828 | Adenylate cyclase type 7 | IDA | PubMed:15581358 | |
| P51828 | Adenylate cyclase type 7 | IDA | PubMed:2491850 | |
| P51829 | Adenylate cyclase type 7 | IDA | PubMed:15581358 | |
| P51829 | Adenylate cyclase type 7 | IDA | PubMed:2491850 | |
| Q29450 | Adenylate cyclase type 7 | IDA | PubMed:15581358 | |
| Q29450 | Adenylate cyclase type 7 | IDA | PubMed:2491850 | |
| Q29450 | Adenylate cyclase type 7 | IDA | PubMed:8557110 | |
| Q29450 | Adenylate cyclase type 7 | IDA | PubMed:96149441 |
