PANTHER Gene Information   
Gene Symbol(s): Adcy8
Organism: Rattus norvegicus
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Gene Name: Adenylate cyclase type 8
Gene ID: 2036
Protein ID: P40146
Persistent Id: PTN000229417
Alternate Ids:
Adcy8{ECO:0000312|RGD:2036}(Symbol) Adenylate cyclase type VIII {ECO:0000250|UniProtKB:P40145}(Synonym)
L26986(EMBL) AAA20504(EMBL-CDS)
CHEMBL2095179(ChEMBL) 2036(RGD)
ADCY8_RAT(UniProtKB-ID) 8392852(GI)
29241(GeneID) 4.6.1.1 {ECO:0000269|PubMed:8163524, ECO:0000269|PubMed:8557635}(EC)
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PANTHER Classification
PANTHER Family: ADENYLATE CYCLASE TYPE 1 (PTHR45627)
PANTHER Subfamily: ADENYLATE CYCLASE TYPE 8 (PTHR45627:SF1)  
PANTHER GO-slim Molecular Function: adenylate cyclase activity
PANTHER GO-slim Biological Process: purine ribonucleotide biosynthetic process
adenylate cyclase-activating G protein-coupled receptor signaling pathway
cyclic nucleotide metabolic process
PANTHER GO-slim Cellular Component: plasma membrane
PANTHER protein class: adenylate cyclase
Pathway Categories: Endothelin signaling pathway
   Adenylate cyclase
GABA-B receptor II signaling
   adenylate cyclase
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
   Adenylyl cyclase
GENE ONTOLOGY DATABASE ANNOTATIONS      Click to Expand...
GO MF Complete: calcium- and calmodulin-responsive adenylate cyclase activity, phosphatase binding, ATP binding, calmodulin binding, protein binding, protein homodimerization activity, actin binding, metal ion binding, protein heterodimerization activity, protein dimerization activity, adenylate cyclase activity, protein phosphatase 2A binding
GO BP Complete: activation of protein kinase A activity, positive regulation of long-term synaptic potentiation, positive regulation of long-term synaptic depression, regulation of cellular response to stress, memory, locomotory behavior, cellular response to calcium ion, cellular response to glucose stimulus, cellular response to glucagon stimulus, positive regulation of synaptic plasticity, cellular response to morphine, positive regulation of insulin secretion, glucose mediated signaling pathway, positive regulation of insulin secretion involved in cellular response to glucose stimulus, intracellular signal transduction, cAMP biosynthetic process, G protein-coupled opioid receptor signaling pathway, cellular response to forskolin, protein homooligomerization, regulation of cytosolic calcium ion concentration, adenylate cyclase-activating G protein-coupled receptor signaling pathway, neuroinflammatory response, positive regulation of cytosolic calcium ion concentration, long-term memory, glucose homeostasis, modulation of chemical synaptic transmission, positive regulation of CREB transcription factor activity, protein complex oligomerization, cAMP/PKA signal transduction
GO CC Complete: presynaptic membrane, postsynaptic density, excitatory synapse, neuronal cell body membrane, plasma membrane raft, plasma membrane, Schaffer collateral - CA1 synapse, dendrite, hippocampal mossy fiber to CA3 synapse, caveola, presynaptic active zone, clathrin-coated pit, membrane raft, actin cytoskeleton, glutamatergic synapse, basolateral plasma membrane, apical plasma membrane, axon, clathrin-coated vesicle membrane
REACTOME DATABASE ANNOTATIONS   Click to Expand...
Reactome Pathways: Signaling by GPCR, Signaling by Hedgehog, GABA B receptor activation, Neuronal System, Transmission across Chemical Synapses, Neurotransmitter receptors and postsynaptic signal transmission, Opioid Signalling, Adenylate cyclase activating pathway, G alpha (i) signalling events, G alpha (z) signalling events, GABA receptor activation, PKA activation, Hedgehog 'off' state, DAG and IP3 signaling, PLC beta mediated events, Signal Transduction, Calmodulin induced events, Ca-dependent events, CaM pathway, PKA-mediated phosphorylation of CREB, Adenylate cyclase inhibitory pathway, GPCR downstream signalling, Activation of GABAB receptors, G-protein mediated events, Intracellular signaling by second messengers

Orthologs