PANTHER Gene Information

Gene Symbol(s):

ADCY8

Organism:

Macaca mulatta

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Tree

Gene Name:

Adenylate cyclase type 8

Gene ID:

ENSMMUG00000010440.4

Protein ID:

A0A1D5Q874

Persistent Id:

PTN000229414

Alternate Ids:

A0A1D5Q874_MACMU(UniProtKB-ID)	XM_001084919(refSeq)
ENSMMUT00000059655(Ensembl_TRS)	A0A1D5Q874(Synonym)
ENSMMUG00000010440(Ensembl)	ENSMMUP00000044242(Ensembl_PRO)
109087485(GI)	695792(GeneID)
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PANTHER Classification

PANTHER Family:	ADENYLATE CYCLASE TYPE 1 (PTHR45627)
PANTHER Subfamily:	ADENYLATE CYCLASE TYPE 8 (PTHR45627:SF1)
PANTHER GO-slim Molecular Function:	adenylate cyclase activity
PANTHER GO-slim Biological Process:	purine ribonucleotide biosynthetic process adenylate cyclase-activating G protein-coupled receptor signaling pathway cyclic nucleotide metabolic process
PANTHER GO-slim Cellular Component:	plasma membrane
PANTHER protein class:	adenylate cyclase

Pathway Categories:

Endothelin signaling pathway

Adenylate cyclase

GABA-B receptor II signaling

adenylate cyclase

Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway

Adenylyl cyclase

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	calcium- and calmodulin-responsive adenylate cyclase activity, ATP binding, metal ion binding, lyase activity, adenylate cyclase activity
GO BP Complete:	cAMP biosynthetic process, positive regulation of long-term synaptic potentiation, regulation of cytosolic calcium ion concentration, positive regulation of long-term synaptic depression, regulation of cellular response to stress, adenylate cyclase-activating G protein-coupled receptor signaling pathway, neuroinflammatory response, memory, long-term memory, locomotory behavior, cellular response to glucagon stimulus, positive regulation of synaptic plasticity, glucose homeostasis, modulation of chemical synaptic transmission, cellular response to morphine, positive regulation of insulin secretion, glucose mediated signaling pathway, positive regulation of insulin secretion involved in cellular response to glucose stimulus, intracellular signal transduction
GO CC Complete:	presynaptic membrane, postsynaptic density, excitatory synapse, neuronal cell body membrane, plasma membrane, Schaffer collateral - CA1 synapse, dendrite, hippocampal mossy fiber to CA3 synapse, presynaptic active zone, membrane, glutamatergic synapse, basolateral plasma membrane, apical plasma membrane, axon

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Orthologs

ID	Organism	Type
HUMAN\|HGNC=239\|UniProtKB=P40145	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000020589.6\|UniProtKB=A0A2I3SK46	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000015786.3\|UniProtKB=A0A2I2ZTJ4	Gorilla gorilla gorilla	LDO
MOUSE\|MGI=MGI=1341110\|UniProtKB=P97490	Mus musculus	LDO
RAT\|RGD=2036\|UniProtKB=P40146	Rattus norvegicus	LDO
BOVIN\|Ensembl=ENSBTAG00000014600.6\|UniProtKB=E1BQ12	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000031717.3\|UniProtKB=A0A287AWF4	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000024601.4\|UniProtKB=F6R859	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000006436.6\|UniProtKB=M3W5W8	Felis catus	LDO
CANLF\|Ensembl=ENSCAFG00845013615.1\|UniProtKB=A0A8I3NFX0	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000001430.4\|UniProtKB=F7BCI5	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000008103.4\|UniProtKB=F7FY04	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010007962.1\|UniProtKB=A0A1D5PNE8	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000010598.4\|UniProtKB=G1KKD9	Anolis carolinensis	LDO
XENLA\|Gene=adcy8.S\|UniProtKB=A0A1L8FTY2	Xenopus laevis	O
XENLA\|Gene=adcy8.L\|UniProtKB=A0A1L8G048	Xenopus laevis	LDO
XENTR\|Ensembl=ENSXETG00000036330\|UniProtKB=A0A6I8SFS5	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000013598.2\|UniProtKB=H2MEQ6	Oryzias latipes	O
DANRE\|ZFIN=ZDB-GENE-041014-154\|UniProtKB=Q5RHR2	Danio rerio	O
DANRE\|ZFIN=ZDB-GENE-130530-619\|UniProtKB=E7FC63	Danio rerio	O
LEPOC\|Ensembl=ENSLOCG00000016676.1\|UniProtKB=W5NIZ6	lepisosteus oculatus	O
ORYLA\|Ensembl=ENSORLG00000006410.2\|UniProtKB=A0A3B3HKU1	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-070912-197\|UniProtKB=B7UCF8	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000012663.1\|UniProtKB=W5N4M7	lepisosteus oculatus	LDO
CIOIN\|Ensembl=ENSCING00000000490.3\|UniProtKB=F6YCG7	Ciona intestinalis	LDO
BRAFL\|Gene=LOC118405038\|UniProtKB=A0A9J7HJ10	Branchiostoma floridae	LDO
DROME\|FlyBase=FBgn0024150\|UniProtKB=Q9VP76	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP002262\|UniProtKB=A0A1S4GF11	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC013722\|UniProtKB=A0A139WI81	Tribolium castaneum	LDO
DAPPU\|EnsemblGenome=DAPPUDRAFT_318338\|UniProtKB=E9GII3	Daphnia pulex	O
DAPPU\|EnsemblGenome=DAPPUDRAFT_247897\|UniProtKB=E9GT35	Daphnia pulex	LDO
HELRO\|EnsemblGenome=HelroG171005\|UniProtKB=T1F3P4	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g234384\|UniProtKB=A7RRQ7	Nematostella vectensis	O
TRIAD\|EnsemblGenome=TriadG21914\|UniProtKB=B3RQI4	Trichoplax adhaerens	O
BATDJ\|Gene_ORFName=BATDEDRAFT_23648\|UniProtKB=F4NXY1	Batrachochytrium dendrobatidis	O
DICDI\|dictyBase=DDB_G0281545\|UniProtKB=Q03100	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_51614\|UniProtKB=F1A4L3	Dictyostelium purpureum	O
GIAIC\|EnsemblGenome=GL50803_16599\|UniProtKB=A8B947	Giardia intestinalis	O
PARTE\|EnsemblGenome=GSPATT00035944001\|UniProtKB=A0C7P7	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00028571001\|UniProtKB=A0BG69	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00020771001\|UniProtKB=A0DVQ1	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00017090001\|UniProtKB=A0DI52	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00008342001\|UniProtKB=A0CM46	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00035991001\|UniProtKB=A0C7U3	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00035327001\|UniProtKB=A0C5Y1	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00000356001\|UniProtKB=A0BBK4	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00037686001\|UniProtKB=A0CEN0	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00037840001\|UniProtKB=A0CF34	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00028233001\|UniProtKB=A0BF81	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00022215001\|UniProtKB=A0E179	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00008067001\|UniProtKB=A0CL53	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00013081001\|UniProtKB=A0D3H6	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00030444001\|UniProtKB=A0BMP1	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00008009001\|UniProtKB=A0CKZ5	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00035245001\|UniProtKB=A0C5P9	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00036203001\|UniProtKB=A0C8F3	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00019986001\|UniProtKB=A0DTD8	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00017694001\|UniProtKB=A0DJY3	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00021918001\|UniProtKB=A0E0D3	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00000775001\|UniProtKB=A0CJU6	Paramecium tetraurelia	O
PARTE\|Gene_ORFName=PTMB.171c\|UniProtKB=Q6BG52	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00025644001\|UniProtKB=A0EC90	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00005251001\|UniProtKB=A0BPN4	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00032566001\|UniProtKB=A0BVZ7	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00030881001\|UniProtKB=A0BNX5	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00025082001\|UniProtKB=A0EAN1	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00029118001\|UniProtKB=A0BHR5	Paramecium tetraurelia	O