PANTHER Gene Information

Gene Symbol(s):

Adcy5

Organism:

Rattus norvegicus

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Gene Name:

Adenylate cyclase type 5

Gene ID:

71014

Protein ID:

Q04400

Persistent Id:

PTN000229462

Alternate Ids:

Adcy5(Symbol)	NM_022600(refSeq)
71014(RGD)	64532(GeneID)
ADCY5_RAT(UniProtKB-ID)	CHEMBL2880(ChEMBL)
4.6.1.1 {ECO:0000269\|PubMed:1409703}(EC)	Adenylyl cyclase 5(Synonym)
AAB39764(EMBL-CDS)	2833201(GI)
M96159(EMBL)
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PANTHER Classification

PANTHER Family:	ADENYLATE CYCLASE TYPE 1 (PTHR45627)
PANTHER Subfamily:	ADENYLATE CYCLASE TYPE 5 (PTHR45627:SF7)
PANTHER GO-slim Molecular Function:	adenylate cyclase activity
PANTHER GO-slim Biological Process:	adenylate cyclase-activating G protein-coupled receptor signaling pathway
PANTHER GO-slim Cellular Component:	plasma membrane
PANTHER protein class:	adenylate cyclase

Pathway Categories:

Endothelin signaling pathway

Adenylate cyclase

GABA-B receptor II signaling

adenylate cyclase

Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway

Adenylyl cyclase

Inflammation mediated by chemokine and cytokine signaling pathway

adenylate cyclase

GENE ONTOLOGY DATABASE ANNOTATIONS

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GO MF Complete:	calcium- and calmodulin-responsive adenylate cyclase activity, ATP binding, scaffold protein binding, metal ion binding, adenylate cyclase binding, adenylate cyclase activity
GO BP Complete:	cAMP biosynthetic process, heart development, regulation of insulin secretion involved in cellular response to glucose stimulus, G protein-coupled adenosine receptor signaling pathway, adenylate cyclase-activating dopamine receptor signaling pathway, locomotory behavior, adenylate cyclase-inhibiting dopamine receptor signaling pathway, cellular response to forskolin, adenylate cyclase-activating G protein-coupled receptor signaling pathway, intracellular signal transduction, neuromuscular process controlling balance, positive regulation of cytosolic calcium ion concentration
GO CC Complete:	endosome, sarcolemma, membrane, cilium, plasma membrane

REACTOME DATABASE ANNOTATIONS Click to Expand...

Reactome Pathways:

Signaling by GPCR, Signaling by Hedgehog, GABA B receptor activation, Integration of energy metabolism, Neuronal System, Transmission across Chemical Synapses, Neurotransmitter receptors and postsynaptic signal transmission, Opioid Signalling, Adenylate cyclase activating pathway, G alpha (i) signalling events, G alpha (z) signalling events, GABA receptor activation, PKA activation, Hedgehog 'off' state, DAG and IP3 signaling, PLC beta mediated events, Adrenaline,noradrenaline inhibits insulin secretion, Signal Transduction, Calmodulin induced events, Ca-dependent events, CaM pathway, PKA-mediated phosphorylation of CREB, Adenylate cyclase inhibitory pathway, Metabolism, GPCR downstream signalling, Regulation of insulin secretion, Activation of GABAB receptors, G-protein mediated events, Intracellular signaling by second messengers

Orthologs

ID	Organism	Type
HUMAN\|HGNC=236\|UniProtKB=O95622	Homo sapiens	LDO
PANTR\|Ensembl=ENSPTRG00000015304.5\|UniProtKB=H2QN88	Pan troglodytes	LDO
GORGO\|Ensembl=ENSGGOG00000025276.2\|UniProtKB=G3S0S7	Gorilla gorilla gorilla	LDO
MACMU\|Ensembl=ENSMMUG00000002230.4\|UniProtKB=A0A1D5QWQ7	Macaca mulatta	LDO
MOUSE\|MGI=MGI=99673\|UniProtKB=P84309	Mus musculus	LDO
BOVIN\|Ensembl=ENSBTAG00000018777.6\|UniProtKB=E1BHU9	Bos taurus	LDO
PIG\|Ensembl=ENSSSCG00000027952.4\|UniProtKB=I3L9P4	Sus scrofa	LDO
HORSE\|Ensembl=ENSECAG00000009948.3\|UniProtKB=F6R9N4	Equus caballus	LDO
FELCA\|Ensembl=ENSFCAG00000000939.6\|UniProtKB=A0A5F5XZ18	Felis catus	LDO
CANLF\|Gene=ADCY5\|UniProtKB=P30803	Canis lupus familiaris	O
CANLF\|Ensembl=ENSCAFG00845024171.1\|UniProtKB=A0A8I3S8L1	Canis lupus familiaris	LDO
MONDO\|Ensembl=ENSMODG00000018333.4\|UniProtKB=A0A5F8H8A6	Monodelphis domestica	LDO
ORNAN\|Ensembl=ENSOANG00000035984.1\|UniProtKB=A0A6I8NIN7	Ornithorhynchus anatinus	LDO
CHICK\|Ensembl=ENSGALG00010018531.1\|UniProtKB=A0A1D5P0J0	Gallus gallus	LDO
ANOCA\|Ensembl=ENSACAG00000010774.3\|UniProtKB=A0A803TIC8	Anolis carolinensis	LDO
XENLA\|Gene=adcy5.S\|UniProtKB=A0A1L8ENI2	Xenopus laevis	O
XENLA\|Gene=LOC108701255\|UniProtKB=A0A8J1LTG1	Xenopus laevis	LDO
XENTR\|Ensembl=ENSXETG00000024163\|UniProtKB=A0A803K6A2	Xenopus tropicalis	LDO
ORYLA\|Ensembl=ENSORLG00000009753.2\|UniProtKB=A0A3B3I4R3	Oryzias latipes	LDO
DANRE\|ZFIN=ZDB-GENE-081104-470\|UniProtKB=D2CFN3	Danio rerio	LDO
LEPOC\|Ensembl=ENSLOCG00000002507.1\|UniProtKB=W5M3J7	lepisosteus oculatus	LDO
BRAFL\|Gene=LOC118425098\|UniProtKB=A0A9J7N4J0	Branchiostoma floridae	LDO
STRPU\|EnsemblGenome=LOC582776\|UniProtKB=A0A7M7P472	Strongylocentrotus purpuratus	LDO
CAEEL\|WormBase=WBGene00000071\|UniProtKB=Q966F9	Caenorhabditis elegans	LDO
CAEBR\|Gene_ORFName=CBG09353\|UniProtKB=A8X9A6	Caenorhabditis briggsae	LDO
PRIPA\|EnsemblGenome=WBGene00097952\|UniProtKB=A0A2A6BB56	Pristionchus pacificus	LDO
DROME\|FlyBase=FBgn0052301\|UniProtKB=Q9W037	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0052305\|UniProtKB=Q8IRF5	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0040508\|UniProtKB=Q9VK53	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0040506\|UniProtKB=Q9VK50	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0040509\|UniProtKB=Q9VK52	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0040510\|UniProtKB=Q9VK51	Drosophila melanogaster	O
DROME\|FlyBase=FBgn0040507\|UniProtKB=Q9W038	Drosophila melanogaster	O
ANOGA\|EnsemblGenome=AGAP007631\|UniProtKB=A0A1S4GVP2	Anopheles gambiae	O
TRICA\|EnsemblGenome=TC030697\|UniProtKB=D6WIB3	Tribolium castaneum	O
DROME\|FlyBase=FBgn0263131\|UniProtKB=A8JNU1	Drosophila melanogaster	LDO
ANOGA\|EnsemblGenome=AGAP029576\|UniProtKB=A0A453Z0V1	Anopheles gambiae	LDO
TRICA\|EnsemblGenome=TC033004\|UniProtKB=A0A139WHS6	Tribolium castaneum	LDO
DAPPU\|Gene_ORFName=DAPPUDRAFT_39757\|UniProtKB=E9FRE2	Daphnia pulex	LDO
IXOSC\|EnsemblGenome=ISCW011601\|UniProtKB=B7Q9S7	Ixodes scapularis	LDO
HELRO\|EnsemblGenome=HelroG173257\|UniProtKB=T1F6L9	helobdella robusta	LDO
NEMVE\|EnsemblGenome=NEMVEDRAFT_v1g234384\|UniProtKB=A7RRQ7	Nematostella vectensis	LDO
TRIAD\|EnsemblGenome=TriadG21914\|UniProtKB=B3RQI4	Trichoplax adhaerens	LDO
BATDJ\|Gene_ORFName=BATDEDRAFT_23648\|UniProtKB=F4NXY1	Batrachochytrium dendrobatidis	O
DICDI\|dictyBase=DDB_G0281545\|UniProtKB=Q03100	Dictyostelium discoideum	O
DICPU\|EnsemblGenome=DICPUDRAFT_51614\|UniProtKB=F1A4L3	Dictyostelium purpureum	O
GIAIC\|EnsemblGenome=GL50803_16599\|UniProtKB=A8B947	Giardia intestinalis	O
PARTE\|EnsemblGenome=GSPATT00035944001\|UniProtKB=A0C7P7	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00028571001\|UniProtKB=A0BG69	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00020771001\|UniProtKB=A0DVQ1	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00017090001\|UniProtKB=A0DI52	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00008342001\|UniProtKB=A0CM46	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00035991001\|UniProtKB=A0C7U3	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00035327001\|UniProtKB=A0C5Y1	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00000356001\|UniProtKB=A0BBK4	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00037686001\|UniProtKB=A0CEN0	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00037840001\|UniProtKB=A0CF34	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00028233001\|UniProtKB=A0BF81	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00022215001\|UniProtKB=A0E179	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00008067001\|UniProtKB=A0CL53	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00013081001\|UniProtKB=A0D3H6	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00030444001\|UniProtKB=A0BMP1	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00008009001\|UniProtKB=A0CKZ5	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00035245001\|UniProtKB=A0C5P9	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00036203001\|UniProtKB=A0C8F3	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00019986001\|UniProtKB=A0DTD8	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00017694001\|UniProtKB=A0DJY3	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00021918001\|UniProtKB=A0E0D3	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00000775001\|UniProtKB=A0CJU6	Paramecium tetraurelia	O
PARTE\|Gene_ORFName=PTMB.171c\|UniProtKB=Q6BG52	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00025644001\|UniProtKB=A0EC90	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00005251001\|UniProtKB=A0BPN4	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00032566001\|UniProtKB=A0BVZ7	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00030881001\|UniProtKB=A0BNX5	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00025082001\|UniProtKB=A0EAN1	Paramecium tetraurelia	O
PARTE\|EnsemblGenome=GSPATT00029118001\|UniProtKB=A0BHR5	Paramecium tetraurelia	O