Pathway Component Details
| Name: | Mouse double minute 2 (MDM-2) |
| Definition: | MDM2 can inactivate several functions of the tumor suppressor p53 and can degrade p53. |
| Category ID: | G01563 |
| Synonyms: | |
| Upstream: |
Tumor protein p53
(p53)
|
| Downstream: |
Mouse double minute 2
(Mdm2)
|
| Number Families/Subfamilies: | 3 |
| Number of Associated Sequences: | 13 |
| GO Molecular Function: |
-
|
| GO Biological Process: |
-
|
| GO Cellular Component: |
-
|
| PANTHER protein class: |
-
|
| References: | Medline:14707284 Medline:1614537 |
Sequence Association
| Panther Subfamily | Associated Sequence | Definition | Confidence Code | Evidence |
| PTHR12183:SF37 | H2R875 | Protein Mdm4 | ISS | |
| O15151 | Protein Mdm4 | ISS | ||
| O35618 | Protein Mdm4 | ISS | ||
| Q5XIN1 | Protein Mdm4 | ISS | ||
| PTHR46858:SF12 | F1N736 | Protein Mdm4 | ISS | |
| F6WXF0 | Protein Mdm4 | ISS | ||
| PTHR46858:SF13 | A0A2I3RE00 | E3 ubiquitin-protein ligase Mdm2 | ISS | PubMed:7477327 |
| A0A8I6G5V3 | E3 ubiquitin-protein ligase Mdm2 | ISS | PubMed:7477327 | |
| F1MYE6 | E3 ubiquitin-protein ligase Mdm2 | ISS | PubMed:7477327 | |
| G7N7L5 | E3 ubiquitin-protein ligase Mdm2 | ISS | PubMed:7477327 | |
| O42354 | E3 ubiquitin-protein ligase Mdm2 | IGI | PubMed:7477327 | |
| P23804 | E3 ubiquitin-protein ligase Mdm2 | IGI | PubMed:7477327 | |
| Q00987 | E3 ubiquitin-protein ligase Mdm2 | IGI | PubMed:7477327 |
