Pathway Component Details
| Name: | protein kinase C (PKC) |
| Definition: | FUNCTION: This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. FUNCTION: PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Binds 3 calcium ions per subunit. The ions are bound to the C2 domain (By similarity). SUBUNIT: Interacts with PRKCABP (By similarity). SIMILARITY: Belongs to the Ser/Thr protein kinase family. PKC subfamily. SIMILARITY: Contains 1 C2 domain. SIMILARITY: Contains 2 zinc-dependent phorbol-ester and DAG binding domains. |
| Category ID: | P00075 |
| Synonyms: | |
| Upstream: | |
| Downstream: | |
| Number Families/Subfamilies: | 5 |
| Number of Associated Sequences: | 19 |
| GO Molecular Function: |
-
|
| GO Biological Process: |
-
|
| GO Cellular Component: |
-
|
| PANTHER protein class: |
-
|
| References: | Medline:8573150 Medline:11509451 http://cti.itc.virginia.edu/~cmg/Demo/pdb/pkc/pkc.html Medline:10860763 |
Sequence Association
| Panther Subfamily | Associated Sequence | Definition | Confidence Code | Evidence |
| PTHR24351:SF182 | F1MDC9 | Protein kinase C | ISS | PubMed:10395542 |
| F1MDC9 | Protein kinase C | ISS | PubMed:10644715 | |
| F1MDC9 | Protein kinase C | ISS | PubMed:10747026 | |
| F1MDC9 | Protein kinase C | ISS | PubMed:11032873 | |
| F1MDC9 | Protein kinase C | ISS | PubMed:11554554 | |
| F1MDC9 | Protein kinase C | ISS | PubMed:12640464 | |
| F1MDC9 | Protein kinase C | ISS | PubMed:12810623 | |
| F1MDC9 | Protein kinase C | ISS | PubMed:14600145 | |
| F1MDC9 | Protein kinase C | ISS | PubMed:15572354 | |
| F1MDC9 | Protein kinase C | ISS | PubMed:22050614 | |
| F1MDC9 | Protein kinase C | ISS | PubMed:2611232 | |
| F1MDC9 | Protein kinase C | ISS | PubMed:2837282 | |
| F1MDC9 | Protein kinase C | ISS | PubMed:3045562 | |
| F1MDC9 | Protein kinase C | ISS | PubMed:3370672 | |
| F1MDC9 | Protein kinase C | ISS | PubMed:3755548 | |
| F1MDC9 | Protein kinase C | ISS | PubMed:88083621 | |
| F1MDC9 | Protein kinase C | ISS | PubMed:88223367 | |
| PTHR24356:SF159 | F7BIC2 | Protein kinase C epsilon type | ISS | PubMed:10395542 |
| F7BIC2 | Protein kinase C epsilon type | ISS | PubMed:10644715 | |
| F7BIC2 | Protein kinase C epsilon type | ISS | PubMed:10747026 | |
| F7BIC2 | Protein kinase C epsilon type | ISS | PubMed:11032873 | |
| F7BIC2 | Protein kinase C epsilon type | ISS | PubMed:11554554 | |
| F7BIC2 | Protein kinase C epsilon type | ISS | PubMed:12640464 | |
| F7BIC2 | Protein kinase C epsilon type | ISS | PubMed:12810623 | |
| F7BIC2 | Protein kinase C epsilon type | ISS | PubMed:14600145 | |
| F7BIC2 | Protein kinase C epsilon type | ISS | PubMed:15572354 | |
| F7BIC2 | Protein kinase C epsilon type | ISS | PubMed:22050614 | |
| F7BIC2 | Protein kinase C epsilon type | ISS | PubMed:2611232 | |
| F7BIC2 | Protein kinase C epsilon type | ISS | PubMed:2837282 | |
| F7BIC2 | Protein kinase C epsilon type | ISS | PubMed:3045562 | |
| F7BIC2 | Protein kinase C epsilon type | ISS | PubMed:3370672 | |
| F7BIC2 | Protein kinase C epsilon type | ISS | PubMed:3755548 | |
| F7BIC2 | Protein kinase C epsilon type | ISS | PubMed:88083621 | |
| F7BIC2 | Protein kinase C epsilon type | ISS | PubMed:88223367 | |
| K7CBH8 | Protein kinase C epsilon type | ISS | PubMed:10395542 | |
| K7CBH8 | Protein kinase C epsilon type | ISS | PubMed:10644715 | |
| K7CBH8 | Protein kinase C epsilon type | ISS | PubMed:10747026 | |
| K7CBH8 | Protein kinase C epsilon type | ISS | PubMed:11032873 | |
| K7CBH8 | Protein kinase C epsilon type | ISS | PubMed:11554554 | |
| K7CBH8 | Protein kinase C epsilon type | ISS | PubMed:12640464 | |
| K7CBH8 | Protein kinase C epsilon type | ISS | PubMed:12810623 | |
| K7CBH8 | Protein kinase C epsilon type | ISS | PubMed:14600145 | |
| K7CBH8 | Protein kinase C epsilon type | ISS | PubMed:15572354 | |
| K7CBH8 | Protein kinase C epsilon type | ISS | PubMed:22050614 | |
| K7CBH8 | Protein kinase C epsilon type | ISS | PubMed:2611232 | |
| K7CBH8 | Protein kinase C epsilon type | ISS | PubMed:2837282 | |
| K7CBH8 | Protein kinase C epsilon type | ISS | PubMed:3045562 | |
| K7CBH8 | Protein kinase C epsilon type | ISS | PubMed:3370672 | |
| K7CBH8 | Protein kinase C epsilon type | ISS | PubMed:3755548 | |
| K7CBH8 | Protein kinase C epsilon type | ISS | PubMed:88083621 | |
| K7CBH8 | Protein kinase C epsilon type | ISS | PubMed:88223367 | |
| P16054 | Protein kinase C epsilon type | ISS | PubMed:10395542 | |
| P16054 | Protein kinase C epsilon type | ISS | PubMed:10644715 | |
| P16054 | Protein kinase C epsilon type | ISS | PubMed:10747026 | |
| P16054 | Protein kinase C epsilon type | ISS | PubMed:11032873 | |
| P16054 | Protein kinase C epsilon type | ISS | PubMed:12640464 | |
| P16054 | Protein kinase C epsilon type | ISS | PubMed:12810623 | |
| P16054 | Protein kinase C epsilon type | ISS | PubMed:15572354 | |
| P16054 | Protein kinase C epsilon type | ISS | PubMed:22050614 | |
| P16054 | Protein kinase C epsilon type | ISS | PubMed:2611232 | |
| P16054 | Protein kinase C epsilon type | ISS | PubMed:2837282 | |
| P16054 | Protein kinase C epsilon type | ISS | PubMed:3045562 | |
| P16054 | Protein kinase C epsilon type | ISS | PubMed:3755548 | |
| Q02156 | Protein kinase C epsilon type | ISS | PubMed:10395542 | |
| Q02156 | Protein kinase C epsilon type | ISS | PubMed:10644715 | |
| Q02156 | Protein kinase C epsilon type | ISS | PubMed:10747026 | |
| Q02156 | Protein kinase C epsilon type | ISS | PubMed:11032873 | |
| Q02156 | Protein kinase C epsilon type | ISS | PubMed:14600145 | |
| Q02156 | Protein kinase C epsilon type | ISS | PubMed:15572354 | |
| Q02156 | Protein kinase C epsilon type | ISS | PubMed:22050614 | |
| Q02156 | Protein kinase C epsilon type | ISS | PubMed:2611232 | |
| Q02156 | Protein kinase C epsilon type | ISS | PubMed:2837282 | |
| Q02156 | Protein kinase C epsilon type | ISS | PubMed:3045562 | |
| Q02156 | Protein kinase C epsilon type | ISS | PubMed:3755548 | |
| PTHR24356:SF162 | F7H3B3 | Protein kinase C | ISS | PubMed:10395542 |
| F7H3B3 | Protein kinase C | ISS | PubMed:10644715 | |
| F7H3B3 | Protein kinase C | ISS | PubMed:10747026 | |
| F7H3B3 | Protein kinase C | ISS | PubMed:11032873 | |
| F7H3B3 | Protein kinase C | ISS | PubMed:11554554 | |
| F7H3B3 | Protein kinase C | ISS | PubMed:12359310 | |
| F7H3B3 | Protein kinase C | ISS | PubMed:12429574 | |
| F7H3B3 | Protein kinase C | ISS | PubMed:12471040 | |
| F7H3B3 | Protein kinase C | ISS | PubMed:12954613 | |
| F7H3B3 | Protein kinase C | ISS | PubMed:15572354 | |
| F7H3B3 | Protein kinase C | ISS | PubMed:2611232 | |
| F7H3B3 | Protein kinase C | ISS | PubMed:2837282 | |
| F7H3B3 | Protein kinase C | ISS | PubMed:3045562 | |
| F7H3B3 | Protein kinase C | ISS | PubMed:3755548 | |
| F7H3B3 | Protein kinase C | ISS | PubMed:86289426 | |
| F7H3B3 | Protein kinase C | ISS | PubMed:88241036 | |
| P05128 | Protein kinase C gamma type (Fragment) | ISS | PubMed:10395542 | |
| P05128 | Protein kinase C gamma type (Fragment) | ISS | PubMed:10644715 | |
| P05128 | Protein kinase C gamma type (Fragment) | ISS | PubMed:10747026 | |
| P05128 | Protein kinase C gamma type (Fragment) | ISS | PubMed:11032873 | |
| P05128 | Protein kinase C gamma type (Fragment) | ISS | PubMed:11554554 | |
| P05128 | Protein kinase C gamma type (Fragment) | ISS | PubMed:12359310 | |
| P05128 | Protein kinase C gamma type (Fragment) | ISS | PubMed:12429574 | |
| P05128 | Protein kinase C gamma type (Fragment) | ISS | PubMed:12471040 | |
| P05128 | Protein kinase C gamma type (Fragment) | ISS | PubMed:12954613 | |
| P05128 | Protein kinase C gamma type (Fragment) | ISS | PubMed:15572354 | |
| P05128 | Protein kinase C gamma type (Fragment) | ISS | PubMed:2611232 | |
| P05128 | Protein kinase C gamma type (Fragment) | ISS | PubMed:2837282 | |
| P05128 | Protein kinase C gamma type (Fragment) | ISS | PubMed:3045562 | |
| P05128 | Protein kinase C gamma type (Fragment) | ISS | PubMed:3755548 | |
| P05128 | Protein kinase C gamma type (Fragment) | ISS | PubMed:86289426 | |
| P05129 | Protein kinase C gamma type | ISS | PubMed:10395542 | |
| P05129 | Protein kinase C gamma type | ISS | PubMed:10644715 | |
| P05129 | Protein kinase C gamma type | ISS | PubMed:10747026 | |
| P05129 | Protein kinase C gamma type | ISS | PubMed:11032873 | |
| P05129 | Protein kinase C gamma type | ISS | PubMed:12429574 | |
| P05129 | Protein kinase C gamma type | ISS | PubMed:12471040 | |
| P05129 | Protein kinase C gamma type | ISS | PubMed:12954613 | |
| P05129 | Protein kinase C gamma type | ISS | PubMed:15572354 | |
| P05129 | Protein kinase C gamma type | ISS | PubMed:2611232 | |
| P05129 | Protein kinase C gamma type | ISS | PubMed:2837282 | |
| P05129 | Protein kinase C gamma type | ISS | PubMed:3045562 | |
| P05129 | Protein kinase C gamma type | ISS | PubMed:3755548 | |
| P63318 | Protein kinase C gamma type | ISS | PubMed:10395542 | |
| P63318 | Protein kinase C gamma type | ISS | PubMed:10644715 | |
| P63318 | Protein kinase C gamma type | ISS | PubMed:10747026 | |
| P63318 | Protein kinase C gamma type | ISS | PubMed:11032873 | |
| P63318 | Protein kinase C gamma type | ISS | PubMed:12359310 | |
| P63318 | Protein kinase C gamma type | ISS | PubMed:12429574 | |
| P63318 | Protein kinase C gamma type | ISS | PubMed:15572354 | |
| P63318 | Protein kinase C gamma type | ISS | PubMed:2611232 | |
| P63318 | Protein kinase C gamma type | ISS | PubMed:2837282 | |
| P63318 | Protein kinase C gamma type | ISS | PubMed:3045562 | |
| P63318 | Protein kinase C gamma type | ISS | PubMed:3755548 | |
| P63319 | Protein kinase C gamma type | ISS | PubMed:10395542 | |
| P63319 | Protein kinase C gamma type | ISS | PubMed:10644715 | |
| P63319 | Protein kinase C gamma type | ISS | PubMed:10747026 | |
| P63319 | Protein kinase C gamma type | ISS | PubMed:11032873 | |
| P63319 | Protein kinase C gamma type | ISS | PubMed:11554554 | |
| P63319 | Protein kinase C gamma type | ISS | PubMed:12359310 | |
| P63319 | Protein kinase C gamma type | ISS | PubMed:12429574 | |
| P63319 | Protein kinase C gamma type | ISS | PubMed:12471040 | |
| P63319 | Protein kinase C gamma type | ISS | PubMed:12954613 | |
| P63319 | Protein kinase C gamma type | ISS | PubMed:15572354 | |
| P63319 | Protein kinase C gamma type | ISS | PubMed:2611232 | |
| P63319 | Protein kinase C gamma type | ISS | PubMed:2837282 | |
| P63319 | Protein kinase C gamma type | ISS | PubMed:3045562 | |
| P63319 | Protein kinase C gamma type | ISS | PubMed:3755548 | |
| P63319 | Protein kinase C gamma type | ISS | PubMed:86289426 | |
| P63319 | Protein kinase C gamma type | ISS | PubMed:88241036 | |
| PTHR24356:SF193 | F6RA79 | Protein kinase C | ISS | PubMed:10395542 |
| F6RA79 | Protein kinase C | ISS | PubMed:10644715 | |
| F6RA79 | Protein kinase C | ISS | PubMed:10747026 | |
| F6RA79 | Protein kinase C | ISS | PubMed:11032873 | |
| F6RA79 | Protein kinase C | ISS | PubMed:11554554 | |
| F6RA79 | Protein kinase C | ISS | 125549 | |
| F6RA79 | Protein kinase C | ISS | PubMed:14605019 | |
| F6RA79 | Protein kinase C | ISS | PubMed:15572354 | |
| F6RA79 | Protein kinase C | ISS | PubMed:2611232 | |
| F6RA79 | Protein kinase C | ISS | PubMed:2837282 | |
| F6RA79 | Protein kinase C | ISS | PubMed:3045562 | |
| F6RA79 | Protein kinase C | ISS | PubMed:3755547 | |
| F6RA79 | Protein kinase C | ISS | PubMed:3755548 | |
| F6RA79 | Protein kinase C | ISS | PubMed:86289425 | |
| F6RA79 | Protein kinase C | ISS | PubMed:87115883 | |
| F6RA79 | Protein kinase C | ISS | PubMed:88030055 | |
| H2QDQ1 | Protein kinase C | ISS | PubMed:10395542 | |
| H2QDQ1 | Protein kinase C | ISS | PubMed:10644715 | |
| H2QDQ1 | Protein kinase C | ISS | PubMed:10747026 | |
| H2QDQ1 | Protein kinase C | ISS | PubMed:11032873 | |
| H2QDQ1 | Protein kinase C | ISS | PubMed:11554554 | |
| H2QDQ1 | Protein kinase C | ISS | 125549 | |
| H2QDQ1 | Protein kinase C | ISS | PubMed:14605019 | |
| H2QDQ1 | Protein kinase C | ISS | PubMed:15572354 | |
| H2QDQ1 | Protein kinase C | ISS | PubMed:2611232 | |
| H2QDQ1 | Protein kinase C | ISS | PubMed:2837282 | |
| H2QDQ1 | Protein kinase C | ISS | PubMed:3045562 | |
| H2QDQ1 | Protein kinase C | ISS | PubMed:3755547 | |
| H2QDQ1 | Protein kinase C | ISS | PubMed:3755548 | |
| H2QDQ1 | Protein kinase C | ISS | PubMed:86289425 | |
| H2QDQ1 | Protein kinase C | ISS | PubMed:87115883 | |
| H2QDQ1 | Protein kinase C | ISS | PubMed:88030055 | |
| H9EMT3 | Protein kinase C | ISS | PubMed:10395542 | |
| H9EMT3 | Protein kinase C | ISS | PubMed:10644715 | |
| H9EMT3 | Protein kinase C | ISS | PubMed:10747026 | |
| H9EMT3 | Protein kinase C | ISS | PubMed:11032873 | |
| H9EMT3 | Protein kinase C | ISS | PubMed:11554554 | |
| H9EMT3 | Protein kinase C | ISS | 125549 | |
| H9EMT3 | Protein kinase C | ISS | PubMed:14605019 | |
| H9EMT3 | Protein kinase C | ISS | PubMed:15572354 | |
| H9EMT3 | Protein kinase C | ISS | PubMed:2611232 | |
| H9EMT3 | Protein kinase C | ISS | PubMed:2837282 | |
| H9EMT3 | Protein kinase C | ISS | PubMed:3045562 | |
| H9EMT3 | Protein kinase C | ISS | PubMed:3755547 | |
| H9EMT3 | Protein kinase C | ISS | PubMed:3755548 | |
| H9EMT3 | Protein kinase C | ISS | PubMed:86289425 | |
| H9EMT3 | Protein kinase C | ISS | PubMed:87115883 | |
| H9EMT3 | Protein kinase C | ISS | PubMed:88030055 | |
| P17252 | Protein kinase C alpha type | ISS | PubMed:10395542 | |
| P17252 | Protein kinase C alpha type | ISS | PubMed:10644715 | |
| P17252 | Protein kinase C alpha type | ISS | PubMed:10747026 | |
| P17252 | Protein kinase C alpha type | ISS | PubMed:11032873 | |
| P17252 | Protein kinase C alpha type | ISS | 125549 | |
| P17252 | Protein kinase C alpha type | ISS | PubMed:14605019 | |
| P17252 | Protein kinase C alpha type | ISS | PubMed:15572354 | |
| P17252 | Protein kinase C alpha type | ISS | PubMed:2611232 | |
| P17252 | Protein kinase C alpha type | ISS | PubMed:2837282 | |
| P17252 | Protein kinase C alpha type | ISS | PubMed:3045562 | |
| P17252 | Protein kinase C alpha type | ISS | PubMed:3755547 | |
| P17252 | Protein kinase C alpha type | ISS | PubMed:3755548 | |
| P17252 | Protein kinase C alpha type | ISS | PubMed:86289425 | |
| P17252 | Protein kinase C alpha type | ISS | PubMed:87115883 | |
| P17252 | Protein kinase C alpha type | ISS | PubMed:88030055 | |
| P20444 | Protein kinase C alpha type | ISS | PubMed:10395542 | |
| P20444 | Protein kinase C alpha type | ISS | PubMed:10644715 | |
| P20444 | Protein kinase C alpha type | ISS | PubMed:10747026 | |
| P20444 | Protein kinase C alpha type | ISS | PubMed:11032873 | |
| P20444 | Protein kinase C alpha type | ISS | 125549 | |
| P20444 | Protein kinase C alpha type | ISS | PubMed:14605019 | |
| P20444 | Protein kinase C alpha type | ISS | PubMed:15572354 | |
| P20444 | Protein kinase C alpha type | ISS | PubMed:2611232 | |
| P20444 | Protein kinase C alpha type | ISS | PubMed:2837282 | |
| P20444 | Protein kinase C alpha type | ISS | PubMed:3045562 | |
| P20444 | Protein kinase C alpha type | ISS | PubMed:3755548 | |
| PTHR24356:SF365 | P09215 | Protein kinase C delta type | ISS | PubMed:10395542 |
| P09215 | Protein kinase C delta type | ISS | PubMed:10644715 | |
| P09215 | Protein kinase C delta type | ISS | PubMed:10747026 | |
| P09215 | Protein kinase C delta type | ISS | PubMed:11032873 | |
| P09215 | Protein kinase C delta type | ISS | PubMed:11976687 | |
| P09215 | Protein kinase C delta type | ISS | PubMed:15572354 | |
| P09215 | Protein kinase C delta type | ISS | PubMed:2611232 | |
| P09215 | Protein kinase C delta type | ISS | PubMed:2837282 | |
| P09215 | Protein kinase C delta type | ISS | PubMed:3045562 | |
| P09215 | Protein kinase C delta type | ISS | PubMed:3755548 | |
| P28867 | Protein kinase C delta type | ISS | PubMed:10395542 | |
| P28867 | Protein kinase C delta type | ISS | PubMed:10644715 | |
| P28867 | Protein kinase C delta type | ISS | PubMed:10747026 | |
| P28867 | Protein kinase C delta type | ISS | PubMed:11032873 | |
| P28867 | Protein kinase C delta type | ISS | PubMed:11976687 | |
| P28867 | Protein kinase C delta type | ISS | PubMed:15572354 | |
| P28867 | Protein kinase C delta type | ISS | PubMed:2611232 | |
| P28867 | Protein kinase C delta type | ISS | PubMed:2837282 | |
| P28867 | Protein kinase C delta type | ISS | PubMed:3045562 | |
| P28867 | Protein kinase C delta type | ISS | PubMed:3755548 | |
| Q05655 | Protein kinase C delta type | ISS | PubMed:10395542 | |
| Q05655 | Protein kinase C delta type | ISS | PubMed:10644715 | |
| Q05655 | Protein kinase C delta type | ISS | PubMed:10747026 | |
| Q05655 | Protein kinase C delta type | ISS | PubMed:11032873 | |
| Q05655 | Protein kinase C delta type | ISS | PubMed:11976687 | |
| Q05655 | Protein kinase C delta type | ISS | PubMed:15572354 | |
| Q05655 | Protein kinase C delta type | ISS | PubMed:2611232 | |
| Q05655 | Protein kinase C delta type | ISS | PubMed:2837282 | |
| Q05655 | Protein kinase C delta type | ISS | PubMed:3045562 | |
| Q05655 | Protein kinase C delta type | ISS | PubMed:3755548 | |
| Q5PU49 | Protein kinase C delta type | ISS | PubMed:10395542 | |
| Q5PU49 | Protein kinase C delta type | ISS | PubMed:10644715 | |
| Q5PU49 | Protein kinase C delta type | ISS | PubMed:10747026 | |
| Q5PU49 | Protein kinase C delta type | ISS | PubMed:11032873 | |
| Q5PU49 | Protein kinase C delta type | ISS | PubMed:11976687 | |
| Q5PU49 | Protein kinase C delta type | ISS | PubMed:15572354 | |
| Q5PU49 | Protein kinase C delta type | ISS | PubMed:2611232 | |
| Q5PU49 | Protein kinase C delta type | ISS | PubMed:2837282 | |
| Q5PU49 | Protein kinase C delta type | ISS | PubMed:3045562 | |
| Q5PU49 | Protein kinase C delta type | ISS | PubMed:3755548 |
