Pathway Component Details
| Name: | Furin |
| Definition: | Furin is an enzyme responsible for the proteolytic activation of pro-BACE-1 in the Golgi apparatus |
| Category ID: | P00105 |
| Synonyms: | |
| Upstream: | |
| Downstream: |
Pro-beta-secretase 1
(Pro-BACE-1)
Beta-site amyloid precursor protein-cleaving enzyme (BACE-1) |
| Number Families/Subfamilies: | 9 |
| Number of Associated Sequences: | 48 |
| GO Molecular Function: |
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| GO Biological Process: |
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| GO Cellular Component: |
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| PANTHER protein class: |
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| References: |
Sequence Association
| Panther Subfamily | Associated Sequence | Definition | Confidence Code | Evidence |
| PTHR42884:SF1 | A0A8I3N1T9 | Furin, paired basic amino acid cleaving enzyme | ISS | PubMed:10956649 |
| A0A8I3N1T9 | Furin, paired basic amino acid cleaving enzyme | ISS | PubMed:11861638 | |
| A0A8I3N1T9 | Furin, paired basic amino acid cleaving enzyme | ISS | PubMed:95328031 | |
| A0A8V0X4D8 | Furin, paired basic amino acid cleaving enzyme | IDA | PubMed:10956649 | |
| B0JYR0 | Furin (Paired basic amino acid cleaving enzyme) | IDA | PubMed:10956649 | |
| B0JYR0 | Furin (Paired basic amino acid cleaving enzyme) | IDA | PubMed:11861638 | |
| B0JYR0 | Furin (Paired basic amino acid cleaving enzyme) | IDA | PubMed:95328031 | |
| F7CEB1 | Furin | ISS | PubMed:10956649 | |
| F7CEB1 | Furin | ISS | PubMed:1722329 | |
| G7MVY8 | Furin preproprotein | ISS | PubMed:10956649 | |
| G7MVY8 | Furin preproprotein | ISS | PubMed:11861638 | |
| G7MVY8 | Furin preproprotein | ISS | PubMed:95328031 | |
| H2QA34 | Furin (Paired basic amino acid cleaving enzyme) | ISS | PubMed:10956649 | |
| H2QA34 | Furin (Paired basic amino acid cleaving enzyme) | ISS | PubMed:11861638 | |
| H2QA34 | Furin (Paired basic amino acid cleaving enzyme) | ISS | PubMed:95328031 | |
| P09958 | Furin | IDA | PubMed:10956649 | |
| P09958 | Furin | IDA | PubMed:11861638 | |
| P09958 | Furin | IDA | PubMed:95328031 | |
| P23188 | Furin | IDA | PubMed:10956649 | |
| P23188 | Furin | IDA | PubMed:11861638 | |
| P23188 | Furin | IDA | PubMed:95328031 | |
| P23377 | Furin | IDA | PubMed:10956649 | |
| P23377 | Furin | IDA | PubMed:11861638 | |
| PTHR42884:SF13 | A0A9J7MV19 | Neuroendocrine convertase 2-like | ISS | |
| F6Q5F4 | Proprotein convertase subtilisin_kexin type 2 | IDA | ||
| F7G632 | Proprotein convertase subtilisin_kexin type 2 | ISS | ||
| F7GNE5 | Neuroendocrine convertase 2 isoform 1 preproprotein | ISS | ||
| G5ECN9 | Neuroendocrine convertase 2 | IDA | ||
| H2QJZ8 | Proprotein convertase subtilisin_kexin type 2 | ISS | ||
| P16519 | Neuroendocrine convertase 2 | IDA | ||
| P21661 | Neuroendocrine convertase 2 | IDA | ||
| P28841 | Neuroendocrine convertase 2 | IDA | ||
| Q7QK68 | AGAP002176-PA | IDA | ||
| Q9VBC7 | Neuroendocrine convertase 2 | IDA | ||
| PTHR42884:SF14 | A0A8I3RR59 | Neuroendocrine convertase 1 | ISS | |
| F1MFR6 | Neuroendocrine convertase 1 | IDA | ||
| H2QR92 | Neuroendocrine convertase 1 | ISS | ||
| H9FVB9 | Neuroendocrine convertase 1 | ISS | ||
| P28840 | Neuroendocrine convertase 1 | IDA | ||
| P29120 | Neuroendocrine convertase 1 | IDA | ||
| P63239 | Neuroendocrine convertase 1 | IDA | ||
| Q09175 | Dibasic-processing endoprotease | IDA | PubMed:10956649 | |
| PTHR42884:SF16 | P29121 | Proprotein convertase subtilisin_kexin type 4 | ISS | |
| Q6UW60 | Proprotein convertase subtilisin_kexin type 4 | IDA | ||
| Q78EH2 | Proprotein convertase subtilisin_kexin type 4 | IDA | ||
| PTHR42884:SF23 | P30432 | Furin-like protease 2 | IDA | PubMed:10956649 |
| P51559 | Endoprotease bli-4 | IDA | ||
| PTHR42884:SF28 | A0A2I3SSR3 | Proprotein convertase subtilisin_kexin type 7 | ISS | |
| A0A8I3MUZ4 | Proprotein convertase subtilisin_kexin type 7 | ISS | ||
| F6WWR1 | Proprotein convertase subtilisin_kexin type 7 | ISS | ||
| Q16549 | Proprotein convertase subtilisin_kexin type 7 | IDA | ||
| Q61139 | Proprotein convertase subtilisin_kexin type 7 | IDA | ||
| Q62849 | Proprotein convertase subtilisin_kexin type 7 | IDA | ||
| PTHR42884:SF3 | O17798 | Furin-like protease kpc-1 | IDA | PubMed:10956649 |
| P26016 | Furin-like protease 1, isoforms 1_1-X_2 | IDA | PubMed:10956649 | |
| P26016 | Furin-like protease 1, isoforms 1_1-X_2 | IDA | PubMed:7737999 | |
| PTHR42884:SF7 | Q04592 | Proprotein convertase subtilisin_kexin type 5 | IDA | |
| PTHR42884:SF8 | F1MCT1 | Proprotein convertase subtilisin_kexin type 6 | ISS | |
| F6XJP7 | Proprotein convertase subtilisin_kexin type 6 | IDA | ||
| F7H767 | Proprotein convertase subtilisin_kexin type 6 | ISS | ||
| H2R439 | Proprotein convertase subtilisin_kexin type 6 | ISS | ||
| P29122 | Proprotein convertase subtilisin_kexin type 6 | IDA | ||
| Q63415 | Proprotein convertase subtilisin_kexin type 6 | IDA |
