Pathway Component Details
| Name: | Src homology 2 domain-containing tyrosine phosphatase 2 (SHP2) |
| Definition: | A Src homology domain 2 containing intracellular tyrosine phosphatase. |
| Category ID: | P00181 |
| Synonyms: | |
| Upstream: |
Fibroblast Growth Factor Receptor Substrate 2
(FRS-2)
|
| Downstream: |
Growth factor receptor-bound protein 2
(Grb2)
Focal Adhesion Kinase (FAK) |
| Number Families/Subfamilies: | 3 |
| Number of Associated Sequences: | 15 |
| GO Molecular Function: |
-
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| GO Biological Process: |
-
|
| GO Cellular Component: |
-
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| PANTHER protein class: |
-
|
| References: | OMIM:176876 |
Sequence Association
| Panther Subfamily | Associated Sequence | Definition | Confidence Code | Evidence |
| PTHR46257:SF1 | Q7ZW17 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:1382983 |
| Q7ZW17 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:14525967 | |
| Q7ZW17 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:14534538 | |
| Q7ZW17 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:7681589 | |
| Q7ZW17 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:8096088 | |
| Q7ZW17 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:95163101 | |
| PTHR46257:SF4 | A0A3Q1M739 | Tyrosine-protein phosphatase non-receptor type | ISS | |
| F7CWQ1 | Tyrosine-protein phosphatase non-receptor type | ISS | ||
| I0FMS6 | Tyrosine-protein phosphatase non-receptor type | ISS | ||
| P29350 | Tyrosine-protein phosphatase non-receptor type 6 | ISS | ||
| P29351 | Tyrosine-protein phosphatase non-receptor type 6 | ISS | ||
| P81718 | Tyrosine-protein phosphatase non-receptor type 6 | ISS | ||
| PTHR46559:SF1 | A0A8I3PMT9 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:1382983 |
| A0A8I3PMT9 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:14525967 | |
| A0A8I3PMT9 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:14534538 | |
| A0A8I3PMT9 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:7681589 | |
| A0A8I3PMT9 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:8096088 | |
| A0A8I3PMT9 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:95163101 | |
| F1N339 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:1382983 | |
| F1N339 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:14525967 | |
| F1N339 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:14534538 | |
| F1N339 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:7681589 | |
| F1N339 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:8096088 | |
| F1N339 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:95163101 | |
| F6WVD2 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:1382983 | |
| F6WVD2 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:14525967 | |
| F6WVD2 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:14534538 | |
| F6WVD2 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:7681589 | |
| F6WVD2 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:8096088 | |
| F6WVD2 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:95163101 | |
| H2RIH8 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:1382983 | |
| H2RIH8 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:14525967 | |
| H2RIH8 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:14534538 | |
| H2RIH8 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:7681589 | |
| H2RIH8 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:8096088 | |
| H2RIH8 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:95163101 | |
| H9Z053 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:1382983 | |
| H9Z053 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:14525967 | |
| H9Z053 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:14534538 | |
| H9Z053 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:7681589 | |
| H9Z053 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:8096088 | |
| H9Z053 | Tyrosine-protein phosphatase non-receptor type | ISS | PubMed:95163101 | |
| P35235 | Tyrosine-protein phosphatase non-receptor type 11 | ISS | PubMed:14525967 | |
| P35235 | Tyrosine-protein phosphatase non-receptor type 11 | ISS | PubMed:14534538 | |
| P35235 | Tyrosine-protein phosphatase non-receptor type 11 | ISS | PubMed:8096088 | |
| P41499 | Tyrosine-protein phosphatase non-receptor type 11 | ISS | PubMed:1382983 | |
| P41499 | Tyrosine-protein phosphatase non-receptor type 11 | ISS | PubMed:14525967 | |
| Q90687 | Tyrosine-protein phosphatase non-receptor type 11 | ISS | PubMed:1382983 | |
| Q90687 | Tyrosine-protein phosphatase non-receptor type 11 | ISS | PubMed:14525967 | |
| Q90687 | Tyrosine-protein phosphatase non-receptor type 11 | ISS | PubMed:14534538 | |
| Q90687 | Tyrosine-protein phosphatase non-receptor type 11 | ISS | PubMed:7681589 | |
| Q90687 | Tyrosine-protein phosphatase non-receptor type 11 | ISS | PubMed:8096088 | |
| Q90687 | Tyrosine-protein phosphatase non-receptor type 11 | ISS | PubMed:95163101 |
