PANTHER Pathway  >   Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade >   Mitogen-activated protein kinase kinase

Pathway Component Details   
Name: Mitogen-activated protein kinase kinase (MEK)
Definition: MEK (MAPK kinase) is the focal point of many mitogenic signalling pathways, including insulin. MEK is activated in the cytosol by phosphorylation on two serines by Raf. Activated MEK subsequently phosphorylates ERK.
Category ID: P00891
Synonyms:
Upstream: Raf Oncogene  (Raf)
Downstream: Mitogen-activated protein kinase  (ERK)
Number Families/Subfamilies: 6
Number of Associated Sequences: 23
GO Molecular Function: -
GO Biological Process: -
GO Cellular Component: -
PANTHER protein class: -
References:

Sequence Association
Panther Subfamily Associated Sequence Definition Confidence Code Evidence
PTHR48013:SF11 Q7PRZ7 AGAP000310-PA IC  
PTHR48013:SF15 B1NA68 Dual specificity mitogen-activated protein kinase kinase 4 ISS PubMed:10207617  
  B1NA68 Dual specificity mitogen-activated protein kinase kinase 4 ISS PubMed:11730323  
  B1NA68 Dual specificity mitogen-activated protein kinase kinase 4 ISS PubMed:12040174  
  B1NA68 Dual specificity mitogen-activated protein kinase kinase 4 ISS PubMed:7716521  
  O61444 MAP kinase kinase 4, isoform A IC PubMed:11730323  
  O61444 MAP kinase kinase 4, isoform A IC PubMed:12040174  
  O61444 MAP kinase kinase 4, isoform A IC PubMed:7600581  
PTHR48013:SF21 A0A3Q1MNG1 Mitogen-activated protein kinase kinase 3 ISS PubMed:10207617  
  A0A3Q1MNG1 Mitogen-activated protein kinase kinase 3 ISS PubMed:11730323  
  A0A3Q1MNG1 Mitogen-activated protein kinase kinase 3 ISS PubMed:8900184  
  A0A6I8PHX7 Mitogen-activated protein kinase kinase 3 ISS PubMed:11730323  
  A0A6I8PHX7 Mitogen-activated protein kinase kinase 3 ISS PubMed:11971971  
  A0A6I8PHX7 Mitogen-activated protein kinase kinase 3 ISS PubMed:8900184  
  A0A6I8PHX7 Mitogen-activated protein kinase kinase 3 ISS PubMed:97059154  
  M0R7E7 Mitogen activated protein kinase kinase 3 ISS PubMed:10207617  
  M0R7E7 Mitogen activated protein kinase kinase 3 ISS PubMed:11730323  
  M0R7E7 Mitogen activated protein kinase kinase 3 ISS PubMed:8900184  
  O09110 Dual specificity mitogen-activated protein kinase kinase 3 IC PubMed:10207617  
  O09110 Dual specificity mitogen-activated protein kinase kinase 3 IC PubMed:11730323  
  O09110 Dual specificity mitogen-activated protein kinase kinase 3 IC PubMed:8900184  
  P46734 Dual specificity mitogen-activated protein kinase kinase 3 ISS PubMed:10207617  
  P46734 Dual specificity mitogen-activated protein kinase kinase 3 ISS PubMed:11730323  
  P46734 Dual specificity mitogen-activated protein kinase kinase 3 ISS PubMed:8900184  
PTHR48013:SF31 Q24324 Dual specificity mitogen-activated protein kinase kinase dSOR1 IC OMIM:176872  
PTHR48013:SF5 F6XT65 Mitogen-activated protein kinase kinase 1 ISS PubMed:10395662  
  F6XT65 Mitogen-activated protein kinase kinase 1 ISS PubMed:11238629  
  F6XT65 Mitogen-activated protein kinase kinase 1 ISS PubMed:11730323  
  F6XT65 Mitogen-activated protein kinase kinase 1 ISS PubMed:12876277  
  F6XT65 Mitogen-activated protein kinase kinase 1 ISS 13928886  
  F6XT65 Mitogen-activated protein kinase kinase 1 ISS PubMed:1411546  
  F6XT65 Mitogen-activated protein kinase kinase 1 ISS PubMed:1499729  
  F6XT65 Mitogen-activated protein kinase kinase 1 ISS OMIM:176872  
  F6XT65 Mitogen-activated protein kinase kinase 1 ISS PubMed:8039496  
  F6XT65 Mitogen-activated protein kinase kinase 1 ISS PubMed:8157000  
  F6XT65 Mitogen-activated protein kinase kinase 1 ISS PubMed:8388392  
  F6XT65 Mitogen-activated protein kinase kinase 1 ISS PubMed:8394352  
  F6XT65 Mitogen-activated protein kinase kinase 1 ISS PubMed:92362878  
  F6XT65 Mitogen-activated protein kinase kinase 1 ISS PubMed:93178455  
  F6XT65 Mitogen-activated protein kinase kinase 1 ISS PubMed:94313981  
  F7C389 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:10395662  
  F7C389 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:11238629  
  F7C389 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:11730323  
  F7C389 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:12876277  
  F7C389 Dual specificity mitogen-activated protein kinase kinase 1 ISS 13928886  
  F7C389 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:1411546  
  F7C389 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:1499729  
  F7C389 Dual specificity mitogen-activated protein kinase kinase 1 ISS OMIM:176872  
  F7C389 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:8039496  
  F7C389 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:8157000  
  F7C389 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:8388392  
  F7C389 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:8394352  
  F7C389 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:92362878  
  F7C389 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:93178455  
  P31938 Dual specificity mitogen-activated protein kinase kinase 1 IC PubMed:10395662  
  P31938 Dual specificity mitogen-activated protein kinase kinase 1 IC PubMed:11238629  
  P31938 Dual specificity mitogen-activated protein kinase kinase 1 IC PubMed:11730323  
  P31938 Dual specificity mitogen-activated protein kinase kinase 1 IC PubMed:12876277  
  P31938 Dual specificity mitogen-activated protein kinase kinase 1 IC 13928886  
  P31938 Dual specificity mitogen-activated protein kinase kinase 1 IC PubMed:1411546  
  P31938 Dual specificity mitogen-activated protein kinase kinase 1 IC PubMed:1499729  
  P31938 Dual specificity mitogen-activated protein kinase kinase 1 IC OMIM:176872  
  P31938 Dual specificity mitogen-activated protein kinase kinase 1 IC PubMed:8039496  
  P31938 Dual specificity mitogen-activated protein kinase kinase 1 IC PubMed:8388392  
  P31938 Dual specificity mitogen-activated protein kinase kinase 1 IC PubMed:92362878  
  P31938 Dual specificity mitogen-activated protein kinase kinase 1 IC PubMed:93178455  
  P31938 Dual specificity mitogen-activated protein kinase kinase 1 IC PubMed:94313981  
  Q01986 Dual specificity mitogen-activated protein kinase kinase 1 IC PubMed:10395662  
  Q01986 Dual specificity mitogen-activated protein kinase kinase 1 IC PubMed:11238629  
  Q01986 Dual specificity mitogen-activated protein kinase kinase 1 IC PubMed:11730323  
  Q01986 Dual specificity mitogen-activated protein kinase kinase 1 IC PubMed:12876277  
  Q01986 Dual specificity mitogen-activated protein kinase kinase 1 IC 13928886  
  Q01986 Dual specificity mitogen-activated protein kinase kinase 1 IC OMIM:176872  
  Q01986 Dual specificity mitogen-activated protein kinase kinase 1 IC PubMed:8039496  
  Q01986 Dual specificity mitogen-activated protein kinase kinase 1 IC PubMed:8157000  
  Q01986 Dual specificity mitogen-activated protein kinase kinase 1 IC PubMed:8388392  
  Q01986 Dual specificity mitogen-activated protein kinase kinase 1 IC PubMed:8394352  
  Q02750 Dual specificity mitogen-activated protein kinase kinase 1 IC PubMed:10395662  
  Q02750 Dual specificity mitogen-activated protein kinase kinase 1 IC PubMed:11238629  
  Q02750 Dual specificity mitogen-activated protein kinase kinase 1 IC PubMed:11730323  
  Q02750 Dual specificity mitogen-activated protein kinase kinase 1 IC OMIM:176872  
  Q02750 Dual specificity mitogen-activated protein kinase kinase 1 IC PubMed:8039496  
  Q02750 Dual specificity mitogen-activated protein kinase kinase 1 IC PubMed:8388392  
  Q02750 Dual specificity mitogen-activated protein kinase kinase 1 IC PubMed:93178455  
  Q0VD16 MAP2K1 protein ISS PubMed:10395662  
  Q0VD16 MAP2K1 protein ISS PubMed:11238629  
  Q0VD16 MAP2K1 protein ISS PubMed:11730323  
  Q0VD16 MAP2K1 protein ISS PubMed:12876277  
  Q0VD16 MAP2K1 protein ISS 13928886  
  Q0VD16 MAP2K1 protein ISS PubMed:1411546  
  Q0VD16 MAP2K1 protein ISS PubMed:1499729  
  Q0VD16 MAP2K1 protein ISS OMIM:176872  
  Q0VD16 MAP2K1 protein ISS PubMed:8039496  
  Q0VD16 MAP2K1 protein ISS PubMed:8157000  
  Q0VD16 MAP2K1 protein ISS PubMed:8388392  
  Q0VD16 MAP2K1 protein ISS PubMed:8394352  
  Q0VD16 MAP2K1 protein ISS PubMed:92362878  
  Q0VD16 MAP2K1 protein ISS PubMed:93178455  
  Q9XT09 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:10395662  
  Q9XT09 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:11238629  
  Q9XT09 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:11730323  
  Q9XT09 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:12876277  
  Q9XT09 Dual specificity mitogen-activated protein kinase kinase 1 ISS 13928886  
  Q9XT09 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:1499729  
  Q9XT09 Dual specificity mitogen-activated protein kinase kinase 1 ISS OMIM:176872  
  Q9XT09 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:8039496  
  Q9XT09 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:8388392  
  Q9XT09 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:92362878  
  Q9XT09 Dual specificity mitogen-activated protein kinase kinase 1 ISS PubMed:93178455  
PTHR48013:SF8 K7BYT0 Mitogen-activated protein kinase kinase 2 ISS PubMed:10395662  
  K7BYT0 Mitogen-activated protein kinase kinase 2 ISS PubMed:11238629  
  K7BYT0 Mitogen-activated protein kinase kinase 2 ISS PubMed:11730323  
  K7BYT0 Mitogen-activated protein kinase kinase 2 ISS OMIM:176872  
  K7BYT0 Mitogen-activated protein kinase kinase 2 ISS 18959214  
  K7BYT0 Mitogen-activated protein kinase kinase 2 ISS PubMed:8380494  
  K7BYT0 Mitogen-activated protein kinase kinase 2 ISS PubMed:8388392  
  K7BYT0 Mitogen-activated protein kinase kinase 2 ISS PubMed:8393135  
  K7BYT0 Mitogen-activated protein kinase kinase 2 ISS PubMed:9398267  
  K7BYT0 Mitogen-activated protein kinase kinase 2 ISS PubMed:98060792  
  P36506 Dual specificity mitogen-activated protein kinase kinase 2 IC PubMed:10395662  
  P36506 Dual specificity mitogen-activated protein kinase kinase 2 IC PubMed:11238629  
  P36506 Dual specificity mitogen-activated protein kinase kinase 2 IC PubMed:11730323  
  P36506 Dual specificity mitogen-activated protein kinase kinase 2 IC OMIM:176872  
  P36506 Dual specificity mitogen-activated protein kinase kinase 2 IC 18959214  
  P36506 Dual specificity mitogen-activated protein kinase kinase 2 IC PubMed:8380494  
  P36506 Dual specificity mitogen-activated protein kinase kinase 2 IC PubMed:8393135  
  P36507 Dual specificity mitogen-activated protein kinase kinase 2 IC PubMed:10395662  
  P36507 Dual specificity mitogen-activated protein kinase kinase 2 IC PubMed:11238629  
  P36507 Dual specificity mitogen-activated protein kinase kinase 2 IC PubMed:11730323  
  P36507 Dual specificity mitogen-activated protein kinase kinase 2 IC OMIM:176872  
  P36507 Dual specificity mitogen-activated protein kinase kinase 2 IC 18959214  
  P36507 Dual specificity mitogen-activated protein kinase kinase 2 IC PubMed:8380494  
  P36507 Dual specificity mitogen-activated protein kinase kinase 2 IC PubMed:8388392  
  P36507 Dual specificity mitogen-activated protein kinase kinase 2 IC PubMed:8393135  
  P36507 Dual specificity mitogen-activated protein kinase kinase 2 IC PubMed:98060792  
  Q1HG70 Dual specificity mitogen-activated protein kinase kinase 2 ISS PubMed:10395662  
  Q1HG70 Dual specificity mitogen-activated protein kinase kinase 2 ISS PubMed:11238629  
  Q1HG70 Dual specificity mitogen-activated protein kinase kinase 2 ISS PubMed:11730323  
  Q1HG70 Dual specificity mitogen-activated protein kinase kinase 2 ISS OMIM:176872  
  Q1HG70 Dual specificity mitogen-activated protein kinase kinase 2 ISS 18959214  
  Q1HG70 Dual specificity mitogen-activated protein kinase kinase 2 ISS PubMed:8380494  
  Q1HG70 Dual specificity mitogen-activated protein kinase kinase 2 ISS PubMed:8388392  
  Q1HG70 Dual specificity mitogen-activated protein kinase kinase 2 ISS PubMed:8393135  
  Q1HG70 Dual specificity mitogen-activated protein kinase kinase 2 ISS PubMed:9398267  
  Q1HG70 Dual specificity mitogen-activated protein kinase kinase 2 ISS PubMed:98060792  
  Q63932 Dual specificity mitogen-activated protein kinase kinase 2 IC PubMed:10395662  
  Q63932 Dual specificity mitogen-activated protein kinase kinase 2 IC PubMed:11238629  
  Q63932 Dual specificity mitogen-activated protein kinase kinase 2 IC PubMed:11730323  
  Q63932 Dual specificity mitogen-activated protein kinase kinase 2 IC OMIM:176872  
  Q63932 Dual specificity mitogen-activated protein kinase kinase 2 IC 18959214  
  Q63932 Dual specificity mitogen-activated protein kinase kinase 2 IC PubMed:8380494  
  Q63932 Dual specificity mitogen-activated protein kinase kinase 2 IC PubMed:8393135  
  Q63932 Dual specificity mitogen-activated protein kinase kinase 2 IC PubMed:98060792  
  Q90891 Dual specificity mitogen-activated protein kinase kinase 2 IC PubMed:10395662  
  Q90891 Dual specificity mitogen-activated protein kinase kinase 2 IC PubMed:11238629  
  Q90891 Dual specificity mitogen-activated protein kinase kinase 2 IC PubMed:11730323  
  Q90891 Dual specificity mitogen-activated protein kinase kinase 2 IC OMIM:176872  
  Q90891 Dual specificity mitogen-activated protein kinase kinase 2 IC PubMed:8380494  
  Q90891 Dual specificity mitogen-activated protein kinase kinase 2 IC PubMed:8388392  
  Q90891 Dual specificity mitogen-activated protein kinase kinase 2 IC PubMed:8393135  
  Q90891 Dual specificity mitogen-activated protein kinase kinase 2 IC PubMed:9398267  
  Q90891 Dual specificity mitogen-activated protein kinase kinase 2 IC PubMed:98060792