Pathway Component Details
| Name: | 3-phosphoinositide-dependent protein kinase 1 and 2 (PDK1/2) |
| Definition: | Phosphoinositide-dependent protein kinases 1/2 (PDK1/2) are allosterically regulated by PIP3, thereby transducing a signal from PI3K to downstream effectors. Activated PDK phosphorylates and activates protein kinase B. |
| Category ID: | P00903 |
| Synonyms: | |
| Upstream: | |
| Downstream: |
protein kinase B
(AKT)
|
| Number Families/Subfamilies: | 2 |
| Number of Associated Sequences: | 12 |
| GO Molecular Function: |
-
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| GO Biological Process: |
-
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| GO Cellular Component: |
-
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| PANTHER protein class: |
-
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| References: | OMIM:605213 |
Sequence Association
| Panther Subfamily | Associated Sequence | Definition | Confidence Code | Evidence |
| PTHR24356:SF163 | A0A2I3TN41 | 3-phosphoinositide-dependent protein kinase 1 | ISS | PubMed:11256888 |
| A0A2I3TN41 | 3-phosphoinositide-dependent protein kinase 1 | ISS | PubMed:12855688 | |
| A0A2I3TN41 | 3-phosphoinositide-dependent protein kinase 1 | ISS | PubMed:14585963 | |
| A0A2I3TN41 | 3-phosphoinositide-dependent protein kinase 1 | ISS | PubMed:15210700 | |
| A0A2I3TN41 | 3-phosphoinositide-dependent protein kinase 1 | ISS | PubMed:15531926 | |
| A0A2I3TN41 | 3-phosphoinositide-dependent protein kinase 1 | ISS | 4505695 | |
| A0A2I3TN41 | 3-phosphoinositide-dependent protein kinase 1 | ISS | PubMed:9094314 | |
| A0A2I3TN41 | 3-phosphoinositide-dependent protein kinase 1 | ISS | PubMed:9368760 | |
| A0A2I3TN41 | 3-phosphoinositide-dependent protein kinase 1 | ISS | PubMed:9445477 | |
| A0A2I3TN41 | 3-phosphoinositide-dependent protein kinase 1 | ISS | PubMed:97250749 | |
| A0A8J8XIM6 | non-specific serine_threonine protein kinase | ISS | 4505695 | |
| A0A8V0Z6Y0 | 3-phosphoinositide-dependent protein kinase 1 | ISS | PubMed:14585963 | |
| A0A8V0Z6Y0 | 3-phosphoinositide-dependent protein kinase 1 | ISS | PubMed:15210700 | |
| A0A8V0Z6Y0 | 3-phosphoinositide-dependent protein kinase 1 | ISS | PubMed:9094314 | |
| A0A8V0Z6Y0 | 3-phosphoinositide-dependent protein kinase 1 | ISS | PubMed:9368760 | |
| A0A8V0Z6Y0 | 3-phosphoinositide-dependent protein kinase 1 | ISS | PubMed:97250749 | |
| O15530 | 3-phosphoinositide-dependent protein kinase 1 | TAS | PubMed:14585963 | |
| O15530 | 3-phosphoinositide-dependent protein kinase 1 | TAS | PubMed:15210700 | |
| O15530 | 3-phosphoinositide-dependent protein kinase 1 | TAS | PubMed:9094314 | |
| O15530 | 3-phosphoinositide-dependent protein kinase 1 | TAS | PubMed:9368760 | |
| O15530 | 3-phosphoinositide-dependent protein kinase 1 | TAS | PubMed:9445477 | |
| O15530 | 3-phosphoinositide-dependent protein kinase 1 | TAS | PubMed:97250749 | |
| O55173 | 3-phosphoinositide-dependent protein kinase 1 | ISS | PubMed:11256888 | |
| O55173 | 3-phosphoinositide-dependent protein kinase 1 | ISS | PubMed:14585963 | |
| O55173 | 3-phosphoinositide-dependent protein kinase 1 | ISS | 4505695 | |
| O55173 | 3-phosphoinositide-dependent protein kinase 1 | ISS | PubMed:9368760 | |
| O55173 | 3-phosphoinositide-dependent protein kinase 1 | ISS | PubMed:9445477 | |
| O55173 | 3-phosphoinositide-dependent protein kinase 1 | ISS | PubMed:97250749 | |
| Q03407 | Serine_threonine-protein kinase PKH1 | ISS | 4505695 | |
| Q12236 | Serine_threonine-protein kinase PKH2 | ISS | 4505695 | |
| Q12701 | Serine_threonine-protein kinase ksg1 | ISS | 4505695 | |
| Q9W0V1 | 3-phosphoinositide-dependent protein kinase 1 | ISS | 4505695 | |
| Q9XF67 | 3-phosphoinositide-dependent protein kinase 1 | ISS | 4505695 | |
| Q9Z2A0 | 3-phosphoinositide-dependent protein kinase 1 | ISS | PubMed:11256888 | |
| Q9Z2A0 | 3-phosphoinositide-dependent protein kinase 1 | ISS | PubMed:12855688 | |
| Q9Z2A0 | 3-phosphoinositide-dependent protein kinase 1 | ISS | PubMed:14585963 | |
| Q9Z2A0 | 3-phosphoinositide-dependent protein kinase 1 | ISS | PubMed:15531926 | |
| Q9Z2A0 | 3-phosphoinositide-dependent protein kinase 1 | ISS | 4505695 | |
| Q9Z2A0 | 3-phosphoinositide-dependent protein kinase 1 | ISS | PubMed:9368760 | |
| Q9Z2A0 | 3-phosphoinositide-dependent protein kinase 1 | ISS | PubMed:9445477 | |
| PTHR24356:SF405 | Q03306 | Serine_threonine-protein kinase PKH3 | ISS |
